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Bofu Huang, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gunn K, Myllykoski M, Cao JZ, Ahmed M, Huang B, Rouaisnel B, Diplas BH, Levitt MM, Looper R, Doench JG, Ligon KL, Kornblum HI, McBrayer SK, Yan H, Duy C, Godley LA, Koivunen P, Losman JA. (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers. Cancer Discov. 2023 Feb 27. PMID: 36847506.
    Citations:    Fields:    
  2. Sun R, Huang B, Wei LJ. Comparing Short- and Long-Term Treatment Duration of Bevacizumab for Advanced Ovarian Cancer. J Clin Oncol. 2023 Feb 10; JCO2202596. PMID: 36763910.
    Citations:    Fields:    
  3. Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin YF, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman MA, Zacharias LG, Mathews TP, Losman JA, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdullah KG, Harris IS, Kaelin WG, McBrayer SK. De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma. Cancer Cell. 2022 09 12; 40(9):939-956.e16. PMID: 35985343; PMCID: PMC9515386.
    Citations: 5     Fields:    Translation:Animals
  4. Stransky LA, Vigeant SM, Huang B, West D, Denize T, Walton E, Signoretti S, Kaelin WG. Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway. Proc Natl Acad Sci U S A. 2022 04 05; 119(14):e2120403119. PMID: 35357972; PMCID: PMC9168943.
    Citations: 1     Fields:    Translation:HumansCells
  5. Powles T, Park SH, Voog E, Caserta C, Valderrama BP, Gurney H, Kalofonos H, Radulovic S, Demey W, Ullén A, Loriot Y, Sridhar SS, Tsuchiya N, Kopyltsov E, Sternberg CN, Bellmunt J, Aragon-Ching JB, Petrylak DP, Laliberte R, Wang J, Huang B, Davis C, Fowst C, Costa N, Blake-Haskins JA, di Pietro A, Grivas P. Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma. N Engl J Med. 2020 09 24; 383(13):1218-1230. PMID: 32945632.
    Citations: 182     Fields:    Translation:HumansCTClinical Trials
  6. Huang B, Wei LJ, Ludmir EB. Estimating Treatment Effect as the Primary Analysis in a Comparative Study: Moving Beyond P Value. J Clin Oncol. 2020 06 10; 38(17):2001-2002. PMID: 32315271.
    Citations: 5     Fields:    
  7. Motzer RJ, Penkov K, Haanen J, Rini B, Albiges L, Campbell MT, Venugopal B, Kollmannsberger C, Negrier S, Uemura M, Lee JL, Vasiliev A, Miller WH, Gurney H, Schmidinger M, Larkin J, Atkins MB, Bedke J, Alekseev B, Wang J, Mariani M, Robbins PB, Chudnovsky A, Fowst C, Hariharan S, Huang B, di Pietro A, Choueiri TK. Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma. N Engl J Med. 2019 03 21; 380(12):1103-1115. PMID: 30779531; PMCID: PMC6716603.
    Citations: 607     Fields:    Translation:HumansCTClinical Trials
  8. Sun R, Nie L, Huang B, Kim DH, Wei LJ. Quantifying Immunoscore performance. Lancet. 2018 11 03; 392(10158):1624. PMID: 30496077.
    Citations:    Fields:    Translation:HumansCells
  9. Huang B, Tian L, Talukder E, Rothenberg M, Kim DH, Wei LJ. Evaluating Treatment Effect Based on Duration of Response for a Comparative Oncology Study. JAMA Oncol. 2018 06 01; 4(6):874-876. PMID: 29710201; PMCID: PMC6584319.
    Citations: 8     Fields:    Translation:Humans
  10. Segal NH, He AR, Doi T, Levy R, Bhatia S, Pishvaian MJ, Cesari R, Chen Y, Davis CB, Huang B, Thall AD, Gopal AK. Phase I Study of Single-Agent Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Patients with Advanced Cancer. Clin Cancer Res. 2018 04 15; 24(8):1816-1823. PMID: 29549159.
    Citations: 71     Fields:    Translation:HumansCTClinical Trials
  11. Shi X, Garcia G, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF. Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome. Nat Cell Biol. 2017 Oct; 19(10):1178-1188. PMID: 28846093; PMCID: PMC5695680.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  12. Shen S, Lim G, You Z, Ding W, Huang P, Ran C, Doheny J, Caravan P, Tate S, Hu K, Kim H, McCabe M, Huang B, Xie Z, Kwon D, Chen L, Mao J. Gut microbiota is critical for the induction of chemotherapy-induced pain. Nat Neurosci. 2017 Sep; 20(9):1213-1216. PMID: 28714953; PMCID: PMC5575957.
