Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jorge Sepulcre, Ph.D., D.M.Sc., M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG061811 (SEPULCRE, JORGE) Sep 1, 2019 - May 31, 2024
    NIH
    Sensory and Motor Streams in Preclinical and Clinical Stages of Alzheimer's Disease
    Role: Principal Investigator
  2. R01AG061445 (SEPULCRE, JORGE) Aug 15, 2019 - Apr 30, 2024
    NIH
    Genetic Profiles of the Spatiotemporal Causality of Tau and Amyloid in the Elderly Brain
    Role: Principal Investigator
  3. RF1AG052653 (LI, QUANZHENG) Aug 15, 2017 - Jun 30, 2021
    NIH
    Study of Brain Spreading Pathways of Tau and Amyloid-Beta in (pre)clinical AD
    Role: Co-Principal Investigator
  4. K23EB019023 (SEPULCRE, JORGE) Aug 1, 2014 - Jul 31, 2019
    NIH
    In Vivo Visualization of TAU and Amyloid-Beta Networks for Early AD Detection
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gutiérrez-Zúñiga R, Diez I, Bueichekú E, Kim CM, Orwig W, Montal V, Fuentes B, Díez-Tejedor E, Fernández MG, Sepulcre J. Connectomic-genetic signatures in the cerebral small vessel disease. Neurobiol Dis. 2022 06 01; 167:105671. PMID: 35231560.
    Citations:    Fields:    
  2. Basaia S, Agosta F, Diez I, Bueichekú E, d'Oleire Uquillas F, Delgado-Alvarado M, Caballero-Gaudes C, Rodriguez-Oroz M, Stojkovic T, Kostic VS, Filippi M, Sepulcre J. Neurogenetic traits outline vulnerability to cortical disruption in Parkinson's disease. Neuroimage Clin. 2022; 33:102941. PMID: 35091253.
    Citations:    Fields:    Translation:Humans
  3. Bueichekú E, Gonzalez-de-Echavarri JM, Ortiz-Teran L, Montal V, d'Oleire Uquillas F, De Marcos L, Orwig W, Kim CM, Ortiz-Teran E, Basaia S, Diez I, Sepulcre J. Divergent connectomic organization delineates genetic evolutionary traits in the human brain. Sci Rep. 2021 10 04; 11(1):19692. PMID: 34608211.
    Citations:    Fields:    Translation:Humans
  4. Rodriguez-Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz AP, Properzi MJ, Scott MR, Amariglio R, Papp KV, Marshall GA, Fortea J, Johnson KA, Sperling RA, Vannini P. Association of cortical microstructure with amyloid-ß and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults. Mol Psychiatry. 2021 12; 26(12):7813-7822. PMID: 34588623.
    Citations:    Fields:    
  5. Leaston J, Ferris CF, Kulkarni P, Chandramohan D, van de Ven AL, Qiao J, Timms L, Sepulcre J, El Fakhri G, Ma C, Normandin MD, Gharagouzloo C. Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities. PLoS One. 2021; 16(8):e0256749. PMID: 34449808.
    Citations: 1     Fields:    Translation:HumansAnimals
  6. Gao Q, Xiang Y, Zhang J, Luo N, Liang M, Gong L, Yu J, Cui Q, Sepulcre J, Chen H. A reachable probability approach for the analysis of spatio-temporal dynamics in the human functional network. Neuroimage. 2021 11; 243:118497. PMID: 34428571.
    Citations: 1     Fields:    Translation:Humans
  7. Diez I, Sepulcre J. Unveiling the neuroimaging-genetic intersections in the human brain. Curr Opin Neurol. 2021 08 01; 34(4):480-487. PMID: 34227572.
    Citations: 1     Fields:    Translation:HumansCells
  8. Orwig W, Diez I, Bueichekú E, Vannini P, Beaty R, Sepulcre J. Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain. Front Hum Neurosci. 2021; 15:694274. PMID: 34381343.
    Citations: 1     
  9. Costumero V, Rosell Negre P, Bustamante JC, Fuentes-Claramonte P, Adrián-Ventura J, Palomar-García MÁ, Miró-Padilla A, Llopis JJ, Sepulcre J, Barrós-Loscertales A. Distance disintegration characterizes node-level topological dysfunctions in cocaine addiction. Addict Biol. 2021 11; 26(6):e13072. PMID: 34137121.
    Citations:    Fields:    Translation:Humans
  10. Dong D, Yao D, Wang Y, Hong SJ, Genon S, Xin F, Jung K, He H, Chang X, Duan M, Bernhardt BC, Margulies DS, Sepulcre J, Eickhoff SB, Luo C. Compressed sensorimotor-to-transmodal hierarchical organization in schizophrenia. Psychol Med. 2021 Jun 08; 1-14. PMID: 34100349.
    Citations: 1     Fields:    
  11. Ortiz-Teran E, Diez I, Sepulcre J, Lopez-Pascual J, Ortiz T. Connectivity adaptations in dopaminergic systems define the brain maturity of investors. Sci Rep. 2021 06 03; 11(1):11671. PMID: 34083626.
    Citations:    Fields:    Translation:Humans
  12. Jimenez-Marin A, Diez I, Labayru G, Sistiaga A, Caballero MC, Andres-Benito P, Sepulcre J, Ferrer I, Lopez de Munain A, Cortes JM. Transcriptional signatures of synaptic vesicle genes define myotonic dystrophy type I neurodegeneration. Neuropathol Appl Neurobiol. 2021 12; 47(7):1092-1108. PMID: 33955002.
