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Davide Cappon, Ph.D.

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Biography
Harvard Medical School, BIDMC-Berenson-Allen Center for Noninvasive Brain StimulationFellowship09/2020Cognitive Behavioral Neurology - Neuromodulation in Dementia
Harvard Medical School, Hebrew Rehabilitation Center-Marcus Institute for Aging ResearchFellowship01/2022Geriatric Neuropsychiatry & Behavioral Neurology
2023 - 2025
NARSAD Young Investigator Award

Overview
Davide Balos Cappon, MS, PhD is an Instructor in Neurology at Harvard Medical School, an Assistant Scientist of the Hinda and Arthur Marcus Institute for Aging Research, and a board-certified psychologist specialized in clinical neuropsychologist practicing at the Deanna and Sidney Wolk Center for Memory Health at Hebrew SeniorLife (HSL).

Dr. Cappon, as a clinician-scientist, has a multidisciplinary background with specific training and expertise in clinical translational research involving device-based neuromodulation techniques such as transcranial magnetic stimulation (TMS), transcranial electrical stimulation (tES) and deep brain stimulation (DBS). He conducted numerous studies examining the mechanisms, safety, and efficacy of these novel noninvasive therapeutic approaches to improve psychiatric symptoms and cognitive functions in aging and neurodegenerative diseases.

A major focus of Dr. Cappon’s research is on making precise symptom-specific circuit-based neuromodulation therapy more accessible to older adults with cognitive and mood disorders. He has developed novel methods and procedures for the safe, remotely monitored, multi-channel application of tES to older adults in their homes (HB-tES). Dr. Cappon is now investigating the use of a personalized novel and scalable home-based neuromodulation interventions that address the undertreatment of depression and other psychiatric symptoms in the context of dementia.

At HSL, another central theme of Dr. Cappon's research is preserving and lengthening healthy aging across the lifespan. Serving on the executive committee of the HSL's Healthy Aging Initiative in collaboration with investigators from the Marcus Institute, Dr. Cappon is working on expanding our understanding of multimodal factors determining lifelong health. The initiative will identify physical and mental health markers across the lifespan and promote multimodal interventions that support health and prevent age-related cognitive decline, adopting a whole-person approach to health, aging, and well-being.

