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Jakob Hartmann, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Martinelli S, Anderzhanova EA, Bajaj T, Wiechmann S, Dethloff F, Weckmann K, Heinz DE, Ebert T, Hartmann J, Geiger TM, Döngi M, Hafner K, Pöhlmann ML, Jollans L, Philipsen A, Schmidt SV, Schmidt U, Maccarrone G, Stein V, Hausch F, Turck CW, Schmidt MV, Gellner AK, Kuster B, Gassen NC. Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion. Nat Commun. 2021 07 30; 12(1):4643. PMID: 34330919.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  2. Hartmann J, Bajaj T, Klengel C, Chatzinakos C, Ebert T, Dedic N, McCullough KM, Lardenoije R, Joëls M, Meijer OC, McCann KE, Dudek SM, Sarabdjitsingh RA, Daskalakis NP, Klengel T, Gassen NC, Schmidt MV, Ressler KJ. Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5. Cell Rep. 2021 Jun 01; 35(9):109185. PMID: 34077736.
    Citations: 1     Fields:    
  3. Häusl AS, Brix LM, Hartmann J, Pöhlmann ML, Lopez JP, Menegaz D, Brivio E, Engelhardt C, Roeh S, Bajaj T, Rudolph L, Stoffel R, Hafner K, Goss HM, Reul JMHM, Deussing JM, Eder M, Ressler KJ, Gassen NC, Chen A, Schmidt MV. The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice. Mol Psychiatry. 2021 Jul; 26(7):3060-3076. PMID: 33649453.
    Citations: 3     Fields:    
  4. McCullough KM, Missig G, Robble MA, Foilb AR, Wells AM, Hartmann J, Anderson KJ, Neve RL, Nestler EJ, Ressler KJ, Carlezon WA. Nucleus Accumbens Medium Spiny Neuron Subtypes Differentially Regulate Stress-Associated Alterations in Sleep Architecture. Biol Psychiatry. 2021 06 15; 89(12):1138-1149. PMID: 33715826.
    Citations:    Fields:    Translation:AnimalsCells
  5. McCullough KM, Chatzinakos C, Hartmann J, Missig G, Neve RL, Fenster RJ, Carlezon WA, Daskalakis NP, Ressler KJ. Author Correction: Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning. Nat Commun. 2020 Oct 27; 11(1):5529. PMID: 33110083.
    Citations:    Fields:    
  6. McCullough KM, Chatzinakos C, Hartmann J, Missig G, Neve RL, Fenster RJ, Carlezon WA, Daskalakis NP, Ressler KJ. Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning. Nat Commun. 2020 10 14; 11(1):5180. PMID: 33057013.
    Citations: 3     Fields:    Translation:AnimalsCells
  7. Huckins LM, Chatzinakos C, Breen MS, Hartmann J, Klengel T, da Silva Almeida AC, Dobbyn A, Girdhar K, Hoffman GE, Klengel C, Logue MW, Lori A, Maihofer AX, Morrison FG, Nguyen HT, Park Y, Ruderfer D, Sloofman LG, van Rooij SJH, Baker DG, Chen CY, Cox N, Duncan LE, Geyer MA, Glatt SJ, Im HK, Risbrough VB, Smoller JW, Stein DJ, Yehuda R, Liberzon I, Koenen KC, Jovanovic T, Kellis M, Miller MW, Bacanu SA, Nievergelt CM, Buxbaum JD, Sklar P, Ressler KJ, Stahl EA, Daskalakis NP. Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Rep. 2020 06 02; 31(9):107716. PMID: 32492425.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  8. Dedic N, Kühne C, Gomes KS, Hartmann J, Ressler KJ, Schmidt MV, Deussing JM. Deletion of CRH From GABAergic Forebrain Neurons Promotes Stress Resilience and Dampens Stress-Induced Changes in Neuronal Activity. Front Neurosci. 2019; 13:986. PMID: 31619956.
    Citations: 7     
  9. van Weert LTCM, Buurstede JC, Sips HCM, Vettorazzi S, Mol IM, Hartmann J, Prekovic S, Zwart W, Schmidt MV, Roozendaal B, Tuckermann JP, Sarabdjitsingh RA, Meijer OC. Identification of mineralocorticoid receptor target genes in the mouse hippocampus. J Neuroendocrinol. 2019 08; 31(8):e12735. PMID: 31121060.
    Citations: 7     Fields:    Translation:AnimalsCells
  10. Maddox SA, Hartmann J, Ross RA, Ressler KJ. Deconstructing the Gestalt: Mechanisms of Fear, Threat, and Trauma Memory Encoding. Neuron. 2019 04 03; 102(1):60-74. PMID: 30946827.
    Citations: 19     Fields:    Translation:HumansCells
  11. Dedic N, Kühne C, Jakovcevski M, Hartmann J, Genewsky AJ, Gomes KS, Anderzhanova E, Pöhlmann ML, Chang S, Kolarz A, Vogl AM, Dine J, Metzger MW, Schmid B, Almada RC, Ressler KJ, Wotjak CT, Grinevich V, Chen A, Schmidt MV, Wurst W, Refojo D, Deussing JM. Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nat Neurosci. 2018 06; 21(6):803-807. PMID: 29786085.