    Citations: 2     Fields:    Translation:HumansCells
  13. Kim CM, Montal V, Diez I, Orwig W, Sepulcre J. Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging. Hum Brain Mapp. 2021 07; 42(10):2990-3004. PMID: 33955621.
    Citations: 1     Fields:    Translation:Humans
  14. Mayblyum DV, Becker JA, Jacobs HIL, Buckley RF, Schultz AP, Sepulcre J, Sanchez JS, Rubinstein ZB, Katz SR, Moody KA, Vannini P, Papp KV, Rentz DM, Price JC, Sperling RA, Johnson KA, Hanseeuw BJ. Comparing PET and MRI Biomarkers Predicting Cognitive Decline in Preclinical Alzheimer Disease. Neurology. 2021 May 05. PMID: 33952655.
    Citations: 3     Fields:    
  15. Yang F, Chowdhury SR, Jacobs HIL, Sepulcre J, Wedeen VJ, Johnson KA, Dutta J. Longitudinal predictive modeling of tau progression along the structural connectome. Neuroimage. 2021 08 15; 237:118126. PMID: 33957234.
    Citations: 1     Fields:    Translation:Humans
  16. DuBois JM, Mathotaarachchi S, Rousset OG, Sziklas V, Sepulcre J, Guiot MC, Hall JA, Massarweh G, Soucy JP, Rosa-Neto P, Kobayashi E. Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia. Neuroimage Clin. 2021; 29:102552. PMID: 33401137.
    Citations:    Fields:    Translation:Humans
  17. Orwig W, Diez I, Vannini P, Beaty R, Sepulcre J. Creative Connections: Computational Semantic Distance Captures Individual Creativity and Resting-State Functional Connectivity. J Cogn Neurosci. 2021 03; 33(3):499-509. PMID: 33284079.
    Citations:    Fields:    Translation:Humans
  18. Song TA, Chowdhury SR, Yang F, Jacobs HIL, Sepulcre J, Wedeen VJ, Johnson KA, Dutta J. A physics-informed geometric learning model for pathological tau spread in Alzheimer's disease. Med Image Comput Comput Assist Interv. 2020 Oct; 12267:418-427. PMID: 33263115.
    Citations: 1     Fields:    
  19. Labayru G, Jimenez-Marin A, Fernández E, Villanua J, Zulaica M, Cortes JM, Díez I, Sepulcre J, López de Munain A, Sistiaga A. Neurodegeneration trajectory in pediatric and adult/late DM1: A follow-up MRI study across a decade. Ann Clin Transl Neurol. 2020 10; 7(10):1802-1815. PMID: 32881379.
    Citations: 4     Fields:    Translation:Humans
  20. Chow HM, Garnett EO, Li H, Etchell A, Sepulcre J, Drayna D, Chugani D, Chang SE. Linking Lysosomal Enzyme Targeting Genes and Energy Metabolism with Altered Gray Matter Volume in Children with Persistent Stuttering. Neurobiol Lang (Camb). 2020 Aug; 1(3):365-380. PMID: 34041495.
    Citations: 5     
  21. Beucke JC, Simon D, Sepulcre J, Talukdar T, Feusner JD, Kaufmann C, Kathmann N. Heightened degree connectivity of the striatum in obsessive-compulsive disorder induced by symptom provocation. J Affect Disord. 2020 11 01; 276:1069-1076. PMID: 32768879.
    Citations:    Fields:    Translation:Humans
  22. d'Oleire Uquillas F, Jacobs HIL, Schultz AP, Hanseeuw BJ, Buckley RF, Sepulcre J, Pascual-Leone A, Donovan NJ, Johnson KA, Sperling RA, Vannini P. Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. Cereb Cortex. 2020 03 14; 30(3):1974-1983. PMID: 31696223.
    Citations:    Fields:    Translation:Humans
  23. Bueichekú E, Aznárez-Sanado M, Diez I, d'Oleire Uquillas F, Ortiz-Terán L, Qureshi AY, Suñol M, Basaia S, Ortiz-Terán E, Pastor MA, Sepulcre J. Central neurogenetic signatures of the visuomotor integration system. Proc Natl Acad Sci U S A. 2020 03 24; 117(12):6836-6843. PMID: 32144139.
    Citations: 5     Fields:    Translation:Humans
  24. Diez I, Larson AG, Nakhate V, Dunn EC, Fricchione GL, Nicholson TR, Sepulcre J, Perez DL. Early-life trauma endophenotypes and brain circuit-gene expression relationships in functional neurological (conversion) disorder. Mol Psychiatry. 2021 08; 26(8):3817-3828. PMID: 32051548.
    Citations: 13     Fields:    Translation:Humans
  25. Costumero V, d'Oleire Uquillas F, Diez I, Andorrà M, Basaia S, Bueichekú E, Ortiz-Terán L, Belloch V, Escudero J, Ávila C, Sepulcre J. Distance disintegration delineates the brain connectivity failure of Alzheimer's disease. Neurobiol Aging. 2020 04; 88:51-60. PMID: 31941578.
    Citations:    Fields:    Translation:Humans
  26. Bueichekú E, Ávila C, Miró-Padilla A, Sepulcre J. Visual search task immediate training effects on task-related functional connectivity. Brain Imaging Behav. 2019 Dec; 13(6):1566-1579. PMID: 30443892.
