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Jorge Sepulcre, Ph.D., D.M.Sc., M.D.

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Mentoring
Available: 07/02/19, Expires: 07/01/21

We aim to develop graph theoretical tools to visualize and study BPNs in preclinical -that is, normal older individuals at risk for Alzheimer’s disease (AD) by virtue of advanced age- and clinical AD subjects using positron emission tomography (PET). Particularly, we will construct group-level brain graphs using multi-regression models and PET images from two key AD pathological radioligands:

  1. 11C-labeled Pittsburgh Compound-B (11C-PIB) that binds fibrillar amyloid-beta (Aβ) plaques; and
  2. F18-T807 that binds TAU neurofibrillary tangles.

Then, we will develop graph theory metrics to estimate network propagation patterns in group-level Aβ and TAU brain pathological networks (BPNs). Finally, we will investigate individual mapping of BPNs and its relationship with individual risk for AD, functional connectivity breakdown, and neuropsychological profiles.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG061811 (SEPULCRE, JORGE) Sep 1, 2019 - May 31, 2024
    NIH
    Sensory and Motor Streams in Preclinical and Clinical Stages of Alzheimer's Disease
    Role: Principal Investigator
  2. R01AG061445 (SEPULCRE, JORGE) Aug 15, 2019 - Apr 30, 2024
    NIH
    Genetic Profiles of the Spatiotemporal Causality of Tau and Amyloid in the Elderly Brain
    Role: Principal Investigator
  3. RF1AG052653 (LI, QUANZHENG) Aug 15, 2017 - Jun 30, 2021
    NIH
    Study of Brain Spreading Pathways of Tau and Amyloid-Beta in (pre)clinical AD
    Role: Co-Principal Investigator
  4. K23EB019023 (SEPULCRE, JORGE) Aug 1, 2014 - Jul 31, 2019
    NIH
    In Vivo Visualization of TAU and Amyloid-Beta Networks for Early AD Detection
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. DuBois JM, Mathotaarachchi S, Rousset OG, Sziklas V, Sepulcre J, Guiot MC, Hall JA, Massarweh G, Soucy JP, Rosa-Neto P, Kobayashi E. Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia. Neuroimage Clin. 2021; 29:102552. PMID: 33401137.
    Citations:    Fields:    
  2. Orwig W, Diez I, Vannini P, Beaty R, Sepulcre J. Creative Connections: Computational Semantic Distance Captures Individual Creativity and Resting-State Functional Connectivity. J Cogn Neurosci. 2021 Mar; 33(3):499-509. PMID: 33284079.
    Citations:    Fields:    
  3. Song TA, Chowdhury SR, Yang F, Jacobs HIL, Sepulcre J, Wedeen VJ, Johnson KA, Dutta J. A physics-informed geometric learning model for pathological tau spread in Alzheimer's disease. Med Image Comput Comput Assist Interv. 2020 Oct; 12267:418-427. PMID: 33263115.
    Citations:    Fields:    
  4. Labayru G, Jimenez-Marin A, Fernández E, Villanua J, Zulaica M, Cortes JM, Díez I, Sepulcre J, López de Munain A, Sistiaga A. Neurodegeneration trajectory in pediatric and adult/late DM1: A follow-up MRI study across a decade. Ann Clin Transl Neurol. 2020 10; 7(10):1802-1815. PMID: 32881379.
    Citations:    Fields:    
  5. Beucke JC, Simon D, Sepulcre J, Talukdar T, Feusner JD, Kaufmann C, Kathmann N. Heightened degree connectivity of the striatum in obsessive-compulsive disorder induced by symptom provocation. J Affect Disord. 2020 11 01; 276:1069-1076. PMID: 32768879.
    Citations:    Fields:    Translation:Humans
  6. d'Oleire Uquillas F, Jacobs HIL, Schultz AP, Hanseeuw BJ, Buckley RF, Sepulcre J, Pascual-Leone A, Donovan NJ, Johnson KA, Sperling RA, Vannini P. Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. Cereb Cortex. 2020 03 14; 30(3):1974-1983. PMID: 31696223.
    Citations:    Fields:    
  7. Bueichekú E, Aznárez-Sanado M, Diez I, d'Oleire Uquillas F, Ortiz-Terán L, Qureshi AY, Suñol M, Basaia S, Ortiz-Terán E, Pastor MA, Sepulcre J. Central neurogenetic signatures of the visuomotor integration system. Proc Natl Acad Sci U S A. 2020 03 24; 117(12):6836-6843. PMID: 32144139.
    Citations: 2     Fields:    Translation:Humans
  8. Diez I, Larson AG, Nakhate V, Dunn EC, Fricchione GL, Nicholson TR, Sepulcre J, Perez DL. Early-life trauma endophenotypes and brain circuit-gene expression relationships in functional neurological (conversion) disorder. Mol Psychiatry. 2020 Feb 12. PMID: 32051548.
