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Thiago de Jesus Borges, Ph.D.


Young Investigator Award
Honorable Mention of the Capes-Interfarma Prize for Innovation and Research
Travel Grant from the American Transplant Congress (ATC)

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 20POST35210659 (Thiago de Jesus Borges) Jan 1, 2020 - Dec 31, 2020
    AHA Postdoctoral Fellowship
    Role: PI
  2. R01AI143887 (RIELLA, LEONARDO V.) Apr 1, 2019 - Mar 31, 2023
    Role of Siglec-E in Regulating Alloimmunity
    Role: Co-Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gassen RB, Fazolo T, Nascimento de Freitas D, Borges TJ, Lima K, Antunes GL, Maito F, Bueno Mendes DA, Báfica A, Rodrigues LC, Stein R, Duarte de Souza AP, Bonorino C. IL-21 treatment recovers follicular helper T cells and neutralizing antibody production in respiratory syncytial virus infection. Immunol Cell Biol. 2021 03; 99(3):309-322. PMID: 33068449.
    Citations: 2     Fields:    Translation:Animals
  2. Eskandari SK, Sulkaj I, Melo MB, Li N, Allos H, Alhaddad JB, Kollar B, Borges TJ, Eskandari AS, Zinter MA, Cai S, Assaker JP, Choi JY, Al Dulaijan BS, Mansouri A, Haik Y, Tannous BA, van Son WJ, Leuvenink HGD, Pomahac B, Riella LV, Tang L, Seelen MAJ, Irvine DJ, Azzi JR. Regulatory T cells engineered with TCR signaling-responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter. Sci Transl Med. 2020 11 11; 12(569). PMID: 33177180.
    Citations:    Fields:    Translation:AnimalsCells
  3. Zaparte A, Cappellari AR, Brandão CA, de Souza JB, Borges TJ, Kist LW, Bogo MR, Zerbini LF, Ribeiro Pinto LF, Glaser T, Gonçalves MCB, Naaldijk Y, Ulrich H, Morrone FB. P2Y2 receptor activation promotes esophageal cancer cells proliferation via ERK1/2 pathway. Eur J Pharmacol. 2021 Jan 15; 891:173687. PMID: 33130276.
    Citations: 1     Fields:    Translation:HumansCells
  4. Cai S, Choi JY, Borges TJ, Zhang H, Miao J, Ichimura T, Li X, Xu S, Chu P, Eskandari SK, Allos H, Alhaddad JB, Muhsin SA, Yatim K, Riella LV, Sage PT, Chandraker AK, Azzi JR. Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo. Sci Rep. 2020 08 28; 10(1):14249. PMID: 32859934.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Rigo MM, Borges TJ, Lang BJ, Murshid A, Wolfgeher D, Calderwood SK, Truman AW, Bonorino C. Host expression system modulates recombinant Hsp70 activity through post-translational modifications. FEBS J. 2020 Mar 06. PMID: 32144867.
    Citations: 2     Fields:    
  6. Kollar B, Rizzo NM, Borges TJ, Haug V, Abdulrazzak O, Kauke M, Safi AF, Lian CG, Marty FM, Rutherford AE, Mitchell RN, Murphy GF, Tullius SG, Riella LV, Pomahac B. Accelerated chronic skin changes without allograft vasculopathy: A 10-year outcome report after face transplantation. Surgery. 2020 06; 167(6):991-998. PMID: 32113580.
    Citations: 1     Fields:    Translation:HumansCells
  7. Murshid A, Borges TJ, Bonorino C, Lang BJ, Calderwood SK. Immunological Outcomes Mediated Upon Binding of Heat Shock Proteins to Scavenger Receptors SCARF1 and LOX-1, and Endocytosis by Mononuclear Phagocytes. Front Immunol. 2019; 10:3035. PMID: 31998315.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  8. Kollar B, Uffing A, Borges TJ, Shubin AV, Aoyama BT, Dagot C, Haug V, Kauke M, Safi AF, Talbot SG, Morelon E, Dakpe S, Pomahac B, Riella LV. MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study. Front Immunol. 2019; 10:2771. PMID: 31849957.
