Harvard Catalyst Profiles

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Thurman Wheeler, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS088202 (WHEELER, THURMAN M) Sep 1, 2014 - Jun 30, 2019
    NIH/NINDS
    Synthetic biomarkers of RNA modulation therapies
    Role: Principal Investigator
  2. K08NS064293 (WHEELER, THURMAN M) Sep 30, 2008 - Aug 31, 2014
    NIH/NINDS
    EXPERIMENTAL THERAPEUTICS IN MOUSE MODELS OF MYOTONIC DYSTROPHY
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hu N, Antoury L, Baran TM, Mitra S, Bennett CF, Rigo F, Foster TH, Wheeler TM. Non-invasive monitoring of alternative splicing outcomes to identify candidate therapies for myotonic dystrophy type 1. Nat Commun. 2018 12 07; 9(1):5227. PMID: 30531949.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Antoury L, Hu N, Balaj L, Das S, Georghiou S, Darras B, Clark T, Breakefield XO, Wheeler TM. Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of muscular dystrophies. Nat Commun. 2018 09 25; 9(1):3906. PMID: 30254196.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Jauvin D, Chrétien J, Pandey SK, Martineau L, Revillod L, Bassez G, Lachon A, MacLeod AR, Gourdon G, Wheeler TM, Thornton CA, Bennett CF, Puymirat J. Targeting DMPK with Antisense Oligonucleotide Improves Muscle Strength in Myotonic Dystrophy Type 1 Mice. Mol Ther Nucleic Acids. 2017 Jun 16; 7:465-474. PMID: 28624222.
    Citations: 3     
  4. Wheeler TM, Baker JN, Chad DA, Zilinski JL, Verzosa S, Mordes DA. Case Records of the Massachusetts General Hospital. Case 30-2015: A 50-Year-Old Man with Cardiogenic Shock. N Engl J Med. 2015 Sep 24; 373(13):1251-61. PMID: 26398074.
    Citations: 1     Fields:    Translation:Humans
  5. Pandey SK, Wheeler TM, Justice SL, Kim A, Younis HS, Gattis D, Jauvin D, Puymirat J, Swayze EE, Freier SM, Bennett CF, Thornton CA, MacLeod AR. Identification and characterization of modified antisense oligonucleotides targeting DMPK in mice and nonhuman primates for the treatment of myotonic dystrophy type 1. J Pharmacol Exp Ther. 2015 Nov; 355(2):329-40. PMID: 26330536.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  6. Nakamori M, Sobczak K, Puwanant A, Welle S, Eichinger K, Pandya S, Dekdebrun J, Heatwole CR, McDermott MP, Chen T, Cline M, Tawil R, Osborne RJ, Wheeler TM, Swanson MS, Moxley RT, Thornton CA. Splicing biomarkers of disease severity in myotonic dystrophy. Ann Neurol. 2013 Dec; 74(6):862-72. PMID: 23929620.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  7. Sobczak K, Wheeler TM, Wang W, Thornton CA. RNA interference targeting CUG repeats in a mouse model of myotonic dystrophy. Mol Ther. 2013 Feb; 21(2):380-7. PMID: 23183533.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  8. Wheeler TM, Leger AJ, Pandey SK, MacLeod AR, Nakamori M, Cheng SH, Wentworth BM, Bennett CF, Thornton CA. Targeting nuclear RNA for in vivo correction of myotonic dystrophy. Nature. 2012 Aug 02; 488(7409):111-5. PMID: 22859208.
    Citations: 154     Fields:    Translation:HumansAnimalsCells
  9. Mankodi A, Wheeler TM, Shetty R, Salceies KM, Becher MW, Thornton CA. Progressive myopathy in an inducible mouse model of oculopharyngeal muscular dystrophy. Neurobiol Dis. 2012 Jan; 45(1):539-46. PMID: 21964252.
    Citations: 4     Fields:    Translation:AnimalsCells
  10. Mulders SA, van den Broek WJ, Wheeler TM, Croes HJ, van Kuik-Romeijn P, de Kimpe SJ, Furling D, Platenburg GJ, Gourdon G, Thornton CA, Wieringa B, Wansink DG. Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):13915-20. PMID: 19667189.
    Citations: 117     Fields:    Translation:AnimalsCells
  11. Wheeler TM, Sobczak K, Lueck JD, Osborne RJ, Lin X, Dirksen RT, Thornton CA. Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA. Science. 2009 Jul 17; 325(5938):336-9. PMID: 19608921.
    Citations: 149     Fields:    Translation:HumansAnimalsCells
  12. Wheeler TM. Myotonic dystrophy: therapeutic strategies for the future. Neurotherapeutics. 2008 Oct; 5(4):592-600. PMID: 19019311.
    Citations: 13     Fields:    Translation:HumansAnimals
  13. Wheeler TM, Lueck JD, Swanson MS, Dirksen RT, Thornton CA. Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy. J Clin Invest. 2007 Dec; 117(12):3952-7. PMID: 18008009.
    Citations: 96     Fields:    Translation:AnimalsCells
  14. Wheeler TM, Thornton CA. Myotonic dystrophy: RNA-mediated muscle disease. Curr Opin Neurol. 2007 Oct; 20(5):572-6. PMID: 17885447.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  15. Kanadia RN, Shin J, Yuan Y, Beattie SG, Wheeler TM, Thornton CA, Swanson MS. Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11748-53. PMID: 16864772.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  16. Bertoni C, Jarrahian S, Wheeler TM, Li Y, Olivares EC, Calos MP, Rando TA. Enhancement of plasmid-mediated gene therapy for muscular dystrophy by directed plasmid integration. Proc Natl Acad Sci U S A. 2006 Jan 10; 103(2):419-24. PMID: 16387861.
    Citations: 34     Fields:    Translation:Animals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.