    Citations: 7     Fields:    
  9. Costumero V, d'Oleire Uquillas F, Diez I, Andorrà M, Basaia S, Bueichekú E, Ortiz-Terán L, Belloch V, Escudero J, Ávila C, Sepulcre J. Distance disintegration delineates the brain connectivity failure of Alzheimer's disease. Neurobiol Aging. 2020 04; 88:51-60. PMID: 31941578.
    Citations:    Fields:    Translation:Humans
  10. Bueichekú E, Ávila C, Miró-Padilla A, Sepulcre J. Visual search task immediate training effects on task-related functional connectivity. Brain Imaging Behav. 2019 Dec; 13(6):1566-1579. PMID: 30443892.
    Citations:    Fields:    Translation:Humans
  11. Vannini P, d'Oleire Uquillas F, Jacobs HIL, Sepulcre J, Gatchel J, Amariglio RE, Hanseeuw B, Papp KV, Hedden T, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults. Neuroimage Clin. 2019; 24:102097. PMID: 31795044.
    Citations: 1     Fields:    Translation:Humans
  12. Labayru G, Diez I, Sepulcre J, Fernández E, Zulaica M, Cortés JM, López de Munain A, Sistiaga A. Regional brain atrophy in gray and white matter is associated with cognitive impairment in Myotonic Dystrophy type 1. Neuroimage Clin. 2019; 24:102078. PMID: 31795042.
    Citations: 5     Fields:    Translation:HumansCells
  13. Benito-Aragón C, Gonzalez-Sarmiento R, Liddell T, Diez I, d'Oleire Uquillas F, Ortiz-Terán L, Bueichekú E, Chow HM, Chang SE, Sepulcre J. Neurofilament-lysosomal genetic intersections in the cortical network of stuttering. Prog Neurobiol. 2020 01; 184:101718. PMID: 31669185.
    Citations: 2     Fields:    Translation:HumansCells
  14. Xin Q, Ortiz-Terán L, Diez I, Perez DL, Ginsburg J, El Fakhri G, Sepulcre J. Sequence Alterations of Cortical Genes Linked to Individual Connectivity of the Human Brain. Cereb Cortex. 2019 08 14; 29(9):3828-3835. PMID: 30307489.
    Citations: 1     Fields:    Translation:HumansCells
  15. Hanseeuw BJ, Betensky RA, Jacobs HIL, Schultz AP, Sepulcre J, Becker JA, Cosio DMO, Farrell M, Quiroz YT, Mormino EC, Buckley RF, Papp KV, Amariglio RA, Dewachter I, Ivanoiu A, Huijbers W, Hedden T, Marshall GA, Chhatwal JP, Rentz DM, Sperling RA, Johnson K. Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study. JAMA Neurol. 2019 Aug 01; 76(8):915-924. PMID: 31157827.
    Citations: 69     Fields:    
  16. Wooten DW, Ortiz-Terán L, Zubcevik N, Zhang X, Huang C, Sepulcre J, Atassi N, Johnson KA, Zafonte RD, El Fakhri G. Multi-Modal Signatures of Tau Pathology, Neuronal Fiber Integrity, and Functional Connectivity in Traumatic Brain Injury. J Neurotrauma. 2019 12 01; 36(23):3233-3243. PMID: 31210098.
    Citations: 5     Fields:    Translation:HumansCells
  17. Pretus C, Marcos-Vidal L, Martínez-García M, Picado M, Ramos-Quiroga JA, Richarte V, Castellanos FX, Sepulcre J, Desco M, Vilarroya Ó, Carmona S. Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder. Hum Brain Mapp. 2019 11 01; 40(16):4645-4656. PMID: 31322305.
    Citations: 1     Fields:    Translation:Humans
  18. Martínez K, Martínez-García M, Marcos-Vidal L, Janssen J, Castellanos FX, Pretus C, Villarroya Ó, Pina-Camacho L, Díaz-Caneja CM, Parellada M, Arango C, Desco M, Sepulcre J, Carmona S. Sensory-to-Cognitive Systems Integration Is Associated With Clinical Severity in Autism Spectrum Disorder. J Am Acad Child Adolesc Psychiatry. 2020 03; 59(3):422-433. PMID: 31260788.
    Citations: 3     Fields:    Translation:Humans
  19. Diez I, Ortiz-Terán L, Williams B, Jalilianhasanpour R, Ospina JP, Dickerson BC, Keshavan MS, LaFrance WC, Sepulcre J, Perez DL. Corticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder. J Neurol Neurosurg Psychiatry. 2019 08; 90(8):929-938. PMID: 30850473.
