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Daniel Dale Kenneth Lingwood, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI137057 (LINGWOOD, DANIEL) Jun 1, 2018 - May 31, 2023
    NIH/NIAID
    Innate-like BCR activity as a template for universal vaccination against influenza virus
    Role: Principal Investigator
  2. R01AI124378 (LINGWOOD, DANIEL) Feb 17, 2017 - Jan 31, 2021
    NIH/NIAID
    CDRH3-independent B cell stimulation to selectively expand VRC01 lineages from a fully humanized immunoglobulin repertoire
    Role: Principal Investigator
  3. DP2DA042422 (LINGWOOD, DANIEL) Jun 1, 2016 - May 31, 2021
    NIH/NIDA
    Defining and Exploiting a Genetic Template for an HIV Vaccine
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Keating CL, Kuhn E, Bals J, Cocco AR, Yousif AS, Matysiak C, Sangesland M, Ronsard L, Smoot M, Moreno TB, Okonkwo V, Setliff I, Georgiev I, Balazs AB, Carr SA, Lingwood D. Spontaneous Glycan Reattachment Following N-Glycanase Treatment of Influenza and HIV Vaccine Antigens. J Proteome Res. 2020 Feb 07; 19(2):733-743. PMID: 31913636.
    Citations:    
  2. Li B, Clohisey SM, Chia BS, Wang B, Cui A, Eisenhaure T, Schweitzer LD, Hoover P, Parkinson NJ, Nachshon A, Smith N, Regan T, Farr D, Gutmann MU, Bukhari SI, Law A, Sangesland M, Gat-Viks I, Digard P, Vasudevan S, Lingwood D, Dockrell DH, Doench JG, Baillie JK, Hacohen N. Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection. Nat Commun. 2020 01 09; 11(1):164. PMID: 31919360.
    Citations:    
  3. Setliff I, Shiakolas AR, Pilewski KA, Murji AA, Mapengo RE, Janowska K, Richardson S, Oosthuysen C, Raju N, Ronsard L, Kanekiyo M, Qin JS, Kramer KJ, Greenplate AR, McDonnell WJ, Graham BS, Connors M, Lingwood D, Acharya P, Morris L, Georgiev IS. High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity. Cell. 2019 Dec 12; 179(7):1636-1646.e15. PMID: 31787378.
    Citations:    
  4. Sangesland M, Ronsard L, Kazer SW, Bals J, Boyoglu-Barnum S, Yousif AS, Barnes R, Feldman J, Quirindongo-Crespo M, McTamney PM, Rohrer D, Lonberg N, Chackerian B, Graham BS, Kanekiyo M, Shalek AK, Lingwood D. Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus. Immunity. 2019 10 15; 51(4):735-749.e8. PMID: 31563464.
    Citations:    
  5. Tokatlian T, Read BJ, Jones CA, Kulp DW, Menis S, Chang JYH, Steichen JM, Kumari S, Allen JD, Dane EL, Liguori A, Sangesland M, Lingwood D, Crispin M, Schief WR, Irvine DJ. Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers. Science. 2019 02 08; 363(6427):649-654. PMID: 30573546.
    Citations:    Fields:    
  6. Nandin IS, Fong C, Deantonio C, Torreno-Pina JA, Pecetta S, Maldonado P, Gasparrini F, Ordovas-Montanes J, Kazer SW, Kjaer S, Borley DW, Nair U, Coleman JA, Lingwood D, Shalek AK, Meffre E, Poignard P, Burton DR, Batista FD. Correction: Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies. J Exp Med. 2017 09 04; 214(9):2811. PMID: 28827449.
    Citations: 2     Fields:    
  7. Sanjuan Nandin I, Fong C, Deantonio C, Torreno-Pina JA, Pecetta S, Maldonado P, Gasparrini F, Ordovas-Montanes J, Kazer SW, Kjaer S, Borley DW, Nair U, Coleman JA, Lingwood D, Shalek AK, Meffre E, Poignard P, Burton DR, Batista FD. Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies. J Exp Med. 2017 Aug 07; 214(8):2471-2490. PMID: 28739603.
