Harvard Catalyst Profiles

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Sylvie Breton, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK097124 (BRETON, SYLVIE) Dec 15, 2012 - Nov 30, 2017
    pH-sensing and activation of acid secretion by the V-ATPase
    Role: Principal Investigator
  2. R01HD069623 (BRETON, SYLVIE) Aug 12, 2011 - May 31, 2021
    Role of epididymal macrophages and dendritic cells in male reproductive function
    Role: Principal Investigator
  3. R01DK085715 (BRETON, SYLVIE) Sep 21, 2009 - Jan 31, 2015
    3-Dimensional modeling of basal cell function in pseudostratified epithelia
    Role: Principal Investigator
  4. R01HD045821 (BRETON, SYLVIE) May 1, 2006 - Mar 31, 2012
    Water and solute transport in the epididymis
    Role: Principal Investigator
  5. R01HD040793 (BRETON, SYLVIE) May 10, 2001 - Apr 30, 2022
    Transfer of grant 5R01HD040793 - Intercellular networks and luminal acidification in the male reproductive tract
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Belardin LB, Brochu K, Légaré C, Battistone MA, Breton S. Purinergic signaling in the male reproductive tract. Front Endocrinol (Lausanne). 2022; 13:1049511. PMID: 36419764; PMCID: PMC9676935.
    Citations:    Fields:    
  2. Belardin LB, Légaré C, Sullivan R, Belleannée C, Breton S. Expression of the pro-inflammatory P2Y14 receptor in the non-vasectomized and vasectomized human epididymis. Andrology. 2022 11; 10(8):1522-1539. PMID: 36029226.
    Citations: 1     Fields:    Translation:HumansCells
  3. Kim B, Breton S. The MAPK/ERK signaling pathway regulates the expression and localization of Cx43 in mouse proximal epididymis†. Biol Reprod. 2022 05 17; 106(5):919-927. PMID: 35156117; PMCID: PMC9113436.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Breton S, Battistone MA. Unexpected Participation of Intercalated Cells in Renal Inflammation and Acute Kidney Injury. Nephron. 2022; 146(3):268-273. PMID: 34657041; PMCID: PMC9010481.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Tourzani DA, Battistone MA, Salicioni AM, Breton S, Visconti PE, Gervasi MG. Caput Ligation Renders Immature Mouse Sperm Motile and Capable to Undergo cAMP-Dependent Phosphorylation. Int J Mol Sci. 2021 Sep 23; 22(19). PMID: 34638585; PMCID: PMC8549708.
    Citations:    Fields:    Translation:AnimalsCells
  6. Mendelsohn AC, Sanmarco LM, Spallanzani RG, Brown D, Quintana FJ, Breton S, Battistone MA. From initial segment to cauda: a regional characterization of mouse epididymal CD11c+ mononuclear phagocytes based on immune phenotype and function. Am J Physiol Cell Physiol. 2020 12 01; 319(6):C997-C1010. PMID: 32991210; PMCID: PMC7792679.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Battistone MA, Mendelsohn AC, Spallanzani RG, Allegretti AS, Liberman RN, Sesma J, Kalim S, Wall SM, Bonventre JV, Lazarowski ER, Brown D, Breton S. Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice. J Clin Invest. 2020 07 01; 130(7):3734-3749. PMID: 32287042; PMCID: PMC7324186.
    Citations: 21     Fields:    Translation:AnimalsCells
  8. Castro MM, Kim B, Games PD, Hill E, Neves CA, Serrão JE, Breton S, Machado-Neves M. Distribution pattern of ZO-1 and claudins in the epididymis of vampire bats. Tissue Barriers. 2020 07 02; 8(3):1779526. PMID: 32552339.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Kim B, Breton S. Androgens are essential for epithelial cell recovery after efferent duct ligation in the initial segment of the mouse epididymis†. Biol Reprod. 2020 02 12; 102(1):76-83. PMID: 31403160.
    Citations: 4     Fields:    Translation:AnimalsCells
  10. Battistone MA, Mendelsohn AC, Spallanzani RG, Brown D, Nair AV, Breton S. Region-specific transcriptomic and functional signatures of mononuclear phagocytes in the epididymis. Mol Hum Reprod. 2020 01 01; 26(1):14-29. PMID: 31778536; PMCID: PMC6992890.
    Citations: 9     Fields:    Translation:AnimalsCells
  11. Battistone MA, Spallanzani RG, Mendelsohn AC, Capen D, Nair AV, Brown D, Breton S. Novel role of proton-secreting epithelial cells in sperm maturation and mucosal immunity. J Cell Sci. 2019 11 18; 133(5). PMID: 31636115.
    Citations: 7     Fields:    Translation:AnimalsCells
  12. Hoyer FF, Naxerova K, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M. Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge. Immunity. 2019 11 19; 51(5):899-914.e7. PMID: 31732166.
