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Jorge Sepulcre, Ph.D., D.M.Sc., M.D.

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Available: 07/01/17, Expires: 07/01/19

We aim to develop graph theoretical tools to visualize and study BPNs in preclinical -that is, normal older individuals at risk for Alzheimer’s disease (AD) by virtue of advanced age- and clinical AD subjects using positron emission tomography (PET). Particularly, we will construct group-level brain graphs using multi-regression models and PET images from two key AD pathological radioligands:

1) 11C-labeled Pittsburgh Compound-B (11C-PIB) that binds fibrillar amyloid-beta (Aβ) plaques; and

2) F18-T807 that binds TAU neurofibrillary tangles.

Then, we will develop graph theory metrics to estimate network propagation patterns in group-level Aβ and TAU brain pathological networks (BPNs). Finally, we will investigate individual mapping of BPNs and its relationship with individual risk for AD, functional connectivity breakdown, and neuropsychological profiles.


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  1. Sepulcre J, Sabuncu MR, Li Q, El Fakhri G, Sperling R, Johnson KA. Tau and amyloid ß proteins distinctively associate to functional network changes in the aging brain. Alzheimers Dement. 2017 Nov; 13(11):1261-1269. PMID: 28366797.
    View in: PubMed
  2. Sepulcre J, Schultz AP, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson KA. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. J Neurosci. 2016 07 13; 36(28):7364-74. PMID: 27413148; PMCID: PMC4945661 [Available on 01/13/17].
  3. Sepulcre J. Functional streams and cortical integration in the human brain. Neuroscientist. 2014 Oct; 20(5):499-508. PMID: 24737695.
    View in: PubMed
  4. Sepulcre J. Integration of visual and motor functional streams in the human brain. Neurosci Lett. 2014 May 01; 567:68-73. PMID: 24699175.
    View in: PubMed
  5. Sepulcre J, Sabuncu MR, Becker A, Sperling R, Johnson KA. In vivo characterization of the early states of the amyloid-beta network. Brain. 2013 Jul; 136(Pt 7):2239-52. PMID: 23801740; PMCID: PMC3692037.
  6. Sepulcre J, Sabuncu MR, Johnson KA. Network assemblies in the functional brain. Curr Opin Neurol. 2012 Aug; 25(4):384-91. PMID: 22766721; PMCID: PMC3471530.
  7. Sepulcre J, Sabuncu MR, Yeo TB, Liu H, Johnson KA. Stepwise connectivity of the modal cortex reveals the multimodal organization of the human brain. J Neurosci. 2012 Aug 01; 32(31):10649-61. PMID: 22855814.
    View in: PubMed
  8. Sepulcre J, Liu H, Talukdar T, Martincorena I, Yeo BT, Buckner RL. The organization of local and distant functional connectivity in the human brain. PLoS Comput Biol. 2010 Jun 10; 6(6):e1000808. PMID: 20548945; PMCID: PMC2883589.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.