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Kyle Patrick Lillis, Ph.D.

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Marquette University, Milwaukee, WIB.S.2001Biomedical Engineering
Marquette University, Milwaukee, WIM.S.2003Biomedical Engineering
Boston University, Boston, MAPh.D.2009Bioengineering

Kyle Lillis is a bioengineer and neuroscientist studying the basic mechanisms of post-traumatic epilepsy. Epilepsy is a condition of recurrent seizures, which in about 1/3 of patients cannot be controlled by medication. As with many neurological disorders, the treatments are poorly understood and have extensive side effects. Kyle’s approach to advancing our understanding of epilepsy involves development and implementation of novel optical tools to investigate the changes that occur in the brain following injury. During his Ph.D. research at Boston University, he developed high speed laser-scanning techniques for microscopic imaging of seizure activity in rodent brain slices. His current research at MGH focuses largely on continuously imaging neuronal activity in injured brain tissue, ranging in scale from rodent brain slice cultures to pigs in vivo, as epileptic neural circuits forms. The goal of this research is to inform development of new anti-epileptic drugs with better seizure control and fewer side effects.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS112538 (LILLIS, KYLE PATRICK) Aug 1, 2020 - Apr 30, 2025
    Mechanisms of interictal spike generation
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Balena T, Lillis K, Rahmati N, Bahari F, Dzhala V, Berdichevsky E, Staley K. A dynamic balance between neuronal death and clearance after acute brain injury. bioRxiv. 2023 Feb 14. PMID: 36824708; PMCID: PMC9948967.
  2. Costine-Bartell BA, Martinez-Ramirez L, Normoyle K, Stinson T, Staley KJ, Lillis KP. 2-Photon imaging of fluorescent proteins in living swine. bioRxiv. 2023 Feb 14. PMID: 36824934; PMCID: PMC9949062.
  3. Lillis KP. Connectome the Dots for Presurgical Predictions. Epilepsy Curr. 2022 Nov-Dec; 22(6):378-380. PMID: 36426193; PMCID: PMC9661618.
  4. Lillis KP. Molecular Layer Heterotopia: Harmless Brain Warts or Ictal Main Force? Epilepsy Curr. 2022 Jul-Aug; 22(4):258-260. PMID: 36187144; PMCID: PMC9483762.
  5. Lau LA, Staley KJ, Lillis KP. In vitro ictogenesis is stochastic at the single neuron level. Brain. 2022 04 18; 145(2):531-541. PMID: 34431994; PMCID: PMC9014754.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Lillis KP. Putting the Neuro in Neurovascular Coupling. Epilepsy Curr. 2022 Jun; 22(3):184-186. PMID: 36474829; PMCID: PMC9684592.
  7. Lillis K. Optokindling, GABA Dwindling. Epilepsy Curr. 2021 Nov-Dec; 21(6):455-456. PMID: 34924857; PMCID: PMC8652322.
  8. Lillis KP. Imaging Interneuron Impairment in Ictogenesis: A Spatiotemporal Sweet Spot of Seizure Sampling in Scn1a+/. Epilepsy Curr. 2021 Oct; 21(5):376-378. PMID: 34924841; PMCID: PMC8655246.
  9. Rahmati N, Normoyle KP, Glykys J, Dzhala VI, Lillis KP, Kahle KT, Raiyyani R, Jacob T, Staley KJ. Unique Actions of GABA Arising from Cytoplasmic Chloride Microdomains. J Neurosci. 2021 06 09; 41(23):4957-4975. PMID: 33903223; PMCID: PMC8197632.
    Citations: 1     Fields:    Translation:AnimalsCells
  10. Lillis KP. The (Extracellular) Matrix Reloaded: Imaging Matrix Metalloproteinase Activity. Epilepsy Curr. 2021 Mar-Apr; 21(2):120-121. PMID: 34025289; PMCID: PMC8010872.
    Citations: 2     
  11. Lillis KP. TLR4 Signaling Contributes to Post-Traumatic Epileptogenesis Through Insertion of Inwardly Rectifying AMPA Receptors: Not a Happy CP-AMPAR. Epilepsy Curr. 2020 Nov-Dec; 20(6):375-377. PMID: 34025258; PMCID: PMC7818210.
