Harvard Catalyst Profiles

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Bo Ruben Rueda, Ph.D.

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Overview
Molecular interrogation of gynecologic tumors:
My group molecularly interrogates gynecologic tumors to identify genes or proteins and their corresponding signaling pathways that contribute to malignant transformation, the pathology of the disease, recurrence and/or resistance to therapy. Once key factors or pathways are identified, we actively test novel anticancer drugs to determine their efficacy in tumor explant models. In addition, we assess the efficacy of dual or sequential therapy. Specifically, we assess whether novel anti-cancer agents work better as a single agent or in conjunction with the standard of care or another anti-cancer agent.

Investigation into the functional significance of the functional contribution of gynecologic cancer stem cells:
My group has extensively studied and continues to conduct research focused on the functional contribution of sub populations of gynecologic cancer cells that have stem like characteristics a contributing to the pathology and high recurrence rate. Our research provided valuable rationale for identifying targetable cells and testing combination therapies that can be tested in clinical trials for women with recurrent and refractory gynecologic cancer.

Define mechanisms that contribute to the genesis, progression or pathology of benign gynecologic diseases:
In addition to in depth studies on gynecologic malignances we also focus on benign diseases that impact reproductive aged women. Specifically, we have and continue to be focused on endometriosis and leiomyoma. These non malignant diseases can have a devastating negative impact on women’s health and quality of life. Despite the prevalence of the disease very little progress have been made in long term solutions with the exception of surgical removal of the of uterus. We have used mouse models as well as primary human tissues to assess the mechanisms by which specific cell signaling factors positively or negatively impact the development, progression and/or pathological properties associated with these diseases. More recently, Dr. Styer and I embarked on an in depth study to assess irregular microRNA (miRNA) expression in leiomyomata compared to matched native myometrium. As a result of these preliminary studies, we have begun in vitro functional studies in primary and immortalized fibroid and myometrial cells. Our ultimate goal is to delineate the functional impact of leiomyoma miRNA expression in the genesis, progression and phenotypic characteristics of the disease. In addition, we anticipate we may uncover novel gene targets that will serve in the development of alternative uterine sparing treatment strategies.

Drug development for treatment of resistant gynecologic cancers:
As a result of our multiple interactions with pharmaceutical companies we have become more proactive in formulating stronger collaborations with the intent to develop novel inhibitors of oncogenic pathways, identify susceptible immune checkpoints, test new immune treatment strategies, and generate specific antibody drug conjugates for the treatment of women diagnosed with endometrial or ovarian cancer.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA176502 (GOLD, LESLIE INA) Jun 13, 2014 - May 31, 2019
    NIH/NCI
    Stabilizing nuclear p27kip1 as a therapeutic target for endometrial cancer
    Role: Co-Principal Investigator
  2. R01CA098333 (RUEDA, BO R) Aug 1, 2003 - May 31, 2009
    NIH/NCI
    Cables role in endometrial differentiation and cancer
    Role: Principal Investigator
  3. R01HD035934 (RUEDA, BO R) Dec 8, 1998 - Jun 30, 2007
    NIH/NICHD
    Regulation of the sphingomyelin pathway in the CL
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lv X, He C, Huang C, Wang H, Hua G, Wang Z, Zhou J, Chen X, Ma B, Timm BK, Maclin V, Dong J, Rueda BR, Davis JS, Wang C. Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development. FASEB J. 2019 Jun 14; fj201900179RR. PMID: 31199671.
    Citations:    
  2. He C, Lv X, Huang C, Angeletti PC, Hua G, Dong J, Zhou J, Wang Z, Ma B, Chen X, Lambert PF, Rueda BR, Davis JS, Wang C. A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. Cell Rep. 2019 Mar 05; 26(10):2636-2650.e5. PMID: 30840887.
    Citations:    
  3. He C, Lv X, Huang C, Hua G, Ma B, Chen X, Angeletti PC, Dong J, Zhou J, Wang Z, Rueda BR, Davis JS, Wang C. YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis. EMBO Rep. 2019 Mar; 20(3). PMID: 30755404.
    Citations:    
  4. Al-Alem LF, Pandya UM, Baker AT, Bellio C, Zarrella BD, Clark J, DiGloria CM, Rueda BR. Ovarian cancer stem cells: What progress have we made? Int J Biochem Cell Biol. 2019 Feb; 107:92-103. PMID: 30572025.
    Citations:    Fields:    
  5. Bellio C, DiGloria C, Foster R, James K, Konstantinopoulos PA, Growdon WB, Rueda BR. PARP Inhibition Induces Enrichment of DNA Repair-Proficient CD133 and CD117 Positive Ovarian Cancer Stem Cells. Mol Cancer Res. 2019 02; 17(2):431-445. PMID: 30401718.
