Harvard Catalyst Profiles

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Ruxandra F. Sirbulescu, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03NS123833 (SIRBULESCU, RUXANDRA F) Aug 1, 2021 - Jul 31, 2023
    Assessing the neuroprotective effect of B cell-therapy after intracerebral hemorrhage
    Role: Principal Investigator
  2. R01NS117598 (SIRBULESCU, RUXANDRA F) May 1, 2021 - Feb 28, 2026
    Neuroprotective B Cell Immunotherapy for Contusion Traumatic Brain Injury
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sîrbulescu RF, Chung JY, Edmiston WJ, Poznansky SA, Poznansky MC, Whalen MJ. Intraparenchymal Application of Mature B Lymphocytes Improves Structural and Functional Outcome after Contusion Traumatic Brain Injury. J Neurotrauma. 2019 09 01; 36(17):2579-2589. PMID: 30997843.
    Citations: 9     Fields:    Translation:AnimalsCells
  2. Alagpulinsa DA, Cao JJL, Driscoll RK, Sîrbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns TA, Markmann JF, Melton DA, Poznansky MC. Alginate-microencapsulation of human stem cell-derived ß cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression. Am J Transplant. 2019 07; 19(7):1930-1940. PMID: 30748094.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  3. Kimizuka Y, Katagiri W, Locascio JJ, Shigeta A, Sasaki Y, Shibata M, Morse K, Sîrbulescu RF, Miyatake M, Reeves P, Suematsu M, Gelfand J, Brauns T, Poznansky MC, Tsukada K, Kashiwagi S. Brief Exposure of Skin to Near-Infrared Laser Modulates Mast Cell Function and Augments the Immune Response. J Immunol. 2018 12 15; 201(12):3587-3603. PMID: 30420435; PMCID: PMC6289684.
    Citations: 6     Fields:    Translation:AnimalsCellsPHPublic Health
  4. Sîrbulescu RF, Boehm CK, Soon E, Wilks MQ, Ilies I, Yuan H, Maxner B, Chronos N, Kaittanis C, Normandin MD, El Fakhri G, Orgill DP, Sluder AE, Poznansky MC. Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions. Wound Repair Regen. 2017 09; 25(5):774-791. PMID: 28922523.
    Citations: 36     Fields:    Translation:AnimalsCells
  5. Sîrbulescu RF, Ilies I, Meyer A, Zupanc GKH. Additive neurogenesis supported by multiple stem cell populations mediates adult spinal cord development: A spatiotemporal statistical mapping analysis in a teleost model of indeterminate growth. Dev Neurobiol. 2017 11; 77(11):1269-1307. PMID: 28707354.
    Citations: 6     Fields:    Translation:AnimalsCells
  6. Morse K, Kimizuka Y, Chan MPK, Shibata M, Shimaoka Y, Takeuchi S, Forbes B, Nirschl C, Li B, Zeng Y, Bronson RT, Katagiri W, Shigeta A, Sîrbulescu RF, Chen H, Tan RYY, Tsukada K, Brauns T, Gelfand J, Sluder A, Locascio JJ, Poznansky MC, Anandasabapathy N, Kashiwagi S. Near-Infrared 1064 nm Laser Modulates Migratory Dendritic Cells To Augment the Immune Response to Intradermal Influenza Vaccine. J Immunol. 2017 08 15; 199(4):1319-1332. PMID: 28710250; PMCID: PMC5555148.
    Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
  7. Vitalo AG, Sîrbulescu RF, Ilies I, Zupanc GK. Absence of gliosis in a teleost model of spinal cord regeneration. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2016 06; 202(6):445-56. PMID: 27225982.
    Citations: 6     Fields:    Translation:AnimalsCells
  8. Sîrbulescu RF, Ilies I, Zupanc GK. Matrix metalloproteinase-2 and -9 in the cerebellum of teleost fish: Functional implications for adult neurogenesis. Mol Cell Neurosci. 2015 Sep; 68:9-23. PMID: 25827096.
    Citations: 8     Fields:    Translation:AnimalsCells
  9. Salisbury JP, Sîrbulescu RF, Moran BM, Auclair JR, Zupanc GK, Agar JN. The central nervous system transcriptome of the weakly electric brown ghost knifefish (Apteronotus leptorhynchus): de novo assembly, annotation, and proteomics validation. BMC Genomics. 2015 Mar 11; 16:166. PMID: 25879418.
    Citations: 5     Fields:    Translation:AnimalsCells
  10. Zupanc GK, Sîrbulescu RF. Cell replacement therapy: lessons from teleost fish. Exp Neurol. 2015 Jan; 263:272-6. PMID: 25448008.
    Citations:    Fields:    Translation:AnimalsCells
  11. Sîrbulescu RF, Ilies I, Vitalo AG, Trull K, Zhu J, Traniello IM, Zupanc GK. Adult stem cells in the knifefish cerebellum. Dev Neurobiol. 2015 Jan; 75(1):39-65. PMID: 25044932.
