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Christine Nai-Mei Sang, M.D.

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Department
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Biography
education and training
Johns Hopkins University, Baltimore, MDMD05/1989Medicine
Harvard University, Boston, MAMPH05/1994Quantitative Methods (epidemiology/biostatistics)
Harvard Business School (Executive Education)-Brigham and Women's Hospital, Cambridge, MA2008Program in Leadership
Neurobiology and Anesthesiology Branch, National Institute of Dental Research, NIH, Bethesda, MD1997Neurobiology of pain
Children's Hospital/Massachusetts General Hospital, Harvard Medical School, Boston, MA1994Anesthesia; 1993-1994 Research Fellow (T32 Institutional NRSA, NIH)
Children's Hospital, Harvard Medical School, Boston, MA1993Clinical Fellow in Anaesthesia
Johns Hopkins University School of Medicine, Baltimore, MD1992Resident/Clinical Fellow in Anesthesiology
Children's Hospital of Philadelphia, Philadelphia, PA1990Intern in Pediatrics

Mentoring
completed student projects
A Phase II Trial of Brief Intravenous Infusion of the iGluR5 Receptor Antagonist LY293558 to Examine Analgesic Efficacy in Lumbar Monoradiculopathy PASTEUR
Summer, 06/01/00 - 09/01/01
Spinal Cord Injury:AMPA/Kainate Receptor Antagonist LY293558 in Central Neuropathic Pain PASTEUR
Summer, 06/15/01 - 08/31/01
Glutamate Receptor Antagonists in Central Neuropathic Pain Following Spinal Cord Injury PASTEUR
Part Time, 01/28/02 - 06/15/02
Cerebrospinal fluid uptake of dextromethorphan and dextrorphan in chronic spinal cord injury PASTEUR
Part Time/Continuation, 01/01/08 - 05/31/11
A Phase II Trial of Selective Glutamate Antagonists in Lumbar Monoradiculopathy and spinal cord injury PASTEUR
Summer, 06/26/00 - 08/18/00

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01NS041503 (SANG, CHRISTINE NAI-MEI) Apr 1, 2003 - Mar 31, 2009
    NIH
    Neuropharmacology of Pain in Spinal Cord Injury
    Role: Principal Investigator
  2. M01RR002635 (GOTTLIEB, GARY L) Dec 1, 1984 - Mar 31, 2010
    NIH
    General Clinical Research Center
    Role: Co-Principal Investigator
  3. M01RR001066 (SLAVIN, PETER L) Feb 1, 1978 - May 31, 2008
    NIH
    General Clinical Research Center
    Role: Co-Principal Investigator
  4. Available upon request

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zackowski KM, Freeman J, Brichetto G, Centonze D, Dalgas U, DeLuca J, Ehde D, Elgott S, Fanning V, Feys P, Finlayson M, Gold SM, Inglese M, Marrie RA, Ploughman M, Sang CN, Sastre-Garriga J, Sincock C, Strum J, van Beek J, Feinstein A. Prioritizing progressive MS rehabilitation research: A call from the International Progressive MS Alliance. Mult Scler. 2021 06; 27(7):989-1001. PMID: 33720795.
    Citations: 4     Fields:    Translation:Humans
  2. Kessler JA, Shaibani A, Sang CN, Christiansen M, Kudrow D, Vinik A, Shin N. Gene therapy for diabetic peripheral neuropathy: A randomized, placebo-controlled phase III study of VM202, a plasmid DNA encoding human hepatocyte growth factor. Clin Transl Sci. 2021 05; 14(3):1176-1184. PMID: 33465273.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  3. Sang CN, Schmidt WK. Aligning New Approaches to Accelerate the Development of Non-opioid Analgesic Therapies. Neurotherapeutics. 2020 07; 17(3):765-769. PMID: 33058022; PMCID: PMC7609808.
    Citations: 1     Fields:    Translation:Humans
  4. Davis KD, Aghaeepour N, Ahn AH, Angst MS, Borsook D, Brenton A, Burczynski ME, Crean C, Edwards R, Gaudilliere B, Hergenroeder GW, Iadarola MJ, Iyengar S, Jiang Y, Kong JT, Mackey S, Saab CY, Sang CN, Scholz J, Segerdahl M, Tracey I, Veasley C, Wang J, Wager TD, Wasan AD, Pelleymounter MA. Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities. Nat Rev Neurol. 2020 07; 16(7):381-400. PMID: 32541893; PMCID: PMC7326705.
