Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jarrod Marto, Ph.D.

Co-Author

This page shows the publications co-authored by Jarrod Marto and Scott Ficarro.
Connection Strength

8.890
  1. mzStudio: A Dynamic Digital Canvas for User-Driven Interrogation of Mass Spectrometry Data. Proteomes. 2017 Aug 01; 5(3).
    View in: PubMed
    Score: 0.747
  2. Leveraging Gas-Phase Fragmentation Pathways for Improved Identification and Selective Detection of Targets Modified by Covalent Probes. Anal Chem. 2016 12 20; 88(24):12248-12254.
    View in: PubMed
    Score: 0.713
  3. Protected amine labels: a versatile molecular scaffold for multiplexed nominal mass and sub-Da isotopologue quantitative proteomic reagents. J Am Soc Mass Spectrom. 2014 Apr; 25(4):636-50.
    View in: PubMed
    Score: 0.586
  4. Online nanoflow multidimensional fractionation for high efficiency phosphopeptide analysis. Mol Cell Proteomics. 2011 Nov; 10(11):O111.011064.
    View in: PubMed
    Score: 0.492
  5. Magnetic bead processor for rapid evaluation and optimization of parameters for phosphopeptide enrichment. Anal Chem. 2009 Jun 01; 81(11):4566-75.
    View in: PubMed
    Score: 0.424
  6. Improved electrospray ionization efficiency compensates for diminished chromatographic resolution and enables proteomics analysis of tyrosine signaling in embryonic stem cells. Anal Chem. 2009 May 01; 81(9):3440-7.
    View in: PubMed
    Score: 0.421
  7. Niobium(V) oxide (Nb2O5): application to phosphoproteomics. Anal Chem. 2008 Jun 15; 80(12):4606-13.
    View in: PubMed
    Score: 0.395
  8. PRM-LIVE with Trapped Ion Mobility Spectrometry and Its Application in Selectivity Profiling of Kinase Inhibitors. Anal Chem. 2021 Oct 04.
    View in: PubMed
    Score: 0.249
  9. A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 01 09; 141(1):191-203.
    View in: PubMed
    Score: 0.205
  10. multiplierz v2.0: A Python-based ecosystem for shared access and analysis of native mass spectrometry data. Proteomics. 2017 Aug; 17(15-16).
    View in: PubMed
    Score: 0.187
  11. Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells. Cell Stem Cell. 2014 Jul 03; 15(1):92-101.
    View in: PubMed
    Score: 0.149
  12. Library dependent LC-MS/MS acquisition via mzAPI/Live. Proteomics. 2013 May; 13(9):1412-6.
    View in: PubMed
    Score: 0.139
  13. Genome-scale proteome quantification by DEEP SEQ mass spectrometry. Nat Commun. 2013; 4:2171.
    View in: PubMed
    Score: 0.136
  14. Proteomic analysis demonstrates activator- and chromatin-specific recruitment to promoters. J Biol Chem. 2012 Oct 12; 287(42):35397-35408.
    View in: PubMed
    Score: 0.132
  15. Nanoflow low pressure high peak capacity single dimension LC-MS/MS platform for high-throughput, in-depth analysis of mammalian proteomes. Anal Chem. 2012 Jun 05; 84(11):5133-9.
    View in: PubMed
    Score: 0.130
  16. C/EBPa and DEK coordinately regulate myeloid differentiation. Blood. 2012 May 24; 119(21):4878-88.
    View in: PubMed
    Score: 0.129
  17. Mass spectrometry-based proteomics: qualitative identification to activity-based protein profiling. Wiley Interdiscip Rev Syst Biol Med. 2012 Mar-Apr; 4(2):141-62.
    View in: PubMed
    Score: 0.127
  18. Online nanoflow reversed phase-strong anion exchange-reversed phase liquid chromatography-tandem mass spectrometry platform for efficient and in-depth proteome sequence analysis of complex organisms. Anal Chem. 2011 Sep 15; 83(18):6996-7005.
    View in: PubMed
    Score: 0.124
  19. Online nanoflow RP-RP-MS reveals dynamics of multicomponent Ku complex in response to DNA damage. J Proteome Res. 2010 Dec 03; 9(12):6242-55.
    View in: PubMed
    Score: 0.117
  20. multiplierz: an extensible API based desktop environment for proteomics data analysis. BMC Bioinformatics. 2009 Oct 29; 10:364.
    View in: PubMed
    Score: 0.109
  21. Optimized Orbitrap HCD for quantitative analysis of phosphopeptides. J Am Soc Mass Spectrom. 2009 Aug; 20(8):1425-34.
    View in: PubMed
    Score: 0.105
  22. Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. J Biol Chem. 2003 Mar 28; 278(13):11579-89.