    Citations: 11     Fields:    Translation:Humans
  20. Sepulcre J, Grothe MJ, d'Oleire Uquillas F, Ortiz-Terán L, Diez I, Yang HS, Jacobs HIL, Hanseeuw BJ, Li Q, El-Fakhri G, Sperling RA, Johnson KA. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nat Med. 2018 12; 24(12):1910-1918. PMID: 30374196.
    Citations: 27     Fields:    Translation:HumansCells
  21. Diez I, Sepulcre J. Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain. Nat Commun. 2018 09 24; 9(1):3876. PMID: 30250030.
    Citations: 3     Fields:    Translation:Humans
  22. Gao Q, Yu Y, Su X, Tao Z, Zhang M, Wang Y, Leng J, Sepulcre J, Chen H. Adaptation of brain functional stream architecture in athletes with fast demands of sensorimotor integration. Hum Brain Mapp. 2019 02 01; 40(2):420-431. PMID: 30277624.
    Citations: 4     Fields:    Translation:Humans
  23. Grothe MJ, Sepulcre J, Gonzalez-Escamilla G, Jelistratova I, Schöll M, Hansson O, Teipel SJ. Molecular properties underlying regional vulnerability to Alzheimer's disease pathology. Brain. 2018 09 01; 141(9):2755-2771. PMID: 30016411.
    Citations: 23     Fields:    Translation:HumansCells
  24. Qian J, Diez I, Ortiz-Terán L, Bonadio C, Liddell T, Goñi J, Sepulcre J. Positive Connectivity Predicts the Dynamic Intrinsic Topology of the Human Brain Network. Front Syst Neurosci. 2018; 12:38. PMID: 30214399.
    Citations: 4     
  25. Peña-Gómez C, Avena-Koenigsberger A, Sepulcre J, Sporns O. Spatiotemporal Network Markers of Individual Variability in the Human Functional Connectome. Cereb Cortex. 2018 08 01; 28(8):2922-2934. PMID: 28981611.
    Citations: 6     Fields:    Translation:Humans
  26. Hanseeuw BJ, Betensky RA, Mormino EC, Schultz AP, Sepulcre J, Becker JA, Jacobs HIL, Buckley RF, LaPoint MR, Vannini P, Donovan NJ, Chhatwal JP, Marshall GA, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. PET staging of amyloidosis using striatum. Alzheimers Dement. 2018 10; 14(10):1281-1292. PMID: 29792874.
    Citations: 21     Fields:    Translation:Humans
  27. Williams B, Jalilianhasanpour R, Matin N, Fricchione GL, Sepulcre J, Keshavan MS, LaFrance WC, Dickerson BC, Perez DL. Individual differences in corticolimbic structural profiles linked to insecure attachment and coping styles in motor functional neurological disorders. J Psychiatr Res. 2018 07; 102:230-237. PMID: 29702433.
    Citations: 4     Fields:    Translation:Humans
  28. Marcos-Vidal L, Martínez-García M, Pretus C, Garcia-Garcia D, Martínez K, Janssen J, Vilarroya O, Castellanos FX, Desco M, Sepulcre J, Carmona S. Local functional connectivity suggests functional immaturity in children with attention-deficit/hyperactivity disorder. Hum Brain Mapp. 2018 06; 39(6):2442-2454. PMID: 29473262.
    Citations: 8     Fields:    Translation:Humans
  29. Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat Neurosci. 2018 03; 21(3):424-431. PMID: 29403032.
    Citations: 54     Fields:    Translation:Humans
  30. Grothe MJ, Barthel H, Sepulcre J, Dyrba M, Sabri O, Teipel SJ. In vivo staging of regional amyloid deposition. Neurology. 2017 Nov 14; 89(20):2031-2038. PMID: 29046362.
    Citations: 70     Fields:    Translation:Humans
  31. Yang J, Hu C, Guo N, Dutta J, Vaina LM, Johnson KA, Sepulcre J, Fakhri GE, Li Q. Partial volume correction for PET quantification and its impact on brain network in Alzheimer's disease. Sci Rep. 2017 10 12; 7(1):13035. PMID: 29026139.
    Citations: 9     Fields:    Translation:Humans
  32. Ruiz de Miras J, Costumero V, Belloch V, Escudero J, Ávila C, Sepulcre J. Complexity analysis of cortical surface detects changes in future Alzheimer's disease converters. Hum Brain Mapp. 2017 12; 38(12):5905-5918. PMID: 28856799.
    Citations: 10     Fields:    Translation:Humans
  33. Perez DL, Williams B, Matin N, LaFrance WC, Costumero-Ramos V, Fricchione GL, Sepulcre J, Keshavan MS, Dickerson BC. Corticolimbic structural alterations linked to health status and trait anxiety in functional neurological disorder. J Neurol Neurosurg Psychiatry. 2017 12; 88(12):1052-1059. PMID: 28844071.