    Citations:    Fields:    Translation:Humans
  27. Vannini P, d'Oleire Uquillas F, Jacobs HIL, Sepulcre J, Gatchel J, Amariglio RE, Hanseeuw B, Papp KV, Hedden T, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults. Neuroimage Clin. 2019; 24:102097. PMID: 31795044.
    Citations: 1     Fields:    Translation:Humans
  28. Labayru G, Diez I, Sepulcre J, Fernández E, Zulaica M, Cortés JM, López de Munain A, Sistiaga A. Regional brain atrophy in gray and white matter is associated with cognitive impairment in Myotonic Dystrophy type 1. Neuroimage Clin. 2019; 24:102078. PMID: 31795042.
    Citations: 12     Fields:    Translation:HumansCells
  29. Benito-Aragón C, Gonzalez-Sarmiento R, Liddell T, Diez I, d'Oleire Uquillas F, Ortiz-Terán L, Bueichekú E, Chow HM, Chang SE, Sepulcre J. Neurofilament-lysosomal genetic intersections in the cortical network of stuttering. Prog Neurobiol. 2020 01; 184:101718. PMID: 31669185.
    Citations: 10     Fields:    Translation:HumansCells
  30. Xin Q, Ortiz-Terán L, Diez I, Perez DL, Ginsburg J, El Fakhri G, Sepulcre J. Sequence Alterations of Cortical Genes Linked to Individual Connectivity of the Human Brain. Cereb Cortex. 2019 08 14; 29(9):3828-3835. PMID: 30307489.
    Citations: 3     Fields:    Translation:HumansCells
  31. Hanseeuw BJ, Betensky RA, Jacobs HIL, Schultz AP, Sepulcre J, Becker JA, Cosio DMO, Farrell M, Quiroz YT, Mormino EC, Buckley RF, Papp KV, Amariglio RA, Dewachter I, Ivanoiu A, Huijbers W, Hedden T, Marshall GA, Chhatwal JP, Rentz DM, Sperling RA, Johnson K. Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study. JAMA Neurol. 2019 Aug 01; 76(8):915-924. PMID: 31157827.
    Citations: 152     Fields:    
  32. Wooten DW, Ortiz-Terán L, Zubcevik N, Zhang X, Huang C, Sepulcre J, Atassi N, Johnson KA, Zafonte RD, El Fakhri G. Multi-Modal Signatures of Tau Pathology, Neuronal Fiber Integrity, and Functional Connectivity in Traumatic Brain Injury. J Neurotrauma. 2019 12 01; 36(23):3233-3243. PMID: 31210098.
    Citations: 9     Fields:    Translation:HumansCells
  33. Pretus C, Marcos-Vidal L, Martínez-García M, Picado M, Ramos-Quiroga JA, Richarte V, Castellanos FX, Sepulcre J, Desco M, Vilarroya Ó, Carmona S. Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder. Hum Brain Mapp. 2019 11 01; 40(16):4645-4656. PMID: 31322305.
    Citations: 2     Fields:    Translation:Humans
  34. Martínez K, Martínez-García M, Marcos-Vidal L, Janssen J, Castellanos FX, Pretus C, Villarroya Ó, Pina-Camacho L, Díaz-Caneja CM, Parellada M, Arango C, Desco M, Sepulcre J, Carmona S. Sensory-to-Cognitive Systems Integration Is Associated With Clinical Severity in Autism Spectrum Disorder. J Am Acad Child Adolesc Psychiatry. 2020 03; 59(3):422-433. PMID: 31260788.
    Citations: 6     Fields:    Translation:Humans
  35. Diez I, Ortiz-Terán L, Williams B, Jalilianhasanpour R, Ospina JP, Dickerson BC, Keshavan MS, LaFrance WC, Sepulcre J, Perez DL. Corticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder. J Neurol Neurosurg Psychiatry. 2019 08; 90(8):929-938. PMID: 30850473.
    Citations: 15     Fields:    Translation:Humans
  36. Sepulcre J, Grothe MJ, d'Oleire Uquillas F, Ortiz-Terán L, Diez I, Yang HS, Jacobs HIL, Hanseeuw BJ, Li Q, El-Fakhri G, Sperling RA, Johnson KA. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nat Med. 2018 12; 24(12):1910-1918. PMID: 30374196.
    Citations: 47     Fields:    Translation:HumansCells
  37. Diez I, Sepulcre J. Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain. Nat Commun. 2018 09 24; 9(1):3876. PMID: 30250030.
    Citations: 8     Fields:    Translation:Humans
  38. Gao Q, Yu Y, Su X, Tao Z, Zhang M, Wang Y, Leng J, Sepulcre J, Chen H. Adaptation of brain functional stream architecture in athletes with fast demands of sensorimotor integration. Hum Brain Mapp. 2019 02 01; 40(2):420-431. PMID: 30277624.
    Citations: 5     Fields:    Translation:Humans
  39. Grothe MJ, Sepulcre J, Gonzalez-Escamilla G, Jelistratova I, Schöll M, Hansson O, Teipel SJ. Molecular properties underlying regional vulnerability to Alzheimer's disease pathology. Brain. 2018 09 01; 141(9):2755-2771. PMID: 30016411.