    Citations: 68     Fields:    Translation:AnimalsCells
  13. Pessino V, Citron YR, Feng S, Huang B. Covalent Protein Labeling by SpyTag-SpyCatcher in Fixed Cells for Super-Resolution Microscopy. Chembiochem. 2017 08 04; 18(15):1492-1495. PMID: 28514494.
    Citations: 13     Fields:    Translation:HumansCells
  14. Huang B, Shang ZF, Li B, Wang Y, Liu XD, Zhang SM, Guan H, Rang WQ, Hu JA, Zhou PK. DNA-PKcs associates with PLK1 and is involved in proper chromosome segregation and cytokinesis. J Cell Biochem. 2014 Jun; 115(6):1077-88. PMID: 24166892.
    Citations: 19     Fields:    Translation:HumansCells
  15. McGorty R, Schnitzbauer J, Zhang W, Huang B. Correction of depth-dependent aberrations in 3D single-molecule localization and super-resolution microscopy. Opt Lett. 2014 Jan 15; 39(2):275-8. PMID: 24562125.
    Citations: 23     Fields:    Translation:AnimalsCells
  16. Tu WZ, Li B, Huang B, Wang Y, Liu XD, Guan H, Zhang SM, Tang Y, Rang WQ, Zhou PK. ?H2AX foci formation in the absence of DNA damage: mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway. FEBS Lett. 2013 Nov 01; 587(21):3437-43. PMID: 24021642.
    Citations: 61     Fields:    Translation:HumansCells
  17. Huang F, Wang X, Ostertag EM, Nuwal T, Huang B, Jan YN, Basbaum AI, Jan LY. TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing. Nat Neurosci. 2013 Sep; 16(9):1284-90. PMID: 23872594.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  18. Ahn JK, Huang B, Bae EK, Park EJ, Hwang JW, Lee J, Koh EM, Cha HS. The role of a-defensin-1 and related signal transduction mechanisms in the production of IL-6, IL-8 and MMPs in rheumatoid fibroblast-like synoviocytes. Rheumatology (Oxford). 2013 Aug; 52(8):1368-76. PMID: 23620556.
    Citations: 13     Fields:    Translation:HumansCells
  19. Lee J, Jeong H, Park EJ, Hwang JW, Huang B, Bae EK, Ahn JK, Cha HS, Koh EM. CIP2A facilitates apoptotic resistance of fibroblast-like synoviocytes in rheumatoid arthritis independent of c-Myc expression. Rheumatol Int. 2013 Sep; 33(9):2241-8. PMID: 23455633.
    Citations: 7     Fields:    Translation:HumansCells
  20. Ribas A, Kefford R, Marshall MA, Punt CJ, Haanen JB, Marmol M, Garbe C, Gogas H, Schachter J, Linette G, Lorigan P, Kendra KL, Maio M, Trefzer U, Smylie M, McArthur GA, Dreno B, Nathan PD, Mackiewicz J, Kirkwood JM, Gomez-Navarro J, Huang B, Pavlov D, Hauschild A. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol. 2013 Feb 10; 31(5):616-22. PMID: 23295794.
    Citations: 295     Fields:    Translation:HumansCTClinical Trials
  21. Ribas A, Chesney JA, Gordon MS, Abernethy AP, Logan TF, Lawson DH, Chmielowksi B, Glaspy JA, Lewis K, Huang B, Wang E, Hsyu PH, Gomez-Navarro J, Gerhardt D, Marshall MA, Gonzalez R. Safety profile and pharmacokinetic analyses of the anti-CTLA4 antibody tremelimumab administered as a one hour infusion. J Transl Med. 2012 Nov 21; 10:236. PMID: 23171508.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  22. Shim SH, Xia C, Zhong G, Babcock HP, Vaughan JC, Huang B, Wang X, Xu C, Bi GQ, Zhuang X. Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):13978-83. PMID: 22891300.
    Citations: 159     Fields:    Translation:Cells
  23. Zhu L, Zhang W, Elnatan D, Huang B. Faster STORM using compressed sensing. Nat Methods. 2012 Apr 22; 9(7):721-3. PMID: 22522657.
    Citations: 114     Fields:    Translation:AnimalsCells
  24. Huang B, Babcock H, Zhuang X. Breaking the diffraction barrier: super-resolution imaging of cells. Cell. 2010 Dec 23; 143(7):1047-58. PMID: 21168201.
