Harvard Catalyst Profiles

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Felix Eiran John Ellett, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Boribong BP, LaSalle TJ, Bartsch YC, Ellett F, Loiselle ME, Davis JP, Gonye ALK, Sykes DB, Hajizadeh S, Kreuzer J, Pillai S, Haas W, Edlow AG, Fasano A, Alter G, Irimia D, Sade-Feldman M, Yonker LM. Neutrophil profiles of pediatric COVID-19 and multisystem inflammatory syndrome in children. Cell Rep Med. 2022 12 20; 3(12):100848. PMID: 36476388; PMCID: PMC9676175.
    Citations: 2     Fields:    Translation:HumansCells
  2. Sakuma M, Wang X, Ellett F, Edd JF, Babatunde KA, Viens A, Mansour MK, Irimia D. Microfluidic capture of chromatin fibres measures neutrophil extracellular traps (NETs) released in a drop of human blood. Lab Chip. 2022 03 01; 22(5):936-944. PMID: 35084421; PMCID: PMC8978531.
    Citations:    Fields:    Translation:HumansCells
  3. Habibabady ZA, Sendil S, Ellett F, Pollok F, Elias GF, French BM, Sun W, Braileanu G, Burdorf L, Irimia D, Pierson RN, Azimzadeh AM. Human erythrocyte fragmentation during ex-vivo pig organ perfusion. Xenotransplantation. 2022 03; 29(2):e12729. PMID: 35112383; PMCID: PMC8995366.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Ellett F, Marand AL, Irimia D. Multifactorial assessment of neutrophil chemotaxis efficiency from a drop of blood. J Leukoc Biol. 2022 06; 111(6):1175-1184. PMID: 35100458; PMCID: PMC9133106.
    Citations:    Fields:    Translation:HumansCells
  5. Boribong BP, LaSalle TJ, Bartsch YC, Ellett F, Loiselle ME, Davis JP, Gonye ALK, Hajizadeh S, Kreuzer J, Pillai S, Haas W, Edlow A, Fasano A, Alter G, Irimia D, Sade-Feldman M, Yonker LM. Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children. bioRxiv. 2021 Dec 20. PMID: 34981052; PMCID: PMC8722589.
    Citations: 1     
  6. Vermeren S, Elks PM, Ellett F. Editorial: Neutrophil Functions in Host Immunity, Inflammation and Tissue Repair. Front Immunol. 2021; 12:810346. PMID: 34917100; PMCID: PMC8669473.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Hadjitheodorou A, Bell GRR, Ellett F, Shastry S, Irimia D, Collins SR, Theriot JA. Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity. Nat Commun. 2021 11 16; 12(1):6619. PMID: 34785640.
    Citations:    Fields:    Translation:HumansCells
  8. Payne JAE, Tailhades J, Ellett F, Kostoulias X, Fulcher AJ, Fu T, Leung R, Louch S, Tran A, Weber SA, Schittenhelm RB, Lieschke GJ, Qin CH, Irima D, Peleg AY, Cryle MJ. Antibiotic-chemoattractants enhance neutrophil clearance of Staphylococcus aureus. Nat Commun. 2021 10 25; 12(1):6157. PMID: 34697316.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Hopke A, Mela A, Ellett F, Carter-House D, Peña JF, Stajich JE, Altamirano S, Lovett B, Egan M, Kale S, Kronholm I, Guerette P, Szewczyk E, McCluskey K, Breslauer D, Shah H, Coad BR, Momany M, Irimia D. Crowdsourced analysis of fungal growth and branching on microfluidic platforms. PLoS One. 2021; 16(9):e0257823. PMID: 34587206; PMCID: PMC8480888.
    Citations: 1     Fields:    Translation:Animals
  10. Sipka T, Peroceschi R, Hassan-Abdi R, Groß M, Ellett F, Begon-Pescia C, Gonzalez C, Lutfalla G, Nguyen-Chi M. Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish. Front Immunol. 2021; 12:636585. PMID: 33841419.
    Citations: 2     Fields:    Translation:AnimalsCells
  11. Muldur S, Ellett F, Marand AL, Marvil C, Branda JA, LeMieux JE, Raff AB, Strle K, Irimia D. Microfluidic Assays for Probing Neutrophil-Borrelia Interactions in Blood During Lyme Disease. Cells Tissues Organs. 2022; 211(3):313-323. PMID: 33735890; PMCID: PMC8448788.