    Citations: 14     Fields:    Translation:Humans
  34. Sepulcre J, Grothe MJ, Sabuncu M, Chhatwal J, Schultz AP, Hanseeuw B, El Fakhri G, Sperling R, Johnson KA. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurol. 2017 07 01; 74(7):813-820. PMID: 28558094.
    Citations: 19     Fields:    Translation:Humans
  35. Ortiz-Terán L, Diez I, Ortiz T, Perez DL, Aragón JI, Costumero V, Pascual-Leone A, El Fakhri G, Sepulcre J. Brain circuit-gene expression relationships and neuroplasticity of multisensory cortices in blind children. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):6830-6835. PMID: 28607055.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  36. Buckley RF, Schultz AP, Hedden T, Papp KV, Hanseeuw BJ, Marshall G, Sepulcre J, Smith EE, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology. 2017 Jul 04; 89(1):29-37. PMID: 28592457.
    Citations: 30     Fields:    Translation:Humans
  37. LaPoint MR, Chhatwal JP, Sepulcre J, Johnson KA, Sperling RA, Schultz AP. The association between tau PET and retrospective cortical thinning in clinically normal elderly. Neuroimage. 2017 08 15; 157:612-622. PMID: 28545932.
    Citations: 27     Fields:    Translation:Humans
  38. Perez DL, Matin N, Barsky A, Costumero-Ramos V, Makaretz SJ, Young SS, Sepulcre J, LaFrance WC, Keshavan MS, Dickerson BC. Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders. J Neurol Neurosurg Psychiatry. 2017 06; 88(6):491-497. PMID: 28416565.
    Citations: 22     Fields:    Translation:Humans
  39. Hanseeuw BJ, Betensky RA, Schultz AP, Papp KV, Mormino EC, Sepulcre J, Bark JS, Cosio DM, LaPoint M, Chhatwal JP, Rentz DM, Sperling RA, Johnson KA. Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline. Ann Neurol. 2017 Apr; 81(4):583-596. PMID: 28253546.
    Citations: 39     Fields:    Translation:Humans
  40. Xia C, Makaretz SJ, Caso C, McGinnis S, Gomperts SN, Sepulcre J, Gomez-Isla T, Hyman BT, Schultz A, Vasdev N, Johnson KA, Dickerson BC. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurol. 2017 04 01; 74(4):427-436. PMID: 28241163.
    Citations: 82     Fields:    Translation:Humans
  41. Sepulcre J, Sabuncu MR, Li Q, El Fakhri G, Sperling R, Johnson KA. Tau and amyloid ß proteins distinctively associate to functional network changes in the aging brain. Alzheimers Dement. 2017 Nov; 13(11):1261-1269. PMID: 28366797.
    Citations: 23     Fields:    Translation:Humans
  42. Schultz AP, Chhatwal JP, Hedden T, Mormino EC, Hanseeuw BJ, Sepulcre J, Huijbers W, LaPoint M, Buckley RF, Johnson KA, Sperling RA. Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals. J Neurosci. 2017 04 19; 37(16):4323-4331. PMID: 28314821.
    Citations: 57     Fields:    Translation:Humans
  43. Duque P, Oltra-Cucarella J, Fernandez O, Sepulcre J, Grupo de Estudio de la Bateria Neuropsicologica Breve En la Esclerosis Multiple GE. [Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level]. Rev Neurol. 2017 Feb 01; 64(3):97-104. PMID: 28128426.
    Citations:    Fields:    Translation:Humans
  44. Prckovska V, Huijbers W, Schultz A, Ortiz-Teran L, Peña-Gomez C, Villoslada P, Johnson K, Sperling R, Sepulcre J. Epicenters of dynamic connectivity in the adaptation of the ventral visual system. Hum Brain Mapp. 2017 04; 38(4):1965-1976. PMID: 28029725.
    Citations:    Fields:    Translation:Humans
  45. Beucke JC, Sepulcre J, Buhlmann U, Kathmann N, Moody T, Feusner JD. Degree connectivity in body dysmorphic disorder and relationships with obsessive and compulsive symptoms. Eur Neuropsychopharmacol. 2016 10; 26(10):1657-66. PMID: 27514293.
    Citations: 1     Fields:    Translation:Humans
  46. Sepulcre J, Schultz AP, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson KA. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. J Neurosci. 2016 07 13; 36(28):7364-74. PMID: 27413148.