    Citations: 23     Fields:    Translation:AnimalsCells
  12. McCullough KM, Morrison FG, Hartmann J, Carlezon WA, Ressler KJ. Quantified Coexpression Analysis of Central Amygdala Subpopulations. eNeuro. 2018 Jan-Feb; 5(1). PMID: 29445764.
    Citations: 32     Fields:    Translation:AnimalsCells
  13. Santarelli S, Zimmermann C, Kalideris G, Lesuis SL, Arloth J, Uribe A, Dournes C, Balsevich G, Hartmann J, Masana M, Binder EB, Spengler D, Schmidt MV. An adverse early life environment can enhance stress resilience in adulthood. Psychoneuroendocrinology. 2017 04; 78:213-221. PMID: 28219813.
    Citations: 25     Fields:    Translation:Animals
  14. Gassen NC, Fries GR, Zannas AS, Hartmann J, Zschocke J, Hafner K, Carrillo-Roa T, Steinbacher J, Preißinger SN, Hoeijmakers L, Knop M, Weber F, Kloiber S, Lucae S, Chrousos GP, Carell T, Ising M, Binder EB, Schmidt MV, Rüegg J, Rein T. Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine. Sci Signal. 2015 Nov 24; 8(404):ra119. PMID: 26602018.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  15. Hartmann J, Wagner KV, Gaali S, Kirschner A, Kozany C, Rühter G, Dedic N, Häusl AS, Hoeijmakers L, Westerholz S, Namendorf C, Gerlach T, Uhr M, Chen A, Deussing JM, Holsboer F, Hausch F, Schmidt MV. Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties. J Neurosci. 2015 Jun 17; 35(24):9007-16. PMID: 26085626.
    Citations: 26     Fields:    Translation:Animals
  16. Wagner KV, Hartmann J, Labermaier C, Häusl AS, Zhao G, Harbich D, Schmid B, Wang XD, Santarelli S, Kohl C, Gassen NC, Matosin N, Schieven M, Webhofer C, Turck CW, Lindemann L, Jaschke G, Wettstein JG, Rein T, Müller MB, Schmidt MV. Homer1/mGluR5 activity moderates vulnerability to chronic social stress. Neuropsychopharmacology. 2015 Mar 13; 40(5):1222-33. PMID: 25409593.
    Citations: 16     Fields:    Translation:Animals
  17. Gassen NC, Hartmann J, Schmidt MV, Rein T. FKBP5/FKBP51 enhances autophagy to synergize with antidepressant action. Autophagy. 2015; 11(3):578-80. PMID: 25714272.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  18. Gaali S, Kirschner A, Cuboni S, Hartmann J, Kozany C, Balsevich G, Namendorf C, Fernandez-Vizarra P, Sippel C, Zannas AS, Draenert R, Binder EB, Almeida OF, Rühter G, Uhr M, Schmidt MV, Touma C, Bracher A, Hausch F. Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat Chem Biol. 2015 Jan; 11(1):33-7. PMID: 25436518.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  19. Gassen NC, Hartmann J, Zschocke J, Stepan J, Hafner K, Zellner A, Kirmeier T, Kollmannsberger L, Wagner KV, Dedic N, Balsevich G, Deussing JM, Kloiber S, Lucae S, Holsboer F, Eder M, Uhr M, Ising M, Schmidt MV, Rein T. Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans. PLoS Med. 2014 Nov; 11(11):e1001755. PMID: 25386878.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  20. Schmidt U, Buell DR, Ionescu IA, Gassen NC, Holsboer F, Cox MB, Novak B, Huber C, Hartmann J, Schmidt MV, Touma C, Rein T, Herrmann L. A role for synapsin in FKBP51 modulation of stress responsiveness: Convergent evidence from animal and human studies. Psychoneuroendocrinology. 2015 Feb; 52:43-58. PMID: 25459892.
    Citations: 9     Fields:    Translation:HumansAnimals
  21. Masana M, Su YA, Liebl C, Wang XD, Jansen L, Westerholz S, Wagner KV, Labermaier C, Scharf SH, Santarelli S, Hartmann J, Schmidt MV, Rein T, Müller MB. The stress-inducible actin-interacting protein DRR1 shapes social behavior. Psychoneuroendocrinology. 2014 Oct; 48:98-110. PMID: 24998413.
    Citations: 8     Fields:    Translation:AnimalsCells
  22. Balsevich G, Uribe A, Wagner KV, Hartmann J, Santarelli S, Labermaier C, Schmidt MV. Interplay between diet-induced obesity and chronic stress in mice: potential role of FKBP51. J Endocrinol. 2014 Jul; 222(1):15-26. PMID: 24781256.
