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Vedagopuram Sreekanth, Ph.D.

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Biography
Regional Centre for Biotechnology, Faridabad, IndiaPh.D.2018Biomedical Sciences/Biotechnology
National Institute of Pharmaceutical Education and Research, Kolkata, IndiaM.S. (Pharm.)2010Medicinal Chemistry
Kakatiya University, Warangal, IndiaB.Pharmacy2008Pharmaceutical Sciences

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Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lim, D., Sreekanth, V. & Choudhary, A. Identifying Anti-CRISPR Small Molecules via High-throughput Assay. Protoc. Exch. 2022. View Publication.
  2. Lim D, Zhou Q, Cox KJ, Law BK, Lee M, Kokkonda P, Sreekanth V, Pergu R, Chaudhary SK, Gangopadhyay SA, Maji B, Lai S, Amako Y, Thompson DB, Subramanian HKK, Mesleh MF, Dancík V, Clemons PA, Wagner BK, Woo CM, Church GM, Choudhary A. A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules. Nat Cell Biol. 2022 Nov 17. PMID: 36396978.
    Citations:    Fields:    
  3. Modell AE, Lim D, Nguyen TM, Sreekanth V, Choudhary A. CRISPR-based therapeutics: current challenges and future applications. Trends Pharmacol Sci. 2022 02; 43(2):151-161. PMID: 34952739.
    Citations: 2     Fields:    Translation:Humans
  4. Nyugen T, Deb A, Kokkonda P, Sreekanth V, Tiwari PK, Shoba V, Lai S, Chaudhary SK, Mercer J, Jan M, Ebert BL, Liu DR, Choudhary A. . Proteolysis Targeting Chimeras With Reduced Off-targets. Biorxiv. 2021. View Publication.
  5. Choudhary A, Lim D, Ebert B, Jan M, Sreekanth V. Zinc finger degradation domains. 2021. View Publication.
  6. Sreekanth V, Pal S, Kumar S, Komalla V, Yadav P, Shyam R, Sengupta S, Bajaj A. Self-assembled supramolecular nanomicelles from a bile acid-docetaxel conjugate are highly tolerable with improved therapeutic efficacy. Biomater Sci. 2021 Aug 21; 9(16):5626-5639. PMID: 34254078.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Sreekanth V, Kar A, Kumar S, Pal S, Yadav P, Sharma Y, Komalla V, Sharma H, Shyam R, Sharma RD, Mukhopadhyay A, Sengupta S, Dasgupta U, Bajaj A. Bile Acid Tethered Docetaxel-Based Nanomicelles Mitigate Tumor Progression through Epigenetic Changes. Angew Chem Int Ed Engl. 2021 03 01; 60(10):5394-5399. PMID: 33258265.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Yang K, Lee M, Jones PA, Liu SS, Zhou A, Xu J, Sreekanth V, Wu JLY, Vo L, Lee EA, Pop R, Lee Y, Wagner BK, Melton DA, Choudhary A, Karp JM. A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of ß cells. Sci Adv. 2020 11; 6(47). PMID: 33208361; PMCID: PMC7673808.
    Citations: 7     Fields:    Translation:Humans
  9. Sreekanth V, Zhou Q, Kokkonda P, Bermudez-Cabrera HC, Lim D, Law BK, Holmes BR, Chaudhary SK, Pergu R, Leger BS, Walker JA, Gifford DK, Sherwood RI, Choudhary A. Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes. ACS Cent Sci. 2020 Dec 23; 6(12):2228-2237. PMID: 33376784.
    Citations: 3     
  10. Choudhary A, Sreekanth V, Lim D. Methods and compositions for cell therapy. 2020. View Publication.
  11. Choudhary A, Sreekanth V, Shoba V. Novel nucleic acid modifiers. 2020. View Publication.
  12. Lim D, Sreekanth V, Cox KJ, Law BK, Wagner BK, Karp JM, Choudhary A. Engineering designer beta cells with a CRISPR-Cas9 conjugation platform. Nat Commun. 2020 08 13; 11(1):4043. PMID: 32792475.
    Citations: 13     Fields:    Translation:HumansCells
  13. Lim D, Sreekanth V, Cox KJ, Law B, Wagner BK, Karp JM, Choudhary A. . A conjugation platform for CRISPR-Cas9 allows efficient ß-cell engineering. Biorxiv. 2019. View Publication.
  14. Sreekanth V, Bajaj A. Recent Advances in Engineering of Lipid Drug Conjugates for Cancer Therapy. ACS Biomater Sci Eng. 2019 Sep 09; 5(9):4148-4166. PMID: 33417775.
    Citations: 4     Fields:    
  15. Bajaj A, Sengupta S, Sreekanth V, Kumar S. . Conjugated anti-proliferative drug nanoparticles and process for preparation thereof. 2017. View Publication.
