Harvard Catalyst Profiles

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David Wayne Melton, M.D.

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University of North Texas, Denton, TXBS05/2008Biochemistry
University of North Texas, Denton, TXBS05/2008Chemistry
University of Texas Health Science Center at San Antonio, San Antonio, TXPhD05/2016Cellular and Structural Biology - Biology of Aging
University of Texas Health Science Center at San Antonio, San Antonio, TXMD05/2017Medicine

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhou L, Ishizaki H, Spitzer M, Taylor KL, Temperley ND, Johnson SL, Brear P, Gautier P, Zeng Z, Mitchell A, Narayan V, McNeil EM, Melton DW, Smith TK, Tyers M, Westwood NJ, Patton EE. ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species. Cell Chem Biol. 2020 Nov 19; 27(11):1452. PMID: 33217312.
    Citations:    Fields:    
  2. Gomez MK, Illuzzi G, Colomer C, Churchman M, Hollis RL, O'Connor MJ, Gourley C, Leo E, Melton DW. Identifying and Overcoming Mechanisms of PARP Inhibitor Resistance in Homologous Recombination Repair-Deficient and Repair-Proficient High Grade Serous Ovarian Cancer Cells. Cancers (Basel). 2020 Jun 09; 12(6). PMID: 32526907.
    Citations: 3     
  3. Ramirez R, Herrera AM, Ramirez J, Qian C, Melton DW, Shireman PK, Jin YF. Deriving a Boolean dynamics to reveal macrophage activation with in vitro temporal cytokine expression profiles. BMC Bioinformatics. 2019 Dec 18; 20(1):725. PMID: 31852428.
    Citations: 4     Fields:    Translation:Cells
  4. Melton DW, Roberts AC, Wang H, Sarwar Z, Wetzel MD, Wells JT, Porter L, Berton MT, McManus LM, Shireman PK. Absence of CCR2 results in an inflammaging environment in young mice with age-independent impairments in muscle regeneration. J Leukoc Biol. 2016 11; 100(5):1011-1025. PMID: 27531927; PMCID: PMC5069084.
    Citations: 11     Fields:    Translation:AnimalsCells
  5. Melton DW, Lei X, Gelfond JA, Shireman PK. Dynamic macrophage polarization-specific miRNA patterns reveal increased soluble VEGF receptor 1 by miR-125a-5p inhibition. Physiol Genomics. 2016 05; 48(5):345-60. PMID: 26884460; PMCID: PMC4855214.
    Citations: 7     Fields:    Translation:AnimalsCells
  6. Fearing CM, Melton DW, Lei X, Hancock H, Wang H, Sarwar ZU, Porter L, McHale M, McManus LM, Shireman PK. Increased Adipocyte Area in Injured Muscle With Aging and Impaired Remodeling in Female Mice. J Gerontol A Biol Sci Med Sci. 2016 08; 71(8):992-1004. PMID: 26273023; PMCID: PMC4945881.
    Citations: 8     Fields:    Translation:AnimalsCells
  7. Melton DW, McManus LM, Gelfond JA, Shireman PK. Temporal phenotypic features distinguish polarized macrophages in vitro. Autoimmunity. 2015 May; 48(3):161-76. PMID: 25826285.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  8. Wang H, Melton DW, Porter L, Sarwar ZU, McManus LM, Shireman PK. Altered macrophage phenotype transition impairs skeletal muscle regeneration. Am J Pathol. 2014 Apr; 184(4):1167-1184. PMID: 24525152; PMCID: PMC3969996.
    Citations: 85     Fields:    Translation:AnimalsCells
  9. Chen Y, Melton DW, Gelfond JA, McManus LM, Shireman PK. MiR-351 transiently increases during muscle regeneration and promotes progenitor cell proliferation and survival upon differentiation. Physiol Genomics. 2012 Nov 01; 44(21):1042-51. PMID: 22968638.
    Citations: 26     Fields:    Translation:AnimalsCells
  10. Xu Y, Brenn T, Brown ER, Doherty V, Melton DW. Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors. Br J Cancer. 2012 Jan 31; 106(3):553-61. PMID: 22223089; PMCID: PMC3273359.