    Citations:    Fields:    
  6. Eavarone DA, Al-Alem L, Lugovskoy A, Prendergast JM, Nazer RI, Stein JN, Dransfield DT, Behrens J, Rueda BR. Humanized anti-Sialyl-Tn antibodies for the treatment of ovarian carcinoma. PLoS One. 2018; 13(7):e0201314. PMID: 30052649.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Cardozo ER, Foster R, Karmon AE, Lee AE, Gatune LW, Rueda BR, Styer AK. MicroRNA 21a-5p overexpression impacts mediators of extracellular matrix formation in uterine leiomyoma. Reprod Biol Endocrinol. 2018 May 11; 16(1):46. PMID: 29747655.
    Citations:    Fields:    Translation:HumansCells
  8. Starbuck K, Al-Alem L, Eavarone DA, Hernandez SF, Bellio C, Prendergast JM, Stein J, Dransfield DT, Zarrella B, Growdon WB, Behrens J, Foster R, Rueda BR. Treatment of ovarian cancer by targeting the tumor stem cell-associated carbohydrate antigen, Sialyl-Thomsen-nouveau. Oncotarget. 2018 May 01; 9(33):23289-23305. PMID: 29796189.
    Citations: 1     Fields:    
  9. Chiu YH, Karmon AE, Gaskins AJ, Arvizu M, Williams PL, Souter I, Rueda BR, Hauser R, Chavarro JE. Serum omega-3 fatty acids and treatment outcomes among women undergoing assisted reproduction. Hum Reprod. 2018 01 01; 33(1):156-165. PMID: 29136189.
    Citations: 2     Fields:    Translation:Humans
  10. Bregar A, Deshpande A, Grange C, Zi T, Stall J, Hirsch H, Reeves J, Sathyanarayanan S, Growdon WB, Rueda BR. Characterization of immune regulatory molecules B7-H4 and PD-L1 in low and high grade endometrial tumors. Gynecol Oncol. 2017 06; 145(3):446-452. PMID: 28347512.
    Citations: 2     Fields:    Translation:Humans
  11. Prendergast JM, Galvao da Silva AP, Eavarone DA, Ghaderi D, Zhang M, Brady D, Wicks J, DeSander J, Behrens J, Rueda BR. Novel anti-Sialyl-Tn monoclonal antibodies and antibody-drug conjugates demonstrate tumor specificity and anti-tumor activity. MAbs. 2017 May/Jun; 9(4):615-627. PMID: 28281872.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  12. Bajwa P, Nielsen S, Lombard JM, Rassam L, Nahar P, Rueda BR, Wilkinson JE, Miller RA, Tanwar PS. Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice. Oncotarget. 2017 Jan 31; 8(5):7265-7275. PMID: 27980219.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  13. Garrett LA, Growdon WB, Rueda BR, Foster R. Influence of a novel histone deacetylase inhibitor panobinostat (LBH589) on the growth of ovarian cancer. J Ovarian Res. 2016 Sep 15; 9(1):58. PMID: 27633667.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  14. Guan Y, Guo L, Zukerberg L, Rueda BR, Styer AK. MicroRNA-15b regulates reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression in human uterine leiomyoma. Reprod Biol Endocrinol. 2016 Aug 17; 14(1):45. PMID: 27530410.
    Citations: 2     Fields:    Translation:HumansCells
  15. Hernandez SF, Chisholm S, Borger D, Foster R, Rueda BR, Growdon WB. Ridaforolimus improves the anti-tumor activity of dual HER2 blockade in uterine serous carcinoma in vivo models with HER2 gene amplification and PIK3CA mutation. Gynecol Oncol. 2016 06; 141(3):570-579. PMID: 27017985.
    Citations:    Fields:    Translation:HumansAnimals
  16. Clark NC, Friel AM, Pru CA, Zhang L, Shioda T, Rueda BR, Peluso JJ, Pru JK. Progesterone receptor membrane component 1 promotes survival of human breast cancer cells and the growth of xenograft tumors. Cancer Biol Ther. 2016; 17(3):262-71. PMID: 26785864.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  17. Roussel-Gervais A, Couture C, Langlais D, Takayasu S, Balsalobre A, Rueda BR, Zukerberg LR, Figarella-Branger D, Brue T, Drouin J. The Cables1 Gene in Glucocorticoid Regulation of Pituitary Corticotrope Growth and Cushing Disease. J Clin Endocrinol Metab. 2016 Feb; 101(2):513-22. PMID: 26695862.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  18. Styer AK, Rueda BR. The Epidemiology and Genetics of Uterine Leiomyoma. Best Pract Res Clin Obstet Gynaecol. 2016 Jul; 34:3-12. PMID: 26725703.