    Citations: 76     Fields:    Translation:HumansPHPublic Health
  5. Huang L, Sang CN, Desai MS. A Chronology for the Identification and Disclosure of Adverse Effects of Succinylcholine. J Anesth Hist. 2019 07; 5(3):65-84. PMID: 31570201.
    Citations: 2     Fields:    Translation:HumansAnimals
  6. Zaccagnino MP, Bader AM, Sang CN, Correll DJ. The Perioperative Surgical Home: A New Role for the Acute Pain Service. Anesth Analg. 2017 Oct; 125(4):1394-1402. PMID: 28795967.
    Citations: 5     Fields:    Translation:Humans
  7. Huang L, Sang CN, Desai MS. Beyond Ether and Chloroform-A Major Breakthrough With Halothane. J Anesth Hist. 2017 Jul; 3(3):87-102. PMID: 28842156.
    Citations: 2     Fields:    
  8. Coppes OJM, Sang CN. Indications for Opioid Antagonists. Curr Pain Headache Rep. 2017 Jun; 21(6):30. PMID: 28547246.
    Citations: 1     Fields:    Translation:Humans
  9. Gessner DM, Sang CN. Revisiting Mechanisms of Extraterritorial Allodynia. Curr Pain Headache Rep. 2017 05; 21(5):25. PMID: 28421380.
    Citations:    Fields:    Translation:Humans
  10. Sang CN, Sundararaman L. Chronic Pain Following Concussion. Curr Pain Headache Rep. 2017 Jan; 21(1):1. PMID: 28050686.
    Citations: 2     Fields:    Translation:Humans
  11. Sang CN, Barnabe KJ, Kern SE. Phase IA Clinical Trial Evaluating the Tolerability, Pharmacokinetics, and Analgesic Efficacy of an Intrathecally Administered Neurotensin A Analogue in Central Neuropathic Pain Following Spinal Cord Injury. Clin Pharmacol Drug Dev. 2016 Jul; 5(4):250-8. PMID: 27310326.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  12. Sang CN, Sathyanarayana R, Sweeney M. Gastroretentive gabapentin (G-GR) formulation reduces intensity of pain associated with postherpetic neuralgia (PHN). Clin J Pain. 2013 Apr; 29(4):281-8. PMID: 22801243.
    Citations: 20     Fields:    Translation:HumansCTClinical Trials
  13. Chizh BA, Sang CN. Use of sensory methods for detecting target engagement in clinical trials of new analgesics. Neurotherapeutics. 2009 Oct; 6(4):749-54. PMID: 19789077.
    Citations: 4     Fields:    Translation:HumansAnimals
  14. Sang CN, Bennett GJ. Novel therapies for the control and prevention of neuropathic pain. Neurotherapeutics. 2009 Oct; 6(4):607-8. PMID: 19789065.
    Citations: 4     Fields:    Translation:HumansAnimals
  15. Kajdasz DK, Iyengar S, Desaiah D, Backonja MM, Farrar JT, Fishbain DA, Jensen TS, Rowbotham MC, Sang CN, Ziegler D, McQuay HJ. Duloxetine for the management of diabetic peripheral neuropathic pain: evidence-based findings from post hoc analysis of three multicenter, randomized, double-blind, placebo-controlled, parallel-group studies. Clin Ther. 2007; 29 Suppl:2536-46. PMID: 18164920.
    Citations: 30     Fields:    Translation:Humans
  16. Campen RB, Sang CN, Duncan LM. Case records of the Massachusetts General Hospital. Case 25-2006. A 41-year-old woman with painful subcutaneous nodules. N Engl J Med. 2006 Aug 17; 355(7):714-22. PMID: 16914708.
    Citations: 8     Fields:    Translation:Humans
  17. Emerging Strategies for the Treatment of Neuropathic Pain, J Campbell, A Basbaum, R. Dubner, R. Dworkin, CN Sang, eds. 2006.
  18. Black DR, Sang CN. Advances and limitations in the evaluation of analgesic combination therapy. Neurology. 2005 Dec 29; 65(12 Suppl 4):S3-6. PMID: 16385102.
    Citations: 5     Fields:    Translation:Humans
  19. MacCollin M, Chiocca EA, Evans DG, Friedman JM, Horvitz R, Jaramillo D, Lev M, Mautner VF, Niimura M, Plotkin SR, Sang CN, Stemmer-Rachamimov A, Roach ES. Diagnostic criteria for schwannomatosis. Neurology. 2005 Jun 14; 64(11):1838-45. PMID: 15955931.
