Harvard Catalyst Profiles

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Li Lan, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM118833 (LAN, LI) Jun 1, 2016 - May 31, 2021
    Transcription-Coupled Homologous Recombination upon DNA Damage
    Role: Principal Investigator
  2. R21AG045545 (LAN, LI) Jul 1, 2013 - Jun 30, 2016
    Oxidative DNA base damage and repair at telomeres and the relevance to cell senes
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhou X, Xu X, Lu D, Chen K, Wu Y, Yang X, Xiong W, Chen X, Lan L, Li W, Shen S, He W, Feng X. Repeated early-life exposure to anaesthesia and surgery causes subsequent anxiety-like behaviour and gut microbiota dysbiosis in juvenile rats. Br J Anaesth. 2022 Sep 07. PMID: 36088134.
    Citations:    Fields:    
  2. Li L, Lan LY, Huang L, Ye C, Andrade J, Wilson PC. Selecting Representative Samples From Complex Biological Datasets Using K-Medoids Clustering. Front Genet. 2022; 13:954024. PMID: 35910222; PMCID: PMC9335369.
  3. Yang H, Wang Y, Xiang Y, Yadav T, Ouyang J, Phoon L, Zhu X, Shi Y, Zou L, Lan L. FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation. Proc Natl Acad Sci U S A. 2022 03 22; 119(12):e2116251119. PMID: 35290126; PMCID: PMC8944906.
    Citations: 2     Fields:    Translation:HumansCells
  4. Hopkins JL, Lan L, Zou L. DNA repair defects in cancer and therapeutic opportunities. Genes Dev. 2022 03 01; 36(5-6):278-293. PMID: 35318271; PMCID: PMC8973847.
    Citations:    Fields:    Translation:HumansCells
  5. Yang H, Lan L. Immunostaining and Protein Pull-Down of Methyl-5-Cytosine-Marked RNA:DNA Hybrids. Methods Mol Biol. 2022; 2528:271-276. PMID: 35704197.
    Citations:    Fields:    
  6. Guthmiller JJ, Han J, Utset HA, Li L, Lan LY, Henry C, Stamper CT, McMahon M, O'Dell G, Fernández-Quintero ML, Freyn AW, Amanat F, Stovicek O, Gentles L, Richey ST, de la Peña AT, Rosado V, Dugan HL, Zheng NY, Tepora ME, Bitar DJ, Changrob S, Strohmeier S, Huang M, García-Sastre A, Liedl KR, Bloom JD, Nachbagauer R, Palese P, Krammer F, Coughlan L, Ward AB, Wilson PC. Broadly neutralizing antibodies target a haemagglutinin anchor epitope. Nature. 2022 02; 602(7896):314-320. PMID: 34942633; PMCID: PMC8828479.
    Citations: 7     Fields:    Translation:HumansCells
  7. Li L, Dugan HL, Stamper CT, Lan LY, Asby NW, Knight M, Stovicek O, Zheng NY, Madariaga ML, Shanmugarajah K, Jansen MO, Changrob S, Utset HA, Henry C, Nelson C, Jedrzejczak RP, Fremont DH, Joachimiak A, Krammer F, Huang J, Khan AA, Wilson PC. Improved integration of single-cell transcriptome and surface protein expression by LinQ-View. Cell Rep Methods. 2021 Aug 23; 1(4):100056. PMID: 35475142; PMCID: PMC9017149.
  8. Vijay R, Guthmiller JJ, Sturtz AJ, Crooks S, Johnson JT, Li L, Lan LY, Pope RL, Chen Y, Rogers KJ, Dutta N, Toombs JE, Wilson ME, Wilson PC, Maury W, Brekken RA, Butler NS. Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiation. J Exp Med. 2021 06 07; 218(6). PMID: 33830176.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  9. Ouyang J, Yadav T, Zhang JM, Yang H, Rheinbay E, Guo H, Haber DA, Lan L, Zou L. RNA transcripts stimulate homologous recombination by forming DR-loops. Nature. 2021 06; 594(7862):283-288. PMID: 33981036; PMCID: PMC8855348.
    Citations: 24     Fields:    Translation:HumansCells
  10. Zhu X, Wang X, Yan W, Yang H, Xiang Y, Lv F, Shi Y, Li HY, Lan L. Ubiquitination-mediated degradation of TRDMT1 regulates homologous recombination and therapeutic response. NAR Cancer. 2021 Mar; 3(1):zcab010. PMID: 33778494.
    Citations: 3     
  11. Surette FA, Guthmiller JJ, Li L, Sturtz AJ, Vijay R, Pope RL, McClellan BL, Pack AD, Zander RA, Shao P, Lan LY, Fernandez-Ruiz D, Heath WR, Wilson PC, Butler NS. Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity. PLoS Pathog. 2021 02; 17(2):e1009288. PMID: 33529242.
    Citations: 1     Fields:    Translation:AnimalsCells
  12. Zhang JM, Genois MM, Ouyang J, Lan L, Zou L. Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies. Mol Cell. 2021 03 04; 81(5):1027-1042.e4. PMID: 33453166; PMCID: PMC8245000.
    Citations: 16     Fields:    Translation:HumansCells
  13. Dugan HL, Guthmiller JJ, Arevalo P, Huang M, Chen YQ, Neu KE, Henry C, Zheng NY, Lan LY, Tepora ME, Stovicek O, Bitar D, Palm AE, Stamper CT, Changrob S, Utset HA, Coughlan L, Krammer F, Cobey S, Wilson PC. Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans. Sci Transl Med. 2020 12 09; 12(573). PMID: 33298562.
