Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jarrod Marto, Ph.D.

Co-Author

This page shows the publications co-authored by Jarrod Marto and Scott Ficarro.
Connection Strength

8.681
  1. mzStudio: A Dynamic Digital Canvas for User-Driven Interrogation of Mass Spectrometry Data. Proteomes. 2017 Aug 01; 5(3).
    View in: PubMed
    Score: 0.772
  2. Leveraging Gas-Phase Fragmentation Pathways for Improved Identification and Selective Detection of Targets Modified by Covalent Probes. Anal Chem. 2016 12 20; 88(24):12248-12254.
    View in: PubMed
    Score: 0.737
  3. Protected amine labels: a versatile molecular scaffold for multiplexed nominal mass and sub-Da isotopologue quantitative proteomic reagents. J Am Soc Mass Spectrom. 2014 Apr; 25(4):636-50.
    View in: PubMed
    Score: 0.606
  4. Online nanoflow multidimensional fractionation for high efficiency phosphopeptide analysis. Mol Cell Proteomics. 2011 Nov; 10(11):O111.011064.
    View in: PubMed
    Score: 0.509
  5. Magnetic bead processor for rapid evaluation and optimization of parameters for phosphopeptide enrichment. Anal Chem. 2009 Jun 01; 81(11):4566-75.
    View in: PubMed
    Score: 0.438
  6. Improved electrospray ionization efficiency compensates for diminished chromatographic resolution and enables proteomics analysis of tyrosine signaling in embryonic stem cells. Anal Chem. 2009 May 01; 81(9):3440-7.
    View in: PubMed
    Score: 0.436
  7. Niobium(V) oxide (Nb2O5): application to phosphoproteomics. Anal Chem. 2008 Jun 15; 80(12):4606-13.
    View in: PubMed
    Score: 0.408
  8. A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 01 09; 141(1):191-203.
    View in: PubMed
    Score: 0.212
  9. multiplierz v2.0: A Python-based ecosystem for shared access and analysis of native mass spectrometry data. Proteomics. 2017 Aug; 17(15-16).
    View in: PubMed
    Score: 0.193
  10. Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells. Cell Stem Cell. 2014 Jul 03; 15(1):92-101.
    View in: PubMed
    Score: 0.154
  11. Library dependent LC-MS/MS acquisition via mzAPI/Live. Proteomics. 2013 May; 13(9):1412-6.
    View in: PubMed
    Score: 0.144
  12. Genome-scale proteome quantification by DEEP SEQ mass spectrometry. Nat Commun. 2013; 4:2171.
    View in: PubMed
    Score: 0.140
  13. Proteomic analysis demonstrates activator- and chromatin-specific recruitment to promoters. J Biol Chem. 2012 Oct 12; 287(42):35397-35408.
    View in: PubMed
    Score: 0.137
  14. Nanoflow low pressure high peak capacity single dimension LC-MS/MS platform for high-throughput, in-depth analysis of mammalian proteomes. Anal Chem. 2012 Jun 05; 84(11):5133-9.
    View in: PubMed
    Score: 0.134
  15. C/EBPa and DEK coordinately regulate myeloid differentiation. Blood. 2012 May 24; 119(21):4878-88.
    View in: PubMed
    Score: 0.133
  16. Mass spectrometry-based proteomics: qualitative identification to activity-based protein profiling. Wiley Interdiscip Rev Syst Biol Med. 2012 Mar-Apr; 4(2):141-62.
    View in: PubMed
    Score: 0.131
  17. Online nanoflow reversed phase-strong anion exchange-reversed phase liquid chromatography-tandem mass spectrometry platform for efficient and in-depth proteome sequence analysis of complex organisms. Anal Chem. 2011 Sep 15; 83(18):6996-7005.
    View in: PubMed
    Score: 0.128
  18. Online nanoflow RP-RP-MS reveals dynamics of multicomponent Ku complex in response to DNA damage. J Proteome Res. 2010 Dec 03; 9(12):6242-55.
    View in: PubMed
    Score: 0.121
  19. multiplierz: an extensible API based desktop environment for proteomics data analysis. BMC Bioinformatics. 2009 Oct 29; 10:364.
    View in: PubMed
    Score: 0.113
  20. Optimized Orbitrap HCD for quantitative analysis of phosphopeptides. J Am Soc Mass Spectrom. 2009 Aug; 20(8):1425-34.
    View in: PubMed
    Score: 0.108
  21. Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. J Biol Chem. 2003 Mar 28; 278(13):11579-89.
