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Jorge Sepulcre, Ph.D., D.M.Sc., M.D.

Title
Institution
Department
Address

Mentoring
Available: 07/01/17, Expires: 07/01/19

We aim to develop graph theoretical tools to visualize and study BPNs in preclinical -that is, normal older individuals at risk for Alzheimer’s disease (AD) by virtue of advanced age- and clinical AD subjects using positron emission tomography (PET). Particularly, we will construct group-level brain graphs using multi-regression models and PET images from two key AD pathological radioligands:

1) 11C-labeled Pittsburgh Compound-B (11C-PIB) that binds fibrillar amyloid-beta (Aβ) plaques; and

2) F18-T807 that binds TAU neurofibrillary tangles.

Then, we will develop graph theory metrics to estimate network propagation patterns in group-level Aβ and TAU brain pathological networks (BPNs). Finally, we will investigate individual mapping of BPNs and its relationship with individual risk for AD, functional connectivity breakdown, and neuropsychological profiles.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K23EB019023 (SEPULCRE, JORGE) Aug 1, 2014 - Jul 31, 2019
    NIH/NIBIB
    In Vivo Visualization of TAU and Amyloid-Beta Networks for Early AD Detection
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bueichekú E, Ávila C, Miró-Padilla A, Sepulcre J. Visual search task immediate training effects on task-related functional connectivity. Brain Imaging Behav. 2018 Nov 15. PMID: 30443892.
    Citations:    Fields:    
  2. Sepulcre J, Grothe MJ, d'Oleire Uquillas F, Ortiz-Terán L, Diez I, Yang HS, Jacobs HIL, Hanseeuw BJ, Li Q, El-Fakhri G, Sperling RA, Johnson KA. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nat Med. 2018 Dec; 24(12):1910-1918. PMID: 30374196.
    Citations:    Fields:    
  3. Xin Q, Ortiz-Terán L, Diez I, Perez DL, Ginsburg J, El Fakhri G, Sepulcre J. Sequence Alterations of Cortical Genes Linked to Individual Connectivity of the Human Brain. Cereb Cortex. 2018 Oct 11. PMID: 30307489.
    Citations:    Fields:    
  4. Diez I, Sepulcre J. Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain. Nat Commun. 2018 09 24; 9(1):3876. PMID: 30250030.
    Citations:    Fields:    Translation:Humans
  5. Gao Q, Yu Y, Su X, Tao Z, Zhang M, Wang Y, Leng J, Sepulcre J, Chen H. Adaptation of brain functional stream architecture in athletes with fast demands of sensorimotor integration. Hum Brain Mapp. 2019 Feb 01; 40(2):420-431. PMID: 30277624.
    Citations:    Fields:    
  6. Grothe MJ, Sepulcre J, Gonzalez-Escamilla G, Jelistratova I, Schöll M, Hansson O, Teipel SJ. Molecular properties underlying regional vulnerability to Alzheimer's disease pathology. Brain. 2018 Sep 01; 141(9):2755-2771. PMID: 30016411.
    Citations:    Fields:    
  7. Qian J, Diez I, Ortiz-Terán L, Bonadio C, Liddell T, Goñi J, Sepulcre J. Positive Connectivity Predicts the Dynamic Intrinsic Topology of the Human Brain Network. Front Syst Neurosci. 2018; 12:38. PMID: 30214399.
    Citations:    
  8. Peña-Gómez C, Avena-Koenigsberger A, Sepulcre J, Sporns O. Spatiotemporal Network Markers of Individual Variability in the Human Functional Connectome. Cereb Cortex. 2018 Aug 01; 28(8):2922-2934. PMID: 28981611.
    Citations: 3     Fields:    
  9. Hanseeuw BJ, Betensky RA, Mormino EC, Schultz AP, Sepulcre J, Becker JA, Jacobs HIL, Buckley RF, LaPoint MR, Vannini P, Donovan NJ, Chhatwal JP, Marshall GA, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. PET staging of amyloidosis using striatum. Alzheimers Dement. 2018 Oct; 14(10):1281-1292. PMID: 29792874.
    Citations: 2     Fields:    
  10. Williams B, Jalilianhasanpour R, Matin N, Fricchione GL, Sepulcre J, Keshavan MS, LaFrance WC, Dickerson BC, Perez DL. Individual differences in corticolimbic structural profiles linked to insecure attachment and coping styles in motor functional neurological disorders. J Psychiatr Res. 2018 Jul; 102:230-237. PMID: 29702433.