    Citations: 93     Fields:    Translation:Humans
  20. Sang CN and Hayes K. . Anticonvulsants in Neuropathic Pain. Wall and Melzack's Textbook of Pain. 2005.
  21. McCarberg W, Aronoff G, Freeman R, Sang CN. Managing Neuropathic Pain. A Continuing Medical Education Initiative. 2005.
  22. Jenkins KR, Wang KT, Sarin A, Coccoli S, Sang CN. . Fosphenytoin relieves central neuropathic pain following spinal cord injury. Christopher Reeve Foundation Annual Meeting. 2005.
  23. Sang, CN, Argoff C, Backonja M, Fishbain D. . Emerging Therapies in the Treatment of Neuropathic Pain,. 2005.
  24. Sang CN, Ramadan NM, Wallihan RG, Chappell AS, Freitag FG, Smith TR, Silberstein SD, Johnson KW, Phebus LA, Bleakman D, Ornstein PL, Arnold B, Tepper SJ, Vandenhende F. LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine. Cephalalgia. 2004 Jul; 24(7):596-602. PMID: 15196302.
    Citations: 52     Fields:    Translation:HumansCTClinical Trials
  25. Stojanovic MP, Sang CN, Cohen SP. Epidural steroid injections. Anesth Analg. 2003 Mar; 96(3):908. PMID: 12598284.
    Citations:    Fields:    Translation:Humans
  26. Sang CN, Max MB, Gracely RH. Stability and reliability of detection thresholds for human A-Beta and A-delta sensory afferents determined by cutaneous electrical stimulation. J Pain Symptom Manage. 2003 Jan; 25(1):64-73. PMID: 12565190.
    Citations: 13     Fields:    Translation:HumansCells
  27. Sang CN. Pitfalls with trials of novel analgesics. Pain: Current Understanding, Emerging Therapies, and Novel Approaches to Drug Discovery, Bountra C, Munglani R, and Schmidt WK, eds. 2003.
  28. Sang CN, Weaver JJ, Jinga L, Wouden J, Saltarelli MD. The NR2B subunit-selective NMDA receptor antagonist, CP-101,606 reduces pain intensity in patients with central and peripheral neuropathic pain. Society for Neuroscience. 2003.
  29. Santiago-Palma J, Sang CN. Glutamate receptor antagonists in pain. Drugs for Pain, Smith H, ed. 2003.
  30. Gordon SM, Brahim JS, Dubner R, McCullagh LM, Sang C, Dionne RA. Attenuation of pain in a randomized trial by suppression of peripheral nociceptive activity in the immediate postoperative period. Anesth Analg. 2002 Nov; 95(5):1351-7, table of contents. PMID: 12401625.
    Citations: 8     Fields:    Translation:HumansCellsCTClinical Trials
  31. Cluff R, Mehio AK, Cohen SP, Chang Y, Sang CN, Stojanovic MP. The technical aspects of epidural steroid injections: a national survey. Anesth Analg. 2002 Aug; 95(2):403-8, table of contents. PMID: 12145061.
    Citations: 21     Fields:    Translation:Humans
  32. Sang CN, Booher S, Gilron I, Parada S, Max MB. Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials. Anesthesiology. 2002 May; 96(5):1053-61. PMID: 11981142.
    Citations: 47     Fields:    Translation:HumansCTClinical Trials
  33. Stojanovic MP, Vu TN, Caneris O, Slezak J, Cohen SP, Sang CN. The role of fluoroscopy in cervical epidural steroid injections: an analysis of contrast dispersal patterns. Spine (Phila Pa 1976). 2002 Mar 01; 27(5):509-14. PMID: 11880836.
    Citations: 25     Fields:    Translation:HumansCells
  34. Jenkins KR, Kaplan, SE, Leahy L, Sang CN. . Oxcarbazepine in central neuropathic pain with allodynia following spinal cord injury. American Pain Society Abstracts. 2002.
  35. Smith HS, Sang CN. The evolving nature of neuropathic pain: individualizing treatment. Eu J Pain. 2002; 6(Supp1B):13-18.
  36. Sang CN. xcitatory amino acid antagonists in clinical pain. NMDA Antagonists as Potential Analgesic Drugs, Hill RG and Sirinathsinghji DJS. Eds. 2002.