    Citations: 1     Fields:    Translation:Humans
  9. Magee CN, Murakami N, Borges TJ, Shimizu T, Safa K, Ohori S, Cai S, Uffing A, Azzi J, Elyaman W, Charbonnier LM, Liu K, Toprak D, Visner G, Chatila TA, Siebel CW, Najafian N, Riella LV. Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms. Circulation. 2019 09 09; 140(10):846-863. PMID: 31266349.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  10. Pérez-Sáez MJ, Yu B, Uffing A, Murakami N, Borges TJ, Azzi J, El Haji S, Gabardi S, Riella LV. Conversion from tacrolimus to belatacept improves renal function in kidney transplant patients with chronic vascular lesions in allograft biopsy. Clin Kidney J. 2019 Aug; 12(4):586-591. PMID: 31384452.
    Citations: 1     
  11. Krezdorn N, Lian CG, Wells M, Wo L, Tasigiorgos S, Xu S, Borges TJ, Frierson RM, Stanek E, Riella LV, Pomahac B, Murphy GF. Chronic rejection of human face allografts. Am J Transplant. 2019 04; 19(4):1168-1177. PMID: 30312535.
    Citations: 7     Fields:    Translation:Humans
  12. Kollar B, Shubin A, Borges TJ, Tasigiorgos S, Win TS, Lian CG, Dillon ST, Gu X, Wyrobnik I, Murphy GF, Pomahac B, Libermann TA, Riella LV. Increased levels of circulating MMP3 correlate with severe rejection in face transplantation. Sci Rep. 2018 10 08; 8(1):14915. PMID: 30297859.
    Citations: 6     Fields:    Translation:HumansCells
  13. Borges TJ, Murakami N, Machado FD, Murshid A, Lang BJ, Lopes RL, Bellan LM, Uehara M, Antunes KH, Pérez-Saéz MJ, Birrane G, Vianna P, Gonçalves JIB, Zanin RF, Azzi J, Abdi R, Ishido S, Shin JS, Souza APD, Calderwood SK, Riella LV, Bonorino C. March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity. Nat Commun. 2018 08 28; 9(1):3482. PMID: 30154416.
    Citations: 9     Fields:    Translation:AnimalsCells
  14. Fazolo T, Gassen RB, de Freitas DN, Borges TJ, Rigo MM, da Silva RD, Maito F, Cunha A, Gasparin Bueno Mendes DA, Báfica A, Vargas JE, de Souza APD, Bonorino C. Vaccination with RSV M209-223 peptide promotes a protective immune response associated with reduced pulmonary inflammation. Antiviral Res. 2018 09; 157:102-110. PMID: 29990516.
    Citations:    Fields:    Translation:AnimalsCells
  15. Gong J, Lang BJ, Weng D, Eguchi T, Murshid A, Borges TJ, Doshi S, Song B, Stevenson MA, Calderwood SK. Genotoxic stress induces Sca-1-expressing metastatic mammary cancer cells. Mol Oncol. 2018 08; 12(8):1249-1263. PMID: 29738110.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Sula Karreci E, Eskandari SK, Dotiwala F, Routray SK, Kurdi AT, Assaker JP, Luckyanchykov P, Mihali AB, Maarouf O, Borges TJ, Alkhudhayri A, Patel KR, Radwan A, Ghobrial I, McGrath M, Chandraker A, Riella LV, Elyaman W, Abdi R, Lieberman J, Azzi J. Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. JCI Insight. 2017 11 02; 2(21). PMID: 29093262.
    Citations: 11     Fields:    Translation:HumansCells
  17. Win TS, Murakami N, Borges TJ, Chandraker A, Murphy G, Lian C, Barrera V, Ho Sui S, Schoenfeld D, Teague J, Bueno E, Tullius SG, Pomahac B, Clark RA, Riella LV. Longitudinal immunological characterization of the first presensitized recipient of a face transplant. JCI Insight. 2017 Jul 06; 2(13). PMID: 28679959.
    Citations: 2     Fields:    
  18. Paes JA, Virginio VG, Cancela M, Leal FMA, Borges TJ, Jaeger N, Bonorino C, Schrank IS, Ferreira HB. Pro-apoptotic effect of a Mycoplasma hyopneumoniae putative type I signal peptidase on PK(15) swine cells. Vet Microbiol. 2017 Mar; 201:170-176. PMID: 28284605.
