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Chongzhao Ran, PH.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AG059134 (RAN, CHONGZHAO) Aug 15, 2018 - May 31, 2020
    Near infrared Fluorescence Ocular Imaging of Soluble Amyloid Beta Species
    Role: Principal Investigator
  2. R01AG055413 (RAN, CHONGZHAO) Jan 1, 2018 - Dec 31, 2022
    Near infrared fluorescence imaging of reactive oxygen species in Alzheimer's disease
    Role: Principal Investigator
  3. R56DK108813 (RAN, CHONGZHAO) Sep 22, 2016 - Aug 31, 2018
    Imaging brown adipose tissue and monitoring browning
    Role: Principal Investigator
  4. R03AG050038 (RAN, CHONGZHAO) Sep 1, 2015 - Apr 30, 2017
    Near-infrared molecular imaging for monitoring therapy in AD mouse models
    Role: Principal Investigator
  5. R21AG050158 (RAN, CHONGZHAO) Sep 1, 2015 - Mar 31, 2017
    Double-blocking Anti-crosslinking Strategy for AD Drug Development
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wang L, Yang J, Wang H, Ran C, Su Y, Zhao L. A Highly Selective Turn-on Fluorescent Probe for the Detection of Aluminum and Its Application to Bio-Imaging. Sensors (Basel). 2019 May 28; 19(11). PMID: 31141876.
  2. Yang J, Cheng R, Fu H, Yang J, Kumar M, Lu J, Xu Y, Liang SH, Cui M, Ran C. Half-curcumin analogues as PET imaging probes for amyloid beta species. Chem Commun (Camb). 2019 Mar 21; 55(25):3630-3633. PMID: 30849141.
  3. Li B, Ohtomo R, Thunemann M, Adams SR, Yang J, Fu B, Yaseen MA, Ran C, Polimeni JR, Boas DA, Devor A, Lo EH, Arai K, Sakadžic S. Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion. J Cereb Blood Flow Metab. 2019 Mar 04; 271678X19831016. PMID: 30829101.
  4. Zeng Y, Li B, Liang Y, Reeves PM, Qu X, Ran C, Liu Q, Callahan MV, Sluder AE, Gelfand JA, Chen H, Poznansky MC. Dual blockade of CXCL12-CXCR4 and PD-1-PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunosuppression in the tumor microenvironment. FASEB J. 2019 May; 33(5):6596-6608. PMID: 30802149.
  5. Yang J, Yang J, Li Y, Xu Y, Ran C. Near-infrared Fluorescence Ocular Imaging (NIRFOI) of Alzheimer's Disease. Mol Imaging Biol. 2019 02; 21(1):35-43. PMID: 29802553.
    Citations:    Fields:    
  6. Verwer EE, Kavanagh TR, Mischler WJ, Feng Y, Takahashi K, Wang S, Shoup TM, Neelamegam R, Yang J, Guehl NJ, Ran C, Massefski W, Cui Y, El-Chemaly S, Sadow PM, Oldham WM, Kijewski MF, El Fakhri G, Normandin MD, Priolo C. [18F]Fluorocholine and [18F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM. Clin Cancer Res. 2018 Dec 01; 24(23):5925-5938. PMID: 30054282.
    Citations:    Fields:    
  7. Zhou Y, Lu J, Ran C, Zhang J. Recent Advances in Quantitative Nuclear Medicine and Molecular Imaging. Contrast Media Mol Imaging. 2018; 2018:3613156. PMID: 30046294.
    Citations:    Fields:    
  8. Cao WH, Li MH, Pan CQ, Lu Y, Zhang L, Ran CP, Wu SL, Hua WH, Liu SA, Shen G, Chang M, Liu RY, Hao HX, Hu LP, Xie Y. Quantitation of Plasmacytoid Dendritic Cells in Chronic Hepatitis B Patients with HBeAg Positivity During PEG-IFN and Entecavir Therapy. J Interferon Cytokine Res. 2018 May; 38(5):197-205. PMID: 29791282.
    Citations:    Fields:    
  9. Ran C, Albrecht DS, Bredella MA, Yang J, Yang J, Liang SH, Cypess AM, Loggia ML, Atassi N, Moore A. PET Imaging of Human Brown Adipose Tissue with the TSPO Tracer [11C]PBR28. Mol Imaging Biol. 2018 04; 20(2):188-193. PMID: 28983743.
    Citations: 1     Fields:    Translation:Humans
  10. Li B, Zeng Y, Reeves PM, Ran C, Liu Q, Qu X, Liang Y, Liu Z, Yuan J, Leblanc PR, Ye Z, Sluder AE, Gelfand JA, Brauns TA, Chen H, Poznansky MC. AMD3100 Augments the Efficacy of Mesothelin-Targeted, Immune-Activating VIC-008 in Mesothelioma by Modulating Intratumoral Immunosuppression. Cancer Immunol Res. 2018 05; 6(5):539-551. PMID: 29511032.