    Citations:    Fields:    
  11. Marcos-Vidal L, Martínez-García M, Pretus C, Garcia-Garcia D, Martínez K, Janssen J, Vilarroya O, Castellanos FX, Desco M, Sepulcre J, Carmona S. Local functional connectivity suggests functional immaturity in children with attention-deficit/hyperactivity disorder. Hum Brain Mapp. 2018 06; 39(6):2442-2454. PMID: 29473262.
    Citations: 1     Fields:    
  12. Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat Neurosci. 2018 Mar; 21(3):424-431. PMID: 29403032.
    Citations: 3     Fields:    
  13. Grothe MJ, Barthel H, Sepulcre J, Dyrba M, Sabri O, Teipel SJ. In vivo staging of regional amyloid deposition. Neurology. 2017 Nov 14; 89(20):2031-2038. PMID: 29046362.
    Citations: 6     Fields:    Translation:Humans
  14. Yang J, Hu C, Guo N, Dutta J, Vaina LM, Johnson KA, Sepulcre J, Fakhri GE, Li Q. Partial volume correction for PET quantification and its impact on brain network in Alzheimer's disease. Sci Rep. 2017 Oct 12; 7(1):13035. PMID: 29026139.
    Citations: 1     Fields:    
  15. Ruiz de Miras J, Costumero V, Belloch V, Escudero J, Ávila C, Sepulcre J. Complexity analysis of cortical surface detects changes in future Alzheimer's disease converters. Hum Brain Mapp. 2017 12; 38(12):5905-5918. PMID: 28856799.
    Citations:    Fields:    Translation:Humans
  16. Perez DL, Williams B, Matin N, LaFrance WC, Costumero-Ramos V, Fricchione GL, Sepulcre J, Keshavan MS, Dickerson BC. Corticolimbic structural alterations linked to health status and trait anxiety in functional neurological disorder. J Neurol Neurosurg Psychiatry. 2017 12; 88(12):1052-1059. PMID: 28844071.
    Citations: 3     Fields:    Translation:Humans
  17. Sepulcre J, Grothe MJ, Sabuncu M, Chhatwal J, Schultz AP, Hanseeuw B, El Fakhri G, Sperling R, Johnson KA. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurol. 2017 07 01; 74(7):813-820. PMID: 28558094.
    Citations: 8     Fields:    Translation:Humans
  18. Ortiz-Terán L, Diez I, Ortiz T, Perez DL, Aragón JI, Costumero V, Pascual-Leone A, El Fakhri G, Sepulcre J. Brain circuit-gene expression relationships and neuroplasticity of multisensory cortices in blind children. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):6830-6835. PMID: 28607055.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  19. Buckley RF, Schultz AP, Hedden T, Papp KV, Hanseeuw BJ, Marshall G, Sepulcre J, Smith EE, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology. 2017 Jul 04; 89(1):29-37. PMID: 28592457.
    Citations: 9     Fields:    Translation:Humans
  20. LaPoint MR, Chhatwal JP, Sepulcre J, Johnson KA, Sperling RA, Schultz AP. The association between tau PET and retrospective cortical thinning in clinically normal elderly. Neuroimage. 2017 08 15; 157:612-622. PMID: 28545932.
    Citations: 6     Fields:    Translation:Humans
  21. Perez DL, Matin N, Barsky A, Costumero-Ramos V, Makaretz SJ, Young SS, Sepulcre J, LaFrance WC, Keshavan MS, Dickerson BC. Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders. J Neurol Neurosurg Psychiatry. 2017 06; 88(6):491-497. PMID: 28416565.
    Citations: 5     Fields:    Translation:Humans
  22. Hanseeuw BJ, Betensky RA, Schultz AP, Papp KV, Mormino EC, Sepulcre J, Bark JS, Cosio DM, LaPoint M, Chhatwal JP, Rentz DM, Sperling RA, Johnson KA. Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline. Ann Neurol. 2017 Apr; 81(4):583-596. PMID: 28253546.
    Citations: 14     Fields:    Translation:Humans
  23. Xia C, Makaretz SJ, Caso C, McGinnis S, Gomperts SN, Sepulcre J, Gomez-Isla T, Hyman BT, Schultz A, Vasdev N, Johnson KA, Dickerson BC. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurol. 2017 04 01; 74(4):427-436. PMID: 28241163.
