Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Mark Poznansky, Ph.D., M.B.,Ch.B.


Available: 12/02/19, Expires: 11/03/22

The student will participate in laboratory work and computational analysis associated with ongoing research and development work on new vaccines and immunotherapies for specific forms of cancer or infections. Students will learn state of the art high dimensional assay performance and data interpretation using novel computational algorithms. Prior students, over the past 10 years, in this program at the Vaccine and Immunotherapy Center at MGH have been included as coauthors on manuscripts, presenters of posters and named as coinventors on patents.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. RC1AI081282 (HELD, KATHRYN DALE) Sep 25, 2009 - Jan 31, 2013
    Novel agents for mitigation of radiation-induced pulmonary injury
    Role: Co-Principal Investigator
  2. R21AI049858 (POZNANSKY, MARK COLEMAN) Sep 15, 2001 - Aug 31, 2004
    Movement of Recipient T-Cells Away From an Allograft
    Role: Principal Investigator
  3. R01AI049757 (POZNANSKY, MARK COLEMAN) Apr 1, 2001 - Jun 30, 2012
    HIV-1 gp120 induced CTL chemorepulsion:dysregulation of migration &localization
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li B, Li G, Yan X, Zhu D, Lin PP, Wang Z, Qu H, He X, Fu Y, Zhu X, Lin P, Zhang J, Li X, Dai H, Chen H, Poznansky MC, Lin N, Ye Z. Fresh tissue multi-omics profiling reveals immune classification and suggests immunotherapy candidates for conventional chondrosarcoma. Clin Cancer Res. 2021 Aug 23. PMID: 34426437.
    Citations:    Fields:    
  2. Kawai K, Stowe AM, Evans CL, Sîrbulescu RF, Hanidziar D, Lee KM, Tedder TF, Poznansky MC. The 2021 FASEB virtual Catalyst Conference on B Cells in Injury and Regeneration, April 21, 2021. FASEB J. 2021 08; 35(8):e21744. PMID: 34224602.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Scholzen A, de Vries M, Duerr HP, Roest HJ, Sluder AE, Poznansky MC, Kouwijzer MLCE, Garritsen A. Whole Blood Interferon ? Release Is a More Sensitive Marker of Prior Exposure to Coxiella burnetii Than Are Antibody Responses. Front Immunol. 2021; 12:701811. PMID: 34394097.
    Citations:    Fields:    
  4. Mendoza AE, Raju Paul S, El Hechi M, Naar L, Nederpelt C, Mikdad S, van Erp I, Hess JM, Velmahos GC, Poznansky M, Reeves P. Deep immune profiling of whole blood to identify early immune signatures that correlate to patient outcome after major trauma. J Trauma Acute Care Surg. 2021 06 01; 90(6):959-966. PMID: 33755643.
    Citations:    Fields:    
  5. Garcia-Beltran WF, Lam EC, St Denis K, Nitido AD, Garcia ZH, Hauser BM, Feldman J, Pavlovic MN, Gregory DJ, Poznansky MC, Sigal A, Schmidt AG, Iafrate AJ, Naranbhai V, Balazs AB. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Cell. 2021 Apr 29; 184(9):2523. PMID: 33930298.
    Citations: 24     Fields:    
  6. Britton C, Poznansky MC, Reeves P. Polyfunctionality of the CXCR4/CXCL12 axis in health and disease: Implications for therapeutic interventions in cancer and immune-mediated diseases. FASEB J. 2021 04; 35(4):e21260. PMID: 33715207.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Garcia-Beltran WF, Lam EC, St Denis K, Nitido AD, Garcia ZH, Hauser BM, Feldman J, Pavlovic MN, Gregory DJ, Poznansky MC, Sigal A, Schmidt AG, Iafrate AJ, Naranbhai V, Balazs AB. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Cell. 2021 04 29; 184(9):2372-2383.e9. PMID: 33743213.
    Citations: 119     Fields:    Translation:HumansCells
  8. Garcia-Beltran WF, Lam EC, St Denis K, Nitido AD, Garcia ZH, Hauser BM, Feldman J, Pavlovic MN, Gregory DJ, Poznansky MC, Sigal A, Schmidt AG, Iafrate AJ, Naranbhai V, Balazs AB. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. medRxiv. 2021 Mar 12. PMID: 33619506.
  9. Naranbhai V, Chang CC, Beltran WFG, Miller TE, Astudillo MG, Villalba JA, Yang D, Gelfand J, Bernstein BE, Feldman J, Hauser BM, Caradonna TM, Alter G, Murali MR, Jasrasaria R, Quinlan J, Xerras DC, Betancourt JR, Louis DN, Schmidt AG, Lennerz J, Poznansky MC, Iafrate AJ. High Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chelsea, Massachusetts. J Infect Dis. 2020 11 13; 222(12):1955-1959. PMID: 32906151.