  37. Smith HS, Sang CN. The evolving nature of neuropathic pain: individualizing treatment. Eur J Pain. 2002; 6 Suppl B:13-8. PMID: 23570143.
    Citations: 3     Fields:    Translation:Humans
  38. Gordon SM, Brahim JS, Dubner R, McCullagh LK Sang CN, Dionne RA. Attenuation of hyperalgesia in a randomized trial by suppression of pain in the immediate postoperative period. Anesth Analg. 2002; 95(5):1351-7.
  39. Iyengar S, Simmons R, Webster A, Sang CN, Ramadan W. LY293558, and AMPA/GluR5 glutarnate receptor antagonist, is effective in animal and human models of neuropathic pain. Xth World Congress of the International Association for the Study of Pain. 2002.
  40. Sang CN. Glutamate receptor antagonists in central neuropathic pain following spinal cord injury. Research Advances in Spinal Cord Injury Pain, Burchiel K and Yezierski R, eds. In: Spinal Cord Injury Pain: Assessment, Mechanisms, Management. Progress in Pain Research and Management, RP Yezierski, KJ Burchiel (eds). 2002; 23.
  41. 11. Sang CN, Dobosh, L, Miller V, Brown, R. . Combination therapy for refractory pain following spinal cord injury using the low affinity N-methyl-D-aspartate (NMDA) receptor antagonist dextromethorphan and gabapentin. American Pain Society Annual Meeting. 2001.
  42. Finnerup NB, Yezierski RP, Sang CN, Burchiel K, Jensen TS. Treatment of spinal cord injury pain clinical updates. IASP. 2001; IX(2).
  43. Gilron I, Max MB, Lee G, Booher SL, Sang CN, Chappell AS, Dionne RA. Effects of the 2-amino-3-hydroxy-5-methyl-4-isoxazole-proprionic acid/kainate antagonist LY293558 on spontaneous and evoked postoperative pain. Clin Pharmacol Ther. 2000 Sep; 68(3):320-7. PMID: 11014414.
    Citations: 23     Fields:    Translation:HumansCTClinical Trials
  44. Sang CN. NMDA-receptor antagonists in neuropathic pain: experimental methods to clinical trials. J Pain Symptom Manage. 2000 Jan; 19(1 Suppl):S21-5. PMID: 10687335.
    Citations: 14     Fields:    Translation:Humans
  45. Coghill RC, Sang CN, Maisog JM, Iadarola MJ. Pain intensity processing within the human brain: a bilateral, distributed mechanism. J Neurophysiol. 1999 Oct; 82(4):1934-43. PMID: 10515983.
    Citations: 288     Fields:    Translation:Humans
  46. Coghill RC, Sang CN, JM Maisog, et al. . Pain intensity processing within the human Brain: A bilateral, distributed mechanism. American Pain Society. 1999.
  47. Sang CN, Miller VA, Dobosh L, et al. . Temporal summation and reduction of pain thresholds in normal skin in patients with dysesthetic central pain following spinal cord injury. IX World Congress of the International Association for the Study of Pain. 1999.
  48. Dionne RA, Max MB, Gordon SM, Parada S, Sang C, Gracely RH, Sethna NF, MacLean DB. The substance P receptor antagonist CP-99,994 reduces acute postoperative pain. Clin Pharmacol Ther. 1998 Nov; 64(5):562-8. PMID: 9834049.
    Citations: 24     Fields:    Translation:HumansCTClinical Trials
  49. Sang CN, Hostetter MP, Gracely RH, Chappell AS, Schoepp DD, Lee G, Whitcup S, Caruso R, Max MB. AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans. Anesthesiology. 1998 Nov; 89(5):1060-7. PMID: 9821993.
    Citations: 24     Fields:    Translation:HumansCellsCTClinical Trials
  50. Coghill RC, Sang CN, Berman KF, Bennett GJ, Iadarola MJ. Global cerebral blood flow decreases during pain. J Cereb Blood Flow Metab. 1998 Feb; 18(2):141-7. PMID: 9469155.
    Citations: 12     Fields:    Translation:Humans
  51. Sang CN. Advances in neuropathic pain: Glutamate receptor antagonists. Managing pain in the neurologic patient. Neurol Rev Suppl,. 1998; 5.
  52. Coghill RC, Sang CN, Maisog JM, et al. . Distributed representation of painful stimulus intensity in the human brain. Society for Neuroscience . 1997.
