Harvard Catalyst Profiles

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Michael Nicolo Lombardo, Ph.D., Pharm.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Krucinska J, Lombardo MN, Erlandsen H, Estrada A, Si D, Viswanathan K, Wright DL. Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens. Commun Biol. 2022 05 13; 5(1):459. PMID: 35562546; PMCID: PMC9106665.
    Citations:    Translation:Cells
  2. Krucinska J, Lombardo MN, Erlandsen H, Hazeen A, Duay SS, Pattis JG, Robinson VL, May ER, Wright DL. Functional and structural basis of E. coli enolase inhibition by SF2312: a mimic of the carbanion intermediate. Sci Rep. 2019 11 19; 9(1):17106. PMID: 31745118.
    Citations: 3     Fields:    Translation:HumansCells
  3. Lombardo MN, G-Dayanandan N, Keshipeddy S, Zhou W, Si D, Reeve SM, Alverson J, Barney P, Walker L, Hoody J, Priestley ND, Obach RS, Wright DL. Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates. Drug Metab Dispos. 2019 09; 47(9):995-1003. PMID: 31201212; PMCID: PMC7184189.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Krucinska J, Falcone E, Erlandsen H, Hazeen A, Lombardo MN, Estrada A, Robinson VL, Anderson AC, Wright DL. Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens. Biochemistry. 2019 03 05; 58(9):1188-1197. PMID: 30714720; PMCID: PMC6511404.
    Citations: 4     Fields:    Translation:Cells
  5. Carey PR, Whitmer GR, Yoon MJ, Lombardo MN, Pusztai-Carey M, Heidari-Torkabadi H, Che T. Measuring Drug-Induced Changes in Metabolite Populations of Live Bacteria: Real Time Analysis by Raman Spectroscopy. J Phys Chem B. 2018 06 21; 122(24):6377-6385. PMID: 29792435.
    Citations: 2     Fields:    Translation:Cells
  6. Scocchera E, Reeve SM, Keshipeddy S, Lombardo MN, Hajian B, Sochia AE, Alverson JB, Priestley ND, Anderson AC, Wright DL. Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens. ACS Med Chem Lett. 2016 Jul 14; 7(7):692-6. PMID: 27437079; PMCID: PMC4948012.
    Citations: 14     
  7. Lombardo MN, G-Dayanandan N, Wright DL, Anderson AC. Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates. ACS Infect Dis. 2016 02 12; 2(2):149-56. PMID: 27624966; PMCID: PMC5108240.
    Citations: 14     Fields:    Translation:HumansCells
  8. Reeve SM, Lombardo MN, Anderson AC. Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery. Future Microbiol. 2015; 10(11):1727-33. PMID: 26516790.
    Citations: 1     Fields:    Translation:HumansCells
  9. Heidari-Torkabadi H, Che T, Lombardo MN, Wright DL, Anderson AC, Carey PR. Measuring propargyl-linked drug populations inside bacterial cells, and their interaction with a dihydrofolate reductase target, by Raman microscopy. Biochemistry. 2015 May 05; 54(17):2719-26. PMID: 25871808.
    Citations: 4     Fields:    Translation:Cells
  10. Lamb KM, Lombardo MN, Alverson J, Priestley ND, Wright DL, Anderson AC. Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity. Antimicrob Agents Chemother. 2014 Dec; 58(12):7484-91. PMID: 25288083.
    Citations: 13     Fields:    Translation:Cells
  11. G-Dayanandan N, Paulsen JL, Viswanathan K, Keshipeddy S, Lombardo MN, Zhou W, Lamb KM, Sochia AE, Alverson JB, Priestley ND, Wright DL, Anderson AC. Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata. J Med Chem. 2014 Mar 27; 57(6):2643-56. PMID: 24568657.
    Citations: 8     Fields:    Translation:AnimalsCells
  12. Frey KM, Lombardo MN, Wright DL, Anderson AC. Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase. J Struct Biol. 2010 Apr; 170(1):93-7. PMID: 20026215.
    Citations: 30     Fields:    Translation:Cells
  13. Frey KM, Liu J, Lombardo MN, Bolstad DB, Wright DL, Anderson AC. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J Mol Biol. 2009 Apr 17; 387(5):1298-308. PMID: 19249312; PMCID: PMC2723953.
    Citations: 30     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.