Prior to coming to Hebrew SeniorLife, Dr. Cappon was trained at the UCL's Functional Neurosurgery Unit at the National Hospital of Neurology and Neurosurgery in Queen Square London UK and has been engaged in translational research at HMS since January 2018, where he has completed Fellowships in Neuromodulation in dementia at the Berenson Allen Center-Beth Israel Deaconess Medical Center and in geriatric neuropsychiatry at the Marcus Institute for Aging Research at Hebrew Rehabilitation Center.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kahya M, Gouskova NA, Lo OY, Zhou J, Cappon D, Finnerty E, Pascual-Leone A, Lipsitz LA, Hausdorff JM, Manor B. Brain activity during dual-task standing in older adults. J Neuroeng Rehabil. 2022 Nov 11; 19(1):123. PMID: 36369027; PMCID: PMC9652829.
    Citations:    Fields:    Translation:Humans
  2. Cappon D, Gratwicke J, Zrinzo L, Akram H, Hyam J, Hariz M, Limousin P, Foltynie T, Jahanshahi M. Deep Brain Stimulation of the Nucleus Basalis of Meynert for Parkinson's Disease Dementia: A 36?Months Follow Up Study. Mov Disord Clin Pract. 2022 Aug; 9(6):765-774. PMID: 35937485.
    Citations:    
  3. Cappon D, den Boer T, Jordan C, Yu W, Lo A, LaGanke N, Biagi MC, Skorupinski P, Ruffini G, Morales O, Metzger E, Manor B, Pascual-Leone A. Safety and Feasibility of Tele-Supervised Home-Based Transcranial Direct Current Stimulation for Major Depressive Disorder. Front Aging Neurosci. 2021; 13:765370. PMID: 35185515; PMCID: PMC8849231.
    Citations: 1     
  4. Dhaynaut M, Sprugnoli G, Cappon D, Macone J, Sanchez JS, Normandin MD, Guehl NJ, Koch G, Paciorek R, Connor A, Press D, Johnson K, Pascual-Leone A, El Fakhri G, Santarnecchi E. Impact of 40?Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer's Disease: A Case Series. J Alzheimers Dis. 2022; 85(4):1667-1676. PMID: 34958021; PMCID: PMC9023125.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Sprugnoli G, Munsch F, Cappon D, Paciorek R, Macone J, Connor A, El Fakhri G, Salvador R, Ruffini G, Donohoe K, Shafi MM, Press D, Alsop DC, Pascual Leone A, Santarnecchi E. Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer's disease. Alzheimers Res Ther. 2021 12 20; 13(1):203. PMID: 34930421; PMCID: PMC8690894.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  6. Cappon D, den Boer T, Jordan C, Yu W, Metzger E, Pascual-Leone A. Transcranial magnetic stimulation (TMS) for geriatric depression. Ageing Res Rev. 2022 02; 74:101531. PMID: 34839043; PMCID: PMC8996329.
    Citations: 4     Fields:    Translation:Humans
  7. Cappon D, Ryterska A, Akram H, Lagrata S, Cheema S, Hyam J, Zrinzo L, Matharu M, Jahanshahi M. The sensitivity to change of the cluster headache quality of life scale assessed before and after deep brain stimulation of the ventral tegmental area. J Headache Pain. 2021 Jun 06; 22(1):52. PMID: 34092221.
    Citations: 1     Fields:    Translation:Humans
  8. Romanella SM, Roe D, Tatti E, Cappon D, Paciorek R, Testani E, Rossi A, Rossi S, Santarnecchi E. The Sleep Side of Aging and Alzheimer's Disease. Sleep Med. 2021 01; 77:209-225. PMID: 32912799.
    Citations: 6     Fields:    Translation:Humans
  9. Romanella SM, Roe D, Paciorek R, Cappon D, Ruffini G, Menardi A, Rossi A, Rossi S, Santarnecchi E. Sleep, Noninvasive Brain Stimulation, and the Aging Brain: Challenges and Opportunities. Ageing Res Rev. 2020 08; 61:101067. PMID: 32380212.
    Citations: 6     Fields:    Translation:Humans
  10. Dhaynaut M, Cappon D, Paciorek R, Macone J, Connor A, Guehl N, Pascual-Leone A, Santarnecchi E, El Fakhri G. Effects of modulating gamma oscillations via 40Hz transcranial alternating current stimulation (tACS) on Tau PET imaging in mild to moderate Alzheimer’s Disease. Journal of Nuclear Medicine. 2020; 61(1).
  11. Burke MJ, Faria V, Cappon D, Pascual-Leone A, Kaptchuk TJ, Santarnecchi E. Leveraging the Shared Neurobiology of Placebo Effects and Functional Neurological Disorder: A Call for Research. J Neuropsychiatry Clin Neurosci. 2020 Winter; 32(1):101-104. PMID: 31662093.
    Citations:    Fields:    Translation:Humans
  12. Cappon D, Beigi M, Kefalopoulou Z, Zrinzo L, Candelario J, Milabo C, Akram H, Dayal V, Hyam J, Kass-Iliyya L, Silverdale M, Evans J, Limousin P, Hariz M, Joyce E, Foltynie T, Jahanshahi M. Globus pallidal deep brain stimulation for Tourette syndrome: Effects on cognitive function. Parkinsonism Relat Disord. 2019 12; 69:14-18. PMID: 31648149.
    Citations: 1     Fields:    Translation:Humans
  13. Cappon D, Ryterska A, Lagrata S, Miller S, Akram H, Hyam J, Zrinzo L, Matharu M, Jahanshahi M. Ventral tegmental area deep brain stimulation for chronic cluster headache: Effects on cognition, mood, pain report behaviour and quality of life. Cephalalgia. 2019 Aug; 39(9):1099-1110. PMID: 30897944.
    Citations: 5     Fields:    Translation:Humans
  14. Dayal V, Grover T, Limousin P, Akram H, Cappon D, Candelario J, Salazar M, Tripoliti E, Zrinzo L, Hyam J, Jahanshahi M, Hariz M, Foltynie T. The Effect of Short Pulse Width Settings on the Therapeutic Window in Subthalamic Nucleus Deep Brain Stimulation for Parkinson's disease. J Parkinsons Dis. 2018; 8(2):273-279. PMID: 29843252.
    Citations: 4     Fields:    Translation:Humans
  15. Cappon D, Goljahani A, Laera G, Bisiacchi P. Interactions between non invasive transcranial brain stimulation (tACS) and brain oscillations: a quantitative EEG study. Int J Psychophysiol. 2016; 108:92.
  16. Cappon D, Jahanshahi M, Bisiacchi P. Value and Efficacy of Transcranial Direct Current Stimulation in the Cognitive Rehabilitation: A Critical Review Since 2000. Front Neurosci. 2016; 10:157. PMID: 27147949; PMCID: PMC4834357.
    Citations: 27     
  17. Cappon D, D'Ostilio K, Garraux G, Rothwell J, Bisiacchi P. Effects of 10?Hz and 20?Hz Transcranial Alternating Current Stimulation on Automatic Motor Control. Brain Stimul. 2016 Jul-Aug; 9(4):518-24. PMID: 27038707.
    Citations: 10     Fields:    Translation:Humans
  18. Cappon D, D'Ostilio K, Garraux G, Rothwell JC, Bisiacchi P. Cortical modulation of automatic facilitation and inhibition by 10 Hz and 20 Hz transcranial alternating current stimulation (tACS). Brain Stimulation . 2015; 8(2):356-357.
  19. Ciocca M, Cappon D, Priori A, Rothwell J. High-definition transcranial direct current stimulation (HD-tDCS): a TMS study to investigate focal motor cortex (M1) excitability. Clinical Neurophysiology. 2014; (125):S118.
  20. Cappon D, D'Ostilio K., Garraux G, Bisiacchi P, Rothwell J . Effect of transcranial alternating current stimulation (tACS) on automatic and unconscious control of movement. The 32nd European Workshop on Cognitive Neuropsychology, Bressanone, Italy, January 2014. 2014.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.