    Citations: 27     Fields:    Translation:Humans
  24. Sepulcre J, Sabuncu MR, Li Q, El Fakhri G, Sperling R, Johnson KA. Tau and amyloid ß proteins distinctively associate to functional network changes in the aging brain. Alzheimers Dement. 2017 Nov; 13(11):1261-1269. PMID: 28366797.
    Citations: 6     Fields:    Translation:Humans
  25. Schultz AP, Chhatwal JP, Hedden T, Mormino EC, Hanseeuw BJ, Sepulcre J, Huijbers W, LaPoint M, Buckley RF, Johnson KA, Sperling RA. Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals. J Neurosci. 2017 04 19; 37(16):4323-4331. PMID: 28314821.
    Citations: 9     Fields:    Translation:Humans
  26. Duque P, Oltra-Cucarella J, Fernandez O, Sepulcre J, Grupo de Estudio de la Bateria Neuropsicologica Breve En la Esclerosis Multiple GE. [Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level]. Rev Neurol. 2017 Feb 01; 64(3):97-104. PMID: 28128426.
    Citations:    Fields:    Translation:Humans
  27. Prckovska V, Huijbers W, Schultz A, Ortiz-Teran L, Peña-Gomez C, Villoslada P, Johnson K, Sperling R, Sepulcre J. Epicenters of dynamic connectivity in the adaptation of the ventral visual system. Hum Brain Mapp. 2017 04; 38(4):1965-1976. PMID: 28029725.
    Citations:    Fields:    Translation:Humans
  28. Beucke JC, Sepulcre J, Buhlmann U, Kathmann N, Moody T, Feusner JD. Degree connectivity in body dysmorphic disorder and relationships with obsessive and compulsive symptoms. Eur Neuropsychopharmacol. 2016 10; 26(10):1657-66. PMID: 27514293.
    Citations:    Fields:    Translation:Humans
  29. Sepulcre J, Schultz AP, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson KA. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. J Neurosci. 2016 07 13; 36(28):7364-74. PMID: 27413148; PMCID: PMC4945661.
    Citations: 29     Fields:    Translation:Humans
  30. Ortiz-Terán L, Ortiz T, Perez DL, Aragón JI, Diez I, Pascual-Leone A, Sepulcre J. Brain Plasticity in Blind Subjects Centralizes Beyond the Modal Cortices. Front Syst Neurosci. 2016; 10:61. PMID: 27458350; PMCID: PMC4937754.
    Citations: 3     
  31. Teipel S, Grothe MJ, Zhou J, Sepulcre J, Dyrba M, Sorg C, Babiloni C. Measuring Cortical Connectivity in Alzheimer's Disease as a Brain Neural Network Pathology: Toward Clinical Applications. J Int Neuropsychol Soc. 2016 Feb; 22(2):138-63. PMID: 26888613.
    Citations: 14     Fields:    Translation:Humans
  32. Sepulcre J, Masdeu JC. Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer's Disease. Methods Mol Biol. 2016; 1303:509-19. PMID: 26235088.
    Citations: 2     Fields:    Translation:HumansAnimals
  33. Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, Sperling R. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann Neurol. 2016 Jan; 79(1):110-9. PMID: 26505746.
    Citations: 116     Fields:    Translation:Humans
  34. Hu C, Sepulcre J, Johnson KA, Fakhri GE, Lu YM, Li Q. Matched signal detection on graphs: Theory and application to brain imaging data classification. Neuroimage. 2016 Jan 15; 125:587-600. PMID: 26481679.
    Citations: 1     Fields:    Translation:Humans
  35. Abad E, Sepulcre J, Martinez-Lapiscina EH, Zubizarreta I, Garcia-Ojalvo J, Villoslada P. The analysis of semantic networks in multiple sclerosis identifies preferential damage of long-range connectivity. Mult Scler Relat Disord. 2015 Sep; 4(5):387-394. PMID: 26346784.