  53. Sang CN, Gracely RH, Max MB, Bennett GJ. Capsaicin-evoked mechanical allodynia and hyperalgesia cross nerve territories. Evidence for a central mechanism. Anesthesiology. 1996 Sep; 85(3):491-6. PMID: 8853078.
    Citations: 29     Fields:    Translation:HumansCells
  54. Coghill RC, Sang CN, Nelson KA, et al. . Regional brain activation in patients with post-herpetic neuralgia. 8th World Congress on Pain, Vancouver. 1996.
  55. Gordon SM, Dionne RA, Brahim JS, Sang CN, Dubner R. Differential effects of local anesthesia on central hyperalgesia. Presented, International Association for Dental Research. 1996.
  56. Coghill RC, Sang CN, Nelson KA, et al. . Regional brain activation in patients with post-herpetic neuralgia. Society for Neuroscience. 1996.
  57. Coghill RC, Nelson KA, Sang CN, et al. Chronic pain processing by the human brain: Sensory and attentional networks activated during post-herpetic neuralgia. American Pain Society. 1995.
  58. Valley MA, Sang CN. Use of glycopyrrolate to treat intraoperative penile erection. Case report and review of the literature. Reg Anesth. 1994 Nov-Dec; 19(6):423-8. PMID: 7848955.
    Citations: 8     Fields:    Translation:Humans
  59. Sang CN Berde CB, and the safety in pediatric regional analgesia study group. . A multicenter study of safety and risk factors in pediatric postoperative regional anesthesia. Presented, Third International Symposium of Pediatric Pain, International Association for the Study of Pain. 1994.
  60. Sang CN , Sethna NF, Sullivan L, et al. 8LA1386. Evaluation of epinephrine epidural test dose in children under isoflurane anesthesia. Anesthesiology. 1994; 8LA1386.
  61. Sang CN, Berde CB, and the safety in pediatric regional analgesia study group. A multicenter study of safety and risk factors in pediatric regional analgesia. Anesthesiology. 1994; 8 1(A 13):86.
  62. Sang CN, Joyce JP, Farmer ER. Persistent oral ulcers and sore throat. Pemphigus vulgaris (PV). Arch Dermatol. 1991 Jun; 127(6):887-8, 890-1. PMID: 2036037.
    Citations:    Fields:    Translation:Humans
  63. Sang CN, Whelton PK, Hamper UM, Connolly M, Kadir S, White RI, Sanders R, Liang KY, Bias W. Etiologic factors in renovascular fibromuscular dysplasia. A case-control study. Hypertension. 1989 Nov; 14(5):472-9. PMID: 2680961.
    Citations: 28     Fields:    Translation:Humans
  64. Cheng HM, Chylack LT, Sang CN, Orzalesi N, Corongiu FP. GSSG-reducing activity in lenses deficient in glucose-6-phosphate dehydrogenase. Metab Pediatr Syst Ophthalmol. 1983; 7(1):53-7. PMID: 6621360.
    Citations: 1     Fields:    Translation:HumansAnimals
  65. Tarentino AL, Maley F. A comparison of the substrate specificities of endo-beta-N-acetylglucosaminidases from Streptomyces griseus and Diplococcus Pneumoniae. Biochem Biophys Res Commun. 1975 Nov 03; 67(1):455-62. PMID: 1016.
    Citations: 25     Fields:    Translation:Cells
  66. Hendrickson WA, Ward KB. Atomic models for the polypeptide backbones of myohemerythrin and hemerythrin. Biochem Biophys Res Commun. 1975 Oct 27; 66(4):1349-56. PMID: 5.
    Citations: 6     Fields:    Translation:AnimalsCells
  67. Smith RJ, Bryant RG. Metal substitutions incarbonic anhydrase: a halide ion probe study. Biochem Biophys Res Commun. 1975 Oct 27; 66(4):1281-6. PMID: 3.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  68. Schmoldt A, Benthe HF, Haberland G. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol. 1975 Sep 01; 24(17):1639-41. PMID: 10.
    Citations: 44     Fields:    Translation:AnimalsCells
  69. Ehrhart IC, Parker PE, Weidner WJ, Dabney JM, Scott JB, Haddy FJ. Coronary vascular and myocardial responses to carotid body stimulation in the dog. Am J Physiol. 1975 Sep; 229(3):754-60. PMID: 2017.
    Citations: 9     Fields:    Translation:AnimalsCells
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