    Citations: 37     Fields:    Translation:AnimalsCells
  13. Breton S, Nair AV, Battistone MA. Epithelial dynamics in the epididymis: role in the maturation, protection, and storage of spermatozoa. Andrology. 2019 09; 7(5):631-643. PMID: 31044554.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  14. Battistone MA, Merkulova M, Park YJ, Peralta MA, Gombar F, Brown D, Breton S. Unravelling purinergic regulation in the epididymis: activation of V-ATPase-dependent acidification by luminal ATP and adenosine. J Physiol. 2019 04; 597(7):1957-1973. PMID: 30746715; PMCID: PMC6441927.
    Citations: 8     Fields:    Translation:Animals
  15. Carvajal G, Brukman NG, Weigel Muñoz M, Battistone MA, Guazzone VA, Ikawa M, Haruhiko M, Lustig L, Breton S, Cuasnicu PS. Impaired male fertility and abnormal epididymal epithelium differentiation in mice lacking CRISP1 and CRISP4. Sci Rep. 2018 12 03; 8(1):17531. PMID: 30510210.
    Citations: 9     Fields:    Translation:Animals
  16. Breton S, Brown D. Novel Proinflammatory Function of Renal Intercalated Cells. Ann Nutr Metab. 2018; 72 Suppl 2:11-16. PMID: 29925073.
    Citations: 5     Fields:    Translation:HumansCells
  17. Merkulova M, Paunescu TG, Nair AV, Wang CY, Capen DE, Oliver PL, Breton S, Brown D. Targeted deletion of the Ncoa7 gene results in incomplete distal renal tubular acidosis in mice. Am J Physiol Renal Physiol. 2018 07 01; 315(1):F173-F185. PMID: 29384414.
    Citations: 7     Fields:    Translation:Animals
  18. Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Paunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA. Reply to Edemir: Physiological regulation and single-cell RNA sequencing. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):E351-E352. PMID: 29311339; PMCID: PMC5777009.
    Citations: 1     Fields:    Translation:Cells
  19. Battistone MA, Nair AV, Barton CR, Liberman RN, Peralta MA, Capen DE, Brown D, Breton S. Extracellular Adenosine Stimulates Vacuolar ATPase-Dependent Proton Secretion in Medullary Intercalated Cells. J Am Soc Nephrol. 2018 02; 29(2):545-556. PMID: 29222395; PMCID: PMC5791049.
    Citations: 12     Fields:    Translation:AnimalsCells
  20. Menezes TP, Hill E, de Alencar Moura A, Lobo MDP, Monteiro-Moreira ACO, Breton S, Machado-Neves M. Pattern of protein expression in the epididymis of Oligoryzomys nigripes (Cricetidae, Sigmodontinae). Cell Tissue Res. 2018 04; 372(1):135-147. PMID: 29119327.
    Citations: 4     Fields:    Translation:Animals
  21. Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Paunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA. Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq. Proc Natl Acad Sci U S A. 2017 11 14; 114(46):E9989-E9998. PMID: 29089413.
    Citations: 110     Fields:    Translation:AnimalsCells
  22. Park YJ, Battistone MA, Kim B, Breton S. Relative contribution of clear cells and principal cells to luminal pH in the mouse epididymis†. Biol Reprod. 2017 04 01; 96(4):937. PMID: 28371820; PMCID: PMC6322657.
    Citations: 3     Fields:    
  23. Park YJ, Battistone MA, Kim B, Breton S. Relative contribution of clear cells and principal cells to luminal pH in the mouse epididymis. Biol Reprod. 2017 02 01; 96(2):366-375. PMID: 28203710; PMCID: PMC6213081.
    Citations: 13     Fields:    Translation:AnimalsCells
  24. Castro MM, Kim B, Hill E, Fialho MC, Puga LC, Freitas MB, Breton S, Machado-Neves M. The expression patterns of aquaporin 9, vacuolar H+-ATPase, and cytokeratin 5 in the epididymis of the common vampire bat. Histochem Cell Biol. 2017 Jan; 147(1):39-48. PMID: 27549752.
    Citations: 8     Fields:    Translation:Animals
  25. Cotter K, Liberman R, Sun-Wada G, Wada Y, Sgroi D, Naber S, Brown D, Breton S, Forgac M. The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer. Oncotarget. 2016 Jul 19; 7(29):46142-46157. PMID: 27323815.
    Citations: 21     Fields:    Translation:HumansCells
  26. Roy J, Kim B, Hill E, Visconti P, Krapf D, Vinegoni C, Weissleder R, Brown D, Breton S. Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging. Nat Commun. 2016 Feb 12; 7:10666. PMID: 26868824.