    Citations: 13     Fields:    Translation:Humans
  10. Miller TE, Garcia Beltran WF, Bard AZ, Gogakos T, Anahtar MN, Astudillo MG, Yang D, Thierauf J, Fisch AS, Mahowald GK, Fitzpatrick MJ, Nardi V, Feldman J, Hauser BM, Caradonna TM, Marble HD, Ritterhouse LL, Turbett SE, Batten J, Georgantas NZ, Alter G, Schmidt AG, Harris JB, Gelfand JA, Poznansky MC, Bernstein BE, Louis DN, Dighe A, Charles RC, Ryan ET, Branda JA, Pierce VM, Murali MR, Iafrate AJ, Rosenberg ES, Lennerz JK. Clinical sensitivity and interpretation of PCR and serological COVID-19 diagnostics for patients presenting to the hospital. FASEB J. 2020 10; 34(10):13877-13884. PMID: 32856766.
    Citations: 28     Fields:    Translation:HumansCTClinical Trials
  11. Reeves PM, Raju Paul S, Baeten L, Korek SE, Yi Y, Hess J, Sobell D, Scholzen A, Garritsen A, De Groot AS, Moise L, Brauns T, Bowen R, Sluder AE, Poznansky MC. Novel multiparameter correlates of Coxiella burnetii infection and vaccination identified by longitudinal deep immune profiling. Sci Rep. 2020 08 07; 10(1):13311. PMID: 32770104.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Wang J, Tannous BA, Poznansky MC, Chen H. CXCR4 antagonist AMD3100 (plerixafor): From an impurity to a therapeutic agent. Pharmacol Res. 2020 09; 159:105010. PMID: 32544428.
    Citations: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  13. Alagpulinsa DA, Szalat RE, Poznansky MC, Shmookler Reis RJ. Genomic Instability in Multiple Myeloma. Trends Cancer. 2020 10; 6(10):858-873. PMID: 32487486.
    Citations: 4     Fields:    
  14. Meyerowitz EA, Vannier AGL, Friesen MGN, Schoenfeld S, Gelfand JA, Callahan MV, Kim AY, Reeves PM, Poznansky MC. Rethinking the role of hydroxychloroquine in the treatment of COVID-19. FASEB J. 2020 05; 34(5):6027-6037. PMID: 32350928.
    Citations: 46     Fields:    Translation:HumansPHPublic Health
  15. Safley SA, Barber GF, Holdcraft RW, Gazda LS, Duncanson S, Poznansky MC, Sambanis A, Weber CJ. Multiple clinically relevant immunotherapies prolong the function of microencapsulated porcine islet xenografts in diabetic NOD mice without the use of anti-CD154 mAb. Xenotransplantation. 2020 07; 27(4):e12577. PMID: 31903659.
    Citations:    Fields:    Translation:Animals
  16. Scholzen A, Richard G, Moise L, Hartman E, Bleeker-Rovers CP, Reeves PM, Raju Paul S, Martin WD, De Groot AS, Poznansky MC, Sluder AE, Garritsen A. Coxiella burnetii Epitope-Specific T-Cell Responses in Patients with Chronic Q Fever. Infect Immun. 2019 10; 87(10). PMID: 31331958.
    Citations: 3     Fields:    Translation:HumansCells
  17. Zeng Y, Li B, Li T, Liu W, Ran C, Penson RT, Poznansky MC, Du Y, Chen H. CD90low MSCs modulate intratumoral immunity to confer antitumor activity in a mouse model of ovarian cancer. Oncotarget. 2019 Jul 09; 10(43):4479-4491. PMID: 31320999.
    Citations: 2     Fields:    
  18. Sîrbulescu RF, Chung JY, Edmiston WJ, Poznansky SA, Poznansky MC, Whalen MJ. Intraparenchymal Application of Mature B Lymphocytes Improves Structural and Functional Outcome after Contusion Traumatic Brain Injury. J Neurotrauma. 2019 09 01; 36(17):2579-2589. PMID: 30997843.
    Citations: 6     Fields:    Translation:AnimalsCells
  19. Sremac M, Lei J, Penson MFE, Schuetz C, Lakey JRT, Papas KK, Varde PS, Hering B, de Vos P, Brauns T, Markmann J, Poznansky MC. Preliminary Studies of the Impact of CXCL12 on the Foreign Body Reaction to Pancreatic Islets Microencapsulated in Alginate in Nonhuman Primates. Transplant Direct. 2019 May; 5(5):e447. PMID: 31165082.
    Citations: 3     
  20. Alagpulinsa DA, Cao JJL, Driscoll RK, Sîrbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns TA, Markmann JF, Melton DA, Poznansky MC. Alginate-microencapsulation of human stem cell-derived ß cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression. Am J Transplant. 2019 07; 19(7):1930-1940. PMID: 30748094.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  21. Zeng Y, Li B, Liang Y, Reeves PM, Qu X, Ran C, Liu Q, Callahan MV, Sluder AE, Gelfand JA, Chen H, Poznansky MC. Dual blockade of CXCL12-CXCR4 and PD-1-PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunosuppression in the tumor microenvironment. FASEB J. 2019 05; 33(5):6596-6608. PMID: 30802149.
    Citations: 29     Fields:    Translation:AnimalsCells
  22. Scholzen A, Richard G, Moise L, Baeten LA, Reeves PM, Martin WD, Brauns TA, Boyle CM, Raju Paul S, Bucala R, Bowen RA, Garritsen A, De Groot AS, Sluder AE, Poznansky MC. Promiscuous Coxiella burnetii CD4 Epitope Clusters Associated With Human Recall Responses Are Candidates for a Novel T-Cell Targeted Multi-Epitope Q Fever Vaccine. Front Immunol. 2019; 10:207. PMID: 30828331.
    Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  23. Kimizuka Y, Katagiri W, Locascio JJ, Shigeta A, Sasaki Y, Shibata M, Morse K, Sîrbulescu RF, Miyatake M, Reeves P, Suematsu M, Gelfand J, Brauns T, Poznansky MC, Tsukada K, Kashiwagi S. Brief Exposure of Skin to Near-Infrared Laser Modulates Mast Cell Function and Augments the Immune Response. J Immunol. 2018 12 15; 201(12):3587-3603. PMID: 30420435.
    Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
  24. Baeten LA, Podell BK, Sluder AE, Garritsen A, Bowen RA, Poznansky MC. Standardized guinea pig model for Q fever vaccine reactogenicity. PLoS One. 2018; 13(10):e0205882. PMID: 30312355.
    Citations: 4     Fields:    Translation:AnimalsCellsPHPublic Health
  25. Gelfand JA, Nazarian RM, Kashiwagi S, Brauns T, Martin B, Kimizuka Y, Korek S, Botvinick E, Elkins K, Thomas L, Locascio J, Parry B, Kelly KM, Poznansky MC. A pilot clinical trial of a near-infrared laser vaccine adjuvant: safety, tolerability, and cutaneous immune cell trafficking. FASEB J. 2019 02; 33(2):3074-3081. PMID: 30192655.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  26. Alagpulinsa DA, Cao JJL, Sobell D, Poznansky MC. Harnessing CXCL12 signaling to protect and preserve functional ß-cell mass and for cell replacement in type 1 diabetes. Pharmacol Ther. 2019 01; 193:63-74. PMID: 30149101.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  27. Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A. Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation. 2018 08; 102(8):1223-1229. PMID: 29781950.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  28. Reeves PM, Abbaslou MA, Kools FRW, Vutipongsatorn K, Tong X, Gavegnano C, Schinazi RF, Poznansky MC. Correction: Ruxolitinib sensitizes ovarian cancer to reduced dose Taxol, limits tumor growth and improves survival in immune competent mice. Oncotarget. 2018 07 13; 9(54):30472. PMID: 30101001.
    Citations:    Fields:    
  29. Li B, Wang Z, Wu H, Xue M, Lin P, Wang S, Lin N, Huang X, Pan W, Liu M, Yan X, Qu H, Sun L, Li H, Wu Y, Teng W, Wang Z, Zhou X, Chen H, Poznansky MC, Ye Z. Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma. Cancer Res. 2018 07 15; 78(14):3938-3953. PMID: 29735547.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  30. Li B, Zeng Y, Reeves PM, Ran C, Liu Q, Qu X, Liang Y, Liu Z, Yuan J, Leblanc PR, Ye Z, Sluder AE, Gelfand JA, Brauns TA, Chen H, Poznansky MC. AMD3100 Augments the Efficacy of Mesothelin-Targeted, Immune-Activating VIC-008 in Mesothelioma by Modulating Intratumoral Immunosuppression. Cancer Immunol Res. 2018 05; 6(5):539-551. PMID: 29511032.
    Citations: 15     Fields:    Translation:AnimalsCells
  31. Reeves PM, Sluder AE, Paul SR, Scholzen A, Kashiwagi S, Poznansky MC. Application and utility of mass cytometry in vaccine development. FASEB J. 2018 01; 32(1):5-15. PMID: 29092906.
    Citations: 11     Fields:    Translation:HumansAnimals
  32. Sîrbulescu RF, Boehm CK, Soon E, Wilks MQ, Ilies I, Yuan H, Maxner B, Chronos N, Kaittanis C, Normandin MD, El Fakhri G, Orgill DP, Sluder AE, Poznansky MC. Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions. Wound Repair Regen. 2017 09; 25(5):774-791. PMID: 28922523.
    Citations: 24     Fields:    Translation:AnimalsCells
  33. Reeves PM, Abbaslou MA, Kools FRW, Vutipongsatorn K, Tong X, Gavegnano C, Schinazi RF, Poznansky MC. Ruxolitinib sensitizes ovarian cancer to reduced dose Taxol, limits tumor growth and improves survival in immune competent mice. Oncotarget. 2017 11 07; 8(55):94040-94053. PMID: 29212208.
    Citations: 3     Fields:    
  34. Reeves PM, Abbaslou MA, Kools FRW, Poznansky MC. CXCR4 blockade with AMD3100 enhances Taxol chemotherapy to limit ovarian cancer cell growth. Anticancer Drugs. 2017 10; 28(9):935-942. PMID: 28817386.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  35. Mattox AK, Lee J, Westra WH, Pierce RH, Ghossein R, Faquin WC, Diefenbach TJ, Morris LG, Lin DT, Wirth LJ, Lefranc-Torres A, Ishida E, Chakravarty PD, Johnson L, Zeng YC, Chen H, Poznansky MC, Iyengar NM, Pai SI. PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs. Cancer Res. 2017 11 15; 77(22):6365-6374. PMID: 28947422.