    Citations: 22     Fields:    Translation:Animals
  23. Labermaier C, Kohl C, Hartmann J, Devigny C, Altmann A, Weber P, Arloth J, Quast C, Wagner KV, Scharf SH, Czibere L, Widner-Andrä R, Brenndörfer J, Landgraf R, Hausch F, Jones KA, Müller MB, Uhr M, Holsboer F, Binder EB, Schmidt MV. A polymorphism in the Crhr1 gene determines stress vulnerability in male mice. Endocrinology. 2014 Jul; 155(7):2500-10. PMID: 24773341.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  24. Hoeijmakers L, Harbich D, Schmid B, Lucassen PJ, Wagner KV, Schmidt MV, Hartmann J. Depletion of FKBP51 in female mice shapes HPA axis activity. PLoS One. 2014; 9(4):e95796. PMID: 24759731.
    Citations: 11     Fields:    Translation:Animals
  25. Santarelli S, Lesuis SL, Wang XD, Wagner KV, Hartmann J, Labermaier C, Scharf SH, Müller MB, Holsboer F, Schmidt MV. Evidence supporting the match/mismatch hypothesis of psychiatric disorders. Eur Neuropsychopharmacol. 2014 Jun; 24(6):907-18. PMID: 24589292.
    Citations: 35     Fields:    Translation:Animals
  26. Wagner KV, Häusl AS, Pöhlmann ML, Hartmann J, Labermaier C, Müller MB, Schmidt MV. Hippocampal Homer1 levels influence motivational behavior in an operant conditioning task. PLoS One. 2014; 9(1):e85975. PMID: 24465821.
    Citations: 3     Fields:    Translation:Animals
  27. Albu S, Romanowski CP, Letizia Curzi M, Jakubcakova V, Flachskamm C, Gassen NC, Hartmann J, Schmidt MV, Schmidt U, Rein T, Holsboer F, Hausch F, Paez-Pereda M, Kimura M. Deficiency of FK506-binding protein (FKBP) 51 alters sleep architecture and recovery sleep responses to stress in mice. J Sleep Res. 2014 Apr; 23(2):176-85. PMID: 24354785.
    Citations: 14     Fields:    Translation:HumansAnimals
  28. Kollmannsberger LK, Gassen NC, Bultmann A, Hartmann J, Weber P, Schmidt MV, Rein T. Increased glyoxalase-1 levels in Fkbp5 knockout mice caused by glyoxalase-1 gene duplication. G3 (Bethesda). 2013 Aug 07; 3(8):1311-3. PMID: 23733890.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  29. Wang XD, Su YA, Wagner KV, Avrabos C, Scharf SH, Hartmann J, Wolf M, Liebl C, Kühne C, Wurst W, Holsboer F, Eder M, Deussing JM, Müller MB, Schmidt MV. Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss. Nat Neurosci. 2013 Jun; 16(6):706-13. PMID: 23644483.
    Citations: 48     Fields:    Translation:AnimalsCells
  30. Wagner KV, Hartmann J, Mangold K, Wang XD, Labermaier C, Liebl C, Wolf M, Gassen NC, Holsboer F, Rein T, Müller MB, Schmidt MV. Homer1 mediates acute stress-induced cognitive deficits in the dorsal hippocampus. J Neurosci. 2013 Feb 27; 33(9):3857-64. PMID: 23447597.
    Citations: 19     Fields:    Translation:AnimalsCells
  31. Wagner KV, Marinescu D, Hartmann J, Wang XD, Labermaier C, Scharf SH, Liebl C, Uhr M, Holsboer F, Müller MB, Schmidt MV. Differences in FKBP51 regulation following chronic social defeat stress correlate with individual stress sensitivity: influence of paroxetine treatment. Neuropsychopharmacology. 2012 Dec; 37(13):2797-808. PMID: 22871917.
    Citations: 26     Fields:    Translation:Animals
  32. Hartmann J, Wagner KV, Dedic N, Marinescu D, Scharf SH, Wang XD, Deussing JM, Hausch F, Rein T, Schmidt U, Holsboer F, Müller MB, Schmidt MV. Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice. Psychoneuroendocrinology. 2012 Dec; 37(12):2009-21. PMID: 22641006.
    Citations: 15     Fields:    Translation:Animals
  33. Touma C, Gassen NC, Herrmann L, Cheung-Flynn J, Büll DR, Ionescu IA, Heinzmann JM, Knapman A, Siebertz A, Depping AM, Hartmann J, Hausch F, Schmidt MV, Holsboer F, Ising M, Cox MB, Schmidt U, Rein T. FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biol Psychiatry. 2011 Nov 15; 70(10):928-36. PMID: 21907973.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  34. Hartmann J, Wagner KV, Liebl C, Scharf SH, Wang XD, Wolf M, Hausch F, Rein T, Schmidt U, Touma C, Cheung-Flynn J, Cox MB, Smith DF, Holsboer F, Müller MB, Schmidt MV. The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress. Neuropharmacology. 2012 Jan; 62(1):332-9. PMID: 21839098.
    Citations: 68     Fields:    Translation:Animals
  35. Schmidt MV, Liebl C, Sterlemann V, Ganea K, Hartmann J, Harbich D, Alam S, Müller MB. Neuropeptide Y mediates the initial hypothalamic-pituitary-adrenal response to maternal separation in the neonatal mouse. J Endocrinol. 2008 May; 197(2):421-7. PMID: 18434372.
    Citations: 10     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.