    Citations: 46     Fields:    Translation:HumansCells
  40. Qian J, Diez I, Ortiz-Terán L, Bonadio C, Liddell T, Goñi J, Sepulcre J. Positive Connectivity Predicts the Dynamic Intrinsic Topology of the Human Brain Network. Front Syst Neurosci. 2018; 12:38. PMID: 30214399.
    Citations: 5     
  41. Peña-Gómez C, Avena-Koenigsberger A, Sepulcre J, Sporns O. Spatiotemporal Network Markers of Individual Variability in the Human Functional Connectome. Cereb Cortex. 2018 08 01; 28(8):2922-2934. PMID: 28981611.
    Citations: 10     Fields:    Translation:Humans
  42. Hanseeuw BJ, Betensky RA, Mormino EC, Schultz AP, Sepulcre J, Becker JA, Jacobs HIL, Buckley RF, LaPoint MR, Vannini P, Donovan NJ, Chhatwal JP, Marshall GA, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. PET staging of amyloidosis using striatum. Alzheimers Dement. 2018 10; 14(10):1281-1292. PMID: 29792874.
    Citations: 38     Fields:    Translation:Humans
  43. Williams B, Jalilianhasanpour R, Matin N, Fricchione GL, Sepulcre J, Keshavan MS, LaFrance WC, Dickerson BC, Perez DL. Individual differences in corticolimbic structural profiles linked to insecure attachment and coping styles in motor functional neurological disorders. J Psychiatr Res. 2018 07; 102:230-237. PMID: 29702433.
    Citations: 8     Fields:    Translation:Humans
  44. Marcos-Vidal L, Martínez-García M, Pretus C, Garcia-Garcia D, Martínez K, Janssen J, Vilarroya O, Castellanos FX, Desco M, Sepulcre J, Carmona S. Local functional connectivity suggests functional immaturity in children with attention-deficit/hyperactivity disorder. Hum Brain Mapp. 2018 06; 39(6):2442-2454. PMID: 29473262.
    Citations: 11     Fields:    Translation:Humans
  45. Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat Neurosci. 2018 03; 21(3):424-431. PMID: 29403032.
    Citations: 92     Fields:    Translation:Humans
  46. Grothe MJ, Barthel H, Sepulcre J, Dyrba M, Sabri O, Teipel SJ. In vivo staging of regional amyloid deposition. Neurology. 2017 Nov 14; 89(20):2031-2038. PMID: 29046362.
    Citations: 109     Fields:    Translation:Humans
  47. Yang J, Hu C, Guo N, Dutta J, Vaina LM, Johnson KA, Sepulcre J, Fakhri GE, Li Q. Partial volume correction for PET quantification and its impact on brain network in Alzheimer's disease. Sci Rep. 2017 10 12; 7(1):13035. PMID: 29026139.
    Citations: 14     Fields:    Translation:Humans
  48. Ruiz de Miras J, Costumero V, Belloch V, Escudero J, Ávila C, Sepulcre J. Complexity analysis of cortical surface detects changes in future Alzheimer's disease converters. Hum Brain Mapp. 2017 12; 38(12):5905-5918. PMID: 28856799.
    Citations: 10     Fields:    Translation:Humans
  49. Perez DL, Williams B, Matin N, LaFrance WC, Costumero-Ramos V, Fricchione GL, Sepulcre J, Keshavan MS, Dickerson BC. Corticolimbic structural alterations linked to health status and trait anxiety in functional neurological disorder. J Neurol Neurosurg Psychiatry. 2017 12; 88(12):1052-1059. PMID: 28844071.
    Citations: 20     Fields:    Translation:Humans
  50. Sepulcre J, Grothe MJ, Sabuncu M, Chhatwal J, Schultz AP, Hanseeuw B, El Fakhri G, Sperling R, Johnson KA. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurol. 2017 07 01; 74(7):813-820. PMID: 28558094.
    Citations: 28     Fields:    Translation:Humans
  51. Ortiz-Terán L, Diez I, Ortiz T, Perez DL, Aragón JI, Costumero V, Pascual-Leone A, El Fakhri G, Sepulcre J. Brain circuit-gene expression relationships and neuroplasticity of multisensory cortices in blind children. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):6830-6835. PMID: 28607055.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  52. Buckley RF, Schultz AP, Hedden T, Papp KV, Hanseeuw BJ, Marshall G, Sepulcre J, Smith EE, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology. 2017 Jul 04; 89(1):29-37. PMID: 28592457.
    Citations: 39     Fields:    Translation:Humans
  53. LaPoint MR, Chhatwal JP, Sepulcre J, Johnson KA, Sperling RA, Schultz AP. The association between tau PET and retrospective cortical thinning in clinically normal elderly. Neuroimage. 2017 08 15; 157:612-622. PMID: 28545932.
    Citations: 43     Fields:    Translation:Humans
  54. Perez DL, Matin N, Barsky A, Costumero-Ramos V, Makaretz SJ, Young SS, Sepulcre J, LaFrance WC, Keshavan MS, Dickerson BC. Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders. J Neurol Neurosurg Psychiatry. 2017 06; 88(6):491-497. PMID: 28416565.
    Citations: 30     Fields:    Translation:Humans
  55. Hanseeuw BJ, Betensky RA, Schultz AP, Papp KV, Mormino EC, Sepulcre J, Bark JS, Cosio DM, LaPoint M, Chhatwal JP, Rentz DM, Sperling RA, Johnson KA. Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline. Ann Neurol. 2017 Apr; 81(4):583-596. PMID: 28253546.