    Citations: 4     Fields:    Translation:HumansCells
  19. Hernandez SF, Vahidi NA, Park S, Weitzel RP, Tisdale J, Rueda BR, Wolff EF. Characterization of extracellular DDX4- or Ddx4-positive ovarian cells. Nat Med. 2015 Oct; 21(10):1114-6. PMID: 26444630.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  20. Diver EJ, Foster R, Rueda BR, Growdon WB. The Therapeutic Challenge of Targeting HER2 in Endometrial Cancer. Oncologist. 2015 Sep; 20(9):1058-68. PMID: 26099744.
    Citations: 6     Fields:    Translation:HumansCells
  21. Ince TA, Sousa AD, Jones MA, Harrell JC, Agoston ES, Krohn M, Selfors LM, Liu W, Chen K, Yong M, Buchwald P, Wang B, Hale KS, Cohick E, Sergent P, Witt A, Kozhekbaeva Z, Gao S, Agoston AT, Merritt MA, Foster R, Rueda BR, Crum CP, Brugge JS, Mills GB. Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours. Nat Commun. 2015 Jun 17; 6:7419. PMID: 26080861.
    Citations: 31     Fields:    Translation:HumansCells
  22. Growdon WB, Groeneweg J, Byron V, DiGloria C, Borger DR, Tambouret R, Foster R, Chenna A, Sperinde J, Winslow J, Rueda BR. HER2 over-expressing high grade endometrial cancer expresses high levels of p95HER2 variant. Gynecol Oncol. 2015 Apr; 137(1):160-6. PMID: 25602714.
    Citations: 5     Fields:    Translation:Humans
  23. Groeneweg JW, Foster R, Growdon WB, Verheijen RH, Rueda BR. Notch signaling in serous ovarian cancer. J Ovarian Res. 2014 Nov 04; 7:95. PMID: 25366565.
    Citations: 11     Fields:    Translation:HumansCells
  24. Clark RM, Lynch MP, Kolp R, Zukerberg LR, Growdon WB, Rueda BR. The N-methyl-D-aspartate receptor, a precursor to N-methyl-D-aspartate receptor encephalitis, is found in the squamous tissue of ovarian teratomas. Int J Gynecol Pathol. 2014 Nov; 33(6):598-606. PMID: 25272299.
    Citations:    Fields:    Translation:HumansCells
  25. Doyle JO, Lee HJ, Selesniemi K, Styer AK, Rueda BR. The impact of vitrification on murine germinal vesicle oocyte In vitro maturation and aurora kinase A protein expression. J Assist Reprod Genet. 2014 Dec; 31(12):1695-702. PMID: 25318984.
    Citations:    Fields:    Translation:HumansAnimals
  26. Groeneweg JW, Hernandez SF, Byron VF, DiGloria CM, Lopez H, Scialabba V, Kim M, Zhang L, Borger DR, Tambouret R, Foster R, Rueda BR, Growdon WB. Dual HER2 targeting impedes growth of HER2 gene-amplified uterine serous carcinoma xenografts. Clin Cancer Res. 2014 Dec 15; 20(24):6517-6528. PMID: 25294905.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  27. Friel AM, Zhang L, Pru CA, Clark NC, McCallum ML, Blok LJ, Shioda T, Peluso JJ, Rueda BR, Pru JK. Progesterone receptor membrane component 1 deficiency attenuates growth while promoting chemosensitivity of human endometrial xenograft tumors. Cancer Lett. 2015 Jan 28; 356(2 Pt B):434-42. PMID: 25304370.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  28. Groeneweg JW, DiGloria CM, Yuan J, Richardson WS, Growdon WB, Sathyanarayanan S, Foster R, Rueda BR. Inhibition of notch signaling in combination with Paclitaxel reduces platinum-resistant ovarian tumor growth. Front Oncol. 2014; 4:171. PMID: 25072022.
    Citations: 9     
  29. Attaman JA, Stanic AK, Kim M, Lynch MP, Rueda BR, Styer AK. The anti-inflammatory impact of omega-3 polyunsaturated Fatty acids during the establishment of endometriosis-like lesions. Am J Reprod Immunol. 2014 Oct; 72(4):392-402. PMID: 24898804.
    Citations: 2     Fields:    Translation:AnimalsCells
  30. Karmon AE, Cardozo ER, Rueda BR, Styer AK. MicroRNAs in the development and pathobiology of uterine leiomyomata: does evidence support future strategies for clinical intervention? Hum Reprod Update. 2014 Sep-Oct; 20(5):670-87. PMID: 24706045.