    Citations:    Fields:    Translation:Humans
  36. Hu C, Cheng L, Sepulcre J, Johnson KA, Fakhri GE, Lu YM, Li Q. A spectral graph regression model for learning brain connectivity of Alzheimer's disease. PLoS One. 2015; 10(5):e0128136. PMID: 26024224.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  37. Carmona S, Hoekzema E, Castellanos FX, García-García D, Lage-Castellanos A, Van Dijk KR, Navas-Sánchez FJ, Martínez K, Desco M, Sepulcre J. Sensation-to-cognition cortical streams in attention-deficit/hyperactivity disorder. Hum Brain Mapp. 2015 Jul; 36(7):2544-57. PMID: 25821110; PMCID: PMC4484811.
    Citations: 8     Fields:    Translation:Humans
  38. Beucke JC, Sepulcre J, Eldaief MC, Sebold M, Kathmann N, Kaufmann C. Default mode network subsystem alterations in obsessive-compulsive disorder. Br J Psychiatry. 2014 Nov; 205(5):376-82. PMID: 25257066.
    Citations: 14     Fields:    Translation:Humans
  39. Sepulcre J. Functional streams and cortical integration in the human brain. Neuroscientist. 2014 Oct; 20(5):499-508. PMID: 24737695.
    Citations: 8     Fields:    Translation:Humans
  40. Sepulcre J. Integration of visual and motor functional streams in the human brain. Neurosci Lett. 2014 May 01; 567:68-73. PMID: 24699175.
    Citations: 3     Fields:    Translation:Humans
  41. Sepulcre J. An OP4 functional stream in the language-related neuroarchitecture. Cereb Cortex. 2015 Mar; 25(3):658-66. PMID: 24084124.
    Citations: 5     Fields:    Translation:Humans
  42. Johnson KA, Sperling RA, Sepulcre J. Functional connectivity in Alzheimer's disease: measurement and meaning. Biol Psychiatry. 2013 Sep 01; 74(5):318-9. PMID: 23932342.
    Citations: 2     Fields:    Translation:Humans
  43. Sepulcre J, Sabuncu MR, Becker A, Sperling R, Johnson KA. In vivo characterization of the early states of the amyloid-beta network. Brain. 2013 Jul; 136(Pt 7):2239-52. PMID: 23801740; PMCID: PMC3692037.
    Citations: 26     Fields:    Translation:Humans
  44. Beucke JC, Sepulcre J, Talukdar T, Linnman C, Zschenderlein K, Endrass T, Kaufmann C, Kathmann N. Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder. JAMA Psychiatry. 2013 Jun; 70(6):619-29. PMID: 23740050.
    Citations: 50     Fields:    Translation:Humans
  45. Mueller S, Wang D, Fox MD, Yeo BT, Sepulcre J, Sabuncu MR, Shafee R, Lu J, Liu H. Individual variability in functional connectivity architecture of the human brain. Neuron. 2013 Feb 06; 77(3):586-95. PMID: 23395382.
    Citations: 121     Fields:    Translation:HumansAnimals
  46. Hu C, Cheng L, Sepulcre J, El Fakhri G, Lu YM, Lu YM. Matched signal detection on graphs: theory and application to brain network classification. Inf Process Med Imaging. 2013; 23:1-12. PMID: 24683953.
    Citations: 1     Fields:    Translation:Humans
  47. Spreng RN, Sepulcre J, Turner GR, Stevens WD, Schacter DL. Intrinsic architecture underlying the relations among the default, dorsal attention, and frontoparietal control networks of the human brain. J Cogn Neurosci. 2013 Jan; 25(1):74-86. PMID: 22905821; PMCID: PMC3816715.
    Citations: 121     Fields:    Translation:Humans
  48. Sepulcre J, Sabuncu MR, Johnson KA. Network assemblies in the functional brain. Curr Opin Neurol. 2012 Aug; 25(4):384-91. PMID: 22766721; PMCID: PMC3471530.
    Citations: 10     Fields:    Translation:HumansAnimals
  49. Sepulcre J, Sabuncu MR, Yeo TB, Liu H, Johnson KA. Stepwise connectivity of the modal cortex reveals the multimodal organization of the human brain. J Neurosci. 2012 Aug 01; 32(31):10649-61. PMID: 22855814.
    Citations: 43     Fields:    Translation:Humans
  50. Duque P, Ibanez J, Del Barco A, Sepulcre J, de Ramon E, Fernandez-Fernandez O. [Normalisation and validation of the Brief Neuropsychological Battery as the reference neuropsychological test in multiple sclerosis]. Rev Neurol. 2012 Mar 01; 54(5):263-70. PMID: 22362474.