    Citations: 25     Fields:    Translation:HumansCells
  36. Reeves PM, Paul SR, Sluder AE, Brauns TA, Poznansky MC. Q-vaxcelerate: A distributed development approach for a new Coxiella burnetii vaccine. Hum Vaccin Immunother. 2017 12 02; 13(12):2977-2981. PMID: 28933682.
    Citations: 3     Fields:    Translation:HumansCells
  37. Morse K, Kimizuka Y, Chan MPK, Shibata M, Shimaoka Y, Takeuchi S, Forbes B, Nirschl C, Li B, Zeng Y, Bronson RT, Katagiri W, Shigeta A, Sîrbulescu RF, Chen H, Tan RYY, Tsukada K, Brauns T, Gelfand J, Sluder A, Locascio JJ, Poznansky MC, Anandasabapathy N, Kashiwagi S. Near-Infrared 1064 nm Laser Modulates Migratory Dendritic Cells To Augment the Immune Response to Intradermal Influenza Vaccine. J Immunol. 2017 08 15; 199(4):1319-1332. PMID: 28710250.
    Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
  38. Kimizuka Y, Callahan JJ, Huang Z, Morse K, Katagiri W, Shigeta A, Bronson R, Takeuchi S, Shimaoka Y, Chan MPK, Zeng Y, Li B, Chen H, Tan RYY, Dwyer C, Mulley T, Leblanc P, Goudie C, Gelfand J, Tsukada K, Brauns T, Poznansky MC, Bean D, Kashiwagi S. Semiconductor diode laser device adjuvanting intradermal vaccine. Vaccine. 2017 04 25; 35(18):2404-2412. PMID: 28365253.
    Citations: 7     Fields:    Translation:AnimalsPHPublic Health
  39. Agha-Abbaslou M, Bensaci AM, Dike O, Poznansky MC, Hyat A. Adult-Onset Still's Disease: Still a Serious Health Problem (a Case Report and Literature Review). Am J Case Rep. 2017 Feb 03; 18:119-124. PMID: 28154368.
    Citations: 5     Fields:    Translation:Humans
  40. Zhu L, Fan X, Wang B, Liu L, Yan X, Zhou L, Zeng Y, Poznansky MC, Wang L, Chen H, Du Y. Biomechanically primed liver microtumor array as a high-throughput mechanopharmacological screening platform for stroma-reprogrammed combinatorial therapy. Biomaterials. 2017 04; 124:12-24. PMID: 28182873.
    Citations: 10     Fields:    Translation:HumansCells
  41. Abers MS, Ghebremichael MS, Timmons AK, Warren HS, Poznansky MC, Vyas JM. A Critical Reappraisal of Prolonged Neutropenia as a Risk Factor for Invasive Pulmonary Aspergillosis. Open Forum Infect Dis. 2016 Jan; 3(1):ofw036. PMID: 27006961.
    Citations: 6     
  42. Kashiwagi S, Brauns T, Poznansky MC. Classification of Laser Vaccine Adjuvants. J Vaccines Vaccin. 2016 Feb; 7(1). PMID: 27104047.
    Citations: 8     
  43. Jones CN, Dimisko L, Forrest K, Judice K, Poznansky MC, Markmann JF, Vyas JM, Irimia D. Human Neutrophils Are Primed by Chemoattractant Gradients for Blocking the Growth of Aspergillus fumigatus. J Infect Dis. 2016 Feb 01; 213(3):465-75. PMID: 26272935.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  44. Chen T, Yuan J, Duncanson S, Hibert ML, Kodish BC, Mylavaganam G, Maker M, Li H, Sremac M, Santosuosso M, Forbes B, Kashiwagi S, Cao J, Lei J, Thomas M, Hartono C, Sachs D, Markmann J, Sambanis A, Poznansky MC. Alginate encapsulant incorporating CXCL12 supports long-term allo- and xenoislet transplantation without systemic immune suppression. Am J Transplant. 2015 Mar; 15(3):618-27. PMID: 25693473.
    Citations: 22     Fields:    Translation:Animals
  45. Yuan J, Kashiwagi S, Reeves P, Nezivar J, Yang Y, Arrifin NH, Nguyen M, Jean-Mary G, Tong X, Uppal P, Korochkina S, Forbes B, Chen T, Righi E, Bronson R, Chen H, Orsulic S, Brauns T, Leblanc P, Scholler N, Dranoff G, Gelfand J, Poznansky MC. A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma. J Hematol Oncol. 2014 Feb 24; 7:15. PMID: 24565018.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  46. Kashiwagi S, Brauns T, Gelfand J, Poznansky MC. Laser vaccine adjuvants. History, progress, and potential. Hum Vaccin Immunother. 2014; 10(7):1892-907. PMID: 25424797.
    Citations: 11     Fields:    Translation:HumansCells
  47. Leblanc P, Moise L, Luza C, Chantaralawan K, Lezeau L, Yuan J, Field M, Richer D, Boyle C, Martin WD, Fishman JB, Berg EA, Baker D, Zeigler B, Mais DE, Taylor W, Coleman R, Warren HS, Gelfand JA, De Groot AS, Brauns T, Poznansky MC. VaxCelerate II: rapid development of a self-assembling vaccine for Lassa fever. Hum Vaccin Immunother. 2014; 10(10):3022-38. PMID: 25483693.