  16. Sreekanth V, Medatwal N, Kumar S, Pal S, Vamshikrishna M, Kar A, Bhargava P, Naaz A, Kumar N, Sengupta S, Bajaj A. Tethering of Chemotherapeutic Drug/Imaging Agent to Bile Acid-Phospholipid Increases the Efficacy and Bioavailability with Reduced Hepatotoxicity. Bioconjug Chem. 2017 Dec 20; 28(12):2942-2953. PMID: 29083862.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  17. Hussain T, Saha D, Purohit G, Kar A, Kishore Mukherjee A, Sharma S, Sengupta S, Dhapola P, Maji B, Vedagopuram S, Horikoshi NT, Horikoshi N, Pandita RK, Bhattacharya S, Bajaj A, Riou JF, Pandita TK, Chowdhury S. Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex. Sci Rep. 2017 09 14; 7(1):11541. PMID: 28912501; PMCID: PMC5599563.
    Citations: 27     Fields:    Translation:HumansCells
  18. Sreekanth V, Medatwal N, Pal S, Kumar S, Sengupta S, Bajaj A. Molecular Self-Assembly of Bile Acid-Phospholipids Controls the Delivery of Doxorubicin and Mice Survivability. Mol Pharm. 2017 08 07; 14(8):2649-2659. PMID: 28665132.
    Citations: 1     Fields:    Translation:Animals
  19. Kumar S, Bhargava P, Sreekanth V, Bajaj A. Design, synthesis, and physico-chemical interactions of bile acid derived dimeric phospholipid amphiphiles with model membranes. J Colloid Interface Sci. 2015 Jun 15; 448:398-406. PMID: 25746193.
    Citations: 1     Fields:    Translation:Cells
  20. Yadav K, Bhargava P, Bansal S, Singh M, Gupta S, Sandhu G, Kumar S, Sreekanth V, Bajaj A. Nature of the charged head group dictates the anticancer potential of lithocholic acid-tamoxifen conjugates for breast cancer therapy. MedChemComm. 2015; 6:778-787. View Publication.
  21. Singh M, Kundu S, Reddy M A, Sreekanth V, Motiani RK, Sengupta S, Srivastava A, Bajaj A. Injectable small molecule hydrogel as a potential nanocarrier for localized and sustained in vivo delivery of doxorubicin. Nanoscale. 2014 Nov 07; 6(21):12849-55. PMID: 25227567.
    Citations: 15     Fields:    Translation:AnimalsCells
  22. Singh M, Bansal S, Kundu S, Bhargava P, Singh A, Motiani RK, Shyam R, Sreekanth V, Sengupta S, Bajaj A. Synthesis, Structure-Activity Relationship, and Mechanistic Investigation of Lithocholic Acid Amphiphiles for Colon Cancer Therapy. Medchemcomm. 2015 Jan; 6(1):192-201. PMID: 25685308; PMCID: PMC4322782.
    Citations: 5     
  23. Singh K, Verma V, Yadav K, Sreekanth V, Kumar D, Bajaj A, Kumar V. Design, regioselective synthesis and cytotoxic evaluation of 2-aminoimidazole-quinoline hybrids against cancer and primary endothelial cells. Eur J Med Chem. 2014 Nov 24; 87:150-8. PMID: 25247771.
    Citations: 5     Fields:    Translation:HumansCells
  24. Bansal S, Singh M, Kidwai S, Bhargava P, Singh A, Sreekanth V, Singh R, Bajaj A. Bile acid amphiphiles with tunable head groups as highly selective antitubercular agents. MedChemComm. 2014; (5):1761-1768. View Publication.
  25. Bhargava P, Singh M, Sreekanth V, Bajaj A. Nature of the charged headgroup determines the fusogenic potential and membrane properties of lithocholic acid phospholipids. J Phys Chem B. 2014 Aug 07; 118(31):9341-8. PMID: 25029367.
    Citations:    Fields:    Translation:Cells
  26. Sreekanth V, Bajaj A. Number of free hydroxyl groups on bile acid phospholipids determines the fluidity and hydration of model membranes. J Phys Chem B. 2013 Oct 10; 117(40):12135-44. PMID: 24079709.
    Citations:    Fields:    Translation:Cells
  27. Sreekanth V, Bansal S, Motiani RK, Kundu S, Muppu SK, Majumdar TD, Panjamurthy K, Sengupta S, Bajaj A. Design, synthesis, and mechanistic investigations of bile acid-tamoxifen conjugates for breast cancer therapy. Bioconjug Chem. 2013 Sep 18; 24(9):1468-84. PMID: 23909664.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  28. Sreekanth V, Bajaj A. Fluorescence (fluidity/hydration) and calorimetric studies of interactions of bile acid-drug conjugates with model membranes. J Phys Chem B. 2013 Feb 21; 117(7):2123-33. PMID: 23383746.
    Citations: 1     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.