    Citations: 11     Fields:    Translation:AnimalsCells
  27. Breton S, Ruan YC, Park YJ, Kim B. Regulation of epithelial function, differentiation, and remodeling in the epididymis. Asian J Androl. 2016 Jan-Feb; 18(1):3-9. PMID: 26585699; PMCID: PMC4736353.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  28. Kim B, Breton S. The MAPK/ERK-Signaling Pathway Regulates the Expression and Distribution of Tight Junction Proteins in the Mouse Proximal Epididymis. Biol Reprod. 2016 Jan; 94(1):22. PMID: 26658708.
    Citations: 23     Fields:    Translation:AnimalsCells
  29. Merkulova M, Paunescu TG, Azroyan A, Marshansky V, Breton S, Brown D. Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation. Sci Rep. 2015 Oct 07; 5:14827. PMID: 26442671.
    Citations: 45     Fields:    Translation:AnimalsCells
  30. Kim B, Breton S. Localization of the gap junction protein, connexin 43, and E-cadherin/Cadherin-1 in the proximal mouse epididymis. Mol Reprod Dev. 2015 Oct; 82(10):723. PMID: 26331361.
  31. Azroyan A, Cortez-Retamozo V, Bouley R, Liberman R, Ruan YC, Kiselev E, Jacobson KA, Pittet MJ, Brown D, Breton S. Renal intercalated cells sense and mediate inflammation via the P2Y14 receptor. PLoS One. 2015; 10(3):e0121419. PMID: 25799465.
    Citations: 33     Fields:    Translation:AnimalsCells
  32. Kim B, Roy J, Shum WW, Da Silva N, Breton S. Role of testicular luminal factors on Basal cell elongation and proliferation in the mouse epididymis. Biol Reprod. 2015 Jan; 92(1):9. PMID: 25411392; PMCID: PMC4434934.
    Citations: 18     Fields:    Translation:AnimalsCells
  33. Ruan YC, Wang Y, Da Silva N, Kim B, Diao RY, Hill E, Brown D, Chan HC, Breton S. CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway. J Cell Sci. 2014 Oct 15; 127(Pt 20):4396-408. PMID: 25107366.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  34. Paunescu TG, Shum WW, Huynh C, Lechner L, Goetze B, Brown D, Breton S. High-resolution helium ion microscopy of epididymal epithelial cells and their interaction with spermatozoa. Mol Hum Reprod. 2014 Oct; 20(10):929-37. PMID: 25015675.
    Citations: 19     Fields:    Translation:AnimalsCells
  35. Jun HJ, Roy J, Smith TB, Wood LB, Lane K, Woolfenden S, Punko D, Bronson RT, Haigis KM, Breton S, Charest A. ROS1 signaling regulates epithelial differentiation in the epididymis. Endocrinology. 2014 Sep; 155(9):3661-73. PMID: 24971615; PMCID: PMC4138574.
    Citations: 10     Fields:    Translation:AnimalsCells
  36. Shum WW, Smith TB, Cortez-Retamozo V, Grigoryeva LS, Roy JW, Hill E, Pittet MJ, Breton S, Da Silva N. Epithelial basal cells are distinct from dendritic cells and macrophages in the mouse epididymis. Biol Reprod. 2014 May; 90(5):90. PMID: 24648397.
    Citations: 32     Fields:    Translation:AnimalsCells
  37. Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature. 2013 Nov 14; 503(7475):218-23. PMID: 24196716.
    Citations: 286     Fields:    Translation:AnimalsCells
  38. Paunescu TG, Lu HA, Russo LM, Pastor-Soler NM, McKee M, McLaughlin MM, Bartlett BE, Breton S, Brown D. Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells. Am J Physiol Renal Physiol. 2013 Dec 15; 305(12):F1783-95. PMID: 24133120.
    Citations: 9     Fields:    Translation:AnimalsCells
  39. Shum WW, Hill E, Brown D, Breton S. Plasticity of basal cells during postnatal development in the rat epididymis. Reproduction. 2013; 146(5):455-69. PMID: 23960170.
    Citations: 18     Fields:    Translation:AnimalsCells
  40. Breton S, Brown D. Regulation of luminal acidification by the V-ATPase. Physiology (Bethesda). 2013 Sep; 28(5):318-29. PMID: 23997191.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  41. Roy JW, Hill E, Ruan YC, Vedovelli L, Paunescu TG, Brown D, Breton S. Circulating aldosterone induces the apical accumulation of the proton pumping V-ATPase and increases proton secretion in clear cells in the caput epididymis. Am J Physiol Cell Physiol. 2013 Aug 15; 305(4):C436-46. PMID: 23761626.