    Citations: 3     Fields:    
  11. Panagia M, Chen HH, Croteau D, Iris Chen YC, Ran C, Luptak I, Josephson L, Colucci WS, Sosnovik DE. Multiplexed Optical Imaging of Energy Substrates Reveals That Left Ventricular Hypertrophy Is Associated With Brown Adipose Tissue Activation. Circ Cardiovasc Imaging. 2018 Mar; 11(3):e007007. PMID: 29555834.
    Citations: 1     Fields:    
  12. Krishnan HS, Bernard-Gauthier V, Placzek MS, Dahl K, Narayanaswami V, Livni E, Chen Z, Yang J, Collier TL, Ran C, Hooker JM, Liang SH, Vasdev N. Metal Protein-Attenuating Compound for PET Neuroimaging: Synthesis and Preclinical Evaluation of [11C]PBT2. Mol Pharm. 2018 02 05; 15(2):695-702. PMID: 29298483.
    Citations:    Fields:    
  13. Zhang C, Griciuc A, Hudry E, Wan Y, Quinti L, Ward J, Forte AM, Shen X, Ran C, Elmaleh DR, Tanzi RE. Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid ß-Protein by Promoting Microglial Phagocytosis. Sci Rep. 2018 01 18; 8(1):1144. PMID: 29348604.
    Citations:    Fields:    Translation:HumansAnimalsCells
  14. Yang J, Yang J, Ran C. Spectral Unmixing Imaging for Differentiating Brown Adipose Tissue Mass and Its Activation. Contrast Media Mol Imaging. 2018; 2018:6134186. PMID: 29531505.
    Citations:    Fields:    
  15. Yang J, Zhang X, Yuan P, Yang J, Xu Y, Grutzendler J, Shao Y, Moore A, Ran C. Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 11 21; 114(47):12384-12389. PMID: 29109280.
    Citations: 1     Fields:    Translation:HumansAnimals
  16. Li Y, Yang J, Liu H, Yang J, Du L, Feng H, Tian Y, Cao J, Ran C. Tuning the stereo-hindrance of a curcumin scaffold for the selective imaging of the soluble forms of amyloid beta species. Chem Sci. 2017 Nov 01; 8(11):7710-7717. PMID: 29568434.
  17. Yang J, Yang J, Wang L, Moore A, Liang SH, Ran C. Synthesis-free PET imaging of brown adipose tissue and TSPO via combination of disulfiram and 64CuCl2. Sci Rep. 2017 08 15; 7(1):8298. PMID: 28811616.
    Citations:    Fields:    
  18. Shen S, Lim G, You Z, Ding W, Huang P, Ran C, Doheny J, Caravan P, Tate S, Hu K, Kim H, McCabe M, Huang B, Xie Z, Kwon D, Chen L, Mao J. Gut microbiota is critical for the induction of chemotherapy-induced pain. Nat Neurosci. 2017 Sep; 20(9):1213-1216. PMID: 28714953.
    Citations: 4     Fields:    Translation:AnimalsCells
  19. Yang J, Zhang X, Zhu Y, Lenczowski E, Tian Y, Yang J, Zhang C, Hardt M, Qiao C, Tanzi RE, Moore A, Ye H, Ran C. The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants. Chem Sci. 2017 Sep 01; 8(9):6155-6164. PMID: 28989646.
  20. Wang L, Cheng R, Fujinaga M, Yang J, Zhang Y, Hatori A, Kumata K, Yang J, Vasdev N, Du Y, Ran C, Zhang MR, Liang SH. A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation. J Med Chem. 2017 06 22; 60(12):5222-5227. PMID: 28530834.
    Citations: 2     Fields:    Translation:Animals
  21. Kumar AT, Carp SA, Yang J, Ross A, Medarova Z, Ran C. Fluorescence lifetime-based contrast enhancement of indocyanine green-labeled tumors. J Biomed Opt. 2017 04 01; 22(4):40501. PMID: 28397959.
    Citations:    Fields:    Translation:HumansAnimals
  22. Wang P, Ross A, Yoo B, Yang J, Farrar C, Ran C, Pantazopoulos P, Medarova Z, Moore A. Magnetic resonance imaging of intra-pancreatic ductal nanoparticle delivery to islet cells. Diabetes Metab Res Rev. 2017 07; 33(5). PMID: 28032446.
    Citations:    Fields:    Translation:Animals
  23. Yang J, Tu Z, Xu X, Luo J, Yan X, Ran C, Mao X, Ding K, Qiao C. Novel conjugates of endoperoxide and 4-anilinoquinazoline as potential anticancer agents. Bioorg Med Chem Lett. 2017 03 15; 27(6):1341-1345. PMID: 28236592.
