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Ivan A. Adzhubei, PH.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Cassa CA, Jordan DM, Adzhubei I, Sunyaev S. A literature review at genome scale: improving clinical variant assessment. Genet Med. 2018 09; 20(9):936-941. PMID: 29388949.
    Citations:    Fields:    Translation:Humans
  2. Savova V, Pearl EJ, Boke E, Nag A, Adzhubei I, Horb ME, Peshkin L. Transcriptomic insights into genetic diversity of protein-coding genes in X. laevis. Dev Biol. 2017 04 15; 424(2):181-188. PMID: 28283406.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Do R, Balick D, Li H, Adzhubei I, Sunyaev S, Reich D. No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans. Nat Genet. 2015 Feb; 47(2):126-31. PMID: 25581429.
    Citations: 34     Fields:    Translation:HumansAnimals
  4. Adzhubei I, Jordan DM, Sunyaev SR. Predicting functional effect of human missense mutations using PolyPhen-2. Curr Protoc Hum Genet. 2013 Jan; Chapter 7:Unit7.20. PMID: 23315928.
    Citations: 458     Fields:    Translation:HumansCells
  5. Leshchiner I, Alexa K, Kelsey P, Adzhubei I, Austin-Tse CA, Cooney JD, Anderson H, King MJ, Stottmann RW, Garnaas MK, Ha S, Drummond IA, Paw BH, North TE, Beier DR, Goessling W, Sunyaev SR. Mutation mapping and identification by whole-genome sequencing. Genome Res. 2012 Aug; 22(8):1541-8. PMID: 22555591.
    Citations: 53     Fields:    Translation:AnimalsCells
  6. Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR. A method and server for predicting damaging missense mutations. Nat Methods. 2010 Apr; 7(4):248-9. PMID: 20354512.
    Citations: 3503     Fields:    Translation:Humans
  7. Stamatoyannopoulos JA, Adzhubei I, Thurman RE, Kryukov GV, Mirkin SM, Sunyaev SR. Human mutation rate associated with DNA replication timing. Nat Genet. 2009 Apr; 41(4):393-5. PMID: 19287383.
    Citations: 138     Fields:    Translation:HumansCells
  8. Schmidt S, Gerasimova A, Kondrashov FA, Adzhubei IA, Kondrashov AS, Sunyaev S. Erratum. PLoS Genet. 2008 Dec; 4(12). PMID: 19096535.
    Citations:    Fields:    
  9. Schmidt S, Gerasimova A, Kondrashov FA, Adzhubei IA, Adzuhbei IA, Kondrashov AS, Sunyaev S. Hypermutable non-synonymous sites are under stronger negative selection. PLoS Genet. 2008 11; 4(11):e1000281. PMID: 19043566.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  10. Junqueira M, Spirin V, Balbuena TS, Thomas H, Adzhubei I, Sunyaev S, Shevchenko A. Protein identification pipeline for the homology-driven proteomics. J Proteomics. 2008 Aug 21; 71(3):346-56. PMID: 18639657.
    Citations: 14     Fields:    Translation:AnimalsCells
  11. Junqueira M, Spirin V, Santana Balbuena T, Waridel P, Surendranath V, Kryukov G, Adzhubei I, Thomas H, Sunyaev S, Shevchenko A. Separating the wheat from the chaff: unbiased filtering of background tandem mass spectra improves protein identification. J Proteome Res. 2008 Aug; 7(8):3382-95. PMID: 18558732.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  12. Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, Asthana S, Malhotra A, Adzhubei I, Greenbaum JA, Andrews RM, Flicek P, Boyle PJ, Cao H, Carter NP, Clelland GK, Davis S, Day N, Dhami P, Dillon SC, Dorschner MO, Fiegler H, Giresi PG, Goldy J, Hawrylycz M, Haydock A, Humbert R, James KD, Johnson BE, Johnson EM, Frum TT, Rosenzweig ER, Karnani N, Lee K, Lefebvre GC, Navas PA, Neri F, Parker SC, Sabo PJ, Sandstrom R, Shafer A, Vetrie D, Weaver M, Wilcox S, Yu M, Collins FS, Dekker J, Lieb JD, Tullius TD, Crawford GE, Sunyaev S, Noble WS, Dunham I, Denoeud F, Reymond A, Kapranov P, Rozowsky J, Zheng D, Castelo R, Frankish A, Harrow J, Ghosh S, Sandelin A, Hofacker IL, Baertsch R, Keefe D, Dike S, Cheng J, Hirsch HA, Sekinger EA, Lagarde J, Abril JF, Shahab A, Flamm C, Fried C, Hackermüller J, Hertel J, Lindemeyer M, Missal K, Tanzer A, Washietl S, Korbel J, Emanuelsson O, Pedersen JS, Holroyd N, Taylor R, Swarbreck D, Matthews N, Dickson MC, Thomas DJ, Weirauch MT, Gilbert J, Drenkow J, Bell I, Zhao X, Srinivasan KG, Sung WK, Ooi HS, Chiu KP, Foissac S, Alioto T, Brent M, Pachter L, Tress ML, Valencia A, Choo SW, Choo CY, Ucla C, Manzano C, Wyss C, Cheung E, Clark TG, Brown JB, Ganesh M, Patel S, Tammana H, Chrast J, Henrichsen CN, Kai C, Kawai J, Nagalakshmi U, Wu J, Lian Z, Lian J, Newburger P, Zhang X, Bickel P, Mattick JS, Carninci P, Hayashizaki Y, Weissman S, Hubbard T, Myers RM, Rogers J, Stadler PF, Lowe TM, Wei CL, Ruan Y, Struhl K, Gerstein M, Antonarakis SE, Fu Y, Green ED, Karaöz U, Siepel A, Taylor J, Liefer LA, Wetterstrand KA, Good PJ, Feingold EA, Guyer MS, Cooper GM, Asimenos G, Dewey CN, Hou M, Nikolaev S, Montoya-Burgos JI, Löytynoja A, Whelan S, Pardi F, Massingham T, Huang H, Zhang NR, Holmes I, Mullikin JC, Ureta-Vidal A, Paten B, Seringhaus M, Church D, Rosenbloom K, Kent WJ, Stone EA, Batzoglou S, Goldman N, Hardison RC, Haussler D, Miller W, Sidow A, Trinklein ND, Zhang ZD, Barrera L, Stuart R, King DC, Ameur A, Enroth S, Bieda MC, Kim J, Bhinge AA, Jiang N, Liu J, Yao F, Vega VB, Lee CW, Ng P, Shahab A, Yang A, Moqtaderi Z, Zhu Z, Xu X, Squazzo S, Oberley MJ, Inman D, Singer MA, Richmond TA, Munn KJ, Rada-Iglesias A, Wallerman O, Komorowski J, Fowler JC, Couttet P, Bruce AW, Dovey OM, Ellis PD, Langford CF, Nix DA, Euskirchen G, Hartman S, Urban AE, Kraus P, Van Calcar S, Heintzman N, Kim TH, Wang K, Qu C, Hon G, Luna R, Glass CK, Rosenfeld MG, Aldred SF, Cooper SJ, Halees A, Lin JM, Shulha HP, Zhang X, Xu M, Haidar JN, Yu Y, Ruan Y, Iyer VR, Green RD, Wadelius C, Farnham PJ, Ren B, Harte RA, Hinrichs AS, Trumbower H, Clawson H, Hillman-Jackson J, Zweig AS, Smith K, Thakkapallayil A, Barber G, Kuhn RM, Karolchik D, Armengol L, Bird CP, de Bakker PI, Kern AD, Lopez-Bigas N, Martin JD, Stranger BE, Woodroffe A, Davydov E, Dimas A, Eyras E, Hallgrímsdóttir IB, Huppert J, Zody MC, Abecasis GR, Estivill X, Bouffard GG, Guan X, Hansen NF, Idol JR, Maduro VV, Maskeri B, McDowell JC, Park M, Thomas PJ, Young AC, Blakesley RW, Muzny DM, Sodergren E, Wheeler DA, Worley KC, Jiang H, Weinstock GM, Gibbs RA, Graves T, Fulton R, Mardis ER, Wilson RK, Clamp M, Cuff J, Gnerre S, Jaffe DB, Chang JL, Lindblad-Toh K, Lander ES, Koriabine M, Nefedov M, Osoegawa K, Yoshinaga Y, Zhu B, de Jong PJ. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007 Jun 14; 447(7146):799-816. PMID: 17571346.
    Citations: 2059     Fields:    Translation:HumansCells
  13. Jordan IK, Kondrashov FA, Adzhubei IA, Wolf YI, Koonin EV, Kondrashov AS, Sunyaev S. A universal trend of amino acid gain and loss in protein evolution. Nature. 2005 Feb 10; 433(7026):633-8. PMID: 15660107.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  14. Koonin EV, Jordan IK, Kondrashov FA, Adzhubei IA, Wolf YI, Kondrashov AS, Sunyaev SR. Universal and lineage-specific trends in protein evolution evolution. 2005; 272(Suppl 1):570-593.
  15. MS-BLAST. 2004.
  16. PolyPhen. 2003.
  17. Migliavacca E, Adzhubei AA, Adzhubei IA, Guex N, Peitsch M. MDB: A new generation relational structure database implementing mmCIF approaches. 2002.