    Citations: 4     Fields:    Translation:AnimalsCells
  19. Calderwood SK, Murshid A, Borges TJ. Editorial: HSPs-Ambiguous Mediators of Immunity. Front Immunol. 2016; 7:639. PMID: 28082978.
    Citations: 1     Fields:    
  20. Borges TJ, Murakami N, Riella LV. Current status of alloimmunity. Curr Opin Nephrol Hypertens. 2016 11; 25(6):556-562. PMID: 27584931.
    Citations: 1     Fields:    Translation:Humans
  21. Borges TJ, Lang BJ, Lopes RL, Bonorino C. Modulation of Alloimmunity by Heat Shock Proteins. Front Immunol. 2016; 7:303. PMID: 27555846.
    Citations: 5     Fields:    
  22. Murakami N, Borges TJ, Yamashita M, Riella LV. Erratum: Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma. Clin Kidney J. 2016 Aug; 9(4):649. PMID: 27478613.
    Citations: 1     
  23. Lopes RL, Borges TJ, Zanin RF, Bonorino C. IL-10 is required for polarization of macrophages to M2-like phenotype by mycobacterial DnaK (heat shock protein 70). Cytokine. 2016 09; 85:123-9. PMID: 27337694.
    Citations: 13     Fields:    Translation:AnimalsCells
  24. Murshid A, Borges TJ, Lang BJ, Calderwood SK. The Scavenger Receptor SREC-I Cooperates with Toll-Like Receptors to Trigger Inflammatory Innate Immune Responses. Front Immunol. 2016; 7:226. PMID: 27379091.
    Citations: 9     Fields:    
  25. Leal FMDA, Virginio VG, Martello CL, Paes JA, Borges TJ, Jaeger N, Bonorino C, Ferreira HB. Mycoplasma hyopneumoniae and Mycoplasma flocculare differential domains from orthologous surface proteins induce distinct cellular immune responses in mice. Vet Microbiol. 2016 Jul 15; 190:50-57. PMID: 27283856.
    Citations: 3     Fields:    Translation:AnimalsCells
  26. Murakami N, Borges TJ, Yamashita M, Riella LV. Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma. Clin Kidney J. 2016 Jun; 9(3):411-7. PMID: 27274826.
    Citations: 32     
  27. Borges TJ, O'Malley JT, Wo L, Murakami N, Smith B, Azzi J, Tripathi S, Lane JD, Bueno EM, Clark RA, Tullius SG, Chandraker A, Lian CG, Murphy GF, Strom TB, Pomahac B, Najafian N, Riella LV. Codominant Role of Interferon-?- and Interleukin-17-Producing T Cells During Rejection in Full Facial Transplant Recipients. Am J Transplant. 2016 07; 16(7):2158-71. PMID: 26749226.
    Citations: 11     Fields:    Translation:HumansCells
  28. Murshid A, Gong J, Prince T, Borges TJ, Calderwood SK. Scavenger receptor SREC-I mediated entry of TLR4 into lipid microdomains and triggered inflammatory cytokine release in RAW 264.7 cells upon LPS activation. PLoS One. 2015; 10(4):e0122529. PMID: 25836976.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  29. Safa K, Ohori S, Borges TJ, Uehara M, Batal I, Shimizu T, Magee CN, Belizaire R, Abdi R, Wu C, Chandraker A, Riella LV. Salt Accelerates Allograft Rejection through Serum- and Glucocorticoid-Regulated Kinase-1-Dependent Inhibition of Regulatory T Cells. J Am Soc Nephrol. 2015 Oct; 26(10):2341-7. PMID: 25833841.
    Citations: 20     Fields:    Translation:AnimalsCells
  30. Murshid A, Borges TJ, Calderwood SK. Emerging roles for scavenger receptor SREC-I in immunity. Cytokine. 2015 Oct; 75(2):256-60. PMID: 25767073.
    Citations: 10     Fields:    Translation:HumansCells
  31. Murshid A, Gong J, Ahmad R, Borges TJ, Calderwood SK. Scavenger receptor SREC-I promotes double stranded RNA-mediated TLR3 activation in human monocytes. Immunobiology. 2015 Jun; 220(6):823-32. PMID: 25641411.
