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Eric D Gaier, M.D.

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Ithaca College, Ithaca, NYBA05/2005Psychology/Neuroscience
University of Connecticut, Farmington, CTMD05/2013Medicine
University of Connecticut, Farmington, CTPhD05/2013Neuroscience
Mount Auburn Hospital, Cambridge, MA06/2014Internal Medicine (Internship)
Massachusetts Eye and Ear, Boston, MA06/2017Ophthalmology (Residency)
Massachusetts Eye and Ear, Boston, MA07/2018Neuro-Ophthalmology (Clinical Fellowship)
Boston Children's Hospital, Boston, MA07/2019Pediatric Ophthalmology and Adult Strabismus (Clinical Fellowship)

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08EY030164 (GAIER, ERIC DEAN) Aug 1, 2019 - Jul 31, 2024
    Exploiting principles of timing-dependent synaptic plasticity to treat amblyopia
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bleicher ID, Tainsh LT, Gaier ED, Armstrong GW. Outcomes of Zone 3 Open Globe Injuries by Wound Extent: Subcategorization of Zone 3 Injuries Segregates Visual and Anatomic Outcomes. Ophthalmology. 2023 Apr; 130(4):379-386. PMID: 36332844.
    Citations:    Fields:    
  2. Chiou CA, Rajabi F, Fulton AB, Acsadi G, Waitzman DM, Gaier ED. Membrane Frizzled-Related Protein-Related Disease Mimicking Idiopathic Intracranial Hypertension. J Neuroophthalmol. 2022 Oct 18. PMID: 36255095.
    Citations:    Fields:    
  3. Oke I, Gaier ED, Mantagos IS, Shah AS. Periodic trends in Internet Searches for Ocular Symptoms in the US. Ophthalmic Epidemiol. 2022 Sep 14; 1-6. PMID: 36103713.
    Citations:    Fields:    
  4. Leet MP, Bear MF, Gaier ED. Metaplasticity: a key to visual recovery from amblyopia in adulthood? Curr Opin Ophthalmol. 2022 Nov 01; 33(6):512-518. PMID: 36094025; PMCID: PMC9547850.
    Citations:    Fields:    Translation:HumansAnimals
  5. Xiao S, Angjeli E, Gaier ED, Binenbaum G, Hunter DG. Reply. Ophthalmology. 2022 Oct; 129(10):e152-e153. PMID: 35868879.
    Citations:    Fields:    
  6. Mercado CL, Froines CP, Gaier ED, Wang Q, Indaram M, Wan MJ, Shah AS, Koo EB. Prevalence and Characteristics of Cytomegalovirus Ocular Disease in Children: A Multi-Center Study. Clin Ophthalmol. 2022; 16:2209-2217. PMID: 35837488; PMCID: PMC9275512.
    Citations: 1     
  7. Resnick HH, Bear MF, Gaier ED. Partial Recovery of Amblyopia After Fellow Eye Ischemic Optic Neuropathy. J Neuroophthalmol. 2023 03 01; 43(1):76-81. PMID: 36166713; PMCID: PMC9780401.
    Citations: 1     Fields:    Translation:Humans
  8. Liebman DL, Tam EK, Lithgow MY, Kane JE, Fischbein NJ, Lefebvre DR, Chwalisz BK, Gaier ED. Optic Perineuritis Associated With Cryptococcal Meningitis Presenting With a "Hot Orbit" in a Patient With Chronic Lymphocytic Leukemia. J Neuroophthalmol. 2022 06 01; 42(2):272-277. PMID: 35421041; PMCID: PMC9124683.
    Citations:    Fields:    Translation:Humans
  9. Lu ES, Yuan A, Cohen DA, Katz R, Miller JB, Gaier ED. Detection of Choroidal Hypoperfusion in Giant Cell Arteritis Using Swept-Source Optical Coherence Tomographic Angiography. J Neuroophthalmol. 2022 Feb 25. PMID: 35234684; PMCID: PMC9402803.