    Citations: 62     Fields:    Translation:Humans
  56. Xia C, Makaretz SJ, Caso C, McGinnis S, Gomperts SN, Sepulcre J, Gomez-Isla T, Hyman BT, Schultz A, Vasdev N, Johnson KA, Dickerson BC. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurol. 2017 04 01; 74(4):427-436. PMID: 28241163.
    Citations: 111     Fields:    Translation:Humans
  57. Sepulcre J, Sabuncu MR, Li Q, El Fakhri G, Sperling R, Johnson KA. Tau and amyloid ß proteins distinctively associate to functional network changes in the aging brain. Alzheimers Dement. 2017 Nov; 13(11):1261-1269. PMID: 28366797.
    Citations: 35     Fields:    Translation:Humans
  58. Schultz AP, Chhatwal JP, Hedden T, Mormino EC, Hanseeuw BJ, Sepulcre J, Huijbers W, LaPoint M, Buckley RF, Johnson KA, Sperling RA. Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals. J Neurosci. 2017 04 19; 37(16):4323-4331. PMID: 28314821.
    Citations: 88     Fields:    Translation:Humans
  59. Duque P, Oltra-Cucarella J, Fernandez O, Sepulcre J, Grupo de Estudio de la Bateria Neuropsicologica Breve En la Esclerosis Multiple GE. [Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level]. Rev Neurol. 2017 Feb 01; 64(3):97-104. PMID: 28128426.
    Citations:    Fields:    Translation:Humans
  60. Prckovska V, Huijbers W, Schultz A, Ortiz-Teran L, Peña-Gomez C, Villoslada P, Johnson K, Sperling R, Sepulcre J. Epicenters of dynamic connectivity in the adaptation of the ventral visual system. Hum Brain Mapp. 2017 04; 38(4):1965-1976. PMID: 28029725.
    Citations:    Fields:    Translation:Humans
  61. Beucke JC, Sepulcre J, Buhlmann U, Kathmann N, Moody T, Feusner JD. Degree connectivity in body dysmorphic disorder and relationships with obsessive and compulsive symptoms. Eur Neuropsychopharmacol. 2016 10; 26(10):1657-66. PMID: 27514293.
    Citations: 4     Fields:    Translation:Humans
  62. Sepulcre J, Schultz AP, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson KA. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. J Neurosci. 2016 07 13; 36(28):7364-74. PMID: 27413148.
    Citations: 84     Fields:    Translation:Humans
  63. Ortiz-Terán L, Ortiz T, Perez DL, Aragón JI, Diez I, Pascual-Leone A, Sepulcre J. Brain Plasticity in Blind Subjects Centralizes Beyond the Modal Cortices. Front Syst Neurosci. 2016; 10:61. PMID: 27458350.
    Citations: 9     
  64. Teipel S, Grothe MJ, Zhou J, Sepulcre J, Dyrba M, Sorg C, Babiloni C. Measuring Cortical Connectivity in Alzheimer's Disease as a Brain Neural Network Pathology: Toward Clinical Applications. J Int Neuropsychol Soc. 2016 Feb; 22(2):138-63. PMID: 26888613.
    Citations: 36     Fields:    Translation:Humans
  65. Sepulcre J, Masdeu JC. Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer's Disease. Methods Mol Biol. 2016; 1303:509-19. PMID: 26235088.
    Citations: 3     Fields:    Translation:HumansAnimals
  66. Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, Sperling R. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann Neurol. 2016 Jan; 79(1):110-9. PMID: 26505746.
    Citations: 403     Fields:    Translation:Humans
  67. Hu C, Sepulcre J, Johnson KA, Fakhri GE, Lu YM, Li Q. Matched signal detection on graphs: Theory and application to brain imaging data classification. Neuroimage. 2016 Jan 15; 125:587-600. PMID: 26481679.
    Citations: 5     Fields:    Translation:Humans
  68. Abad E, Sepulcre J, Martinez-Lapiscina EH, Zubizarreta I, Garcia-Ojalvo J, Villoslada P. The analysis of semantic networks in multiple sclerosis identifies preferential damage of long-range connectivity. Mult Scler Relat Disord. 2015 Sep; 4(5):387-394. PMID: 26346784.
    Citations: 1     Fields:    Translation:Humans
  69. Hu C, Cheng L, Sepulcre J, Johnson KA, Fakhri GE, Lu YM, Li Q. A spectral graph regression model for learning brain connectivity of Alzheimer's disease. PLoS One. 2015; 10(5):e0128136. PMID: 26024224.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  70. Carmona S, Hoekzema E, Castellanos FX, García-García D, Lage-Castellanos A, Van Dijk KR, Navas-Sánchez FJ, Martínez K, Desco M, Sepulcre J. Sensation-to-cognition cortical streams in attention-deficit/hyperactivity disorder. Hum Brain Mapp. 2015 Jul; 36(7):2544-57. PMID: 25821110.
    Citations: 22     Fields:    Translation:Humans
  71. Beucke JC, Sepulcre J, Eldaief MC, Sebold M, Kathmann N, Kaufmann C. Default mode network subsystem alterations in obsessive-compulsive disorder. Br J Psychiatry. 2014 Nov; 205(5):376-82. PMID: 25257066.