  12. Lillis KP. A Tisket a Tasket: Chandelier ? Basket (Cell Bouton Density in Sclerotic DG). Epilepsy Curr. 2020 Jul-Aug; 20(4):218-220. PMID: 34025232; PMCID: PMC7427173.
    Citations: 1     
  13. Lillis KP. Ictal Inhibition: Sync Globally, Slack Locally. Epilepsy Curr. 2020 May-Jun; 20(3):154-156. PMID: 32550836; PMCID: PMC7281902.
  14. Jacob T, Lillis KP, Wang Z, Swiercz W, Rahmati N, Staley KJ. A Proposed Mechanism for Spontaneous Transitions between Interictal and Ictal Activity. J Neurosci. 2019 01 16; 39(3):557-575. PMID: 30446533; PMCID: PMC6335741.
    Citations: 5     Fields:    Translation:AnimalsCells
  15. Lillis KP, Staley KJ. Optogenetic dissection of ictogenesis: in search of a targeted anti-epileptic therapy. J Neural Eng. 2018 08; 15(4):041001. PMID: 29536948.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  16. Lillis KP, Wang Z, Mail M, Zhao GQ, Berdichevsky Y, Bacskai B, Staley KJ. Evolution of Network Synchronization during Early Epileptogenesis Parallels Synaptic Circuit Alterations. J Neurosci. 2015 Jul 08; 35(27):9920-34. PMID: 26156993; PMCID: PMC4495242.
    Citations: 35     Fields:    Translation:AnimalsCells
  17. Lillis KP, Dulla C, Maheshwari A, Coulter D, Mody I, Heinemann U, Armbruster M, Žiburkus J. WONOEP appraisal: molecular and cellular imaging in epilepsy. Epilepsia. 2015 Apr; 56(4):505-13. PMID: 25779014.
    Citations: 3     Fields:    Translation:HumansAnimals
  18. Lillis KP, Kramer MA, Mertz J, Staley KJ, White JA. Pyramidal cells accumulate chloride at seizure onset. Neurobiol Dis. 2012 Sep; 47(3):358-66. PMID: 22677032.
    Citations: 53     Fields:    Translation:AnimalsCells
  19. Sabolek HR, Swiercz WB, Lillis KP, Cash SS, Huberfeld G, Zhao G, Ste Marie L, Clemenceau S, Barsh G, Miles R, Staley KJ. A candidate mechanism underlying the variance of interictal spike propagation. J Neurosci. 2012 Feb 29; 32(9):3009-21. PMID: 22378874.
    Citations: 32     Fields:    Translation:HumansAnimals
  20. Scheidt RA, Lillis KP, Emerson SJ. Visual, motor and attentional influences on proprioceptive contributions to perception of hand path rectilinearity during reaching. Exp Brain Res. 2010 Jul; 204(2):239-54. PMID: 20532489.
    Citations: 13     Fields:    Translation:Humans
  21. Keck T, Lillis KP, Zhou YD, White JA. Frequency-dependent glycinergic inhibition modulates plasticity in hippocampus. J Neurosci. 2008 Jul 16; 28(29):7359-69. PMID: 18632940.
    Citations: 10     Fields:    Translation:Animals
  22. Lillis KP, Eng A, White JA, Mertz J. Two-photon imaging of spatially extended neuronal network dynamics with high temporal resolution. J Neurosci Methods. 2008 Jul 30; 172(2):178-84. PMID: 18539336.
    Citations: 35     Fields:    Translation:AnimalsCells
  23. Bettencourt JC, Lillis KP, Stupin LR, White JA. Effects of imperfect dynamic clamp: computational and experimental results. J Neurosci Methods. 2008 Apr 30; 169(2):282-9. PMID: 18076999.
    Citations: 34     Fields:    Translation:Animals
  24. Leray A, Lillis K, Mertz J. Enhanced background rejection in thick tissue with differential-aberration two-photon microscopy. Biophys J. 2008 Feb 15; 94(4):1449-58. PMID: 17951295.
    Citations: 8     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.