    Citations: 9     Fields:    Translation:AnimalsCells
  48. Kashiwagi S, Yuan J, Forbes B, Hibert ML, Lee EL, Whicher L, Goudie C, Yang Y, Chen T, Edelblute B, Collette B, Edington L, Trussler J, Nezivar J, Leblanc P, Bronson R, Tsukada K, Suematsu M, Dover J, Brauns T, Gelfand J, Poznansky MC. Near-infrared laser adjuvant for influenza vaccine. PLoS One. 2013; 8(12):e82899. PMID: 24349390.
    Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
  49. Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MC. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17561-6. PMID: 23045683.
    Citations: 306     Fields:    Translation:HumansAnimals
  50. Leblanc PR, Yuan J, Brauns T, Gelfand JA, Poznansky MC. Accelerated vaccine development against emerging infectious diseases. Hum Vaccin Immunother. 2012 Jul; 8(7):1010-2. PMID: 22777091.
    Citations: 2     Fields:    Translation:Humans
  51. Zhang J, Poznansky M, Crumpacker C. Naive and memory CD4? T cells in HIV eradication and immunization. J Infect Dis. 2012 Aug 15; 206(4):617-8; author reply 618. PMID: 22696498.
    Citations: 2     Fields:    Translation:Humans
  52. Kotton CN, Poznansky MC. Vaccination of oncology patients: an effective tool and an opportunity not to be missed. Oncologist. 2012; 17(1):1-2. PMID: 22240542.
    Citations: 4     Fields:    Translation:HumansCells
  53. Righi E, Kashiwagi S, Yuan J, Santosuosso M, Leblanc P, Ingraham R, Forbes B, Edelblute B, Collette B, Xing D, Kowalski M, Mingari MC, Vianello F, Birrer M, Orsulic S, Dranoff G, Poznansky MC. CXCL12/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer. Cancer Res. 2011 Aug 15; 71(16):5522-5534. PMID: 21742774.
    Citations: 90     Fields:    Translation:Animals
  54. Santosuosso M, Righi E, Hill ED, Leblanc PR, Kodish B, Mylvaganam HN, Siddappa NB, Stevceva L, Hu SL, Ghebremichael M, Chenine AL, Hovav AH, Ruprecht RM, Poznansky MC. R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes. PLoS One. 2011 Apr 05; 6(4):e18465. PMID: 21483689.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  55. Siddappa NB, Watkins JD, Wassermann KJ, Song R, Wang W, Kramer VG, Lakhashe S, Santosuosso M, Poznansky MC, Novembre FJ, Villinger F, Else JG, Montefiori DC, Rasmussen RA, Ruprecht RM. R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models. PLoS One. 2010 Jul 21; 5(7):e11689. PMID: 20657739.
    Citations: 35     Fields:    Translation:AnimalsCells
  56. Chenine AL, Siddappa NB, Kramer VG, Sciaranghella G, Rasmussen RA, Lee SJ, Santosuosso M, Poznansky MC, Velu V, Amara RR, Souder C, Anderson DC, Villinger F, Else JG, Novembre FJ, Strobert E, O'Neil SP, Secor WE, Ruprecht RM. Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes. J Infect Dis. 2010 Apr 15; 201(8):1155-63. PMID: 20214475.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  57. Vianello F, Righi E, Poznansky MC. Methods for quantitation of leukocyte chemotaxis and fugetaxis. Methods Mol Biol. 2010; 616:115-24. PMID: 20379872.
    Citations:    Fields:    Translation:HumansAnimalsCells
  58. Lee JY, Buzney CD, Poznansky MC, Sackstein R. Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions. J Leukoc Biol. 2009 Dec; 86(6):1285-94. PMID: 19797295.
    Citations: 11     Fields:    Translation:HumansCells
  59. Santosuosso M, Righi E, Lindstrom V, Leblanc PR, Poznansky MC. HIV-1 envelope protein gp120 is present at high concentrations in secondary lymphoid organs of individuals with chronic HIV-1 infection. J Infect Dis. 2009 Oct 01; 200(7):1050-3. PMID: 19698075.
    Citations: 36     Fields:    Translation:Humans
  60. Goodchild TT, Robinson KA, Pang W, Tondato F, Cui J, Arrington J, Godwin L, Ungs M, Carlesso N, Weich N, Poznansky MC, Chronos NA. Bone marrow-derived B cells preserve ventricular function after acute myocardial infarction. JACC Cardiovasc Interv. 2009 Oct; 2(10):1005-16. PMID: 19850263.
    Citations: 14     Fields:    Translation:AnimalsCells
  61. Jaafar F, Righi E, Lindstrom V, Linton C, Nohadani M, Van Noorden S, Lloyd T, Poznansky J, Stamp G, Dina R, Coleman DV, Poznansky MC. Correlation of CXCL12 expression and FoxP3+ cell infiltration with human papillomavirus infection and clinicopathological progression of cervical cancer. Am J Pathol. 2009 Oct; 175(4):1525-35. PMID: 19808652.