    Citations: 1     Fields:    Translation:HumansCells
  12. Jalali F, Ellett F, Balani P, Duncan MJ, Dewhirst FE, Borisy GG, Irimia D. No man's land: Species-specific formation of exclusion zones bordering Actinomyces graevenitzii microcolonies in nanoliter cultures. Microbiologyopen. 2021 01; 10(1):e1137. PMID: 33544453; PMCID: PMC7882712.
    Citations: 1     Fields:    Translation:HumansCells
  13. Plant T, Eamsamarng S, Sanchez-Garcia MA, Reyes L, Renshaw SA, Coelho P, Mirchandani AS, Morgan JM, Ellett FE, Morrison T, Humphries D, Watts ER, Murphy F, Raffo-Iraolagoitia XL, Zhang A, Cash JL, Loynes C, Elks PM, Van Eeden F, Carlin LM, Furley AJ, Whyte MK, Walmsley SR. Semaphorin 3F signaling actively retains neutrophils at sites of inflammation. J Clin Invest. 2020 06 01; 130(6):3221-3237. PMID: 32191647; PMCID: PMC7259996.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  14. Kim JJ, Ellett F, Thomas CN, Jalali F, Anderson RR, Irimia D, Raff AB. A microscale, full-thickness, human skin on a chip assay simulating neutrophil responses to skin infection and antibiotic treatments. Lab Chip. 2019 09 10; 19(18):3094-3103. PMID: 31423506; PMCID: PMC6776466.
    Citations: 8     Fields:    Translation:HumansCells
  15. Pazhakh V, Ellett F, Croker BA, O'Donnell JA, Pase L, Schulze KE, Greulich RS, Gupta A, Reyes-Aldasoro CC, Andrianopoulos A, Lieschke GJ. ß-glucan-dependent shuttling of conidia from neutrophils to macrophages occurs during fungal infection establishment. PLoS Biol. 2019 09; 17(9):e3000113. PMID: 31483778.
    Citations: 5     Fields:    Translation:AnimalsCells
  16. Frydman GH, Ellett F, Van Cott EM, Hayden D, Majmudar M, Vanderburg CR, Dalzell H, Padmanabhan DL, Davis N, Jorgensen J, Toner M, Fox JG, Tompkins RG. A New Test for the Detection of Direct Oral Anticoagulants (Rivaroxaban and Apixaban) in the Emergency Room Setting. Crit Care Explor. 2019 Aug; 1(8):e0024. PMID: 32166266; PMCID: PMC7063952.
    Citations: 1     
  17. Tsai TY, Collins SR, Chan CK, Hadjitheodorou A, Lam PY, Lou SS, Yang HW, Jorgensen J, Ellett F, Irimia D, Davidson MW, Fischer RS, Huttenlocher A, Meyer T, Ferrell JE, Theriot JA. Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization. Dev Cell. 2019 04 22; 49(2):189-205.e6. PMID: 31014479; PMCID: PMC6708378.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  18. Jones CN, Ellett F, Robertson AL, Forrest KM, Judice K, Balkovec JM, Springer M, Markmann JF, Vyas JM, Warren HS, Irimia D. Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro. Front Immunol. 2019; 10:644. PMID: 31024528.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  19. Ellett F, Jalali F, Marand AL, Jorgensen J, Mutlu BR, Lee J, Raff AB, Irimia D. Microfluidic arenas for war games between neutrophils and microbes. Lab Chip. 2019 03 27; 19(7):1205-1216. PMID: 30865740.
    Citations: 7     Fields:    Translation:HumansCells
  20. Otawara M, Roushan M, Wang X, Ellett F, Yu YM, Irimia D. Microfluidic Assay Measures Increased Neutrophil Extracellular Traps Circulating in Blood after Burn Injuries. Sci Rep. 2018 11 19; 8(1):16983. PMID: 30451882; PMCID: PMC6242863.
    Citations: 8     Fields:    Translation:AnimalsCells
  21. Loynes CA, Lee JA, Robertson AL, Steel MJ, Ellett F, Feng Y, Levy BD, Whyte MKB, Renshaw SA. PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo. Sci Adv. 2018 09; 4(9):eaar8320. PMID: 30191175; PMCID: PMC6124908.
    Citations: 67     Fields:    Translation:AnimalsCells
  22. Muldur S, Marand AL, Ellett F, Irimia D. Measuring spontaneous neutrophil motility signatures from a drop of blood using microfluidics. Methods Cell Biol. 2018; 147:93-107. PMID: 30165965; PMCID: PMC6230268.