    Citations:    Fields:    
  10. Lains I, Diaz JD, Gittinger JW, Gaier ED. Anterior Ischemic Optic Neuropathy Secondary to Carotid Artery Dissection. J Neuroophthalmol. 2021 Dec 01; 41(4):e731-e733. PMID: 33417422; PMCID: PMC8254813.
    Citations:    Fields:    Translation:Humans
  11. Ma KK, Robson CD, Gaier ED, Gise R. Reversal of Visual Loss From Skull Base Osteomyelitis in a Pediatric Patient. J Neuroophthalmol. 2021 Dec 01; 41(4):e728-e730. PMID: 33110009.
    Citations:    Fields:    Translation:Humans
  12. Nagy MA, Lin MM, Wolkow N, Gaier ED. Comment on "Fatal GNAQ-mutated CNS melanoma in an adolescent with nevus of Ota". Pediatr Dermatol. 2021 11; 38(6):1608-1609. PMID: 34931368.
    Citations:    Fields:    
  13. Raja S, Emadi BS, Gaier ED, Gise RA, Fulton AB, Heidary G. Evaluation of the Relationship Between Preferential Looking Testing and Visual Evoked Potentials as a Biomarker of Cerebral Visual Impairment. Front Hum Neurosci. 2021; 15:769259. PMID: 34776912; PMCID: PMC8578861.
    Citations: 1     
  14. Gaier ED, Rasool N, Rizzo JF. Sectoral Sparing Associated With a Cilioretinal Artery in Arteritic Anterior Ischemic Optic Neuropathy. J Neuroophthalmol. 2022 06 01; 42(2):e514-e516. PMID: 34860740.
    Citations:    Fields:    Translation:HumansAnimals
  15. Eleiwa TK, Gaier ED, Haseeb A, ElSheikh RH, Sallam AB, Elhusseiny AM. Adverse Ocular Events following COVID-19 Vaccination. Inflamm Res. 2021 Dec; 70(10-12):1005-1009. PMID: 34561753; PMCID: PMC8475832.
    Citations: 13     Fields:    Translation:HumansCellsPHPublic Health
  16. Xiao S, Angjeli E, Wu HC, Gaier ED, Gomez S, Travers DA, Binenbaum G, Langer R, Hunter DG, Repka MX. Randomized Controlled Trial of a Dichoptic Digital Therapeutic for Amblyopia. Ophthalmology. 2022 01; 129(1):77-85. PMID: 34534556.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  17. Douglas KAA, Douglas VP, Gaier ED, Chwalisz BK. Ptosis as Clinical Presentation in a Patient With Emery-Dreifuss Muscular Dystrophy Type 5. J Neuroophthalmol. 2021 09 01; 41(3):e333-e334. PMID: 33630782; PMCID: PMC8373992.
    Citations:    Fields:    Translation:Humans
  18. Douglas VP, Douglas KAA, Miller JB, Gaier ED. Absent Foveal Avascular Zone in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay. J Neuroophthalmol. 2021 06 01; 41(2):e166-e168. PMID: 32991389.
    Citations: 1     Fields:    Translation:Humans
  19. Xiao S, Gaier ED, Wu HC, Angjeli E, Nuth PL, Bohra LI, Miller AM, Mazow ML, Stout AU, Morse CL, Blumenfeld LC, Glaser SR, Crouch E, Ekdawi NS, Lyon DW, Silbert DI, Hunter DG. Digital therapeutic improves visual acuity and encourages high adherence in amblyopic children in open-label pilot study. J AAPOS. 2021 04; 25(2):87.e1-87.e6. PMID: 33905837.
    Citations: 3     Fields:    Translation:Humans
  20. Tieger MG, Miller JB, Gaier ED. Microvasculopathy in Lyme-Associated Papillitis Revealed by Optical Coherence Tomographic Angiography. J Neuroophthalmol. 2022 03 01; 42(1):e338-e340. PMID: 33770008; PMCID: PMC8458478.