    Citations: 39     Fields:    Translation:Humans
  72. Sepulcre J. Functional streams and cortical integration in the human brain. Neuroscientist. 2014 Oct; 20(5):499-508. PMID: 24737695.
    Citations: 21     Fields:    Translation:Humans
  73. Sepulcre J. Integration of visual and motor functional streams in the human brain. Neurosci Lett. 2014 May 01; 567:68-73. PMID: 24699175.
    Citations: 13     Fields:    Translation:Humans
  74. Sepulcre J. An OP4 functional stream in the language-related neuroarchitecture. Cereb Cortex. 2015 Mar; 25(3):658-66. PMID: 24084124.
    Citations: 12     Fields:    Translation:Humans
  75. Johnson KA, Sperling RA, Sepulcre J. Functional connectivity in Alzheimer's disease: measurement and meaning. Biol Psychiatry. 2013 Sep 01; 74(5):318-9. PMID: 23932342.
    Citations: 4     Fields:    Translation:Humans
  76. Sepulcre J, Sabuncu MR, Becker A, Sperling R, Johnson KA. In vivo characterization of the early states of the amyloid-beta network. Brain. 2013 Jul; 136(Pt 7):2239-52. PMID: 23801740.
    Citations: 58     Fields:    Translation:Humans
  77. Beucke JC, Sepulcre J, Talukdar T, Linnman C, Zschenderlein K, Endrass T, Kaufmann C, Kathmann N. Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder. JAMA Psychiatry. 2013 Jun; 70(6):619-29. PMID: 23740050.
    Citations: 104     Fields:    Translation:Humans
  78. Mueller S, Wang D, Fox MD, Yeo BT, Sepulcre J, Sabuncu MR, Shafee R, Lu J, Liu H. Individual variability in functional connectivity architecture of the human brain. Neuron. 2013 Feb 06; 77(3):586-95. PMID: 23395382.
    Citations: 346     Fields:    Translation:HumansAnimals
  79. Hu C, Cheng L, Sepulcre J, El Fakhri G, Lu YM, Lu YM. Matched signal detection on graphs: theory and application to brain network classification. Inf Process Med Imaging. 2013; 23:1-12. PMID: 24683953.
    Citations: 3     Fields:    Translation:Humans
  80. Spreng RN, Sepulcre J, Turner GR, Stevens WD, Schacter DL. Intrinsic architecture underlying the relations among the default, dorsal attention, and frontoparietal control networks of the human brain. J Cogn Neurosci. 2013 Jan; 25(1):74-86. PMID: 22905821.
    Citations: 250     Fields:    Translation:Humans
  81. Sepulcre J, Sabuncu MR, Johnson KA. Network assemblies in the functional brain. Curr Opin Neurol. 2012 Aug; 25(4):384-91. PMID: 22766721.
    Citations: 14     Fields:    Translation:HumansAnimals
  82. Sepulcre J, Sabuncu MR, Yeo TB, Liu H, Johnson KA. Stepwise connectivity of the modal cortex reveals the multimodal organization of the human brain. J Neurosci. 2012 Aug 01; 32(31):10649-61. PMID: 22855814.
    Citations: 104     Fields:    Translation:Humans
  83. Duque P, Ibanez J, Del Barco A, Sepulcre J, de Ramon E, Fernandez-Fernandez O. [Normalisation and validation of the Brief Neuropsychological Battery as the reference neuropsychological test in multiple sclerosis]. Rev Neurol. 2012 Mar 01; 54(5):263-70. PMID: 22362474.
    Citations: 1     Fields:    Translation:Humans
  84. Sabuncu MR, Desikan RS, Sepulcre J, Yeo BT, Liu H, Schmansky NJ, Reuter M, Weiner MW, Buckner RL, Sperling RA, Fischl B. The dynamics of cortical and hippocampal atrophy in Alzheimer disease. Arch Neurol. 2011 Aug; 68(8):1040-8. PMID: 21825241.
    Citations: 112     Fields:    Translation:Humans
  85. Vélez de Mendizábal N, Carneiro J, Solé RV, Goñi J, Bragard J, Martinez-Forero I, Martinez-Pasamar S, Sepulcre J, Torrealdea J, Bagnato F, Garcia-Ojalvo J, Villoslada P. Modeling the effector - regulatory T cell cross-regulation reveals the intrinsic character of relapses in Multiple Sclerosis. BMC Syst Biol. 2011 Jul 15; 5:114. PMID: 21762505.
    Citations: 15     Fields:    Translation:HumansCells
  86. Yeo BT, Krienen FM, Sepulcre J, Sabuncu MR, Lashkari D, Hollinshead M, Roffman JL, Smoller JW, Zöllei L, Polimeni JR, Fischl B, Liu H, Buckner RL. The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J Neurophysiol. 2011 Sep; 106(3):1125-65. PMID: 21653723.
    Citations: 2219     Fields:    Translation:Humans
  87. Bejarano B, Bianco M, Gonzalez-Moron D, Sepulcre J, Goñi J, Arcocha J, Soto O, Del Carro U, Comi G, Leocani L, Villoslada P. Computational classifiers for predicting the short-term course of Multiple sclerosis. BMC Neurol. 2011 Jun 07; 11:67. PMID: 21649880.