    Citations: 23     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  14. Guthmiller JJ, Lan LY, Fernández-Quintero ML, Han J, Utset HA, Bitar DJ, Hamel NJ, Stovicek O, Li L, Tepora M, Henry C, Neu KE, Dugan HL, Borowska MT, Chen YQ, Liu STH, Stamper CT, Zheng NY, Huang M, Palm AE, García-Sastre A, Nachbagauer R, Palese P, Coughlan L, Krammer F, Ward AB, Liedl KR, Wilson PC. Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses. Immunity. 2020 12 15; 53(6):1230-1244.e5. PMID: 33096040.
    Citations: 21     Fields:    Translation:HumansCells
  15. Chen H, Chen H, Zhang J, Wang Y, Simoneau A, Yang H, Levine AS, Zou L, Chen Z, Lan L. cGAS suppresses genomic instability as a decelerator of replication forks. Sci Adv. 2020 10; 6(42). PMID: 33055160; PMCID: PMC7556829.
    Citations: 32     Fields:    
  16. Tan J, Wang X, Hwang BJ, Gonzales R, Konen O, Lan L, Lu AL. An ordered assembly of MYH glycosylase, SIRT6 protein deacetylase, and Rad9-Rad1-Hus1 checkpoint clamp at oxidatively damaged telomeres. Aging (Albany NY). 2020 Sep 29; 12(18):17761-17785. PMID: 32991318.
    Citations: 6     Fields:    
  17. Tan J, Lan L. The DNA secondary structures at telomeres and genome instability. Cell Biosci. 2020; 10:47. PMID: 32257105; PMCID: PMC7104500.
    Citations: 11     
  18. Tan J, Duan M, Yadav T, Phoon L, Wang X, Zhang JM, Zou L, Lan L. An R-loop-initiated CSB-RAD52-POLD3 pathway suppresses ROS-induced telomeric DNA breaks. Nucleic Acids Res. 2020 02 20; 48(3):1285-1300. PMID: 31777915; PMCID: PMC7026659.
    Citations: 25     Fields:    Translation:HumansCells
  19. Tan J, Wang X, Phoon L, Yang H, Lan L. Resolution of ROS-induced G-quadruplexes and R-loops at transcriptionally active sites is dependent on BLM helicase. FEBS Lett. 2020 05; 594(9):1359-1367. PMID: 31977077.
    Citations: 9     Fields:    Translation:HumansCells
  20. Bernstein DI, Guptill J, Naficy A, Nachbagauer R, Berlanda-Scorza F, Feser J, Wilson PC, Solórzano A, Van der Wielen M, Walter EB, Albrecht RA, Buschle KN, Chen YQ, Claeys C, Dickey M, Dugan HL, Ermler ME, Freeman D, Gao M, Gast C, Guthmiller JJ, Hai R, Henry C, Lan LY, McNeal M, Palm AE, Shaw DG, Stamper CT, Sun W, Sutton V, Tepora ME, Wahid R, Wenzel H, Wohlbold TJ, Innis BL, García-Sastre A, Palese P, Krammer F. Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial. Lancet Infect Dis. 2020 01; 20(1):80-91. PMID: 31630990; PMCID: PMC6928577.
    Citations: 51     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
  21. Chen YQ, Lan LY, Huang M, Henry C, Wilson PC. Hemagglutinin Stalk-Reactive Antibodies Interfere with Influenza Virus Neuraminidase Activity by Steric Hindrance. J Virol. 2019 02 15; 93(4). PMID: 30518651.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  22. Zhang JM, Yadav T, Ouyang J, Lan L, Zou L. Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways. Cell Rep. 2019 01 22; 26(4):955-968.e3. PMID: 30673617.
    Citations: 86     Fields:    Translation:HumansCells
  23. Guthmiller JJ, Dugan HL, Neu KE, Lan LY, Wilson PC. An Efficient Method to Generate Monoclonal Antibodies from Human B Cells. Methods Mol Biol. 2019; 1904:109-145. PMID: 30539468.
    Citations: 15     Fields:    Translation:HumansCells
  24. Moquin DM, Genois MM, Zhang JM, Ouyang J, Yadav T, Buisson R, Yazinski SA, Tan J, Boukhali M, Gagné JP, Poirier GG, Lan L, Haas W, Zou L. Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. Genes Dev. 2019 01 01; 33(1-2):75-89. PMID: 30567999; PMCID: PMC6317314.
    Citations: 8     Fields:    Translation:HumansCells
  25. Chen YQ, Wohlbold TJ, Zheng NY, Huang M, Huang Y, Neu KE, Lee J, Wan H, Rojas KT, Kirkpatrick E, Henry C, Palm AE, Stamper CT, Lan LY, Topham DJ, Treanor J, Wrammert J, Ahmed R, Eichelberger MC, Georgiou G, Krammer F, Wilson PC. Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies. Cell. 2018 04 05; 173(2):417-429.e10. PMID: 29625056.
    Citations: 160     Fields:    Translation:HumansAnimalsCells
  26. Ouyang J, Lan L, Zou L. Regulation of DNA break repair by transcription and RNA. Sci China Life Sci. 2017 Oct; 60(10):1081-1086. PMID: 29075944.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  27. Lau D, Lan LY, Andrews SF, Henry C, Rojas KT, Neu KE, Huang M, Huang Y, DeKosky B, Palm AE, Ippolito GC, Georgiou G, Wilson PC. Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation. Sci Immunol. 2017 Jan 27; 2(7). PMID: 28783670.
    Citations: 89     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.