    Citations: 7     Fields:    Translation:AnimalsCells
  42. Vedovelli L, Rothermel JT, Finberg KE, Wagner CA, Azroyan A, Hill E, Breton S, Brown D, Paunescu TG. Altered V-ATPase expression in renal intercalated cells isolated from B1 subunit-deficient mice by fluorescence-activated cell sorting. Am J Physiol Renal Physiol. 2013 Mar 01; 304(5):F522-32. PMID: 23269648.
    Citations: 26     Fields:    Translation:AnimalsCells
  43. Kim JK, Vinarsky V, Wain J, Zhao R, Jung K, Choi J, Lam A, Pardo-Saganta A, Breton S, Rajagopal J, Yun SH. In vivo imaging of tracheal epithelial cells in mice during airway regeneration. Am J Respir Cell Mol Biol. 2012 Dec; 47(6):864-8. PMID: 22984086.
    Citations: 18     Fields:    Translation:AnimalsCells
  44. Krapf D, Ruan YC, Wertheimer EV, Battistone MA, Pawlak JB, Sanjay A, Pilder SH, Cuasnicu P, Breton S, Visconti PE. cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit. Dev Biol. 2012 Sep 01; 369(1):43-53. PMID: 22750823.
    Citations: 31     Fields:    Translation:AnimalsCells
  45. Ruan YC, Shum WW, Belleannée C, Da Silva N, Breton S. ATP secretion in the male reproductive tract: essential role of CFTR. J Physiol. 2012 Sep 01; 590(17):4209-22. PMID: 22711960.
    Citations: 25     Fields:    Translation:AnimalsCells
  46. Staropoli JF, Haliw L, Biswas S, Garrett L, Hölter SM, Becker L, Skosyrski S, Da Silva-Buttkus P, Calzada-Wack J, Neff F, Rathkolb B, Rozman J, Schrewe A, Adler T, Puk O, Sun M, Favor J, Racz I, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Lopez E, Harati H, Hill E, Krause DS, Guide J, Dragileva E, Gale E, Wheeler VC, Boustany RM, Brown DE, Breton S, Ruether K, Gailus-Durner V, Fuchs H, de Angelis MH, Cotman SL. Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system. PLoS One. 2012; 7(6):e38310. PMID: 22701626.
    Citations: 32     Fields:    Translation:AnimalsCells
  47. Brown D, Bouley R, Paunescu TG, Breton S, Lu HA. New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells. Am J Physiol Cell Physiol. 2012 May 15; 302(10):C1421-33. PMID: 22460710.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  48. Wagner CA, Mohebbi N, Uhlig U, Giebisch GH, Breton S, Brown D, Geibel JP. Angiotensin II stimulates H?-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts. Cell Physiol Biochem. 2011; 28(3):513-20. PMID: 22116365.
    Citations: 12     Fields:    Translation:AnimalsCells
  49. Shum WW, Ruan YC, Da Silva N, Breton S. Establishment of cell-cell cross talk in the epididymis: control of luminal acidification. J Androl. 2011 Nov-Dec; 32(6):576-86. PMID: 21441423.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  50. Shum WW, Da Silva N, Belleannée C, McKee M, Brown D, Breton S. Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells. Am J Physiol Cell Physiol. 2011 Jul; 301(1):C31-43. PMID: 21411727.
    Citations: 19     Fields:    Translation:AnimalsCells
  51. Da Silva N, Cortez-Retamozo V, Reinecker HC, Wildgruber M, Hill E, Brown D, Swirski FK, Pittet MJ, Breton S. A dense network of dendritic cells populates the murine epididymis. Reproduction. 2011 May; 141(5):653-63. PMID: 21310816.
    Citations: 44     Fields:    Translation:AnimalsCells
  52. Zhuang Z, Marshansky V, Breton S, Brown D. Is caveolin involved in normal proximal tubule function? Presence in model PT systems but absence in situ. Am J Physiol Renal Physiol. 2011 Jan; 300(1):F199-206. PMID: 20980408.
    Citations: 18     Fields:    Translation:AnimalsCells
  53. Da Silva N, Pisitkun T, Belleannée C, Miller LR, Nelson R, Knepper MA, Brown D, Breton S. Proteomic analysis of V-ATPase-rich cells harvested from the kidney and epididymis by fluorescence-activated cell sorting. Am J Physiol Cell Physiol. 2010 Jun; 298(6):C1326-42. PMID: 20181927.
    Citations: 24     Fields:    Translation:AnimalsCells
  54. Belleannée C, Da Silva N, Shum WW, Brown D, Breton S. Role of purinergic signaling pathways in V-ATPase recruitment to apical membrane of acidifying epididymal clear cells. Am J Physiol Cell Physiol. 2010 Apr; 298(4):C817-30. PMID: 20071692.
    Citations: 27     Fields:    Translation:AnimalsCells
  55. Paunescu TG, Ljubojevic M, Russo LM, Winter C, McLaughlin MM, Wagner CA, Breton S, Brown D. cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells. Am J Physiol Renal Physiol. 2010 Mar; 298(3):F643-54. PMID: 20053793.
