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Kyle Patrick Lillis, Ph.D.

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Marquette University, Milwaukee, WIB.S.2001Biomedical Engineering
Marquette University, Milwaukee, WIM.S.2003Biomedical Engineering
Boston University, Boston, MAPh.D.2009Bioengineering

Kyle Lillis is a bioengineer and neuroscientist studying the basic mechanisms of post-traumatic epilepsy. Epilepsy is a condition of recurrent seizures, which in about 1/3 of patients cannot be controlled by medication. As with many neurological disorders, the treatments are poorly understood and have extensive side effects. Kyle’s approach to advancing our understanding of epilepsy involves development and implementation of novel optical tools to investigate the changes that occur in the brain following injury. During his Ph.D. research at Boston University, he developed high speed laser-scanning techniques for microscopic imaging of seizure activity in rodent brain slices. His current research at MGH focuses largely on continuously imaging activity in injured brain tissue over the course of weeks as the epileptic neural circuit forms. The goal of this research is to inform development of new anti-epileptic drugs with better seizure control and fewer side effects.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS112538 (LILLIS, KYLE PATRICK) Aug 1, 2020 - Apr 30, 2025
    Mechanisms of interictal spike generation
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lillis KP. Ictal Inhibition: Sync Globally, Slack Locally. Epilepsy Curr. 2020 May-Jun; 20(3):154-156. PMID: 32550836.
  2. Jacob T, Lillis KP, Wang Z, Swiercz W, Rahmati N, Staley KJ. A Proposed Mechanism for Spontaneous Transitions between Interictal and Ictal Activity. J Neurosci. 2019 01 16; 39(3):557-575. PMID: 30446533.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Lillis KP, Staley KJ. Optogenetic dissection of ictogenesis: in search of a targeted anti-epileptic therapy. J Neural Eng. 2018 08; 15(4):041001. PMID: 29536948.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Lillis KP, Wang Z, Mail M, Zhao GQ, Berdichevsky Y, Bacskai B, Staley KJ. Evolution of Network Synchronization during Early Epileptogenesis Parallels Synaptic Circuit Alterations. J Neurosci. 2015 Jul 08; 35(27):9920-34. PMID: 26156993.
    Citations: 23     Fields:    Translation:AnimalsCells
  5. Lillis KP, Dulla C, Maheshwari A, Coulter D, Mody I, Heinemann U, Armbruster M, Žiburkus J. WONOEP appraisal: molecular and cellular imaging in epilepsy. Epilepsia. 2015 Apr; 56(4):505-13. PMID: 25779014.
    Citations: 2     Fields:    Translation:HumansAnimals
  6. Lillis KP, Kramer MA, Mertz J, Staley KJ, White JA. Pyramidal cells accumulate chloride at seizure onset. Neurobiol Dis. 2012 Sep; 47(3):358-66. PMID: 22677032.
    Citations: 42     Fields:    Translation:AnimalsCells
  7. Sabolek HR, Swiercz WB, Lillis KP, Cash SS, Huberfeld G, Zhao G, Ste Marie L, Clemenceau S, Barsh G, Miles R, Staley KJ. A candidate mechanism underlying the variance of interictal spike propagation. J Neurosci. 2012 Feb 29; 32(9):3009-21. PMID: 22378874.
    Citations: 23     Fields:    Translation:HumansAnimals
  8. Scheidt RA, Lillis KP, Emerson SJ. Visual, motor and attentional influences on proprioceptive contributions to perception of hand path rectilinearity during reaching. Exp Brain Res. 2010 Jul; 204(2):239-54. PMID: 20532489.
    Citations: 12     Fields:    Translation:Humans
  9. Keck T, Lillis KP, Zhou YD, White JA. Frequency-dependent glycinergic inhibition modulates plasticity in hippocampus. J Neurosci. 2008 Jul 16; 28(29):7359-69. PMID: 18632940.
    Citations: 8     Fields:    Translation:Animals
  10. Lillis KP, Eng A, White JA, Mertz J. Two-photon imaging of spatially extended neuronal network dynamics with high temporal resolution. J Neurosci Methods. 2008 Jul 30; 172(2):178-84. PMID: 18539336.
    Citations: 32     Fields:    Translation:AnimalsCells
  11. Bettencourt JC, Lillis KP, Stupin LR, White JA. Effects of imperfect dynamic clamp: computational and experimental results. J Neurosci Methods. 2008 Apr 30; 169(2):282-9. PMID: 18076999.
    Citations: 33     Fields:    Translation:Animals
  12. Leray A, Lillis K, Mertz J. Enhanced background rejection in thick tissue with differential-aberration two-photon microscopy. Biophys J. 2008 Feb 15; 94(4):1449-58. PMID: 17951295.
    Citations: 8     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.