    Citations:    Fields:    Translation:HumansCells
  24. Liu H, Yang J, Wang L, Xu Y, Zhang S, Lv J, Ran C, Li Y. Targeting ß-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes. Future Med Chem. 2017 02; 9(2):179-198. PMID: 28127995.
    Citations: 2     Fields:    Translation:HumansCells
  25. Yang J, Yang J, Liang SH, Xu Y, Moore A, Ran C. Imaging hydrogen peroxide in Alzheimer's disease via cascade signal amplification. Sci Rep. 2016 10 20; 6:35613. PMID: 27762326.
    Citations:    Fields:    Translation:Animals
  26. Kwok SJ, Choi M, Bhayana B, Zhang X, Ran C, Yun SH. Two-photon excited photoconversion of cyanine-based dyes. Sci Rep. 2016 Mar 31; 6:23866. PMID: 27029524.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  27. Meimetis LG, Boros E, Carlson JC, Ran C, Caravan P, Weissleder R. Bioorthogonal Fluorophore Linked DFO-Technology Enabling Facile Chelator Quantification and Multimodal Imaging of Antibodies. Bioconjug Chem. 2016 Jan 20; 27(1):257-63. PMID: 26684717.
    Citations: 2     Fields:    Translation:HumansAnimals
  28. Wang L, Yui J, Wang Q, Zhang Y, Mori W, Shimoda Y, Fujinaga M, Kumata K, Yamasaki T, Hatori A, Rotstein BH, Collier TL, Ran C, Vasdev N, Zhang MR, Liang SH. Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([¹¹C]MPPO) Based on a-Ketoheterocyclic Scaffold. ACS Chem Neurosci. 2016 Jan 20; 7(1):109-18. PMID: 26505525.
    Citations: 3     Fields:    Translation:Animals
  29. Zhang X, Tian Y, Zhang H, Kavishwar A, Lynes M, Brownell AL, Sun H, Tseng YH, Moore A, Ran C. Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning. Sci Rep. 2015 Aug 13; 5:13116. PMID: 26269357.
    Citations: 8     Fields:    Translation:AnimalsCells
  30. Zhang X, Tian Y, Zhang C, Tian X, Ross AW, Moir RD, Sun H, Tanzi RE, Moore A, Ran C. Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):9734-9. PMID: 26199414.
    Citations: 15     Fields:    Translation:HumansAnimals
  31. Patel V, Zhang X, Tautiva NA, Nyabera AN, Owa OO, Baidya M, Sung HC, Taunk PS, Abdollahi S, Charles S, Gonnella RA, Gadi N, Duong KT, Fawver JN, Ran C, Jalonen TO, Murray IV. Small molecules and Alzheimer's disease: misfolding, metabolism and imaging. Curr Alzheimer Res. 2015; 12(5):445-61. PMID: 25938871.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  32. Cheng C, Gao N, Yu C, Wang Z, Wang J, Hao E, Wei Y, Mu X, Tian Y, Ran C, Jiao L. Diversity-oriented facile access to highly fluorescent membrane-permeable benz[c,d]indole N-heteroarene BF2 dyes. Org Lett. 2015 Jan 16; 17(2):278-81. PMID: 25551331.
    Citations: 2     Fields:    Translation:Cells
  33. Tian Y, Zhang X, Li Y, Shoup TM, Teng X, Elmaleh DR, Moore A, Ran C. Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease. Chem Commun (Camb). 2014 Dec 25; 50(99):15792-5. PMID: 25372154.
    Citations: 1     Fields:    Translation:Animals
  34. Zhang X, Tian Y, Yuan P, Li Y, Yaseen MA, Grutzendler J, Moore A, Ran C. A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease. Chem Commun (Camb). 2014 Oct 09; 50(78):11550-3. PMID: 25134928.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  35. Zhang X, Kuo C, Moore A, Ran C. Cerenkov luminescence imaging of interscapular brown adipose tissue. J Vis Exp. 2014 Oct 07; (92):e51790. PMID: 25349986.
    Citations: 1     Fields:    Translation:Animals
  36. Zheng X, Zhang X, Kang A, Ran C, Wang G, Hao H. Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way? Neuropharmacology. 2015 Sep; 96(Pt A):94-104. PMID: 24978103.
    Citations: 3     Fields:    Translation:HumansAnimals
  37. Zhang X, Tian Y, Li Z, Tian X, Sun H, Liu H, Moore A, Ran C. Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's disease. J Am Chem Soc. 2013 Nov 06; 135(44):16397-409. PMID: 24116384.
    Citations: 17     Fields:    Translation:AnimalsCells
  38. Zhang X, Kuo C, Moore A, Ran C. In vivo optical imaging of interscapular brown adipose tissue with (18)F-FDG via Cerenkov luminescence imaging. PLoS One. 2013; 8(4):e62007. PMID: 23637947.