    Citations:    Fields:    Translation:Humans
  51. Sabuncu MR, Desikan RS, Sepulcre J, Yeo BT, Liu H, Schmansky NJ, Reuter M, Weiner MW, Buckner RL, Sperling RA, Fischl B. The dynamics of cortical and hippocampal atrophy in Alzheimer disease. Arch Neurol. 2011 Aug; 68(8):1040-8. PMID: 21825241.
    Citations: 62     Fields:    Translation:Humans
  52. Vélez de Mendizábal N, Carneiro J, Solé RV, Goñi J, Bragard J, Martinez-Forero I, Martinez-Pasamar S, Sepulcre J, Torrealdea J, Bagnato F, Garcia-Ojalvo J, Villoslada P. Modeling the effector - regulatory T cell cross-regulation reveals the intrinsic character of relapses in Multiple Sclerosis. BMC Syst Biol. 2011 Jul 15; 5:114. PMID: 21762505; PMCID: PMC3155504.
    Citations: 11     Fields:    Translation:HumansCells
  53. Yeo BT, Krienen FM, Sepulcre J, Sabuncu MR, Lashkari D, Hollinshead M, Roffman JL, Smoller JW, Zöllei L, Polimeni JR, Fischl B, Liu H, Buckner RL. The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J Neurophysiol. 2011 Sep; 106(3):1125-65. PMID: 21653723; PMCID: PMC3174820.
    Citations: 777     Fields:    Translation:Humans
  54. Bejarano B, Bianco M, Gonzalez-Moron D, Sepulcre J, Goñi J, Arcocha J, Soto O, Del Carro U, Comi G, Leocani L, Villoslada P. Computational classifiers for predicting the short-term course of Multiple sclerosis. BMC Neurol. 2011 Jun 07; 11:67. PMID: 21649880; PMCID: PMC3118106.
    Citations: 7     Fields:    Translation:Humans
  55. Drzezga A, Becker JA, Van Dijk KR, Sreenivasan A, Talukdar T, Sullivan C, Schultz AP, Sepulcre J, Putcha D, Greve D, Johnson KA, Sperling RA. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain. 2011 Jun; 134(Pt 6):1635-46. PMID: 21490054.
    Citations: 94     Fields:    Translation:Humans
  56. Stufflebeam SM, Liu H, Sepulcre J, Tanaka N, Buckner RL, Madsen JR. Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging. J Neurosurg. 2011 Jun; 114(6):1693-7. PMID: 21351832; PMCID: PMC3248962.
    Citations: 29     Fields:    Translation:Humans
  57. Goñi J, Arrondo G, Sepulcre J, Martincorena I, Vélez de Mendizábal N, Corominas-Murtra B, Bejarano B, Ardanza-Trevijano S, Peraita H, Wall DP, Villoslada P. The semantic organization of the animal category: evidence from semantic verbal fluency and network theory. Cogn Process. 2011 May; 12(2):183-96. PMID: 20938799.
    Citations: 9     Fields:    Translation:Humans
  58. Sepulcre J, Peraita H, Goni J, Arrondo G, Martincorena I, Duque B, Velez de Mendizabal N, Masdeu JC, Villoslada P. Lexical access changes in patients with multiple sclerosis: a two-year follow-up study. J Clin Exp Neuropsychol. 2011 Feb; 33(2):169-75. PMID: 20835944.
    Citations:    Fields:    Translation:Humans
  59. Sepulcre J, Liu H, Talukdar T, Martincorena I, Yeo BT, Buckner RL. The organization of local and distant functional connectivity in the human brain. PLoS Comput Biol. 2010 Jun 10; 6(6):e1000808. PMID: 20548945; PMCID: PMC2883589.
    Citations: 100     Fields:    Translation:Humans
  60. Andrews-Hanna JR, Reidler JS, Sepulcre J, Poulin R, Buckner RL. Functional-anatomic fractionation of the brain's default network. Neuron. 2010 Feb 25; 65(4):550-62. PMID: 20188659.
    Citations: 535     Fields:    Translation:Humans
  61. Liu H, Stufflebeam SM, Sepulcre J, Hedden T, Buckner RL. Evidence from intrinsic activity that asymmetry of the human brain is controlled by multiple factors. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20499-503. PMID: 19918055; PMCID: PMC2777963.