    Citations: 73     Fields:    Translation:AnimalsCells
  56. Pastor-Soler NM, Fisher JS, Sharpe R, Hill E, Van Hoek A, Brown D, Breton S. Aquaporin 9 expression in the developing rat epididymis is modulated by steroid hormones. Reproduction. 2010 Mar; 139(3):613-21. PMID: 19948840.
    Citations: 16     Fields:    Translation:Animals
  57. Shum WW, Da Silva N, Brown D, Breton S. Regulation of luminal acidification in the male reproductive tract via cell-cell crosstalk. J Exp Biol. 2009 Jun; 212(Pt 11):1753-61. PMID: 19448084.
    Citations: 56     Fields:    Translation:AnimalsCells
  58. Brown D, Paunescu TG, Breton S, Marshansky V. Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking. J Exp Biol. 2009 Jun; 212(Pt 11):1762-72. PMID: 19448085.
    Citations: 67     Fields:    Translation:AnimalsCells
  59. Vidarsson H, Westergren R, Heglind M, Blomqvist SR, Breton S, Enerbäck S. The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis. PLoS One. 2009; 4(2):e4471. PMID: 19214237.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  60. Brown D, Breton S, Ausiello DA, Marshansky V. Sensing, signaling and sorting events in kidney epithelial cell physiology. Traffic. 2009 Mar; 10(3):275-84. PMID: 19170982.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  61. Shum WW, Da Silva N, McKee M, Smith PJ, Brown D, Breton S. Transepithelial projections from basal cells are luminal sensors in pseudostratified epithelia. Cell. 2008 Dec 12; 135(6):1108-17. PMID: 19070580.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  62. Miller RL, Lucero OM, Riemondy KA, Baumgartner BK, Brown D, Breton S, Nelson RD. The V-ATPase B1-subunit promoter drives expression of Cre recombinase in intercalated cells of the kidney. Kidney Int. 2009 Feb; 75(4):435-9. PMID: 19052537.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  63. Belleannée C, Da Silva N, Shum WW, Marsolais M, Laprade R, Brown D, Breton S. Segmental expression of the bradykinin type 2 receptor in rat efferent ducts and epididymis and its role in the regulation of aquaporin 9. Biol Reprod. 2009 Jan; 80(1):134-43. PMID: 18829705; PMCID: PMC2804812.
    Citations: 13     Fields:    Translation:AnimalsCells
  64. Pastor-Soler NM, Hallows KR, Smolak C, Gong F, Brown D, Breton S. Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. Am J Physiol Cell Physiol. 2008 Feb; 294(2):C488-94. PMID: 18160485; PMCID: PMC4303256.
    Citations: 55     Fields:    Translation:AnimalsCells
  65. Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, Brown D, Pastor-Soler N, Ameen N, Laprade R, Ramesh V, Breton S. Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9. J Biol Chem. 2008 Feb 01; 283(5):2986-96. PMID: 18055461.
    Citations: 30     Fields:    Translation:AnimalsCells
  66. Paunescu TG, Da Silva N, Russo LM, McKee M, Lu HA, Breton S, Brown D. Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells. Am J Physiol Renal Physiol. 2008 Jan; 294(1):F130-8. PMID: 17959750.
    Citations: 54     Fields:    Translation:AnimalsCells
  67. Paunescu TG, Russo LM, Da Silva N, Kovacikova J, Mohebbi N, Van Hoek AN, McKee M, Wagner CA, Breton S, Brown D. Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice. Am J Physiol Renal Physiol. 2007 Dec; 293(6):F1915-26. PMID: 17898041.
    Citations: 41     Fields:    Translation:AnimalsCells
  68. Da Silva N, Shum WW, Breton S. Regulation of vacuolar proton pumping ATPase-dependent luminal acidification in the epididymis. Asian J Androl. 2007 Jul; 9(4):476-82. PMID: 17589784.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  69. Da Silva N, Shum WW, El-Annan J, Paunescu TG, McKee M, Smith PJ, Brown D, Breton S. Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit. Am J Physiol Cell Physiol. 2007 Jul; 293(1):C199-210. PMID: 17392376.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  70. Breton S, Brown D. New insights into the regulation of V-ATPase-dependent proton secretion. Am J Physiol Renal Physiol. 2007 Jan; 292(1):F1-10. PMID: 17032935.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  71. Da Silva N, Piétrement C, Brown D, Breton S. Segmental and cellular expression of aquaporins in the male excurrent duct. Biochim Biophys Acta. 2006 Aug; 1758(8):1025-33. PMID: 16935257.