    Citations:    Fields:    Translation:Humans
  21. Cohen DA, Gise R, Gaier ED. Serum Biomarkers in Neuro-Ophthalmology: When to Test. Semin Ophthalmol. 2021 May 19; 36(4):322-328. PMID: 33689572.
    Citations: 1     Fields:    Translation:Humans
  22. Falcone MM, Hunter DG, Gaier ED. Emerging therapies for amblyopia. Semin Ophthalmol. 2021 May 19; 36(4):282-288. PMID: 33656963; PMCID: PMC8122041.
    Citations: 5     Fields:    Translation:Humans
  23. Elhusseiny AM, Fridman G, Nihalani BR, Gaier ED. Pseudo-Duane retraction syndrome after orbital myositis. J AAPOS. 2021 04; 25(2):121-123. PMID: 33652102; PMCID: PMC8217196.
    Citations:    Fields:    Translation:Humans
  24. Gaier ED, Yonekawa Y. Persistent vasa hyaloidea propria/retinae in familial exudative vitreoretinopathy. J AAPOS. 2021 04; 25(2):114-116. PMID: 33358962; PMCID: PMC8215079.
    Citations:    Fields:    Translation:Humans
  25. Xiao S, Gaier ED, Mazow ML, Stout AU, Travers DA, Angjeli E, Wu HC, Binenbaum G, Hunter DG. Improved adherence and treatment outcomes with an engaging, personalized digital therapeutic in amblyopia. Sci Rep. 2020 05 20; 10(1):8328. PMID: 32433490.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  26. Bowe T, Hunter DG, Mantagos IS, Kazlas M, Jastrzembski BG, Gaier ED, Massey G, Franz K, Schumann C, Brown C, Meyers H, Shah AS. Virtual Visits in Ophthalmology: Timely Advice for Implementation During the COVID-19 Public Health Crisis. Telemed J E Health. 2020 09; 26(9):1113-1117. PMID: 32408801.
    Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
  27. Gaier ED, Sahai I, Wiggs JL, McGeeney B, Hoffman J, Peeler CE. Novel homozygous OPA3 mutation in an Afghani family with 3-methylglutaconic aciduria type III and optic atrophy. Ophthalmic Genet. 2019 12; 40(6):570-573. PMID: 31928268.
    Citations: 3     Fields:    Translation:Humans
  28. Gaier ED, Heidary G. Pediatric Idiopathic Intracranial Hypertension. Semin Neurol. 2019 12; 39(6):704-710. PMID: 31847041.
    Citations: 5     Fields:    Translation:Humans
  29. Gaier ED, Tarabishy S, Bayers C, Wolkow N, Gardiner M, Lefebvre DR, Grob S. Poor prognoses of open globe injuries with concomitant orbital fractures. Orbit. 2020 Aug; 39(4):241-250. PMID: 31658857.
    Citations: 2     Fields:    Translation:Humans
  30. Gise R, Gaier ED, Heidary G. Diagnosis and Imaging of Optic Nerve Head Drusen. Semin Ophthalmol. 2019; 34(4):256-263. PMID: 31157991.
    Citations: 6     Fields:    Translation:Humans
  31. Gaier ED, Gise R, Heidary G. Imaging Amblyopia: Insights from Optical Coherence Tomography (OCT). Semin Ophthalmol. 2019; 34(4):303-311. PMID: 31158044.
    Citations: 5     Fields:    Translation:HumansCells
  32. Gaier ED, Wang M, Gilbert AL, Rizzo JF, Cestari DM, Miller JB. Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. PLoS One. 2018; 13(6):e0199793. PMID: 29953490.
    Citations: 20     Fields:    Translation:HumansCellsCTClinical Trials
  33. Fortin E, Gaier ED. Pseudohemangioma in Nonarteritic Anterior Ischemic Optic Neuropathy. Ophthalmology. 2018 06; 125(6):903. PMID: 29784095.
    Citations:    Fields:    Translation:Humans
  34. Jeng-Miller KW, Gaier ED, Turalba AV. Bilateral uveal effusions in a 23-year-old man. Digit J Ophthalmol. 2018; 24(3):13-15. PMID: 30800008; PMCID: PMC6380252.