  18. Adzhubei IA, Adzhubei AA. ISSD Version 2.0: taxonomic range extended. Nucleic Acids Res. 1999 Jan 01; 27(1):268-71. PMID: 9847198.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  19. Adzhubei IA, Adzhubei AA, Neidle S. An Integrated Sequence-Structure Database incorporating matching mRNA sequence, amino acid sequence and protein three-dimensional structure data. Nucleic Acids Res. 1998 Jan 01; 26(1):327-31. PMID: 9399866.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  20. Adzhubei AA, Adzhubei IA. ISSD: A new data source for the analysis of codon sequence - protein structure correlations. 1998.
  21. Adzhubei AA, Adzhubei IA. Is there additional information in the codon sequence?. 1998.
  22. Adzhubei AA, Adzhubei IA, Neidle S. An integrated sequence-structure database of matching codon, amino acid sequences and protein three-dimensional structures: analysis and implications for protein structure prediction. 1997.
  23. Adzhubei AA, Adzhubei IA, Krasheninnikov IA, Neidle S. Preferences of synonymous codon usage relative to protein three-dimensional structure: A guideline for cotranslational protein folding. 1997; 6(Suppl 1):164.
  24. Adzhubei AA, Adzhubei IA, Neidle S. An integrated sequence-structure database of matching codon, amino acid sequences and protein three-dimensional structures: analysis and implications for protein structure prediction. 1997.
  25. Adzhubei AA, Adzhubei IA, Krasheninnikov IA, Neidle S. Non-random usage of 'degenerate' codons is related to protein three-dimensional structure. FEBS Lett. 1996 Dec 09; 399(1-2):78-82. PMID: 8980124.
    Citations: 22     Fields:    Translation:AnimalsCells
  26. Makarov AA, Adzhubei IA, Protasevich II, Lobachov VM, Fasman GD. Melting of the left-handed helical conformation of charged poly-L-lysine. Biopolymers. 1994 Aug; 34(8):1123-4. PMID: 8075392.
    Citations: 5     Fields:    Translation:Cells
  27. Makarov AA, Adzhubei IA, Protasevich II, Lobachov VM, Esipova NG. Scanning microcalorimetry and circular dichroism study of melting of the natural polypeptides in the left-handed helical conformation. J Protein Chem. 1993 Feb; 12(1):85-91. PMID: 8381285.
    Citations: 1     Fields:    Translation:AnimalsCells
  28. Makarov AA, Esipova NG, Adzhubei IA, Lobachov VM, Protasevich II. Circular dichroism melting of poly-L-proline II type conformation in natural polypeptides. 1993.
  29. Lobachev VM, Makarov AA, Adzhubei IA, Esipova NG. [Study of the conformational properties of C-terminal fragments of histones H1, H5, and beta-endorphin by circular dichroism]. Biofizika. 1992 Sep-Oct; 37(5):861-7. PMID: 1472564.
    Citations:    Fields:    Translation:AnimalsCells
  30. Makarov AA, Lobachov VM, Adzhubei IA, Esipova NG. Natural polypeptides in left-handed helical conformation. A circular dichroism study of the linker histones' C-terminal fragments and beta-endorphin. FEBS Lett. 1992 Jul 13; 306(1):63-5. PMID: 1628745.
    Citations: 6     Fields:    Translation:AnimalsCells
  31. Adzhubei, IA. Study of Structural Domains of Linker Histones H1/H5. 1992.
  32. Komar AA, Adzhubei IA, Krasheninnikov IA. Codon distribution in mRNA of yeast secretory proteins and coding of precursor processing and signal peptidase cleavage sites. 1992; 9(Special Issue).
  33. Krasheninnikov IA, Komar AA, Adzhubei IA. Nonuniform size distribution of nascent globin peptides, evidence for pause localization sites, and a contranslational protein-folding model. J Protein Chem. 1991 Oct; 10(5):445-53. PMID: 1799404.
    Citations: 10     Fields:    Translation:AnimalsCells
  34. Makarov AA, Protasevich II, Adzhubei IA, Esipova NG. [Microcalorimetric study of polypeptides in the conformation of the left helix of the poly-L-proline II type]. Biofizika. 1989 May-Jun; 34(3):521-4. PMID: 2765585.
    Citations:    Fields:    Translation:AnimalsCells
  35. Krasheninnikov IA, Komar AA, Adzhubei IA. [Role of the code redundancy in determining cotranslational protein folding]. Biokhimiia. 1989 Feb; 54(2):187-200. PMID: 2742922.
    Citations: 7     Fields:    Translation:AnimalsCells
  36. Krasheninnikov IA, Komar AA, Adzhubei IA. [Frequency of using codons in mRNA and coding of the domain structure of proteins]. Dokl Akad Nauk SSSR. 1989; 305(4):1006-12. PMID: 2752893.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  37. Krasheninnikov IA, Komar AA, Adzhubei IA. [Role of the rare codon clusters in defining the boundaries of polypeptide chain regions with identical secondary structures in the process of co-translational folding of proteins]. Dokl Akad Nauk SSSR. 1988; 303(4):995-9. PMID: 3250842.
    Citations: 3     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.