    Citations: 10     Fields:    Translation:HumansCells
  32. Lopes RL, Borges TJ, Araújo JF, Pinho NG, Bergamin LS, Battastini AM, Muraro SP, Souza AP, Zanin RF, Bonorino C. Extracellular mycobacterial DnaK polarizes macrophages to the M2-like phenotype. PLoS One. 2014; 9(11):e113441. PMID: 25419575.
    Citations: 12     Fields:    Translation:AnimalsCells
  33. Borges TJ, Lopes RL, Pinho NG, Machado FD, Souza AP, Bonorino C. Extracellular Hsp70 inhibits pro-inflammatory cytokine production by IL-10 driven down-regulation of C/EBPß and C/EBPd. Int J Hyperthermia. 2013 Aug; 29(5):455-63. PMID: 23808579.
    Citations: 17     Fields:    Translation:AnimalsCells
  34. Santos AA, Rodrigues-Junior V, Zanin RF, Borges TJ, Bonorino C, Coutinho-Silva R, Takyia CM, Santos DS, Campos MM, Morrone FB. Implication of purinergic P2X7 receptor in M. tuberculosis infection and host interaction mechanisms: a mouse model study. Immunobiology. 2013 Aug; 218(8):1104-12. PMID: 23583008.
    Citations: 16     Fields:    Translation:AnimalsCells
  35. da Silva GL, Sperotto ND, Borges TJ, Bonorino C, Takyia CM, Coutinho-Silva R, Campos MM, Zanin RF, Morrone FB. P2X7 receptor is required for neutrophil accumulation in a mouse model of irritant contact dermatitis. Exp Dermatol. 2013 Mar; 22(3):184-8. PMID: 23489421.
    Citations: 10     Fields:    Translation:AnimalsCells
  36. Fallavena PR, de Jesus Borges T, Paskulin DD, Thurow HS, de Oliveira Paludo FJ, Dos Santos Froes C, Graebin P, Dias FS, de Toledo Nóbrega O, Alho CS. The synergy of -260T T CD14 and -308GG TNF-a genotypes in survival of critically ill patients. Scand J Immunol. 2013 Jan; 77(1):62-8. PMID: 23036097.
    Citations: 1     Fields:    Translation:Humans
  37. Borges TJ, Wieten L, van Herwijnen MJ, Broere F, van der Zee R, Bonorino C, van Eden W. The anti-inflammatory mechanisms of Hsp70. Front Immunol. 2012; 3:95. PMID: 22566973.
    Citations: 74     Fields:    
  38. Paskulin DD, Fallavena PR, Paludo FJ, Borges TJ, Picanço JB, Dias FS, Alho CS. TNF -308G > a promoter polymorphism (rs1800629) and outcome from critical illness. Braz J Infect Dis. 2011 May-Jun; 15(3):231-8. PMID: 21670923.
    Citations: 9     Fields:    Translation:Humans
  39. Pereira LF, de Souza AP, Borges TJ, Bonorino C. Impaired in vivo CD4+ T cell expansion and differentiation in aged mice is not solely due to T cell defects: decreased stimulation by aged dendritic cells. Mech Ageing Dev. 2011 Apr; 132(4):187-94. PMID: 21453718.
    Citations: 29     Fields:    Translation:AnimalsCells
  40. Borges TJ, Porto BN, Teixeira CA, Rodrigues M, Machado FD, Ornaghi AP, de Souza AP, Maito F, Pavanelli WR, Silva JS, Bonorino C. Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4+CD25+ regulatory T cells. PLoS One. 2010 Dec 08; 5(12):e14264. PMID: 21170379.
    Citations: 21     Fields:    Translation:AnimalsCells
  41. de Souza AP, de Jesus Borges T, Pillat MM, Bonorino C. CD4+ T cell response against a non-tumor antigen is unaffected in melanoma-bearing mice. Cancer Immunol Immunother. 2011 Jan; 60(1):145-51. PMID: 20963412.
    Citations: 1     Fields:    Translation:AnimalsCells
  42. Fallavena PR, Borges TJ, Paskulin DD, Paludo FJ, Goetze TB, de Oliveira JR, Nóbrega OT, Dias FS, Alho CS. The influences of CD14 -260C>T polymorphism on survival in ICU critically ill patients. Immunol Invest. 2009; 38(8):797-811. PMID: 19860589.
    Citations: 7     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.