    Citations: 18     Fields:    Translation:Animals
  72. Vallet M, Picard N, Loffing-Cueni D, Fysekidis M, Bloch-Faure M, Deschênes G, Breton S, Meneton P, Loffing J, Aronson PS, Chambrey R, Eladari D. Pendrin regulation in mouse kidney primarily is chloride-dependent. J Am Soc Nephrol. 2006 Aug; 17(8):2153-63. PMID: 16825334.
    Citations: 43     Fields:    Translation:Animals
  73. Pastor-Soler N, Piétrement C, Breton S. Role of acid/base transporters in the male reproductive tract and potential consequences of their malfunction. Physiology (Bethesda). 2005 Dec; 20:417-28. PMID: 16287991.
    Citations: 51     Fields:    Translation:HumansAnimals
  74. Sabolic I, Herak-Kramberger CM, Antolovic R, Breton S, Brown D. Loss of basolateral invaginations in proximal tubules of cadmium-intoxicated rats is independent of microtubules and clathrin. Toxicology. 2006 Feb 01; 218(2-3):149-63. PMID: 16288946.
    Citations: 4     Fields:    Translation:AnimalsCells
  75. Da Silva N, Silberstein C, Beaulieu V, Piétrement C, Van Hoek AN, Brown D, Breton S. Postnatal expression of aquaporins in epithelial cells of the rat epididymis. Biol Reprod. 2006 Feb; 74(2):427-38. PMID: 16221990.
    Citations: 22     Fields:    Translation:AnimalsCells
  76. Pietrement C, Sun-Wada GH, Silva ND, McKee M, Marshansky V, Brown D, Futai M, Breton S. Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis. Biol Reprod. 2006 Jan; 74(1):185-94. PMID: 16192400.
    Citations: 74     Fields:    Translation:Animals
  77. Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP. The B1-subunit of the H(+) ATPase is required for maximal urinary acidification. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13616-21. PMID: 16174750; PMCID: PMC1224669.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  78. Bouley R, Pastor-Soler N, Cohen O, McLaughlin M, Breton S, Brown D. Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra). Am J Physiol Renal Physiol. 2005 Jun; 288(6):F1103-12. PMID: 15644488.
    Citations: 55     Fields:    Translation:AnimalsCells
  79. Miller RL, Zhang P, Smith M, Beaulieu V, Paunescu TG, Brown D, Breton S, Nelson RD. V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice. Am J Physiol Cell Physiol. 2005 May; 288(5):C1134-44. PMID: 15634743.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  80. Beaulieu V, Da Silva N, Pastor-Soler N, Brown CR, Smith PJ, Brown D, Breton S. Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling. J Biol Chem. 2005 Mar 04; 280(9):8452-63. PMID: 15591047.
    Citations: 46     Fields:    Translation:AnimalsCells
  81. Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP. Renal vacuolar H+-ATPase. Physiol Rev. 2004 Oct; 84(4):1263-314. PMID: 15383652.
    Citations: 153     Fields:    Translation:HumansAnimalsCells
  82. Yeung CH, Breton S, Setiawan I, Xu Y, Lang F, Cooper TG. Increased luminal pH in the epididymis of infertile c-ros knockout mice and the expression of sodium-hydrogen exchangers and vacuolar proton pump H+-ATPase. Mol Reprod Dev. 2004 Jun; 68(2):159-68. PMID: 15095336.
    Citations: 21     Fields:    Translation:Animals
  83. Paunescu TG, Da Silva N, Marshansky V, McKee M, Breton S, Brown D. Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis. Am J Physiol Cell Physiol. 2004 Jul; 287(1):C149-62. PMID: 15013950.
    Citations: 42     Fields:    Translation:Animals
  84. El-Annan J, Brown D, Breton S, Bourgoin S, Ausiello DA, Marshansky V. Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ. Am J Physiol Cell Physiol. 2004 Apr; 286(4):C768-78. PMID: 14684384.
    Citations: 13     Fields:    Translation:AnimalsCells
  85. Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S. Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem. 2003 Dec 05; 278(49):49523-9. PMID: 14512417.
    Citations: 118     Fields:    Translation:AnimalsCells
  86. Wagner CA, Lükewille U, Valles P, Breton S, Brown D, Giebisch GH, Geibel JP. A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse. Pflugers Arch. 2003 Aug; 446(5):623-32. PMID: 12748863.
    Citations: 20     Fields:    Translation:Animals
  87. Isnard-Bagnis C, Da Silva N, Beaulieu V, Yu AS, Brown D, Breton S. Detection of ClC-3 and ClC-5 in epididymal epithelium: immunofluorescence and RT-PCR after LCM. Am J Physiol Cell Physiol. 2003 Jan; 284(1):C220-32. PMID: 12475763.