    View in: PubMed
    Score: 0.070
  22. Discovery of a Selective, Covalent IRAK1 Inhibitor with Antiproliferative Activity in MYD88 Mutated B-Cell Lymphoma. ACS Med Chem Lett. 2020 Nov 12; 11(11):2238-2243.
    View in: PubMed
    Score: 0.060
  23. Discovery of Covalent MKK4/7 Dual Inhibitor. Cell Chem Biol. 2020 12 17; 27(12):1553-1560.e8.
    View in: PubMed
    Score: 0.060
  24. Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13. J Med Chem. 2020 07 09; 63(13):6708-6726.
    View in: PubMed
    Score: 0.059
  25. Identification of a potent and selective covalent Pin1 inhibitor. Nat Chem Biol. 2020 09; 16(9):979-987.
    View in: PubMed
    Score: 0.059
  26. Glucose-dependent partitioning of arginine to the urea cycle protects ß-cells from inflammation. Nat Metab. 2020 05; 2(5):432-446.
    View in: PubMed
    Score: 0.058
  27. Discovery and Structure-Activity Relationship Study of (Z)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. J Med Chem. 2020 05 14; 63(9):4880-4895.
    View in: PubMed
    Score: 0.058
  28. Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface. ACS Med Chem Lett. 2020 Jun 11; 11(6):1269-1273.
    View in: PubMed
    Score: 0.058
  29. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Sci Rep. 2020 03 24; 10(1):5324.
    View in: PubMed
    Score: 0.058
  30. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chem Biol. 2020 05 21; 27(5):525-537.e6.
    View in: PubMed
    Score: 0.058
  31. Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat Chem Biol. 2020 03; 16(3):318-326.
    View in: PubMed
    Score: 0.057
  32. Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine. J Med Chem. 2020 02 27; 63(4):1624-1641.
    View in: PubMed
    Score: 0.057
  33. Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. Cancer Cell. 2020 01 13; 37(1):104-122.e12.
    View in: PubMed
    Score: 0.057
  34. Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. ACS Med Chem Lett. 2020 Mar 12; 11(3):346-352.
    View in: PubMed
    Score: 0.056
  35. Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature. 2019 11; 575(7783):545-550.
    View in: PubMed
    Score: 0.056
  36. Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science. 2019 08 02; 365(6452).
    View in: PubMed
    Score: 0.055
  37. Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14. Bioorg Med Chem Lett. 2019 08 01; 29(15):1985-1993.
    View in: PubMed
    Score: 0.055
  38. Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. Cell Chem Biol. 2019 06 20; 26(6):818-829.e9.
    View in: PubMed
    Score: 0.054
  39. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019 06 20; 26(6):804-817.e12.
    View in: PubMed
    Score: 0.054
  40. Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype. Cell Chem Biol. 2019 06 20; 26(6):792-803.e10.
    View in: PubMed
    Score: 0.054
  41. In vitro analysis of RNA polymerase II elongation complex dynamics. Genes Dev. 2019 05 01; 33(9-10):578-589.
    View in: PubMed
    Score: 0.054
  42. In vitro assembly and proteomic analysis of RNA polymerase II complexes. Methods. 2019 04 15; 159-160:96-104.
    View in: PubMed
    Score: 0.054
  43. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell. 2018 08 09; 174(4):897-907.e14.
    View in: PubMed
    Score: 0.052
  44. Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein. Cell Chem Biol. 2018 08 16; 25(8):1006-1016.e8.
    View in: PubMed
    Score: 0.051
  45. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform. Cell Chem Biol. 2018 04 19; 25(4):460-470.e6.
    View in: PubMed
    Score: 0.050
  46. MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia. Cancer Discov. 2018 04; 8(4):478-497.
    View in: PubMed
    Score: 0.050
  47. Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors. Cell Chem Biol. 2018 02 15; 25(2):135-142.e5.
    View in: PubMed
    Score: 0.050
  48. Hepatic Dysfunction Caused by Consumption of a High-Fat Diet. Cell Rep. 2017 Dec 12; 21(11):3317-3328.
    View in: PubMed
    Score: 0.049
  49. Downstream promoter interactions of TFIID TAFs facilitate transcription reinitiation. Genes Dev. 2017 11 01; 31(21):2162-2174.
    View in: PubMed
    Score: 0.049
  50. Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer. Elife. 2017 08 10; 6.