    Citations:    Fields:    Translation:Humans
  35. Koulouri I, Gaier ED, Eliott D, Vavvas DG. Double Optic Disc Pit With Glial Plugs Imaged by Wide-Field Optical Coherence Tomography. Ophthalmic Surg Lasers Imaging Retina. 2018 01 01; 49(1):52-54. PMID: 29304267.
    Citations: 1     Fields:    Translation:Humans
  36. Gaier ED, Rizzo JF, Miller JB, Cestari DM. Focal Capillary Dropout Associated With Optic Disc Drusen Using Optical Coherence Tomographic Angiography. J Neuroophthalmol. 2017 12; 37(4):405-410. PMID: 28520583.
    Citations: 10     Fields:    Translation:HumansCells
  37. Gaier ED, Gilbert AL, Cestari DM, Miller JB. Optical coherence tomographic angiography identifies peripapillary microvascular dilation and focal non-perfusion in giant cell arteritis. Br J Ophthalmol. 2018 08; 102(8):1141-1146. PMID: 29122818.
    Citations: 9     Fields:    Translation:HumansCells
  38. Jeng-Miller KW, Cestari DM, Gaier ED. Congenital anomalies of the optic disc: insights from optical coherence tomography imaging. Curr Opin Ophthalmol. 2017 Nov; 28(6):579-586. PMID: 28817389.
    Citations: 6     Fields:    Translation:Humans
  39. Gaier ED, Boudreault K, Nakata I, Janessian M, Skidd P, DelBono E, Allen KF, Pasquale LR, Place E, Cestari DM, Stacy RC, Rizzo JF, Wiggs JL. Diagnostic genetic testing for patients with bilateral optic neuropathy and comparison of clinical features according to OPA1 mutation status. Mol Vis. 2017; 23:548-560. PMID: 28848318; PMCID: PMC5561143.
    Citations: 5     Fields:    Translation:Humans
  40. Gaier ED, Miller JB. Retinal Loop Vessel Captured with Optical Coherence Tomography-Angiography. Ophthalmology. 2017 08; 124(8):1174. PMID: 28734332.
    Citations:    Fields:    Translation:Humans
  41. Gaier ED, Jakobiec FA, Stagner AM, Emerick K, Yoon MK. PV16-Positive Invasive Conjunctival Squamous Cell Carcinoma in an Anophthalmic Socket. Ophthalmic Plast Reconstr Surg. 2017 May/Jun; 33(3S Suppl 1):S2-S4. PMID: 28476055.
    Citations: 1     Fields:    Translation:HumansCells
  42. Gaier ED, Miller JB, Loewenstein JI. Combined Central Retinal Vein Occlusion and Central Retinal Arterial Obstruction with Cilioretinal Artery Sparing. Ophthalmology. 2017 04; 124(4):576. PMID: 28335940.
    Citations: 1     Fields:    Translation:Humans
  43. Gaier ED, Hunter DG. Advances in Amblyopia Treatment: Paradigm Shifts and Future Directions. Int Ophthalmol Clin. 2017; 57(4):117-128. PMID: 28885251.
    Citations: 3     Fields:    Translation:HumansCells
  44. Gaier ED, Gittinger JW, Cestari DM, Miller JB. Peripapillary Capillary Dilation in Leber Hereditary Optic Neuropathy Revealed by Optical Coherence Tomographic Angiography. JAMA Ophthalmol. 2016 11 01; 134(11):1332-1334. PMID: 27711925.
    Citations: 10     Fields:    Translation:Humans
  45. Gaier ED, Torun N. The enigma of nonarteritic anterior ischemic optic neuropathy: an update for the comprehensive ophthalmologist. Curr Opin Ophthalmol. 2016 Nov; 27(6):498-504. PMID: 27585212.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  46. Cestari DM, Gaier ED, Bouzika P, Blachley TS, De Lott LB, Rizzo JF, Wiggs JL, Kang JH, Pasquale LR, Stein JD. Demographic, Systemic, and Ocular Factors Associated with Nonarteritic Anterior Ischemic Optic Neuropathy. Ophthalmology. 2016 12; 123(12):2446-2455. PMID: 27659545.