    Citations: 18     Fields:    Translation:AnimalsCells
  88. Zharkikh L, Zhu X, Stricklett PK, Kohan DE, Chipman G, Breton S, Brown D, Nelson RD. Renal principal cell-specific expression of green fluorescent protein in transgenic mice. Am J Physiol Renal Physiol. 2002 Dec; 283(6):F1351-64. PMID: 12426236.
    Citations: 11     Fields:    Translation:AnimalsCells
  89. van Balkom BW, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PM. Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells. J Biol Chem. 2003 Jan 10; 278(2):1101-7. PMID: 12374804.
    Citations: 28     Fields:    Translation:AnimalsCells
  90. Fisher JS, Pastor-Soler N, Sharpe RM, Breton S. Modulation of the onset of postnatal development of H(+)-ATPase-rich cells by steroid hormones in rat epididymis. Biol Reprod. 2002 Oct; 67(4):1106-14. PMID: 12297525.
    Citations: 9     Fields:    Translation:Animals
  91. Pastor-Soler N, Isnard-Bagnis C, Herak-Kramberger C, Sabolic I, Van Hoek A, Brown D, Breton S. Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens. Biol Reprod. 2002 Jun; 66(6):1716-22. PMID: 12021052.
    Citations: 27     Fields:    Translation:AnimalsCells
  92. Breton S, Inoue T, Knepper MA, Brown D. Antigen retrieval reveals widespread basolateral expression of syntaxin 3 in renal epithelia. Am J Physiol Renal Physiol. 2002 Mar; 282(3):F523-9. PMID: 11832435.
    Citations: 7     Fields:    Translation:AnimalsCells
  93. Pastor-Soler N, Bagnis C, Sabolic I, Tyszkowski R, McKee M, Van Hoek A, Breton S, Brown D. Aquaporin 9 expression along the male reproductive tract. Biol Reprod. 2001 Aug; 65(2):384-93. PMID: 11466204.
    Citations: 45     Fields:    Translation:AnimalsCells
  94. Breton S. The cellular physiology of carbonic anhydrases. JOP. 2001 Jul; 2(4 Suppl):159-64. PMID: 11875253.
    Citations: 34     Fields:    Translation:HumansAnimals
  95. Herak-Kramberger CM, Breton S, Brown D, Kraus O, Sabolic I. Distribution of the vacuolar H+ atpase along the rat and human male reproductive tract. Biol Reprod. 2001 Jun; 64(6):1699-707. PMID: 11369598.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  96. Bagnis C, Marsolais M, Biemesderfer D, Laprade R, Breton S. Na+/H+-exchange activity and immunolocalization of NHE3 in rat epididymis. Am J Physiol Renal Physiol. 2001 Mar; 280(3):F426-36. PMID: 11181404.
    Citations: 16     Fields:    Translation:Animals
  97. Bagnis C, Marshansky V, Breton S, Brown D. Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition. Am J Physiol Renal Physiol. 2001 Mar; 280(3):F437-48. PMID: 11181405.
    Citations: 37     Fields:    Translation:Animals
  98. Bouley R, Breton S, Sun T, McLaughlin M, Nsumu NN, Lin HY, Ausiello DA, Brown D. Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells. J Clin Invest. 2000 Nov; 106(9):1115-26. PMID: 11067864; PMCID: PMC301414.
    Citations: 74     Fields:    Translation:AnimalsCells
  99. Herak-Kramberger CM, Sabolic I, Blanusa M, Smith PJ, Brown D, Breton S. Cadmium inhibits vacuolar H(+)ATPase-mediated acidification in the rat epididymis. Biol Reprod. 2000 Aug; 63(2):599-606. PMID: 10906070.
    Citations: 9     Fields:    Translation:AnimalsCells
  100. Silver RB, Breton S, Brown D. Potassium depletion increases proton pump (H(+)-ATPase) activity in intercalated cells of cortical collecting duct. Am J Physiol Renal Physiol. 2000 Jul; 279(1):F195-202. PMID: 10894802.
    Citations: 11     Fields:    Translation:Animals
  101. Breton S, Wiederhold T, Marshansky V, Nsumu NN, Ramesh V, Brown D. The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells. J Biol Chem. 2000 Jun 16; 275(24):18219-24. PMID: 10748165.
    Citations: 43     Fields:    Translation:AnimalsCells
  102. Breton S, Nsumu NN, Galli T, Sabolic I, Smith PJ, Brown D. Tetanus toxin-mediated cleavage of cellubrevin inhibits proton secretion in the male reproductive tract. Am J Physiol Renal Physiol. 2000 May; 278(5):F717-25. PMID: 10807583.
    Citations: 19     Fields:    Translation:AnimalsCells
  103. Stevens AL, Breton S, Gustafson CE, Bouley R, Nelson RD, Kohan DE, Brown D. Aquaporin 2 is a vasopressin-independent, constitutive apical membrane protein in rat vas deferens. Am J Physiol Cell Physiol. 2000 Apr; 278(4):C791-802. PMID: 10751327.