    Citations: 60     Fields:    Translation:Humans
  47. Ortiz-Terán L, Ortiz T, Perez DL, Aragón JI, Diez I, Pascual-Leone A, Sepulcre J. Brain Plasticity in Blind Subjects Centralizes Beyond the Modal Cortices. Front Syst Neurosci. 2016; 10:61. PMID: 27458350.
    Citations: 9     
  48. Teipel S, Grothe MJ, Zhou J, Sepulcre J, Dyrba M, Sorg C, Babiloni C. Measuring Cortical Connectivity in Alzheimer's Disease as a Brain Neural Network Pathology: Toward Clinical Applications. J Int Neuropsychol Soc. 2016 Feb; 22(2):138-63. PMID: 26888613.
    Citations: 32     Fields:    Translation:Humans
  49. Sepulcre J, Masdeu JC. Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer's Disease. Methods Mol Biol. 2016; 1303:509-19. PMID: 26235088.
    Citations: 2     Fields:    Translation:HumansAnimals
  50. Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, Sperling R. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann Neurol. 2016 Jan; 79(1):110-9. PMID: 26505746.
    Citations: 293     Fields:    Translation:Humans
  51. Hu C, Sepulcre J, Johnson KA, Fakhri GE, Lu YM, Li Q. Matched signal detection on graphs: Theory and application to brain imaging data classification. Neuroimage. 2016 Jan 15; 125:587-600. PMID: 26481679.
    Citations: 4     Fields:    Translation:Humans
  52. Abad E, Sepulcre J, Martinez-Lapiscina EH, Zubizarreta I, Garcia-Ojalvo J, Villoslada P. The analysis of semantic networks in multiple sclerosis identifies preferential damage of long-range connectivity. Mult Scler Relat Disord. 2015 Sep; 4(5):387-394. PMID: 26346784.
    Citations: 1     Fields:    Translation:Humans
  53. Hu C, Cheng L, Sepulcre J, Johnson KA, Fakhri GE, Lu YM, Li Q. A spectral graph regression model for learning brain connectivity of Alzheimer's disease. PLoS One. 2015; 10(5):e0128136. PMID: 26024224.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  54. Carmona S, Hoekzema E, Castellanos FX, García-García D, Lage-Castellanos A, Van Dijk KR, Navas-Sánchez FJ, Martínez K, Desco M, Sepulcre J. Sensation-to-cognition cortical streams in attention-deficit/hyperactivity disorder. Hum Brain Mapp. 2015 Jul; 36(7):2544-57. PMID: 25821110.
    Citations: 16     Fields:    Translation:Humans
  55. Beucke JC, Sepulcre J, Eldaief MC, Sebold M, Kathmann N, Kaufmann C. Default mode network subsystem alterations in obsessive-compulsive disorder. Br J Psychiatry. 2014 Nov; 205(5):376-82. PMID: 25257066.
    Citations: 31     Fields:    Translation:Humans
  56. Sepulcre J. Functional streams and cortical integration in the human brain. Neuroscientist. 2014 Oct; 20(5):499-508. PMID: 24737695.
    Citations: 19     Fields:    Translation:Humans
  57. Sepulcre J. Integration of visual and motor functional streams in the human brain. Neurosci Lett. 2014 May 01; 567:68-73. PMID: 24699175.
    Citations: 11     Fields:    Translation:Humans
  58. Sepulcre J. An OP4 functional stream in the language-related neuroarchitecture. Cereb Cortex. 2015 Mar; 25(3):658-66. PMID: 24084124.
    Citations: 11     Fields:    Translation:Humans
  59. Johnson KA, Sperling RA, Sepulcre J. Functional connectivity in Alzheimer's disease: measurement and meaning. Biol Psychiatry. 2013 Sep 01; 74(5):318-9. PMID: 23932342.
    Citations: 3     Fields:    Translation:Humans
  60. Sepulcre J, Sabuncu MR, Becker A, Sperling R, Johnson KA. In vivo characterization of the early states of the amyloid-beta network. Brain. 2013 Jul; 136(Pt 7):2239-52. PMID: 23801740.
    Citations: 45     Fields:    Translation:Humans
  61. Beucke JC, Sepulcre J, Talukdar T, Linnman C, Zschenderlein K, Endrass T, Kaufmann C, Kathmann N. Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder. JAMA Psychiatry. 2013 Jun; 70(6):619-29. PMID: 23740050.
    Citations: 80     Fields:    Translation:Humans
  62. Mueller S, Wang D, Fox MD, Yeo BT, Sepulcre J, Sabuncu MR, Shafee R, Lu J, Liu H. Individual variability in functional connectivity architecture of the human brain. Neuron. 2013 Feb 06; 77(3):586-95. PMID: 23395382.