    Citations: 74     Fields:    Translation:HumansCells
  62. Sepulcre J, Masdeu JC, Pastor MA, Goñi J, Barbosa C, Bejarano B, Villoslada P. Brain pathways of verbal working memory: a lesion-function correlation study. Neuroimage. 2009 Aug 15; 47(2):773-8. PMID: 19393745.
    Citations: 9     Fields:    Translation:HumansCells
  63. Arrondo G, Alegre M, Sepulcre J, Iriarte J, Artieda J, Villoslada P. Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosis. Mult Scler. 2009 Apr; 15(4):509-16. PMID: 19282416.
    Citations: 8     Fields:    Translation:Humans
  64. Buckner RL, Sepulcre J, Talukdar T, Krienen FM, Liu H, Hedden T, Andrews-Hanna JR, Sperling RA, Johnson KA. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. J Neurosci. 2009 Feb 11; 29(6):1860-73. PMID: 19211893.
    Citations: 746     Fields:    Translation:Humans
  65. Sepulcre J, Goñi J, Masdeu JC, Bejarano B, Vélez de Mendizábal N, Toledo JB, Villoslada P. Contribution of white matter lesions to gray matter atrophy in multiple sclerosis: evidence from voxel-based analysis of T1 lesions in the visual pathway. Arch Neurol. 2009 Feb; 66(2):173-9. PMID: 19204153.
    Citations: 22     Fields:    Translation:HumansCells
  66. Esteban FJ, Sepulcre J, de Miras JR, Navas J, de Mendizábal NV, Goñi J, Quesada JM, Bejarano B, Villoslada P. Fractal dimension analysis of grey matter in multiple sclerosis. J Neurol Sci. 2009 Jul 15; 282(1-2):67-71. PMID: 19167728.
    Citations: 9     Fields:    Translation:Humans
  67. Villoslada P, Arrondo G, Sepulcre J, Alegre M, Artieda J. Memantine induces reversible neurologic impairment in patients with MS. Neurology. 2009 May 12; 72(19):1630-3. PMID: 19092106.
    Citations: 21     Fields:    Translation:HumansPHPublic Health
  68. Villoslada P, Sepulcre J, Toledo J, Bejarano B, Calabresi PA, Lipkin EG, Chodkowski BA, Reich D, Smith S, Pulicken M, Frohman E, Balcer L, Cutter G. Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis. Neurology. 2008 Nov 18; 71(21):1747; author reply 1747-8. PMID: 19015496.
    Citations: 4     Fields:    Translation:Humans
  69. Sepulcre J, Masdeu JC, Goñi J, Arrondo G, Vélez de Mendizábal N, Bejarano B, Villoslada P. Fatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways. Mult Scler. 2009 Mar; 15(3):337-44. PMID: 18987107.
    Citations: 32     Fields:    Translation:Humans
  70. Sepulcre J, Masdeu JC, Sastre-Garriga J, Goñi J, Vélez-de-Mendizábal N, Duque B, Pastor MA, Bejarano B, Villoslada P. Mapping the brain pathways of declarative verbal memory: Evidence from white matter lesions in the living human brain. Neuroimage. 2008 Sep 01; 42(3):1237-43. PMID: 18585467.
    Citations: 18     Fields:    Translation:Humans
  71. Duque B, Sepulcre J, Bejarano B, Samaranch L, Pastor P, Villoslada P. Memory decline evolves independently of disease activity in MS. Mult Scler. 2008 Aug; 14(7):947-53. PMID: 18573817.
    Citations: 13     Fields:    Translation:Humans
  72. Toledo J, Sepulcre J, Salinas-Alaman A, García-Layana A, Murie-Fernandez M, Bejarano B, Villoslada P. Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis. Mult Scler. 2008 Aug; 14(7):906-12. PMID: 18573835.
    Citations: 40     Fields:    Translation:HumansCells
  73. Goñi J, Esteban FJ, de Mendizábal NV, Sepulcre J, Ardanza-Trevijano S, Agirrezabal I, Villoslada P. A computational analysis of protein-protein interaction networks in neurodegenerative diseases. BMC Syst Biol. 2008 Jun 20; 2:52. PMID: 18570646; PMCID: PMC2443111.