    Citations: 14     Fields:    Translation:Animals
  39. Zhang X, Ran C. Dual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding Proteins. Curr Org Chem. 2013 Mar 01; 17(6). PMID: 24363605.
    Citations: 5     
  40. Wang P, Yigit MV, Ran C, Ross A, Wei L, Dai G, Medarova Z, Moore A. A theranostic small interfering RNA nanoprobe protects pancreatic islet grafts from adoptively transferred immune rejection. Diabetes. 2012 Dec; 61(12):3247-54. PMID: 22923469.
    Citations: 11     Fields:    Translation:HumansAnimals
  41. Ran C, Moore A. Spectral unmixing imaging of wavelength-responsive fluorescent probes: an application for the real-time report of amyloid Beta species in Alzheimer's disease. Mol Imaging Biol. 2012 Jun; 14(3):293-300. PMID: 21739354.
    Citations: 7     Fields:    Translation:Animals
  42. Ran C, Zhang Z, Hooker J, Moore A. In vivo photoactivation without "light": use of Cherenkov radiation to overcome the penetration limit of light. Mol Imaging Biol. 2012 Apr; 14(2):156-62. PMID: 21538154.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  43. Ran C, Zhao W, Moir RD, Moore A. Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One. 2011 Apr 29; 6(4):e19362. PMID: 21559413.
    Citations: 12     Fields:    Translation:HumansCells
  44. Ran C, Xu X, Raymond SB, Ferrara BJ, Neal K, Bacskai BJ, Medarova Z, Moore A. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J Am Chem Soc. 2009 Oct 28; 131(42):15257-61. PMID: 19807070.
    Citations: 40     Fields:    Translation:AnimalsCells
  45. Ran C, Xu D, Dai Q, Penning TM, Blair IA, Harvey RG. Synthesis of 13C2-Benzo[a]pyrene and its 7,8-Dihydrodiol and 7,8-Dione Implicated as Carcinogenic Metabolites. Tetrahedron Lett. 2008 Jul 21; 49(29-30):4531-4533. PMID: 24155502.
    Citations: 4     Fields:    
  46. Ran C, Dai Q, Ruan Q, Penning TM, Blair IA, Harvey RG. Strategies for synthesis of adducts of omicron-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2'-deoxyribonucleosides. J Org Chem. 2008 Feb 01; 73(3):992-1003. PMID: 18181642.
    Citations: 1     Fields:    Translation:Cells
  47. Ran C, Pantazopoulos P, Medarova Z, Moore A. Synthesis and testing of beta-cell-specific streptozotocin-derived near-infrared imaging probes. Angew Chem Int Ed Engl. 2007; 46(47):8998-9001. PMID: 17957665.
    Citations: 3     Fields:    Translation:HumansCells
  48. Zhang Y, Ran C, Zhou G, Sayre LM. Highly potent 3-pyrroline mechanism-based inhibitors of bovine plasma amine oxidase and mass spectrometric confirmation of cofactor derivatization. Bioorg Med Chem. 2007 Feb 15; 15(4):1868-77. PMID: 17150363.
    Citations: 4     Fields:    Translation:AnimalsCells
  49. Kim J, Zhang Y, Ran C, Sayre LM. Inactivation of bovine plasma amine oxidase by haloallylamines. Bioorg Med Chem. 2006 Mar 01; 14(5):1444-53. PMID: 16266805.
    Citations: 2     Fields:    Translation:AnimalsCells
  50. Ran C, Dai Q, Harvey RG. N6-Arylation of 2'-deoxyadenosine via copper-catalyzed direct coupling with aryl halides. J Org Chem. 2005 Apr 29; 70(9):3724-6. PMID: 15845015.
    Citations: 1     Fields:    Translation:Cells
  51. Dai Q, Ran C, Harvey RG. Synthesis of adducts of o-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2'-deoxyribonucleosides. Org Lett. 2005 Mar 17; 7(6):999-1002. PMID: 15760123.
    Citations: 1     Fields:    Translation:Cells
  52. Harvey RG, Dai Q, Ran C, Penning TM. Synthesis of the o-quinones and other oxidized metabolites of polycyclic aromatic hydrocarbons implicated in carcinogenesis. J Org Chem. 2004 Mar 19; 69(6):2024-32. PMID: 15058949.
    Citations: 20     Fields:    Translation:Cells
  53. Liu H, Ran CZ, Xia L, Ni PZ. [Synthesis and anti alpha-adrenoceptor activity in vitro of 4-((4-((2-substitutedphenoxy)ethyl)-1-piperazinyl) methyl)- 1,2-dihydro-quinoline-2-one compounds]. Yao Xue Xue Bao. 2002 Mar; 37(3):181-5. PMID: 12579757.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.