    Citations: 355     Fields:    Translation:HumansAnimals
  25. Dani A, Huang B, Bergan J, Dulac C, Zhuang X. Superresolution imaging of chemical synapses in the brain. Neuron. 2010 Dec 09; 68(5):843-56. PMID: 21144999; PMCID: PMC3057101.
    Citations: 302     Fields:    Translation:AnimalsCells
  26. Rini BI, Stein M, Shannon P, Eddy S, Tyler A, Stephenson JJ, Catlett L, Huang B, Healey D, Gordon M. Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma. Cancer. 2011 Feb 15; 117(4):758-67. PMID: 20922784.
    Citations: 50     Fields:    Translation:HumansCTClinical Trials
  27. Wu M, Huang B, Graham M, Raimondi A, Heuser JE, Zhuang X, De Camilli P. Coupling between clathrin-dependent endocytic budding and F-BAR-dependent tubulation in a cell-free system. Nat Cell Biol. 2010 Sep; 12(9):902-8. PMID: 20729836.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  28. Dani A, Huang B. New resolving power for light microscopy: applications to neurobiology. Curr Opin Neurobiol. 2010 Oct; 20(5):648-52. PMID: 20728340.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  29. Chung KY, Gore I, Fong L, Venook A, Beck SB, Dorazio P, Criscitiello PJ, Healey DI, Huang B, Gomez-Navarro J, Saltz LB. Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer. J Clin Oncol. 2010 Jul 20; 28(21):3485-90. PMID: 20498386.
    Citations: 123     Fields:    Translation:HumansCTClinical Trials
  30. Huang B. Super-resolution optical microscopy: multiple choices. Curr Opin Chem Biol. 2010 Feb; 14(1):10-4. PMID: 19897404.
    Citations: 30     Fields:    
  31. Huang B, Bates M, Zhuang X. Super-resolution fluorescence microscopy. Annu Rev Biochem. 2009; 78:993-1016. PMID: 19489737.
    Citations: 423     Fields:    Translation:Humans
  32. Huang B, Zhao J, Lei Z, Shen S, Li D, Shen GX, Zhang GM, Feng ZH. miR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA. EMBO Rep. 2009 Feb; 10(2):180-5. PMID: 19098714; PMCID: PMC2637310.
    Citations: 136     Fields:    Translation:AnimalsCells
  33. Huang B, Jones SA, Brandenburg B, Zhuang X. Whole-cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution. Nat Methods. 2008 Dec; 5(12):1047-52. PMID: 19029906.
    Citations: 232     Fields:    Translation:Cells
  34. Bates M, Huang B, Zhuang X. Super-resolution microscopy by nanoscale localization of photo-switchable fluorescent probes. Curr Opin Chem Biol. 2008 Oct; 12(5):505-14. PMID: 18809508.
    Citations: 45     Fields:    Translation:Animals
  35. Cao Y, Zhao J, Lei Z, Shen S, Liu C, Li D, Liu J, Shen GX, Zhang GM, Feng ZH, Huang B. Local accumulation of FOXP3+ regulatory T cells: evidence for an immune evasion mechanism in patients with large condylomata acuminata. J Immunol. 2008 Jun 01; 180(11):7681-6. PMID: 18490771.
    Citations: 18     Fields:    Translation:HumansCells
  36. Huang B, Wang W, Bates M, Zhuang X. Three-dimensional super-resolution imaging by stochastic optical reconstruction microscopy. Science. 2008 Feb 08; 319(5864):810-3. PMID: 18174397; PMCID: PMC2633023.
    Citations: 829     Fields:    Translation:AnimalsCells
  37. Bates M, Huang B, Dempsey GT, Zhuang X. Multicolor super-resolution imaging with photo-switchable fluorescent probes. Science. 2007 Sep 21; 317(5845):1749-53. PMID: 17702910; PMCID: PMC2633025.
    Citations: 429     Fields:    Translation:AnimalsCells
  38. Huang B, Zhao J, Shen S, Li H, He KL, Shen GX, Mayer L, Unkeless J, Li D, Yuan Y, Zhang GM, Xiong H, Feng ZH. Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. Cancer Res. 2007 May 01; 67(9):4346-52. PMID: 17483348.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  39. Huang B, Wu H, Bhaya D, Grossman A, Granier S, Kobilka BK, Zare RN. Counting low-copy number proteins in a single cell. Science. 2007 Jan 05; 315(5808):81-4. PMID: 17204646.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.