    Citations: 257     Fields:    Translation:HumansAnimals
  63. Hu C, Cheng L, Sepulcre J, El Fakhri G, Lu YM, Lu YM. Matched signal detection on graphs: theory and application to brain network classification. Inf Process Med Imaging. 2013; 23:1-12. PMID: 24683953.
    Citations: 2     Fields:    Translation:Humans
  64. Spreng RN, Sepulcre J, Turner GR, Stevens WD, Schacter DL. Intrinsic architecture underlying the relations among the default, dorsal attention, and frontoparietal control networks of the human brain. J Cogn Neurosci. 2013 Jan; 25(1):74-86. PMID: 22905821.
    Citations: 214     Fields:    Translation:Humans
  65. Sepulcre J, Sabuncu MR, Johnson KA. Network assemblies in the functional brain. Curr Opin Neurol. 2012 Aug; 25(4):384-91. PMID: 22766721.
    Citations: 13     Fields:    Translation:HumansAnimals
  66. Sepulcre J, Sabuncu MR, Yeo TB, Liu H, Johnson KA. Stepwise connectivity of the modal cortex reveals the multimodal organization of the human brain. J Neurosci. 2012 Aug 01; 32(31):10649-61. PMID: 22855814.
    Citations: 82     Fields:    Translation:Humans
  67. Duque P, Ibanez J, Del Barco A, Sepulcre J, de Ramon E, Fernandez-Fernandez O. [Normalisation and validation of the Brief Neuropsychological Battery as the reference neuropsychological test in multiple sclerosis]. Rev Neurol. 2012 Mar 01; 54(5):263-70. PMID: 22362474.
    Citations: 1     Fields:    Translation:Humans
  68. Sabuncu MR, Desikan RS, Sepulcre J, Yeo BT, Liu H, Schmansky NJ, Reuter M, Weiner MW, Buckner RL, Sperling RA, Fischl B. The dynamics of cortical and hippocampal atrophy in Alzheimer disease. Arch Neurol. 2011 Aug; 68(8):1040-8. PMID: 21825241.
    Citations: 92     Fields:    Translation:Humans
  69. Vélez de Mendizábal N, Carneiro J, Solé RV, Goñi J, Bragard J, Martinez-Forero I, Martinez-Pasamar S, Sepulcre J, Torrealdea J, Bagnato F, Garcia-Ojalvo J, Villoslada P. Modeling the effector - regulatory T cell cross-regulation reveals the intrinsic character of relapses in Multiple Sclerosis. BMC Syst Biol. 2011 Jul 15; 5:114. PMID: 21762505.
    Citations: 15     Fields:    Translation:HumansCells
  70. Yeo BT, Krienen FM, Sepulcre J, Sabuncu MR, Lashkari D, Hollinshead M, Roffman JL, Smoller JW, Zöllei L, Polimeni JR, Fischl B, Liu H, Buckner RL. The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J Neurophysiol. 2011 Sep; 106(3):1125-65. PMID: 21653723.
    Citations: 1675     Fields:    Translation:Humans
  71. Bejarano B, Bianco M, Gonzalez-Moron D, Sepulcre J, Goñi J, Arcocha J, Soto O, Del Carro U, Comi G, Leocani L, Villoslada P. Computational classifiers for predicting the short-term course of Multiple sclerosis. BMC Neurol. 2011 Jun 07; 11:67. PMID: 21649880.
    Citations: 11     Fields:    Translation:Humans
  72. Drzezga A, Becker JA, Van Dijk KR, Sreenivasan A, Talukdar T, Sullivan C, Schultz AP, Sepulcre J, Putcha D, Greve D, Johnson KA, Sperling RA. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain. 2011 Jun; 134(Pt 6):1635-46. PMID: 21490054.
    Citations: 130     Fields:    Translation:Humans
  73. Stufflebeam SM, Liu H, Sepulcre J, Tanaka N, Buckner RL, Madsen JR. Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging. J Neurosurg. 2011 Jun; 114(6):1693-7. PMID: 21351832.
    Citations: 37     Fields:    Translation:Humans
  74. Goñi J, Arrondo G, Sepulcre J, Martincorena I, Vélez de Mendizábal N, Corominas-Murtra B, Bejarano B, Ardanza-Trevijano S, Peraita H, Wall DP, Villoslada P. The semantic organization of the animal category: evidence from semantic verbal fluency and network theory. Cogn Process. 2011 May; 12(2):183-96. PMID: 20938799.
    Citations: 19     Fields:    Translation:Humans
  75. Sepulcre J, Peraita H, Goni J, Arrondo G, Martincorena I, Duque B, Velez de Mendizabal N, Masdeu JC, Villoslada P. Lexical access changes in patients with multiple sclerosis: a two-year follow-up study. J Clin Exp Neuropsychol. 2011 Feb; 33(2):169-75. PMID: 20835944.