    View in: PubMed
    Score: 0.068
  23. Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development. ACS Med Chem Lett. 2021 Aug 12; 12(8):1302-1307.
    View in: PubMed
    Score: 0.061
  24. BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage. Nat Commun. 2021 06 10; 12(1):3542.
    View in: PubMed
    Score: 0.061
  25. Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nat Chem Biol. 2021 09; 17(9):954-963.
    View in: PubMed
    Score: 0.061
  26. Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma. Eur J Med Chem. 2021 Oct 05; 221:113481.
    View in: PubMed
    Score: 0.060
  27. Discovery of a Selective, Covalent IRAK1 Inhibitor with Antiproliferative Activity in MYD88 Mutated B-Cell Lymphoma. ACS Med Chem Lett. 2020 Nov 12; 11(11):2238-2243.
    View in: PubMed
    Score: 0.058
  28. Discovery of Covalent MKK4/7 Dual Inhibitor. Cell Chem Biol. 2020 12 17; 27(12):1553-1560.e8.
    View in: PubMed
    Score: 0.058
  29. Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13. J Med Chem. 2020 07 09; 63(13):6708-6726.
    View in: PubMed
    Score: 0.057
  30. Identification of a potent and selective covalent Pin1 inhibitor. Nat Chem Biol. 2020 09; 16(9):979-987.
    View in: PubMed
    Score: 0.057
  31. Glucose-dependent partitioning of arginine to the urea cycle protects ß-cells from inflammation. Nat Metab. 2020 05; 2(5):432-446.
    View in: PubMed
    Score: 0.057
  32. Discovery and Structure-Activity Relationship Study of (Z)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. J Med Chem. 2020 05 14; 63(9):4880-4895.
    View in: PubMed
    Score: 0.056
  33. Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface. ACS Med Chem Lett. 2020 Jun 11; 11(6):1269-1273.
    View in: PubMed
    Score: 0.056
  34. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Sci Rep. 2020 03 24; 10(1):5324.
    View in: PubMed
    Score: 0.056
  35. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chem Biol. 2020 05 21; 27(5):525-537.e6.
    View in: PubMed
    Score: 0.056
  36. Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat Chem Biol. 2020 03; 16(3):318-326.
    View in: PubMed
    Score: 0.056
  37. Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine. J Med Chem. 2020 02 27; 63(4):1624-1641.
    View in: PubMed
    Score: 0.055
  38. Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. Cancer Cell. 2020 01 13; 37(1):104-122.e12.
    View in: PubMed
    Score: 0.055
  39. Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. ACS Med Chem Lett. 2020 Mar 12; 11(3):346-352.
    View in: PubMed
    Score: 0.055
  40. Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature. 2019 11; 575(7783):545-550.
    View in: PubMed
    Score: 0.054
  41. Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science. 2019 08 02; 365(6452).
    View in: PubMed
    Score: 0.053
  42. Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14. Bioorg Med Chem Lett. 2019 08 01; 29(15):1985-1993.
    View in: PubMed
    Score: 0.053
  43. Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. Cell Chem Biol. 2019 06 20; 26(6):818-829.e9.
    View in: PubMed
    Score: 0.052
  44. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019 06 20; 26(6):804-817.e12.
    View in: PubMed
    Score: 0.052
  45. Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype. Cell Chem Biol. 2019 06 20; 26(6):792-803.e10.
    View in: PubMed
    Score: 0.052
  46. In vitro analysis of RNA polymerase II elongation complex dynamics. Genes Dev. 2019 05 01; 33(9-10):578-589.
    View in: PubMed
    Score: 0.052
  47. In vitro assembly and proteomic analysis of RNA polymerase II complexes. Methods. 2019 04 15; 159-160:96-104.
    View in: PubMed
    Score: 0.052
  48. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell. 2018 08 09; 174(4):897-907.e14.
    View in: PubMed
    Score: 0.050
  49. Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein. Cell Chem Biol. 2018 08 16; 25(8):1006-1016.e8.
    View in: PubMed
    Score: 0.050
  50. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform. Cell Chem Biol. 2018 04 19; 25(4):460-470.e6.
    View in: PubMed
    Score: 0.049
  51. MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia. Cancer Discov. 2018 04; 8(4):478-497.
    View in: PubMed
    Score: 0.048
  52. Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors. Cell Chem Biol. 2018 02 15; 25(2):135-142.e5.
    View in: PubMed
    Score: 0.048
  53. Hepatic Dysfunction Caused by Consumption of a High-Fat Diet. Cell Rep. 2017 Dec 12; 21(11):3317-3328.
    View in: PubMed
    Score: 0.048
  54. Downstream promoter interactions of TFIID TAFs facilitate transcription reinitiation. Genes Dev. 2017 11 01; 31(21):2162-2174.