    Citations: 27     Fields:    Translation:Cells
  74. Sepulcre J, Masdeu JC, Palacios R, Goñi J, Moreno B, Tainta M, Bejarano B, Villoslada P. HLA-DR2 and white matter lesion distribution in MS. J Neuroimaging. 2008 Jul; 18(3):328-31. PMID: 18482373.
    Citations: 1     Fields:    Translation:Humans
  75. Pampliega O, Domercq M, Villoslada P, Sepulcre J, Rodríguez-Antigüedad A, Matute C. Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis. J Neuroimmunol. 2008 Mar; 195(1-2):194-8. PMID: 18378006.
    Citations: 14     Fields:    Translation:HumansCells
  76. Martinez-Forero I, Garcia-Munoz R, Martinez-Pasamar S, Inoges S, Lopez-Diaz de Cerio A, Palacios R, Sepulcre J, Moreno B, Gonzalez Z, Fernandez-Diez B, Melero I, Bendandi M, Villoslada P. IL-10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis. Eur J Immunol. 2008 Feb; 38(2):576-86. PMID: 18200504.
    Citations: 35     Fields:    Translation:HumansCells
  77. Palacios R, Goni J, Martinez-Forero I, Iranzo J, Sepulcre J, Melero I, Villoslada P. A network analysis of the human T-cell activation gene network identifies JAGGED1 as a therapeutic target for autoimmune diseases. PLoS One. 2007 Nov 21; 2(11):e1222. PMID: 18030350; PMCID: PMC2077806.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  78. Riverol M, Sepulcre J, Fernandez-Diez B, Villoslada P, Fernandez-Alonso M, Rubio M, Rodriguez A, Uccelli A, Brieva L. Antibodies against Epstein-Barr virus and herpesvirus type 6 are associated with the early phases of multiple sclerosis. J Neuroimmunol. 2007 Dec; 192(1-2):184-5. PMID: 17869349.
    Citations: 5     Fields:    Translation:HumansCells
  79. Sepulcre J, Murie-Fernandez M, Salinas-Alaman A, García-Layana A, Bejarano B, Villoslada P. Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS. Neurology. 2007 May 01; 68(18):1488-94. PMID: 17470751.
    Citations: 69     Fields:    Translation:HumansCells
  80. Esteban FJ, Sepulcre J, de Mendizábal NV, Goñi J, Navas J, de Miras JR, Bejarano B, Masdeu JC, Villoslada P. Fractal dimension and white matter changes in multiple sclerosis. Neuroimage. 2007 Jul 01; 36(3):543-9. PMID: 17499522.
    Citations: 13     Fields:    Translation:Humans
  81. Moreno B, Hevia H, Santamaria M, Sepulcre J, Muñoz J, García-Trevijano ER, Berasain C, Corrales FJ, Avila MA, Villoslada P. Methylthioadenosine reverses brain autoimmune disease. Ann Neurol. 2006 Sep; 60(3):323-34. PMID: 16786535.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  82. Sepulcre J, Sastre-Garriga J, Cercignani M, Ingle GT, Miller DH, Thompson AJ. Regional gray matter atrophy in early primary progressive multiple sclerosis: a voxel-based morphometry study. Arch Neurol. 2006 Aug; 63(8):1175-80. PMID: 16908748.
    Citations: 32     Fields:    Translation:Humans
  83. Sepulcre J, Vanotti S, Hernández R, Sandoval G, Cáceres F, Garcea O, Villoslada P. Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test. Mult Scler. 2006 Apr; 12(2):187-95. PMID: 16629422.
    Citations: 26     Fields:    Translation:Humans
  84. Sepulcre J, Sanchez-Ibarrola A, Moreno C, de Castro P. Association between peripheral IFN-gamma producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis. Cytokine. 2005 Oct 21; 32(2):111-6. PMID: 16246570.
    Citations: 3     Fields:    Translation:HumansCells
  85. Irimia P, Moya M, Sepulcre J, Martínez-Vila E. Transient blurred vision as the only manifestation of basilar stenosis. Cerebrovasc Dis. 2004; 18(1):88-9. PMID: 15178995.
    Citations: 1     Fields:    Translation:Humans
  86. Pierron H, Sauzay F, Bellon-Serre V, Sepulcre J, Perrimond H, David JM. [Acute accidental oral iron poisoning of drug origin in pediatrics]. Ann Pediatr (Paris). 1987 Apr; 34(4):333-5. PMID: 3605980.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.