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Cheng Wang, Ph.D.

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Biography
Nanjing Agricultural University, NanjingPhD12/2002Reproductive Physiology
Nanjing Agricultural University, NanjingB.S.07/1997Animal Science
2000 - 2001
JASSO Scholarship
2006 - 2008
Lalor Foundation Fellowship
2007 - 2008
Postdoctoral Scholar of the Year Award
2010 - 2015
NIH Pathway to Independence Award
2013 - 2014
New investigator Award

Overview
Research in my laboratory mainly focuses on identifying molecules and signaling pathways that contribute to the physiological and pathological changes in the female reproductive tract (mainly ovarian and cervical tissues), aiming to provide new strategies for early diagnosis and better treatment of reproductive diseases and gynecological malignancies.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. No number (wANG, CHENG) Jul 1, 2017 - Mar 18, 2020
    The Colleen’s Dream Foundation
    Ovarian Cnacer Prevention and Early Detection
    Role Description: Identification of novel biomarkers and strategies to prevent ovarian cancer from development and diagnose ovarian high grade serous carcinoma at an early stage.
    Role: Principle Investigator
  2. R01CA197976 (WANG, CHENG) May 1, 2016 - Apr 30, 2021
    NIH/NCI
    The Hippo/Yap Signaling Pathway In Ovarian High Grade Serous Carcinoma
    Role: Principal Investigator
  3. R01CA201500 (WANG, CHENG) Jan 21, 2016 - Dec 31, 2020
    NIH/NCI
    Novel Mechanisms of Cervical Cancer Development and Progression
    Role: Principal Investigator
  4. R00HD059985 (WANG, CHENG) Sep 17, 2012 - Jun 30, 2015
    NIH/NICHD
    GPR30 Mediated-Estrogen Action on Ovarian Physiology and Ovarian Cancer
    Role: Principal Investigator
  5. K99HD059985 (WANG, CHENG) Sep 15, 2010 - Aug 31, 2012
    NIH/NICHD
    GPR30 Mediated-Estrogen Action on Ovarian Physiology and Ovarian Cancer
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lv X, He C, Huang C, Wang H, Hua G, Wang Z, Zhou J, Chen X, Ma B, Timm BK, Maclin V, Dong J, Rueda BR, Davis JS, Wang C. Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development. FASEB J. 2019 09; 33(9):10049-10064. PMID: 31199671.
    Citations:    
  2. Wang C, Davis JS. At the center of cervical carcinogenesis: synergism between high-risk HPV and the hyperactivated YAP1. Mol Cell Oncol. 2019; 6(5):e1612677. PMID: 31528691.
    Citations:    
  3. He C, Lv X, Huang C, Angeletti PC, Hua G, Dong J, Zhou J, Wang Z, Ma B, Chen X, Lambert PF, Rueda BR, Davis JS, Wang C. A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. Cell Rep. 2019 03 05; 26(10):2636-2650.e5. PMID: 30840887.
    Citations:    
  4. He C, Lv X, Huang C, Hua G, Ma B, Chen X, Angeletti PC, Dong J, Zhou J, Wang Z, Rueda BR, Davis JS, Wang C. YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis. EMBO Rep. 2019 03; 20(3). PMID: 30755404.
    Citations:    
  5. Wang F, Xu C, Reece EA, Li X, Wu Y, Harman C, Yu J, Dong D, Wang C, Yang P, Zhong J, Yang P. Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy. Nat Commun. 2017 05 05; 8:15182. PMID: 28474670.
    Citations:    
  6. Lv X, He C, Huang C, Hua G, Wang Z, Remmenga SW, Rodabough KJ, Karpf AR, Dong J, Davis JS, Wang C. G-1 Inhibits Breast Cancer Cell Growth via Targeting Colchicine-Binding Site of Tubulin to Interfere with Microtubule Assembly. Mol Cancer Ther. 2017 06; 16(6):1080-1091. PMID: 28258163.
    Citations:    
  7. Hua G, He C, Lv X, Fan L, Wang C, Remmenga SW, Rodabaugh KJ, Yang L, Lele SM, Yang P, Karpf AR, Davis JS, Wang C. The four and a half LIM domains 2 (FHL2) regulates ovarian granulosa cell tumor progression via controlling AKT1 transcription. Cell Death Dis. 2016 07 14; 7:e2297. PMID: 27415427.
    Citations:    
  8. He C, Mao D, Hua G, Lv X, Chen X, Angeletti PC, Dong J, Remmenga SW, Rodabaugh KJ, Zhou J, Lambert PF, Yang P, Davis JS, Wang C. The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression. EMBO Mol Med. 2015 Nov; 7(11):1426-49. PMID: 26417066.
    Citations:    
  9. Hua G, Lv X, He C, Remmenga SW, Rodabough KJ, Dong J, Yang L, Lele SM, Yang P, Zhou J, Karst A, Drapkin RI, Davis JS, Wang C. YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells. Oncogene. 2016 04 28; 35(17):2247-65. PMID: 26364602.
    Citations:    
  10. He C, Lv X, Hua G, Lele SM, Remmenga S, Dong J, Davis JS, Wang C. YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression. Oncogene. 2015 Dec 10; 34(50):6040-54. PMID: 25798835.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.