    Citations: 105     Fields:    Translation:HumansCells
  11. Li W, Melton DW. Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance. Oncogene. 2012 May 10; 31(19):2412-22. PMID: 21996734.
    Citations: 41     Fields:    Translation:HumansCells
  12. Song L, Winter AG, Selfridge J, Melton DW. A novel transcript for DNA repair gene Ercc1 in mouse skin. Transgenic Res. 2011 Feb; 20(1):109-22. PMID: 20407824.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Wu Y, Melton DW, Zhang Y, Hornsby PJ. Improved coinfection with amphotropic pseudotyped retroviral vectors. J Biomed Biotechnol. 2009; 2009:901079. PMID: 19478961.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  14. Doig J, Anderson C, Lawrence NJ, Selfridge J, Brownstein DG, Melton DW. Mice with skin-specific DNA repair gene (Ercc1) inactivation are hypersensitive to ultraviolet irradiation-induced skin cancer and show more rapid actinic progression. Oncogene. 2006 Oct 12; 25(47):6229-38. PMID: 16682947.
    Citations: 18     Fields:    Translation:AnimalsCells
  15. Mort R, Mo L, McEwan C, Melton DW. Lack of involvement of nucleotide excision repair gene polymorphisms in colorectal cancer. Br J Cancer. 2003 Jul 21; 89(2):333-7. PMID: 12865926; PMCID: PMC2394251.
    Citations: 43     Fields:    Translation:HumansCells
  16. Lammert E, Cleaver O, Melton D, Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science. 2001 Oct 19; 294(5542):564-7. PMID: 11577200.
    Citations: 327     Fields:    Translation:AnimalsCells
  17. Melton DW, Ketchen AM, Kind AJ, McEwan C, Paisley D, Selfridge J. A one-step gene amplification system for use in cultured mammalian cells and transgenic animals. Transgenic Res. 2001 Apr; 10(2):133-42. PMID: 11305360.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  18. Tomescu D, Kavanagh G, Ha T, Campbell H, Melton DW. Nucleotide excision repair gene XPD polymorphisms and genetic predisposition to melanoma. Carcinogenesis. 2001 Mar; 22(3):403-8. PMID: 11238179.
    Citations: 19     Fields:    Translation:HumansCells
  19. Selbert S, Bentley DJ, Melton DW, Rannie D, Lourenço P, Watson CJ, Clarke AR. Efficient BLG-Cre mediated gene deletion in the mammary gland. Transgenic Res. 1998 Sep; 7(5):387-96. PMID: 9859227.
    Citations: 49     Fields:    Translation:AnimalsCells
  20. Melton DW, Ketchen AM, Núñez F, Bonatti-Abbondandolo S, Abbondandolo A, Squires S, Johnson RT. Cells from ERCC1-deficient mice show increased genome instability and a reduced frequency of S-phase-dependent illegitimate chromosome exchange but a normal frequency of homologous recombination. J Cell Sci. 1998 Feb; 111 ( Pt 3):395-404. PMID: 9427687.
    Citations: 27     Fields:    Translation:AnimalsCells
  21. Bentley D, Selfridge J, Millar JK, Samuel K, Hole N, Ansell JD, Melton DW. DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability. Nat Genet. 1996 Aug; 13(4):489-91. PMID: 8696349.
    Citations: 48     Fields:    Translation:AnimalsCells
  22. Porter RM, Leitgeb S, Melton DW, Swensson O, Eady RA, Magin TM. Gene targeting at the mouse cytokeratin 10 locus: severe skin fragility and changes of cytokeratin expression in the epidermis. J Cell Biol. 1996 Mar; 132(5):925-36. PMID: 8603923; PMCID: PMC2120736.
    Citations: 26     Fields:    Translation:AnimalsCells
  23. Thompson S, Clarke AR, Pow AM, Hooper ML, Melton DW. Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells. Cell. 1989 Jan 27; 56(2):313-21. PMID: 2912572.
    Citations: 97     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.