    Citations: 31     Fields:    Translation:HumansCells
  62. Hovav AH, Santosuosso M, Bivas-Benita M, Plair A, Cheng A, Elnekave M, Righi E, Chen T, Kashiwagi S, Panas MW, Xiang SH, Furmanov K, Letvin NL, Poznansky MC. X4 human immunodeficiency virus type 1 gp120 down-modulates expression and immunogenicity of codelivered antigens. J Virol. 2009 Nov; 83(21):10941-50. PMID: 19692474.
    Citations: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  63. Stevceva L, Yoon V, Carville A, Pacheco B, Santosuosso M, Korioth-Schmitz B, Mansfield K, Poznansky MC. The efficacy of T cell-mediated immune responses is reduced by the envelope protein of the chimeric HIV-1/SIV-KB9 virus in vivo. J Immunol. 2008 Oct 15; 181(8):5510-21. PMID: 18832708.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  64. Huttenlocher A, Poznansky MC. Reverse leukocyte migration can be attractive or repulsive. Trends Cell Biol. 2008 Jun; 18(6):298-306. PMID: 18468440.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  65. Papeta N, Chen T, Vianello F, Gererty L, Malik A, Mok YT, Tharp WG, Bagley J, Zhao G, Stevceva L, Yoon V, Sykes M, Sachs D, Iacomini J, Poznansky MC. Long-term survival of transplanted allogeneic cells engineered to express a T cell chemorepellent. Transplantation. 2007 Jan 27; 83(2):174-83. PMID: 17264814.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  66. Vianello F, Poznansky MC. Generation of a tissue-engineered thymic organoid. Methods Mol Biol. 2007; 380:163-70. PMID: 17876092.
    Citations:    Fields:    Translation:HumansAnimalsCells
  67. Stevceva L, Yoon V, Anastasiades D, Poznansky MC. Immune responses to HIV Gp120 that facilitate viral escape. Curr HIV Res. 2007 Jan; 5(1):47-54. PMID: 17266556.
    Citations: 5     Fields:    Translation:HumansCells
  68. Goodchild T, Pang W, Tondato F, Cui J, Otsuka Y, Frowein S, Ungs M, Robinson K, Poznansky M, Chronos N. Safety of intramyocardial injection of autologous bone marrow cells to treat myocardial ischemia in pigs. Cardiovasc Revasc Med. 2006 Jul-Sep; 7(3):136-45. PMID: 16945820.
    Citations: 1     Fields:    Translation:AnimalsCells
  69. Vianello F, Papeta N, Chen T, Kraft P, White N, Hart WK, Kircher MF, Swart E, Rhee S, Palù G, Irimia D, Toner M, Weissleder R, Poznansky MC. Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control. J Immunol. 2006 Mar 01; 176(5):2902-14. PMID: 16493048.
    Citations: 46     Fields:    Translation:AnimalsCells
  70. Adams GB, Chabner KT, Alley IR, Olson DP, Szczepiorkowski ZM, Poznansky MC, Kos CH, Pollak MR, Brown EM, Scadden DT. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature. 2006 Feb 02; 439(7076):599-603. PMID: 16382241.
    Citations: 241     Fields:    Translation:AnimalsCells
  71. Irimia D, Liu SY, Tharp WG, Samadani A, Toner M, Poznansky MC. Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients. Lab Chip. 2006 Feb; 6(2):191-8. PMID: 16450027.
    Citations: 57     Fields:    Translation:HumansCells
  72. Tharp WG, Yadav R, Irimia D, Upadhyaya A, Samadani A, Hurtado O, Liu SY, Munisamy S, Brainard DM, Mahon MJ, Nourshargh S, van Oudenaarden A, Toner MG, Poznansky MC. Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo. J Leukoc Biol. 2006 Mar; 79(3):539-54. PMID: 16365152.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  73. Vianello F, Kraft P, Mok YT, Hart WK, White N, Poznansky MC. A CXCR4-dependent chemorepellent signal contributes to the emigration of mature single-positive CD4 cells from the fetal thymus. J Immunol. 2005 Oct 15; 175(8):5115-25. PMID: 16210615.
    Citations: 23     Fields:    Translation:AnimalsCells
  74. Vianello F, Olszak IT, Poznansky MC. Fugetaxis: active movement of leukocytes away from a chemokinetic agent. J Mol Med (Berl). 2005 Oct; 83(10):752-63. PMID: 16142473.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  75. Brainard DM, Tharp WG, Granado E, Miller N, Trocha AK, Ren XH, Conrad B, Terwilliger EF, Wyatt R, Walker BD, Poznansky MC. Migration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120. J Virol. 2004 May; 78(10):5184-93. PMID: 15113900.
    Citations: 12     Fields:    Translation:AnimalsCells
  76. Antohe F, Lin L, Kao GY, Poznansky MJ, Allen TM. Transendothelial movement of liposomes in vitro mediated by cancer cells, neutrophils or histamine. J Liposome Res. 2004; 14(1-2):1-25. PMID: 15461929.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  77. Robertson P, Poznansky MC. T-lymphocyte development and models of thymopoietic reconstitution. Transpl Infect Dis. 2003 Mar; 5(1):38-42. PMID: 12791073.