    Citations: 31     Fields:    Translation:Humans
  47. Gaier ED, Boudreault K, Rizzo JF, Falardeau J, Cestari DM. Atypical Optic Neuritis. Curr Neurol Neurosci Rep. 2015 Dec; 15(12):76. PMID: 26467052.
    Citations: 9     Fields:    Translation:Humans
  48. Allen KF, Gaier ED, Wiggs JL. Genetics of Primary Inherited Disorders of the Optic Nerve: Clinical Applications. Cold Spring Harb Perspect Med. 2015 Jul 01; 5(7):a017277. PMID: 26134840.
    Citations: 13     Fields:    Translation:Humans
  49. Gaier ED, Kleppinger A, Ralle M, Covault J, Mains RE, Kenny AM, Eipper BA. Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum. BMC Endocr Disord. 2014 Jul 15; 14:58. PMID: 25022877.
    Citations: 4     Fields:    Translation:Humans
  50. Gaier ED, Eipper BA, Mains RE. Pam heterozygous mice reveal essential role for Cu in amygdalar behavioral and synaptic function. Ann N Y Acad Sci. 2014 May; 1314:15-23. PMID: 24593825.
    Citations: 14     Fields:    Translation:AnimalsCells
  51. Gaier ED, Rodriguiz RM, Zhou J, Ralle M, Wetsel WC, Eipper BA, Mains RE. In vivo and in vitro analyses of amygdalar function reveal a role for copper. J Neurophysiol. 2014 May; 111(10):1927-39. PMID: 24554785.
    Citations: 13     Fields:    Translation:AnimalsCells
  52. Gaier ED, Miller MB, Ralle M, Aryal D, Wetsel WC, Mains RE, Eipper BA. Peptidylglycine a-amidating monooxygenase heterozygosity alters brain copper handling with region specificity. J Neurochem. 2013 Dec; 127(5):605-19. PMID: 24032518.
    Citations: 14     Fields:    Translation:AnimalsCells
  53. Gaier ED, Eipper BA, Mains RE. Copper signaling in the mammalian nervous system: synaptic effects. J Neurosci Res. 2013 Jan; 91(1):2-19. PMID: 23115049.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  54. Gaier ED, Kleppinger A, Ralle M, Mains RE, Kenny AM, Eipper BA. High serum Cu and Cu/Zn ratios correlate with impairments in bone density, physical performance and overall health in a population of elderly men with frailty characteristics. Exp Gerontol. 2012 Jul; 47(7):491-6. PMID: 22484083.
    Citations: 13     Fields:    Translation:Humans
  55. Gaier ED, Rodriguiz RM, Ma XM, Sivaramakrishnan S, Bousquet-Moore D, Wetsel WC, Eipper BA, Mains RE. Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. J Neurosci. 2010 Oct 13; 30(41):13656-69. PMID: 20943906.
    Citations: 14     Fields:    Translation:AnimalsCells
  56. Ma XM, Kiraly DD, Gaier ED, Wang Y, Kim EJ, Levine ES, Eipper BA, Mains RE. Kalirin-7 is required for synaptic structure and function. J Neurosci. 2008 Nov 19; 28(47):12368-82. PMID: 19020030.
    Citations: 95     Fields:    Translation:AnimalsCells
  57. Peck JH, Gaier E, Stevens E, Repicky S, Harris-Warrick RM. Amine modulation of Ih in a small neural network. J Neurophysiol. 2006 Dec; 96(6):2931-40. PMID: 16943317.
    Citations: 30     Fields:    Translation:AnimalsCells
  58. Liu Q, Chen B, Gaier E, Joshi J, Wang ZW. Low conductance gap junctions mediate specific electrical coupling in body-wall muscle cells of Caenorhabditis elegans. J Biol Chem. 2006 Mar 24; 281(12):7881-9. PMID: 16434400.
    Citations: 42     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.