    Citations: 2     Fields:    
  8. Villar RF, Patel J, Weaver GC, Kanekiyo M, Wheatley AK, Yassine HM, Costello CE, Chandler KB, McTamney PM, Nabel GJ, McDermott AB, Mascola JR, Carr SA, Lingwood D. Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation. Sci Rep. 2016 10 31; 6:36298. PMID: 27796362.
    Citations: 1     Fields:    Translation:HumansCells
  9. Weaver GC, Villar RF, Kanekiyo M, Nabel GJ, Mascola JR, Lingwood D. In vitro reconstitution of B cell receptor-antigen interactions to evaluate potential vaccine candidates. Nat Protoc. 2016 Feb; 11(2):193-213. PMID: 26741406.
    Citations: 1     Fields:    Translation:HumansCells
  10. Yassine HM, Boyington JC, McTamney PM, Wei CJ, Kanekiyo M, Kong WP, Gallagher JR, Wang L, Zhang Y, Joyce MG, Lingwood D, Moin SM, Andersen H, Okuno Y, Rao SS, Harris AK, Kwong PD, Mascola JR, Nabel GJ, Graham BS. Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection. Nat Med. 2015 Sep; 21(9):1065-70. PMID: 26301691.
    Citations: 84     Fields:    Translation:AnimalsCellsPHPublic Health
  11. Wheatley AK, Whittle JR, Lingwood D, Kanekiyo M, Yassine HM, Ma SS, Narpala SR, Prabhakaran MS, Matus-Nicodemos RA, Bailer RT, Nabel GJ, Graham BS, Ledgerwood JE, Koup RA, McDermott AB. H5N1 Vaccine-Elicited Memory B Cells Are Genetically Constrained by the IGHV Locus in the Recognition of a Neutralizing Epitope in the Hemagglutinin Stem. J Immunol. 2015 Jul 15; 195(2):602-10. PMID: 26078272.
    Citations: 12     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  12. Zhou T, Lynch RM, Chen L, Acharya P, Wu X, Doria-Rose NA, Joyce MG, Lingwood D, Soto C, Bailer RT, Ernandes MJ, Kong R, Longo NS, Louder MK, McKee K, O'Dell S, Schmidt SD, Tran L, Yang Z, Druz A, Luongo TS, Moquin S, Srivatsan S, Yang Y, Zhang B, Zheng A, Pancera M, Kirys T, Georgiev IS, Gindin T, Peng HP, Yang AS, Mullikin JC, Gray MD, Stamatatos L, Burton DR, Koff WC, Cohen MS, Haynes BF, Casazza JP, Connors M, Corti D, Lanzavecchia A, Sattentau QJ, Weiss RA, West AP, Bjorkman PJ, Scheid JF, Nussenzweig MC, Shapiro L, Mascola JR, Kwong PD. Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell. 2015 Jun 04; 161(6):1280-92. PMID: 26004070.
    Citations: 67     Fields:    Translation:HumansCells
  13. Lingwood D. Lipocalin 2 as a membrane-reorganizing agent. Sci Signal. 2014 Aug 12; 7(338):pe19. PMID: 25118326.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Whittle JR, Wheatley AK, Wu L, Lingwood D, Kanekiyo M, Ma SS, Narpala SR, Yassine HM, Frank GM, Yewdell JW, Ledgerwood JE, Wei CJ, McDermott AB, Graham BS, Koup RA, Nabel GJ. Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages. J Virol. 2014 Apr; 88(8):4047-57. PMID: 24501410.
    Citations: 36     Fields:    Translation:HumansCells
  15. Lingwood D, McTamney PM, Yassine HM, Whittle JR, Guo X, Boyington JC, Wei CJ, Nabel GJ. Structural and genetic basis for development of broadly neutralizing influenza antibodies. Nature. 2012 Sep 27; 489(7417):566-70. PMID: 22932267.
    Citations: 72     Fields:    Translation:HumansCells
  16. Kaiser HJ, Surma MA, Mayer F, Levental I, Grzybek M, Klemm RW, Da Cruz S, Meisinger C, Müller V, Simons K, Lingwood D. Molecular convergence of bacterial and eukaryotic surface order. J Biol Chem. 2011 Nov 25; 286(47):40631-7. PMID: 21965671.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  17. Kaiser HJ, Orlowski A, Róg T, Nyholm TK, Chai W, Feizi T, Lingwood D, Vattulainen I, Simons K. Lateral sorting in model membranes by cholesterol-mediated hydrophobic matching. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16628-33. PMID: 21930944.