    Citations: 3     Fields:    Translation:HumansCells
  23. Ellett F, Pazhakh V, Pase L, Benard EL, Weerasinghe H, Azabdaftari D, Alasmari S, Andrianopoulos A, Lieschke GJ. Macrophages protect Talaromyces marneffei conidia from myeloperoxidase-dependent neutrophil fungicidal activity during infection establishment in vivo. PLoS Pathog. 2018 06; 14(6):e1007063. PMID: 29883484; PMCID: PMC6010348.
    Citations: 20     Fields:    Translation:AnimalsCells
  24. Raymond SL, Hawkins RB, Murphy TJ, Rincon JC, Stortz JA, López MC, Ungaro R, Ellett F, Baker HV, Wynn JL, Moldawer LL, Irimia D, Larson SD. Impact of toll-like receptor 4 stimulation on human neonatal neutrophil spontaneous migration, transcriptomics, and cytokine production. J Mol Med (Berl). 2018 07; 96(7):673-684. PMID: 29808244; PMCID: PMC6091213.
    Citations: 8     Fields:    Translation:HumansCells
  25. Ellett F, Jorgensen J, Marand AL, Liu YM, Martinez MM, Sein V, Butler KL, Lee J, Irimia D. Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay. Nat Biomed Eng. 2018 Apr; 2(4):207-214. PMID: 30283724.
    Citations: 29     Fields:    
  26. Boneschansker L, Jorgensen J, Ellett F, Briscoe DM, Irimia D. Convergent and Divergent Migratory Patterns of Human Neutrophils inside Microfluidic Mazes. Sci Rep. 2018 01 30; 8(1):1887. PMID: 29382882.
    Citations: 8     Fields:    Translation:HumansCells
  27. Ellett F, Irimia D. Microstructured Devices for Optimized Microinjection and Imaging of Zebrafish Larvae. J Vis Exp. 2017 12 08; (130). PMID: 29286475.
    Citations: 2     Fields:    Translation:Animals
  28. Weng L, Ellett F, Edd J, Wong KHK, Uygun K, Irimia D, Stott SL, Toner M. A highly-occupied, single-cell trapping microarray for determination of cell membrane permeability. Lab Chip. 2017 11 21; 17(23):4077-4088. PMID: 29068447.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  29. Raymond SL, Mathias BJ, Murphy TJ, Rincon JC, López MC, Ungaro R, Ellett F, Jorgensen J, Wynn JL, Baker HV, Moldawer LL, Irimia D, Larson SD. Neutrophil chemotaxis and transcriptomics in term and preterm neonates. Transl Res. 2017 12; 190:4-15. PMID: 28873345; PMCID: PMC5705589.
    Citations: 15     Fields:    Translation:HumansCells
  30. Jalali F, Ellett F, Irimia D. Rapid antibiotic sensitivity testing in microwell arrays. Technology (Singap World Sci). 2017 06; 5(2):107-114. PMID: 28781994; PMCID: PMC5542807.
    Citations: 1     
  31. Ellett F, Irimia D. Microstructured Surface Arrays for Injection of Zebrafish Larvae. Zebrafish. 2017 04; 14(2):140-145. PMID: 28151697.
    Citations: 4     Fields:    Translation:Animals
  32. Ellett F, Jorgensen J, Frydman GH, Jones CN, Irimia D. Neutrophil Interactions Stimulate Evasive Hyphal Branching by Aspergillus fumigatus. PLoS Pathog. 2017 01; 13(1):e1006154. PMID: 28076396; PMCID: PMC5261818.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  33. Chandrasekaran A, Ellett F, Jorgensen J, Irimia D. Temporal gradients limit the accumulation of neutrophils towards sources of chemoattractant. Microsyst Nanoeng. 2017; 3. PMID: 28713624; PMCID: PMC5507070.
    Citations: 7     
  34. Frydman GH, Le A, Ellett F, Jorgensen J, Fox JG, Tompkins RG, Irimia D. Technical Advance: Changes in neutrophil migration patterns upon contact with platelets in a microfluidic assay. J Leukoc Biol. 2017 03; 101(3):797-806. PMID: 27630219; PMCID: PMC5295852.
    Citations: 8     Fields:    Translation:HumansCells
  35. Bhuiyan MS, Ellett F, Murray GL, Kostoulias X, Cerqueira GM, Schulze KE, Mahamad Maifiah MH, Li J, Creek DJ, Lieschke GJ, Peleg AY. Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):9599-604. PMID: 27506797; PMCID: PMC5003227.