    Citations: 14     Fields:    Translation:Humans
  88. Drzezga A, Becker JA, Van Dijk KR, Sreenivasan A, Talukdar T, Sullivan C, Schultz AP, Sepulcre J, Putcha D, Greve D, Johnson KA, Sperling RA. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain. 2011 Jun; 134(Pt 6):1635-46. PMID: 21490054.
    Citations: 148     Fields:    Translation:Humans
  89. Stufflebeam SM, Liu H, Sepulcre J, Tanaka N, Buckner RL, Madsen JR. Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging. J Neurosurg. 2011 Jun; 114(6):1693-7. PMID: 21351832.
    Citations: 39     Fields:    Translation:Humans
  90. Goñi J, Arrondo G, Sepulcre J, Martincorena I, Vélez de Mendizábal N, Corominas-Murtra B, Bejarano B, Ardanza-Trevijano S, Peraita H, Wall DP, Villoslada P. The semantic organization of the animal category: evidence from semantic verbal fluency and network theory. Cogn Process. 2011 May; 12(2):183-96. PMID: 20938799.
    Citations: 23     Fields:    Translation:Humans
  91. Sepulcre J, Peraita H, Goni J, Arrondo G, Martincorena I, Duque B, Velez de Mendizabal N, Masdeu JC, Villoslada P. Lexical access changes in patients with multiple sclerosis: a two-year follow-up study. J Clin Exp Neuropsychol. 2011 Feb; 33(2):169-75. PMID: 20835944.
    Citations: 3     Fields:    Translation:Humans
  92. Sepulcre J, Liu H, Talukdar T, Martincorena I, Yeo BT, Buckner RL. The organization of local and distant functional connectivity in the human brain. PLoS Comput Biol. 2010 Jun 10; 6(6):e1000808. PMID: 20548945.
    Citations: 170     Fields:    Translation:Humans
  93. Andrews-Hanna JR, Reidler JS, Sepulcre J, Poulin R, Buckner RL. Functional-anatomic fractionation of the brain's default network. Neuron. 2010 Feb 25; 65(4):550-62. PMID: 20188659.
    Citations: 991     Fields:    Translation:Humans
  94. Liu H, Stufflebeam SM, Sepulcre J, Hedden T, Buckner RL. Evidence from intrinsic activity that asymmetry of the human brain is controlled by multiple factors. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20499-503. PMID: 19918055.
    Citations: 118     Fields:    Translation:HumansCells
  95. Sepulcre J, Masdeu JC, Pastor MA, Goñi J, Barbosa C, Bejarano B, Villoslada P. Brain pathways of verbal working memory: a lesion-function correlation study. Neuroimage. 2009 Aug 15; 47(2):773-8. PMID: 19393745.
    Citations: 14     Fields:    Translation:HumansCells
  96. Arrondo G, Alegre M, Sepulcre J, Iriarte J, Artieda J, Villoslada P. Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosis. Mult Scler. 2009 Apr; 15(4):509-16. PMID: 19282416.
    Citations: 11     Fields:    Translation:Humans
  97. Buckner RL, Sepulcre J, Talukdar T, Krienen FM, Liu H, Hedden T, Andrews-Hanna JR, Sperling RA, Johnson KA. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. J Neurosci. 2009 Feb 11; 29(6):1860-73. PMID: 19211893.
    Citations: 1242     Fields:    Translation:Humans
  98. Sepulcre J, Goñi J, Masdeu JC, Bejarano B, Vélez de Mendizábal N, Toledo JB, Villoslada P. Contribution of white matter lesions to gray matter atrophy in multiple sclerosis: evidence from voxel-based analysis of T1 lesions in the visual pathway. Arch Neurol. 2009 Feb; 66(2):173-9. PMID: 19204153.
    Citations: 41     Fields:    Translation:HumansCells
  99. Esteban FJ, Sepulcre J, de Miras JR, Navas J, de Mendizábal NV, Goñi J, Quesada JM, Bejarano B, Villoslada P. Fractal dimension analysis of grey matter in multiple sclerosis. J Neurol Sci. 2009 Jul 15; 282(1-2):67-71. PMID: 19167728.
    Citations: 23     Fields:    Translation:Humans
  100. Villoslada P, Arrondo G, Sepulcre J, Alegre M, Artieda J. Memantine induces reversible neurologic impairment in patients with MS. Neurology. 2009 May 12; 72(19):1630-3. PMID: 19092106.
    Citations: 29     Fields:    Translation:HumansPHPublic Health
  101. Villoslada P, Sepulcre J, Toledo J, Bejarano B, Calabresi PA, Lipkin EG, Chodkowski BA, Reich D, Smith S, Pulicken M, Frohman E, Balcer L, Cutter G. Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis. Neurology. 2008 Nov 18; 71(21):1747; author reply 1747-8. PMID: 19015496.
    Citations: 6     Fields:    Translation:Humans
  102. Sepulcre J, Masdeu JC, Goñi J, Arrondo G, Vélez de Mendizábal N, Bejarano B, Villoslada P. Fatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways. Mult Scler. 2009 Mar; 15(3):337-44. PMID: 18987107.
    Citations: 51     Fields:    Translation:Humans
  103. Sepulcre J, Masdeu JC, Sastre-Garriga J, Goñi J, Vélez-de-Mendizábal N, Duque B, Pastor MA, Bejarano B, Villoslada P. Mapping the brain pathways of declarative verbal memory: Evidence from white matter lesions in the living human brain. Neuroimage. 2008 Sep 01; 42(3):1237-43. PMID: 18585467.