    Citations: 27     Fields:    Translation:Cells
  18. Lingwood D, Binnington B, Róg T, Vattulainen I, Grzybek M, Coskun U, Lingwood CA, Simons K. Cholesterol modulates glycolipid conformation and receptor activity. Nat Chem Biol. 2011 May; 7(5):260-2. PMID: 21460830.
    Citations: 54     Fields:    Translation:HumansCells
  19. Levental I, Lingwood D, Grzybek M, Coskun U, Simons K. Palmitoylation regulates raft affinity for the majority of integral raft proteins. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22050-4. PMID: 21131568.
    Citations: 106     Fields:    Translation:AnimalsCells
  20. Lingwood D, Simons K. Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 01; 327(5961):46-50. PMID: 20044567.
    Citations: 949     Fields:    Translation:HumansAnimalsCells
  21. Lingwood D, Schuck S, Ferguson C, Gerl M, Simons K. Morphological homeostasis by autophagy. Autophagy. 2009 Oct; 5(7):1039-40. PMID: 19587538.
    Citations: 2     Fields:    Translation:Cells
  22. Lingwood D, Kaiser HJ, Levental I, Simons K. Lipid rafts as functional heterogeneity in cell membranes. Biochem Soc Trans. 2009 Oct; 37(Pt 5):955-60. PMID: 19754431.
    Citations: 61     Fields:    Translation:Cells
  23. Kaiser HJ, Lingwood D, Levental I, Sampaio JL, Kalvodova L, Rajendran L, Simons K. Order of lipid phases in model and plasma membranes. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16645-50. PMID: 19805351.
    Citations: 112     Fields:    Translation:Cells
  24. Lingwood D, Schuck S, Ferguson C, Gerl MJ, Simons K. Generation of cubic membranes by controlled homotypic interaction of membrane proteins in the endoplasmic reticulum. J Biol Chem. 2009 May 01; 284(18):12041-8. PMID: 19258319.
    Citations: 18     Fields:    Translation:HumansCells
  25. Lingwood D, Ries J, Schwille P, Simons K. Plasma membranes are poised for activation of raft phase coalescence at physiological temperature. Proc Natl Acad Sci U S A. 2008 Jul 22; 105(29):10005-10. PMID: 18621689.
    Citations: 110     Fields:    Translation:HumansAnimalsCells
  26. Lingwood D, Simons K. Detergent resistance as a tool in membrane research. Nat Protoc. 2007; 2(9):2159-65. PMID: 17853872.
    Citations: 90     Fields:    Translation:AnimalsCells
  27. Lingwood D, Harauz G, Ballantyne JS. Decoupling the Na+-K+-ATPase in vivo: a possible new role in the gills of freshwater fishes. Comp Biochem Physiol A Mol Integr Physiol. 2006 Aug; 144(4):451-7. PMID: 16730202.
    Citations: 1     Fields:    Translation:AnimalsCells
  28. Lingwood D, Ballantyne JS. Alkaline phosphatase-immunoglobulin conjugate binds to lipids in vitro, independent of antibody selectivity. J Immunol Methods. 2006 Apr 20; 311(1-2):174-7. PMID: 16524587.
    Citations: 1     Fields:    
  29. Lingwood D, Harauz G, Ballantyne JS. Regulation of fish gill Na(+)-K(+)-ATPase by selective sulfatide-enriched raft partitioning during seawater adaptation. J Biol Chem. 2005 Nov 04; 280(44):36545-50. PMID: 16096276.
    Citations: 6     Fields:    Translation:Animals
  30. Lingwood D, Fisher LJ, Callahan JW, Ballantyne JS. Sulfatide and Na+-K+-ATPase: a salinity-sensitive relationship in the gill basolateral membrane of rainbow trout. J Membr Biol. 2004 Sep 15; 201(2):77-84. PMID: 15630545.
    Citations: 1     Fields:    Translation:Animals
  31. Binnington B, Lingwood D, Nutikka A, Lingwood CA. Effect of globotriaosyl ceramide fatty acid alpha-hydroxylation on the binding by verotoxin 1 and verotoxin 2. Neurochem Res. 2002 Aug; 27(7-8):807-13. PMID: 12374217.
    Citations: 15     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.