    View in: PubMed
    Score: 0.048
  51. Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C. Cell Chem Biol. 2017 Aug 17; 24(8):1005-1016.e3.
    View in: PubMed
    Score: 0.048
  52. A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2. Cell Rep. 2017 03 28; 18(13):3167-3177.
    View in: PubMed
    Score: 0.047
  53. Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells. Proc Natl Acad Sci U S A. 2017 03 14; 114(11):E2186-E2194.
    View in: PubMed
    Score: 0.047
  54. STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1. Structure. 2017 02 07; 25(2):287-294.
    View in: PubMed
    Score: 0.046
  55. Structure-guided development of covalent TAK1 inhibitors. Bioorg Med Chem. 2017 02 01; 25(3):838-846.
    View in: PubMed
    Score: 0.046
  56. A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions. ACS Infect Dis. 2017 02 10; 3(2):112-118.
    View in: PubMed
    Score: 0.046
  57. Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine. J Biol Chem. 2017 Jan 06; 292(1):112-120.
    View in: PubMed
    Score: 0.046
  58. Differential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets. Cell Death Differ. 2017 02; 24(2):251-262.
    View in: PubMed
    Score: 0.046
  59. Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nat Chem Biol. 2016 10; 12(10):876-84.
    View in: PubMed
    Score: 0.045
  60. Phosphoproteomic profiling of mouse primary HSPCs reveals new regulators of HSPC mobilization. Blood. 2016 09 15; 128(11):1465-74.
    View in: PubMed
    Score: 0.045
  61. LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. Cell Stem Cell. 2016 07 07; 19(1):66-80.
    View in: PubMed
    Score: 0.045
  62. Direct Analysis of Phosphorylation Sites on the Rpb1 C-Terminal Domain of RNA Polymerase II. Mol Cell. 2016 Jan 21; 61(2):297-304.
    View in: PubMed
    Score: 0.043
  63. Development of Selective Covalent Janus Kinase 3 Inhibitors. J Med Chem. 2015 Aug 27; 58(16):6589-606.
    View in: PubMed
    Score: 0.042
  64. Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6. Nat Struct Mol Biol. 2015 Sep; 22(9):703-711.
    View in: PubMed
    Score: 0.042
  65. The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells. Nat Med. 2015 Jun; 21(6):572-80.
    View in: PubMed
    Score: 0.041
  66. Development of small molecules targeting the pseudokinase Her3. Bioorg Med Chem Lett. 2015 Aug 15; 25(16):3382-9.
    View in: PubMed
    Score: 0.041
  67. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec; 10(12):1006-12.
    View in: PubMed
    Score: 0.040
  68. PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair. Cancer Discov. 2014 Dec; 4(12):1430-47.
    View in: PubMed
    Score: 0.040
  69. Identification of kinase inhibitor targets in the lung cancer microenvironment by chemical and phosphoproteomics. Mol Cancer Ther. 2014 Nov; 13(11):2751-62.
    View in: PubMed
    Score: 0.039
  70. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31; 511(7511):616-20.
    View in: PubMed
    Score: 0.039
  71. In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24):8895-900.
    View in: PubMed
    Score: 0.039
  72. Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors. Oncogene. 2015 Jan 15; 34(3):373-83.
    View in: PubMed
    Score: 0.038
  73. Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angew Chem Int Ed Engl. 2014 Jan 03; 53(1):199-204.
    View in: PubMed
    Score: 0.037
  74. Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases. Nat Struct Mol Biol. 2013 Oct; 20(10):1221-3.
    View in: PubMed
    Score: 0.037
  75. Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem. 2013 Aug 30; 288(35):25477-25489.
    View in: PubMed
    Score: 0.036
  76. Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Rep. 2013 Mar 28; 3(3):747-58.
    View in: PubMed
    Score: 0.036
  77. Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. Cancer Cell. 2012 Oct 16; 22(4):547-60.
    View in: PubMed
    Score: 0.035
  78. Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature. 2012 Jul 26; 487(7408):491-5.
    View in: PubMed
    Score: 0.034
  79. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27; 19(1):140-54.
    View in: PubMed
    Score: 0.033
  80. Sub1 and RPA associate with RNA polymerase II at different stages of transcription. Mol Cell. 2011 Nov 04; 44(3):397-409.
    View in: PubMed
    Score: 0.032
  81. Crystal structure of a coiled-coil domain from human ROCK I. PLoS One. 2011 Mar 21; 6(3):e18080.
    View in: PubMed
    Score: 0.031
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.