    Citations: 26     Fields:    Translation:Humans
  104. Duque B, Sepulcre J, Bejarano B, Samaranch L, Pastor P, Villoslada P. Memory decline evolves independently of disease activity in MS. Mult Scler. 2008 Aug; 14(7):947-53. PMID: 18573817.
    Citations: 15     Fields:    Translation:Humans
  105. Toledo J, Sepulcre J, Salinas-Alaman A, García-Layana A, Murie-Fernandez M, Bejarano B, Villoslada P. Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis. Mult Scler. 2008 Aug; 14(7):906-12. PMID: 18573835.
    Citations: 61     Fields:    Translation:HumansCells
  106. Goñi J, Esteban FJ, de Mendizábal NV, Sepulcre J, Ardanza-Trevijano S, Agirrezabal I, Villoslada P. A computational analysis of protein-protein interaction networks in neurodegenerative diseases. BMC Syst Biol. 2008 Jun 20; 2:52. PMID: 18570646.
    Citations: 38     Fields:    Translation:Cells
  107. Sepulcre J, Masdeu JC, Palacios R, Goñi J, Moreno B, Tainta M, Bejarano B, Villoslada P. HLA-DR2 and white matter lesion distribution in MS. J Neuroimaging. 2008 Jul; 18(3):328-31. PMID: 18482373.
    Citations: 2     Fields:    Translation:Humans
  108. Pampliega O, Domercq M, Villoslada P, Sepulcre J, Rodríguez-Antigüedad A, Matute C. Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis. J Neuroimmunol. 2008 Mar; 195(1-2):194-8. PMID: 18378006.
    Citations: 19     Fields:    Translation:HumansCells
  109. Martinez-Forero I, Garcia-Munoz R, Martinez-Pasamar S, Inoges S, Lopez-Diaz de Cerio A, Palacios R, Sepulcre J, Moreno B, Gonzalez Z, Fernandez-Diez B, Melero I, Bendandi M, Villoslada P. IL-10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis. Eur J Immunol. 2008 Feb; 38(2):576-86. PMID: 18200504.
    Citations: 53     Fields:    Translation:HumansCells
  110. Palacios R, Goni J, Martinez-Forero I, Iranzo J, Sepulcre J, Melero I, Villoslada P. A network analysis of the human T-cell activation gene network identifies JAGGED1 as a therapeutic target for autoimmune diseases. PLoS One. 2007 Nov 21; 2(11):e1222. PMID: 18030350.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  111. Riverol M, Sepulcre J, Fernandez-Diez B, Villoslada P, Fernandez-Alonso M, Rubio M, Rodriguez A, Uccelli A, Brieva L. Antibodies against Epstein-Barr virus and herpesvirus type 6 are associated with the early phases of multiple sclerosis. J Neuroimmunol. 2007 Dec; 192(1-2):184-5. PMID: 17869349.
    Citations: 6     Fields:    Translation:HumansCells
  112. Sepulcre J, Murie-Fernandez M, Salinas-Alaman A, García-Layana A, Bejarano B, Villoslada P. Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS. Neurology. 2007 May 01; 68(18):1488-94. PMID: 17470751.
    Citations: 90     Fields:    Translation:HumansCells
  113. Esteban FJ, Sepulcre J, de Mendizábal NV, Goñi J, Navas J, de Miras JR, Bejarano B, Masdeu JC, Villoslada P. Fractal dimension and white matter changes in multiple sclerosis. Neuroimage. 2007 Jul 01; 36(3):543-9. PMID: 17499522.
    Citations: 23     Fields:    Translation:Humans
  114. Moreno B, Hevia H, Santamaria M, Sepulcre J, Muñoz J, García-Trevijano ER, Berasain C, Corrales FJ, Avila MA, Villoslada P. Methylthioadenosine reverses brain autoimmune disease. Ann Neurol. 2006 Sep; 60(3):323-34. PMID: 16786535.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  115. Sepulcre J, Sastre-Garriga J, Cercignani M, Ingle GT, Miller DH, Thompson AJ. Regional gray matter atrophy in early primary progressive multiple sclerosis: a voxel-based morphometry study. Arch Neurol. 2006 Aug; 63(8):1175-80. PMID: 16908748.
    Citations: 62     Fields:    Translation:Humans
  116. Sepulcre J, Vanotti S, Hernández R, Sandoval G, Cáceres F, Garcea O, Villoslada P. Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test. Mult Scler. 2006 Apr; 12(2):187-95. PMID: 16629422.
    Citations: 50     Fields:    Translation:Humans
  117. Sepulcre J, Sanchez-Ibarrola A, Moreno C, de Castro P. Association between peripheral IFN-gamma producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis. Cytokine. 2005 Oct 21; 32(2):111-6. PMID: 16246570.
    Citations: 4     Fields:    Translation:HumansCells
  118. Irimia P, Moya M, Sepulcre J, Martínez-Vila E. Transient blurred vision as the only manifestation of basilar stenosis. Cerebrovasc Dis. 2004; 18(1):88-9. PMID: 15178995.
    Citations: 1     Fields:    Translation:Humans
  119. Pierron H, Sauzay F, Bellon-Serre V, Sepulcre J, Perrimond H, David JM. [Acute accidental oral iron poisoning of drug origin in pediatrics]. Ann Pediatr (Paris). 1987 Apr; 34(4):333-5. PMID: 3605980.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.