    Citations: 1     Fields:    Translation:HumansCells
  78. Adams GB, Chabner KT, Foxall RB, Weibrecht KW, Rodrigues NP, Dombkowski D, Fallon R, Poznansky MC, Scadden DT. Heterologous cells cooperate to augment stem cell migration, homing, and engraftment. Blood. 2003 Jan 01; 101(1):45-51. PMID: 12393569.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  79. Poznansky MC, Olszak IT, Evans RH, Wang Z, Foxall RB, Olson DP, Weibrecht K, Luster AD, Scadden DT. Thymocyte emigration is mediated by active movement away from stroma-derived factors. J Clin Invest. 2002 Apr; 109(8):1101-10. PMID: 11956248.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  80. Segal R, Poznansky MC, Connors L, Sands K, Barlam T. Changing patterns of presentations of patients with HIV-related disease at a tertiary referral centre and its implications for physician training. Int J STD AIDS. 2001 Jul; 12(7):453-9. PMID: 11394981.
    Citations: 1     Fields:    Translation:HumansCells
  81. Poznansky MC, Olszak IT, Foxall RB, Piascik A, Adams GB, Evans RH, Cheng T, Scadden DT. Tissue source dictates lineage outcome of human fetal CD34(+)CD38(-) cells. Exp Hematol. 2001 Jun; 29(6):766-74. PMID: 11378272.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  82. Poznansky MC, Evans RH, Foxall RB, Olszak IT, Piascik AH, Hartman KE, Brander C, Meyer TH, Pykett MJ, Chabner KT, Kalams SA, Rosenzweig M, Scadden DT. Efficient generation of human T cells from a tissue-engineered thymic organoid. Nat Biotechnol. 2000 Jul; 18(7):729-34. PMID: 10888839.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  83. Olszak IT, Poznansky MC, Evans RH, Olson D, Kos C, Pollak MR, Brown EM, Scadden DT. Extracellular calcium elicits a chemokinetic response from monocytes in vitro and in vivo. J Clin Invest. 2000 May; 105(9):1299-305. PMID: 10792005.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  84. Poznansky MC, Olszak IT, Foxall R, Evans RH, Luster AD, Scadden DT. Active movement of T cells away from a chemokine. Nat Med. 2000 May; 6(5):543-8. PMID: 10802710.
    Citations: 92     Fields:    Translation:HumansCells
  85. Poznansky MC, La Vecchio J, Silva-Arietta S, Porter-Brooks J, Brody K, Olszak IT, Adams GB, Ramstedt U, Marasco WA, Scadden DT. Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells and monocytes derived from CD34+ cells transduced with an intracellular antibody directed against human immunodeficiency virus type 1 Tat. Hum Gene Ther. 1999 Oct 10; 10(15):2505-14. PMID: 10543615.
    Citations: 4     Fields:    Translation:HumansCells
  86. Adams GB, McMullen M, Turner S, Olszak IT, Scadden DT, McClure MO, Poznansky MC. Isolation and transduction of CD34+ cells from small quantities of peripheral blood from HIV-1-infected patients not treated with hemopoietic growth factors. . 1999 May 01; 21(1):1-8. PMID: 10235508.
    Citations:    Translation:HumansCells
  87. Adams GB, Pym AS, Poznansky MC, McClure MO, Weber JN. The in vivo effects of combination antiretroviral drug therapy on peripheral blood CD34+ cell colony-forming units from HIV type 1-infected patients. AIDS Res Hum Retroviruses. 1999 Apr 10; 15(6):551-9. PMID: 10221532.
    Citations: 5     Fields:    Translation:HumansCells
  88. Poznansky MC, Foxall R, Mhashilkar A, Coker R, Jones S, Ramstedt U, Marasco W. Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells from HIV-infected individuals that express intracellular antibodies against HIV-1 gp120 or Tat. Hum Gene Ther. 1998 Mar 01; 9(4):487-96. PMID: 9525310.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  89. el Oakley RM, Brand NJ, Burton PB, McMullen MC, Adams GB, Poznansky MC, Barton PJ, Yacoub MH. Efficiency of a high-titer retroviral vector for gene transfer into skeletal myoblasts. J Thorac Cardiovasc Surg. 1998 Jan; 115(1):1-8. PMID: 9451039.
    Citations: 3     Fields:    Translation:HumansCells
  90. Landau R, Coker R, Vermeulen E, Touquet R, Fothergill J, Poznansky MC. Patients unaware of their HIV status present to inner city accident and emergency department with respiratory complications. J Accid Emerg Med. 1997 Sep; 14(5):304-6. PMID: 9315932.
    Citations: 1     Fields:    Translation:Humans
  91. Coker R, Poznansky M. Survival and treatment of AIDS patients 1984-1993. Genitourin Med. 1997 Apr; 73(2):148. PMID: 9215107.
    Citations:    Fields:    Translation:Humans
  92. Poznansky MC, Adams GB. The development of a gene therapy for HIV infection. Int J STD AIDS. 1997 Mar; 8(3):145-7; quiz 148-9. PMID: 9089023.
    Citations:    Fields:    Translation:HumansAnimalsCells
  93. Poznansky MC, Walters J, Cruikshank A, Pollock R, Dendrowskyj P, Lewis K, Parry JV, Fothergill J, Weber J. The rising prevalence of HIV-1 infection in patients attending an inner city accident and emergency department. J Accid Emerg Med. 1996 Nov; 13(6):424-5. PMID: 8947806.