    Citations: 7     Fields:    Translation:AnimalsCells
  12. Sîrbulescu RF, Ilies I, Zupanc GK. Quantitative analysis reveals dominance of gliogenesis over neurogenesis in an adult brainstem oscillator. Dev Neurobiol. 2014 Sep; 74(9):934-52. PMID: 24639054.
    Citations: 7     Fields:    Translation:AnimalsCells
  13. Ilies I, Traniello IM, Sîrbulescu RF, Zupanc GK. Determination of relative age using growth increments of scales as a minimally invasive method in the tropical freshwater Apteronotus leptorhynchus. J Fish Biol. 2014 May; 84(5):1312-25. PMID: 24697593.
    Citations: 3     Fields:    Translation:Animals
  14. Zupanc GK, Ilies I, Sîrbulescu RF, Zupanc MM. Large-scale identification of proteins involved in the development of a sexually dimorphic behavior. J Neurophysiol. 2014 Apr; 111(8):1646-54. PMID: 24478160.
    Citations: 5     Fields:    Translation:Animals
  15. Traniello IM, Sîrbulescu RF, Ilies I, Zupanc GK. Age-related changes in stem cell dynamics, neurogenesis, apoptosis, and gliosis in the adult brain: a novel teleost fish model of negligible senescence. Dev Neurobiol. 2014 May; 74(5):514-30. PMID: 24293183.
    Citations: 11     Fields:    Translation:AnimalsCells
  16. Zupanc GK, Sîrbulescu RF. Teleost fish as a model system to study successful regeneration of the central nervous system. Curr Top Microbiol Immunol. 2013; 367:193-233. PMID: 23239273.
    Citations: 18     Fields:    Translation:Animals
  17. Teles MC, Sîrbulescu RF, Wellbrock UM, Oliveira RF, Zupanc GK. Adult neurogenesis in the brain of the Mozambique tilapia, Oreochromis mossambicus. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2012 Jun; 198(6):427-49. PMID: 22491885.
    Citations: 7     Fields:    Translation:AnimalsCells
  18. Zupanc GK, Sîrbulescu RF, Ilies I. Radial glia in the cerebellum of adult teleost fish: implications for the guidance of migrating new neurons. Neuroscience. 2012 May 17; 210:416-30. PMID: 22465441.
    Citations: 6     Fields:    Translation:AnimalsCells
  19. Zupanc GK, Sîrbulescu RF. Adult neurogenesis and neuronal regeneration in the central nervous system of teleost fish. Eur J Neurosci. 2011 Sep; 34(6):917-29. PMID: 21929625.
    Citations: 30     Fields:    Translation:AnimalsCells
  20. Dauth S, Sîrbulescu RF, Jordans S, Rehders M, Avena L, Oswald J, Lerchl A, Saftig P, Brix K. Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits. BMC Neurosci. 2011 Jul 27; 12:74. PMID: 21794126.
    Citations: 26     Fields:    Translation:AnimalsCells
  21. Sîrbulescu RF, Zupanc GK. Spinal cord repair in regeneration-competent vertebrates: adult teleost fish as a model system. Brain Res Rev. 2011 Jun 24; 67(1-2):73-93. PMID: 21059372.
    Citations: 13     Fields:    Translation:HumansAnimals
  22. Sîrbulescu RF, Zupanc GK. Inhibition of caspase-3-mediated apoptosis improves spinal cord repair in a regeneration-competent vertebrate system. Neuroscience. 2010 Dec 01; 171(2):599-612. PMID: 20837106.
    Citations: 12     Fields:    Translation:AnimalsCells
  23. Sîrbulescu RF, Zupanc GK. Effect of temperature on spinal cord regeneration in the weakly electric fish, Apteronotus leptorhynchus. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2010 May; 196(5):359-68. PMID: 20339850.
    Citations: 4     Fields:    Translation:Animals
  24. Sîrbulescu RF, Zupanc GK. Dynamics of caspase-3-mediated apoptosis during spinal cord regeneration in the teleost fish, Apteronotus leptorhynchus. Brain Res. 2009 Dec 22; 1304:14-25. PMID: 19782669.
    Citations: 4     Fields:    Translation:AnimalsCells
  25. Sîrbulescu RF, Ilies I, Zupanc GK. Structural and functional regeneration after spinal cord injury in the weakly electric teleost fish, Apteronotus leptorhynchus. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009 Jul; 195(7):699-714. PMID: 19430939.
    Citations: 13     Fields:    Translation:AnimalsCells
  26. Zupanc GK, Wellbrock UM, Sîrbulescu RF, Rajendran RS. Generation, long-term persistence, and neuronal differentiation of cells with nuclear aberrations in the adult zebrafish brain. Neuroscience. 2009 Apr 10; 159(4):1338-48. PMID: 19217927.
    Citations: 7     Fields:    Translation:AnimalsCells
  27. Zupanc GK, Sîrbulescu RF, Nichols A, Ilies I. Electric interactions through chirping behavior in the weakly electric fish, Apteronotus leptorhynchus. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2006 Feb; 192(2):159-73. PMID: 16247622.
    Citations: 21     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.