    Citations: 3     Fields:    Translation:Humans
  76. Sepulcre J, Liu H, Talukdar T, Martincorena I, Yeo BT, Buckner RL. The organization of local and distant functional connectivity in the human brain. PLoS Comput Biol. 2010 Jun 10; 6(6):e1000808. PMID: 20548945.
    Citations: 147     Fields:    Translation:Humans
  77. Andrews-Hanna JR, Reidler JS, Sepulcre J, Poulin R, Buckner RL. Functional-anatomic fractionation of the brain's default network. Neuron. 2010 Feb 25; 65(4):550-62. PMID: 20188659.
    Citations: 823     Fields:    Translation:Humans
  78. Liu H, Stufflebeam SM, Sepulcre J, Hedden T, Buckner RL. Evidence from intrinsic activity that asymmetry of the human brain is controlled by multiple factors. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20499-503. PMID: 19918055.
    Citations: 104     Fields:    Translation:HumansCells
  79. Sepulcre J, Masdeu JC, Pastor MA, Goñi J, Barbosa C, Bejarano B, Villoslada P. Brain pathways of verbal working memory: a lesion-function correlation study. Neuroimage. 2009 Aug 15; 47(2):773-8. PMID: 19393745.
    Citations: 12     Fields:    Translation:HumansCells
  80. Arrondo G, Alegre M, Sepulcre J, Iriarte J, Artieda J, Villoslada P. Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosis. Mult Scler. 2009 Apr; 15(4):509-16. PMID: 19282416.
    Citations: 10     Fields:    Translation:Humans
  81. Buckner RL, Sepulcre J, Talukdar T, Krienen FM, Liu H, Hedden T, Andrews-Hanna JR, Sperling RA, Johnson KA. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. J Neurosci. 2009 Feb 11; 29(6):1860-73. PMID: 19211893.
    Citations: 1054     Fields:    Translation:Humans
  82. Sepulcre J, Goñi J, Masdeu JC, Bejarano B, Vélez de Mendizábal N, Toledo JB, Villoslada P. Contribution of white matter lesions to gray matter atrophy in multiple sclerosis: evidence from voxel-based analysis of T1 lesions in the visual pathway. Arch Neurol. 2009 Feb; 66(2):173-9. PMID: 19204153.
    Citations: 35     Fields:    Translation:HumansCells
  83. Esteban FJ, Sepulcre J, de Miras JR, Navas J, de Mendizábal NV, Goñi J, Quesada JM, Bejarano B, Villoslada P. Fractal dimension analysis of grey matter in multiple sclerosis. J Neurol Sci. 2009 Jul 15; 282(1-2):67-71. PMID: 19167728.
    Citations: 20     Fields:    Translation:Humans
  84. Villoslada P, Arrondo G, Sepulcre J, Alegre M, Artieda J. Memantine induces reversible neurologic impairment in patients with MS. Neurology. 2009 May 12; 72(19):1630-3. PMID: 19092106.
    Citations: 27     Fields:    Translation:HumansPHPublic Health
  85. Villoslada P, Sepulcre J, Toledo J, Bejarano B, Calabresi PA, Lipkin EG, Chodkowski BA, Reich D, Smith S, Pulicken M, Frohman E, Balcer L, Cutter G. Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis. Neurology. 2008 Nov 18; 71(21):1747; author reply 1747-8. PMID: 19015496.
    Citations: 6     Fields:    Translation:Humans
  86. Sepulcre J, Masdeu JC, Goñi J, Arrondo G, Vélez de Mendizábal N, Bejarano B, Villoslada P. Fatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways. Mult Scler. 2009 Mar; 15(3):337-44. PMID: 18987107.
    Citations: 48     Fields:    Translation:Humans
  87. Sepulcre J, Masdeu JC, Sastre-Garriga J, Goñi J, Vélez-de-Mendizábal N, Duque B, Pastor MA, Bejarano B, Villoslada P. Mapping the brain pathways of declarative verbal memory: Evidence from white matter lesions in the living human brain. Neuroimage. 2008 Sep 01; 42(3):1237-43. PMID: 18585467.
    Citations: 24     Fields:    Translation:Humans
  88. Duque B, Sepulcre J, Bejarano B, Samaranch L, Pastor P, Villoslada P. Memory decline evolves independently of disease activity in MS. Mult Scler. 2008 Aug; 14(7):947-53. PMID: 18573817.
    Citations: 13     Fields:    Translation:Humans
  89. Toledo J, Sepulcre J, Salinas-Alaman A, García-Layana A, Murie-Fernandez M, Bejarano B, Villoslada P. Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis. Mult Scler. 2008 Aug; 14(7):906-12. PMID: 18573835.
