Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Marcy Elizabeth MacDonald, Ph.D.

Co-Author

This page shows the publications co-authored by Marcy MacDonald and Vanessa Wheeler.
Connection Strength

3.222
  1. Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum. Hum Mol Genet. 2003 Feb 01; 12(3):273-81.
    View in: PubMed
    Score: 0.264
  2. Huntington's disease. Neuromolecular Med. 2003; 4(1-2):7-20.
    View in: PubMed
    Score: 0.262
  3. Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice. Hum Mol Genet. 2002 Mar 15; 11(6):633-40.
    View in: PubMed
    Score: 0.248
  4. Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out. Hum Mol Genet. 2020 11 04; 29(18):3044-3053.
    View in: PubMed
    Score: 0.226
  5. Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice. Hum Mol Genet. 2000 Mar 01; 9(4):503-13.
    View in: PubMed
    Score: 0.215
  6. Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse. Hum Mol Genet. 1999 Jan; 8(1):115-22.
    View in: PubMed
    Score: 0.199
  7. HttQ111/+ Huntington's Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction. J Huntingtons Dis. 2018; 7(1):17-33.
    View in: PubMed
    Score: 0.185
  8. Chromosome substitution strain assessment of a Huntington's disease modifier locus. Mamm Genome. 2015 Apr; 26(3-4):119-30.
    View in: PubMed
    Score: 0.152
  9. A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice. PLoS One. 2013; 8(11):e80923.
    View in: PubMed
    Score: 0.139
  10. Dominant effects of the Huntington's disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategy. Hum Mol Genet. 2013 Aug 15; 22(16):3227-38.
    View in: PubMed
    Score: 0.134
  11. A novel approach to investigate tissue-specific trinucleotide repeat instability. BMC Syst Biol. 2010 Mar 19; 4:29.
    View in: PubMed
    Score: 0.108
  12. Huntingtin facilitates polycomb repressive complex 2. Hum Mol Genet. 2010 Feb 15; 19(4):573-83.
    View in: PubMed
    Score: 0.106
  13. Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes. Neurobiol Dis. 2009 Jan; 33(1):37-47.
    View in: PubMed
    Score: 0.098
  14. Factors associated with HD CAG repeat instability in Huntington disease. J Med Genet. 2007 Nov; 44(11):695-701.
    View in: PubMed
    Score: 0.090
  15. Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice. Hum Mol Genet. 2006 Jun 15; 15(12):2015-24.
    View in: PubMed
    Score: 0.083
  16. Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice. Hum Mol Genet. 2003 Mar 01; 12(5):497-508.
    View in: PubMed
    Score: 0.066
  17. Genetic modifiers of Huntington disease differentially influence motor and cognitive domains. Am J Hum Genet. 2022 Mar 18.
    View in: PubMed
    Score: 0.062
  18. Huntington's Disease Pathogenesis: Two Sequential Components. J Huntingtons Dis. 2021; 10(1):35-51.
    View in: PubMed
    Score: 0.057
  19. Association Analysis of Chromosome X to Identify Genetic Modifiers of Huntington's Disease. J Huntingtons Dis. 2021; 10(3):367-375.
    View in: PubMed
    Score: 0.057
  20. Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells. Hum Mol Genet. 2000 Nov 22; 9(19):2799-809.
    View in: PubMed
    Score: 0.057
  21. Population-specific genetic modification of Huntington's disease in Venezuela. PLoS Genet. 2018 05; 14(5):e1007274.
    View in: PubMed
    Score: 0.048
  22. A modifier of Huntington's disease onset at the MLH1 locus. Hum Mol Genet. 2017 10 01; 26(19):3859-3867.
    View in: PubMed
    Score: 0.046
  23. Haplotype-based stratification of Huntington's disease. Eur J Hum Genet. 2017 11; 25(11):1202-1209.
    View in: PubMed
    Score: 0.045
  24. The Genetic Modifiers of Motor OnsetAge (GeM MOA) Website: Genome-wide Association Analysis for Genetic Modifiers of Huntington's Disease. J Huntingtons Dis. 2015; 4(3):279-84.
    View in: PubMed
    Score: 0.038
  25. HD CAGnome: a search tool for huntingtin CAG repeat length-correlated genes. PLoS One. 2014; 9(4):e95556.
    View in: PubMed
    Score: 0.036
  26. Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative. Hum Mol Genet. 2011 Nov 01; 20(21):4258-67.
    View in: PubMed
    Score: 0.030
  27. Estimating the probability of de novo HD cases from transmissions of expanded penetrant CAG alleles in the Huntington disease gene from male carriers of high normal alleles (27-35 CAG). Am J Med Genet A. 2009 Jul; 149A(7):1375-81.
    View in: PubMed
    Score: 0.026
  28. Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models. Neurobiol Dis. 2009 Sep; 35(3):319-36.
    View in: PubMed
    Score: 0.026
  29. Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study. BMC Med Genet. 2006 Aug 17; 7:71.
    View in: PubMed
    Score: 0.021
  30. Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice. Neurobiol Dis. 2006 Jul; 23(1):190-7.
    View in: PubMed
    Score: 0.021
  31. A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study. Am J Hum Genet. 2003 Sep; 73(3):682-7.
    View in: PubMed
    Score: 0.017
  32. Neocortical neurons cultured from mice with expanded CAG repeats in the huntingtin gene: unaltered vulnerability to excitotoxins and other insults. Neuroscience. 2003; 120(3):617-25.
    View in: PubMed
    Score: 0.016
  33. The HD mutation does not alter neuronal death in the striatum of Hdh(Q92) knock-in mice after mild focal ischemia. Neurobiol Dis. 2002 Oct; 11(1):147-54.
    View in: PubMed
    Score: 0.016
  34. Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice. Hum Mol Genet. 2002 Sep 15; 11(19):2233-41.
    View in: PubMed
    Score: 0.016
  35. The HD mutation causes progressive lethal neurological disease in mice expressing reduced levels of huntingtin. Hum Mol Genet. 2001 Oct 15; 10(22):2515-23.
    View in: PubMed
    Score: 0.015
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.