    View in: PubMed
    Score: 0.047
  55. Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer. Elife. 2017 08 10; 6.
    View in: PubMed
    Score: 0.047
  56. Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C. Cell Chem Biol. 2017 Aug 17; 24(8):1005-1016.e3.
    View in: PubMed
    Score: 0.047
  57. A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2. Cell Rep. 2017 03 28; 18(13):3167-3177.
    View in: PubMed
    Score: 0.046
  58. Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells. Proc Natl Acad Sci U S A. 2017 03 14; 114(11):E2186-E2194.
    View in: PubMed
    Score: 0.045
  59. STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1. Structure. 2017 02 07; 25(2):287-294.
    View in: PubMed
    Score: 0.045
  60. Structure-guided development of covalent TAK1 inhibitors. Bioorg Med Chem. 2017 02 01; 25(3):838-846.
    View in: PubMed
    Score: 0.045
  61. A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions. ACS Infect Dis. 2017 02 10; 3(2):112-118.
    View in: PubMed
    Score: 0.045
  62. Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine. J Biol Chem. 2017 Jan 06; 292(1):112-120.
    View in: PubMed
    Score: 0.044
  63. Differential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets. Cell Death Differ. 2017 02; 24(2):251-262.
    View in: PubMed
    Score: 0.044
  64. Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nat Chem Biol. 2016 10; 12(10):876-84.
    View in: PubMed
    Score: 0.044
  65. Phosphoproteomic profiling of mouse primary HSPCs reveals new regulators of HSPC mobilization. Blood. 2016 09 15; 128(11):1465-74.
    View in: PubMed
    Score: 0.043
  66. LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. Cell Stem Cell. 2016 07 07; 19(1):66-80.
    View in: PubMed
    Score: 0.043
  67. Direct Analysis of Phosphorylation Sites on the Rpb1 C-Terminal Domain of RNA Polymerase II. Mol Cell. 2016 Jan 21; 61(2):297-304.
    View in: PubMed
    Score: 0.042
  68. Development of Selective Covalent Janus Kinase 3 Inhibitors. J Med Chem. 2015 Aug 27; 58(16):6589-606.
    View in: PubMed
    Score: 0.041
  69. Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6. Nat Struct Mol Biol. 2015 Sep; 22(9):703-711.
    View in: PubMed
    Score: 0.041
  70. The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells. Nat Med. 2015 Jun; 21(6):572-80.
    View in: PubMed
    Score: 0.040
  71. Development of small molecules targeting the pseudokinase Her3. Bioorg Med Chem Lett. 2015 Aug 15; 25(16):3382-9.
    View in: PubMed
    Score: 0.040
  72. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec; 10(12):1006-12.
    View in: PubMed
    Score: 0.038
  73. PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair. Cancer Discov. 2014 Dec; 4(12):1430-47.
    View in: PubMed
    Score: 0.038
  74. Identification of kinase inhibitor targets in the lung cancer microenvironment by chemical and phosphoproteomics. Mol Cancer Ther. 2014 Nov; 13(11):2751-62.
    View in: PubMed
    Score: 0.038
  75. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31; 511(7511):616-20.
    View in: PubMed
    Score: 0.038
  76. In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24):8895-900.
    View in: PubMed
    Score: 0.037
  77. Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors. Oncogene. 2015 Jan 15; 34(3):373-83.
    View in: PubMed
    Score: 0.037
  78. Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angew Chem Int Ed Engl. 2014 Jan 03; 53(1):199-204.
    View in: PubMed
    Score: 0.036
  79. Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases. Nat Struct Mol Biol. 2013 Oct; 20(10):1221-3.
    View in: PubMed
    Score: 0.036
  80. Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem. 2013 Aug 30; 288(35):25477-25489.
    View in: PubMed
    Score: 0.035
  81. Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Rep. 2013 Mar 28; 3(3):747-58.
    View in: PubMed
    Score: 0.034
  82. Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. Cancer Cell. 2012 Oct 16; 22(4):547-60.
    View in: PubMed
    Score: 0.033
  83. Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature. 2012 Jul 26; 487(7408):491-5.
    View in: PubMed
    Score: 0.033
  84. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27; 19(1):140-54.
    View in: PubMed
    Score: 0.032
  85. Sub1 and RPA associate with RNA polymerase II at different stages of transcription. Mol Cell. 2011 Nov 04; 44(3):397-409.
    View in: PubMed
    Score: 0.031
  86. Crystal structure of a coiled-coil domain from human ROCK I. PLoS One. 2011 Mar 21; 6(3):e18080.
    View in: PubMed
    Score: 0.030
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.