    Citations: 51     Fields:    Translation:HumansCells
  90. Goñi J, Esteban FJ, de Mendizábal NV, Sepulcre J, Ardanza-Trevijano S, Agirrezabal I, Villoslada P. A computational analysis of protein-protein interaction networks in neurodegenerative diseases. BMC Syst Biol. 2008 Jun 20; 2:52. PMID: 18570646.
    Citations: 34     Fields:    Translation:Cells
  91. Sepulcre J, Masdeu JC, Palacios R, Goñi J, Moreno B, Tainta M, Bejarano B, Villoslada P. HLA-DR2 and white matter lesion distribution in MS. J Neuroimaging. 2008 Jul; 18(3):328-31. PMID: 18482373.
    Citations: 2     Fields:    Translation:Humans
  92. Pampliega O, Domercq M, Villoslada P, Sepulcre J, Rodríguez-Antigüedad A, Matute C. Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis. J Neuroimmunol. 2008 Mar; 195(1-2):194-8. PMID: 18378006.
    Citations: 18     Fields:    Translation:HumansCells
  93. Martinez-Forero I, Garcia-Munoz R, Martinez-Pasamar S, Inoges S, Lopez-Diaz de Cerio A, Palacios R, Sepulcre J, Moreno B, Gonzalez Z, Fernandez-Diez B, Melero I, Bendandi M, Villoslada P. IL-10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis. Eur J Immunol. 2008 Feb; 38(2):576-86. PMID: 18200504.
    Citations: 48     Fields:    Translation:HumansCells
  94. Palacios R, Goni J, Martinez-Forero I, Iranzo J, Sepulcre J, Melero I, Villoslada P. A network analysis of the human T-cell activation gene network identifies JAGGED1 as a therapeutic target for autoimmune diseases. PLoS One. 2007 Nov 21; 2(11):e1222. PMID: 18030350.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  95. Riverol M, Sepulcre J, Fernandez-Diez B, Villoslada P, Fernandez-Alonso M, Rubio M, Rodriguez A, Uccelli A, Brieva L. Antibodies against Epstein-Barr virus and herpesvirus type 6 are associated with the early phases of multiple sclerosis. J Neuroimmunol. 2007 Dec; 192(1-2):184-5. PMID: 17869349.
    Citations: 6     Fields:    Translation:HumansCells
  96. Sepulcre J, Murie-Fernandez M, Salinas-Alaman A, García-Layana A, Bejarano B, Villoslada P. Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS. Neurology. 2007 May 01; 68(18):1488-94. PMID: 17470751.
    Citations: 82     Fields:    Translation:HumansCells
  97. Esteban FJ, Sepulcre J, de Mendizábal NV, Goñi J, Navas J, de Miras JR, Bejarano B, Masdeu JC, Villoslada P. Fractal dimension and white matter changes in multiple sclerosis. Neuroimage. 2007 Jul 01; 36(3):543-9. PMID: 17499522.
    Citations: 23     Fields:    Translation:Humans
  98. Moreno B, Hevia H, Santamaria M, Sepulcre J, Muñoz J, García-Trevijano ER, Berasain C, Corrales FJ, Avila MA, Villoslada P. Methylthioadenosine reverses brain autoimmune disease. Ann Neurol. 2006 Sep; 60(3):323-34. PMID: 16786535.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  99. Sepulcre J, Sastre-Garriga J, Cercignani M, Ingle GT, Miller DH, Thompson AJ. Regional gray matter atrophy in early primary progressive multiple sclerosis: a voxel-based morphometry study. Arch Neurol. 2006 Aug; 63(8):1175-80. PMID: 16908748.
    Citations: 58     Fields:    Translation:Humans
  100. Sepulcre J, Vanotti S, Hernández R, Sandoval G, Cáceres F, Garcea O, Villoslada P. Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test. Mult Scler. 2006 Apr; 12(2):187-95. PMID: 16629422.
    Citations: 38     Fields:    Translation:Humans
  101. Sepulcre J, Sanchez-Ibarrola A, Moreno C, de Castro P. Association between peripheral IFN-gamma producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis. Cytokine. 2005 Oct 21; 32(2):111-6. PMID: 16246570.
    Citations: 4     Fields:    Translation:HumansCells
  102. Irimia P, Moya M, Sepulcre J, Martínez-Vila E. Transient blurred vision as the only manifestation of basilar stenosis. Cerebrovasc Dis. 2004; 18(1):88-9. PMID: 15178995.
    Citations: 1     Fields:    Translation:Humans
  103. Pierron H, Sauzay F, Bellon-Serre V, Sepulcre J, Perrimond H, David JM. [Acute accidental oral iron poisoning of drug origin in pediatrics]. Ann Pediatr (Paris). 1987 Apr; 34(4):333-5. PMID: 3605980.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.