    Citations: 48     Fields:    Translation:AnimalsCells
  36. Irimia D, Ellett F. Big insights from small volumes: deciphering complex leukocyte behaviors using microfluidics. J Leukoc Biol. 2016 08; 100(2):291-304. PMID: 27194799; PMCID: PMC4945356.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  37. Keatinge M, Bui H, Menke A, Chen YC, Sokol AM, Bai Q, Ellett F, Da Costa M, Burke D, Gegg M, Trollope L, Payne T, McTighe A, Mortiboys H, de Jager S, Nuthall H, Kuo MS, Fleming A, Schapira AH, Renshaw SA, Highley JR, Chacinska A, Panula P, Burton EA, O'Neill MJ, Bandmann O. Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death. Hum Mol Genet. 2015 Dec 01; 24(23):6640-52. PMID: 26376862; PMCID: PMC4634372.
    Citations: 41     Fields:    Translation:AnimalsCells
  38. Ellett F, Elks PM, Robertson AL, Ogryzko NV, Renshaw SA. Defining the phenotype of neutrophils following reverse migration in zebrafish. J Leukoc Biol. 2015 Dec; 98(6):975-81. PMID: 26071567; PMCID: PMC4661044.
    Citations: 32     Fields:    Translation:AnimalsCells
  39. Palha N, Guivel-Benhassine F, Briolat V, Lutfalla G, Sourisseau M, Ellett F, Wang CH, Lieschke GJ, Herbomel P, Schwartz O, Levraud JP. Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish. PLoS Pathog. 2013; 9(9):e1003619. PMID: 24039582.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  40. Hall CJ, Boyle RH, Astin JW, Flores MV, Oehlers SH, Sanderson LE, Ellett F, Lieschke GJ, Crosier KE, Crosier PS. Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating ß-oxidation-dependent mitochondrial ROS production. Cell Metab. 2013 Aug 06; 18(2):265-78. PMID: 23931757.
    Citations: 82     Fields:    Translation:AnimalsCells
  41. Pase L, Layton JE, Wittmann C, Ellett F, Nowell CJ, Reyes-Aldasoro CC, Varma S, Rogers KL, Hall CJ, Keightley MC, Crosier PS, Grabher C, Heath JK, Renshaw SA, Lieschke GJ. Neutrophil-delivered myeloperoxidase dampens the hydrogen peroxide burst after tissue wounding in zebrafish. Curr Biol. 2012 Oct 09; 22(19):1818-24. PMID: 22940471.
    Citations: 40     Fields:    Translation:AnimalsCells
  42. Goldshmit Y, Matteo R, Sztal T, Ellett F, Frisca F, Moreno K, Crombie D, Lieschke GJ, Currie PD, Sabbadini RA, Pébay A. Blockage of lysophosphatidic acid signaling improves spinal cord injury outcomes. Am J Pathol. 2012 Sep; 181(3):978-92. PMID: 22819724; PMCID: PMC3432439.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  43. Svahn AJ, Graeber MB, Ellett F, Lieschke GJ, Rinkwitz S, Bennett MR, Becker TS. Development of ramified microglia from early macrophages in the zebrafish optic tectum. Dev Neurobiol. 2013 Jan; 73(1):60-71. PMID: 22648905.
    Citations: 52     Fields:    Translation:AnimalsCells
  44. Benard EL, van der Sar AM, Ellett F, Lieschke GJ, Spaink HP, Meijer AH. Infection of zebrafish embryos with intracellular bacterial pathogens. J Vis Exp. 2012 Mar 15; (61). PMID: 22453760.
    Citations: 88     Fields:    Translation:AnimalsCells
  45. Dworkin S, Darido C, Georgy SR, Wilanowski T, Srivastava S, Ellett F, Pase L, Han Y, Meng A, Heath JK, Lieschke GJ, Jane SM. Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways. Development. 2012 Feb; 139(3):525-36. PMID: 22223680.
    Citations: 18     Fields:    Translation:AnimalsCells
  46. Fang L, Green SR, Baek JS, Lee SH, Ellett F, Deer E, Lieschke GJ, Witztum JL, Tsimikas S, Miller YI. In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish. J Clin Invest. 2011 Dec; 121(12):4861-9. PMID: 22105168; PMCID: PMC3225997.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.