    Citations: 3     Fields:    Translation:HumansCells
  94. Coker RJ, Poznansky MC. Physicians' experience and survival in patients with AIDS. N Engl J Med. 1996 Aug 01; 335(5):349; author reply 350-1. PMID: 8668216.
    Citations: 2     Fields:    Translation:Humans
  95. Poznansky MC, Coker R, Skinner C, Hill A, Bailey S, Whitaker L, Renton A, Weber J. HIV positive patients first presenting with an AIDS defining illness: characteristics and survival. BMJ. 1995 Jul 15; 311(6998):156-8. PMID: 7613426.
    Citations: 12     Fields:    Translation:Humans
  96. Coker RJ, Desmond N, Poznansky M, Smith C, Shafi MS, Bell D, Riordan JF, Murphy S. Experience of HIV disease in a London District General Hospital. Int J STD AIDS. 1995 Jan-Feb; 6(1):47-9. PMID: 7727583.
    Citations: 1     Fields:    Translation:Humans
  97. Poznansky MC, Torkington J, Turner G, Bankes MJ, Parry JV, Connell JA, Touquet R, Weber J. Prevalence of HIV infection in patients attending an inner city accident and emergency department. BMJ. 1994 Mar 05; 308(6929):636. PMID: 8148714.
    Citations: 4     Fields:    Translation:HumansCells
  98. Langhoff E, Terwilliger EF, Bos HJ, Kalland KH, Poznansky MC, Bacon OM, Haseltine WA. Replication of human immunodeficiency virus type 1 in primary dendritic cell cultures. Proc Natl Acad Sci U S A. 1991 Sep 15; 88(18):7998-8002. PMID: 1910172.
    Citations: 51     Fields:    Translation:HumansCells
  99. Poznansky M, Lever A, Bergeron L, Haseltine W, Sodroski J. Gene transfer into human lymphocytes by a defective human immunodeficiency virus type 1 vector. J Virol. 1991 Jan; 65(1):532-6. PMID: 1985215.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  100. Poznansky MC, Walker B, Haseltine WA, Sodroski J, Langhoff E. A rapid method for quantitating the frequency of peripheral blood cells containing HIV-1 DNA. J Acquir Immune Defic Syndr (1988). 1991; 4(4):368-73. PMID: 1672549.
    Citations: 8     Translation:HumansCells
  101. Poznansky MC, Clissold PM, Lachmann PJ. The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha chain of the complement component, C3. J Immunol. 1989 Dec 01; 143(11):3860-2. PMID: 2584723.
    Citations: 3     Fields:    Translation:HumansCells
  102. Poznansky MC, Clissold PM, Lachmann PJ. The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha-chain of the complement component, C3. J Immunol. 1989 Aug 15; 143(4):1254-8. PMID: 2473125.
    Citations: 2     Fields:    Translation:HumansCells
  103. Poznansky MJ, Hutchison SK, Davis PJ. Enzyme replacement therapy in fibroblasts from a patient with cholesteryl ester storage disease. FASEB J. 1989 Feb; 3(2):152-6. PMID: 2644147.
    Citations: 6     Fields:    Translation:HumansCells
  104. Gruber B, Poznansky M, Boss E, Partin J, Gorevic P, Kaplan AP. Characterization and functional studies of rheumatoid synovial mast cells. Activation by secretagogues, anti-IgE, and a histamine-releasing lymphokine. Arthritis Rheum. 1986 Aug; 29(8):944-55. PMID: 2427092.
    Citations: 20     Fields:    Translation:HumansCells
  105. Poznansky MC, Gordon AC, Grant IW, Wyllie AH. A cellular abnormality in glucocorticoid resistant asthma. Clin Exp Immunol. 1985 Jul; 61(1):135-42. PMID: 3876177.
    Citations: 6     Fields:    Translation:HumansCells
  106. Poznansky MC, Gordon AC, Douglas JG, Krajewski AS, Wyllie AH, Grant IW. Resistance to methylprednisolone in cultures of blood mononuclear cells from glucocorticoid-resistant asthmatic patients. Clin Sci (Lond). 1984 Dec; 67(6):639-45. PMID: 6488705.
    Citations: 14     Fields:    Translation:HumansCells
  107. Poznansky MJ. Enzyme-protein conjugates: new possibilities for enzyme therapy. Pharmacol Ther. 1983; 21(1):53-76. PMID: 6353439.
    Citations: 1     Fields:    Translation:HumansAnimals
  108. Poznansky MJ, Shandling M, Salkie MA, Elliott JF, Lau E. Advantages in the use of L-asparaginase-albumin polymer as an antitumor agent. Cancer Res. 1982 Mar; 42(3):1020-5. PMID: 6895861.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  109. Poznansky M, Lange Y. Transbilayer movement of cholesterol in dipalmitoyllecithin-cholesterol vesicles. Nature. 1976 Feb 05; 259(5542):420-1. PMID: 1250389.
    Citations: 12     Fields:    Translation:Cells
  110. Chang TM, Poznansky MJ. Semipermeable microcapsules containing catalase for enzyme replacement in acatalasaemic mice. Nature. 1968 Apr 20; 218(5138):243-5. PMID: 5648221.
    Citations: 13     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.