    Citations: 12     Fields:    Translation:AnimalsCells
  104. Brown D, Breton S. Sorting proteins to their target membranes. Kidney Int. 2000 Mar; 57(3):816-24. PMID: 10720934.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  105. Brown D, Breton S. H(+)V-ATPase-dependent luminal acidification in the kidney collecting duct and the epididymis/vas deferens: vesicle recycling and transcytotic pathways. J Exp Biol. 2000 Jan; 203(Pt 1):137-45. PMID: 10600682.
    Citations: 37     Fields:    Translation:Animals
  106. Jensen LJ, Stuart-Tilley AK, Peters LL, Lux SE, Alper SL, Breton S. Immunolocalization of AE2 anion exchanger in rat and mouse epididymis. Biol Reprod. 1999 Oct; 61(4):973-80. PMID: 10491632.
    Citations: 16     Fields:    Translation:Animals
  107. Shayakul C, Breton S, Brown D, Alper SL. Gene therapy of inherited renal tubular disease. Am J Kidney Dis. 1999 Aug; 34(2):374-9. PMID: 10430991.
    Citations:    Fields:    Translation:HumansAnimals
  108. Sabolic I, Herak-Kramberger CM, Breton S, Brown D. Na/K-ATPase in intercalated cells along the rat nephron revealed by antigen retrieval. J Am Soc Nephrol. 1999 May; 10(5):913-22. PMID: 10232676.
    Citations: 19     Fields:    Translation:Animals
  109. Jensen LJ, Schmitt BM, Berger UV, Nsumu NN, Boron WF, Hediger MA, Brown D, Breton S. Localization of sodium bicarbonate cotransporter (NBC) protein and messenger ribonucleic acid in rat epididymis. Biol Reprod. 1999 Mar; 60(3):573-9. PMID: 10026101.
    Citations: 23     Fields:    Translation:Animals
  110. Breton S, Tyszkowski R, Sabolic I, Brown D. Postnatal development of H+ ATPase (proton-pump)-rich cells in rat epididymis. Histochem Cell Biol. 1999 Feb; 111(2):97-105. PMID: 10090570.
    Citations: 17     Fields:    Translation:Animals
  111. Breton S, Hammar K, Smith PJ, Brown D. Proton secretion in the male reproductive tract: involvement of Cl--independent HCO-3 transport. Am J Physiol. 1998 10; 275(4):C1134-42. PMID: 9755067.
    Citations: 18     Fields:    Translation:AnimalsCells
  112. Emma F, Breton S, Morrison R, Wright S, Strange K. Effect of cell swelling on membrane and cytoplasmic distribution of pICln. Am J Physiol. 1998 06; 274(6):C1545-51. PMID: 9696697.
    Citations: 4     Fields:    Translation:AnimalsCells
  113. Breton S, Lisanti MP, Tyszkowski R, McLaughlin M, Brown D. Basolateral distribution of caveolin-1 in the kidney. Absence from H+-atpase-coated endocytic vesicles in intercalated cells. J Histochem Cytochem. 1998 Feb; 46(2):205-14. PMID: 9446827.
    Citations: 31     Fields:    Translation:AnimalsCells
  114. Breton S, Brown D. Cold-induced microtubule disruption and relocalization of membrane proteins in kidney epithelial cells. J Am Soc Nephrol. 1998 Feb; 9(2):155-66. PMID: 9527391.
    Citations: 31     Fields:    Translation:AnimalsCells
  115. Brown D, Sabolic I, Breton S. Polarized expression of membrane proteins in renal epithelial cells: involvement of specialized transport vesicles and intracellular pathways. Adv Nephrol Necker Hosp. 1997; 27:297-315. PMID: 9408453.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  116. Brown D, Smith PJ, Breton S. Role of V-ATPase-rich cells in acidification of the male reproductive tract. J Exp Biol. 1997 Jan; 200(Pt 2):257-62. PMID: 9050233.
    Citations: 32     Fields:    Translation:AnimalsCells
  117. Brown D, Breton S. Mitochondria-rich, proton-secreting epithelial cells. J Exp Biol. 1996 Nov; 199(Pt 11):2345-58. PMID: 9114500.
    Citations: 61     Fields:    Translation:AnimalsCells
  118. Breton S, Smith PJ, Lui B, Brown D. Acidification of the male reproductive tract by a proton pumping (H+)-ATPase. Nat Med. 1996 Apr; 2(4):470-2. PMID: 8597961.
    Citations: 64     Fields:    Translation:Animals
  119. Breton S, Alper SL, Gluck SL, Sly WS, Barker JE, Brown D. Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice. Am J Physiol. 1995 Dec; 269(6 Pt 2):F761-74. PMID: 8594870.
    Citations: 35     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.