    Citations: 7     Fields:    Translation:Humans
  31. Groeneweg JW, Hall TR, Zhang L, Kim M, Byron VF, Tambouret R, Sathayanrayanan S, Foster R, Rueda BR, Growdon WB. Inhibition of gamma-secretase activity impedes uterine serous carcinoma growth in a human xenograft model. Gynecol Oncol. 2014 Jun; 133(3):607-15. PMID: 24667249.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  32. Stanic AK, Kim M, Styer AK, Rueda BR. Dendritic cells attenuate the early establishment of endometriosis-like lesions in a murine model. Reprod Sci. 2014 Oct; 21(10):1228-36. PMID: 24594835.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  33. Bradford LS, Rauh-Hain A, Clark RM, Groeneweg JW, Zhang L, Borger D, Zukerberg LR, Growdon WB, Foster R, Rueda BR. Assessing the efficacy of targeting the phosphatidylinositol 3-kinase/AKT/mTOR signaling pathway in endometrial cancer. Gynecol Oncol. 2014 May; 133(2):346-52. PMID: 24561032.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  34. Young BC, Stanic AK, Panda B, Rueda BR, Panda A. Longitudinal expression of Toll-like receptors on dendritic cells in uncomplicated pregnancy and postpartum. Am J Obstet Gynecol. 2014 May; 210(5):445.e1-6. PMID: 24291497.
    Citations: 2     Fields:    Translation:HumansCells
  35. Wang L, Gala M, Yamamoto M, Pino MS, Kikuchi H, Shue DS, Shirasawa S, Austin TR, Lynch MP, Rueda BR, Zukerberg LR, Chung DC. Adrenomedullin is a therapeutic target in colorectal cancer. Int J Cancer. 2014 May 01; 134(9):2041-50. PMID: 24519534.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  36. Fallon EM, Nehra D, Carlson SJ, Brown DW, Nedder AP, Rueda BR, Puder M. Evaluation of anastomotic strength and drug safety after short-term sunitinib administration in rabbits. J Surg Res. 2014 Mar; 187(1):101-6. PMID: 24189178.
    Citations:    Fields:    Translation:Animals
  37. He L, Guo L, Vathipadiekal V, Sergent PA, Growdon WB, Engler DA, Rueda BR, Birrer MJ, Orsulic S, Mohapatra G. Identification of LMX1B as a novel oncogene in human ovarian cancer. Oncogene. 2014 Aug 14; 33(33):4226-35. PMID: 24056967.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  38. Pavlides SC, Huang KT, Reid DA, Wu L, Blank SV, Mittal K, Guo L, Rothenberg E, Rueda B, Cardozo T, Gold LI. Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer. Endocrinology. 2013 Nov; 154(11):4030-45. PMID: 24035998.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  39. Kulkarni-Datar K, Orsulic S, Foster R, Rueda BR. Ovarian tumor initiating cell populations persist following paclitaxel and carboplatin chemotherapy treatment in vivo. Cancer Lett. 2013 Oct 10; 339(2):237-46. PMID: 23791886.
    Citations: 8     Fields:    Translation:AnimalsCells
  40. Arnason T, Pino MS, Yilmaz O, Kirley SD, Rueda BR, Chung DC, Zukerberg LR. Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice. Cancer Biol Ther. 2013 Jul; 14(7):672-8. PMID: 23792637.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  41. Rueda BR, Davis JS. No REST for fibroids. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):1980-1. PMID: 23355686.
    Citations:    Fields:    Translation:HumansAnimals
  42. Foster R, Buckanovich RJ, Rueda BR. Ovarian cancer stem cells: working towards the root of stemness. Cancer Lett. 2013 Sep 10; 338(1):147-57. PMID: 23138176.
    Citations: 36     Fields:    Translation:HumansCells
  43. Nehra D, Le HD, Fallon EM, Carlson SJ, Woods D, White YA, Pan AH, Guo L, Rodig SJ, Tilly JL, Rueda BR, Puder M. Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids. Aging Cell. 2012 Dec; 11(6):1046-54. PMID: 22978268.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  44. Fallon EM, Nehra D, Carlson SJ, Potemkin AK, Mitchell PD, Nedder AP, Rueda BR, Puder M. Sunitinib reduces recurrent pelvic adhesions in a rabbit model. J Surg Res. 2012 Dec; 178(2):860-5. PMID: 22884447.
    Citations: 1     Fields:    Translation:Animals
  45. Pant A, Lee II, Lu Z, Rueda BR, Schink J, Kim JJ. Inhibition of AKT with the orally active allosteric AKT inhibitor, MK-2206, sensitizes endometrial cancer cells to progestin. PLoS One. 2012; 7(7):e41593. PMID: 22911820.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  46. Fallon EM, Nehra D, Le HD, Nedder AP, Guo L, Mitchell PD, Rueda BR, Puder M. Effect of sunitinib on functional reproductive outcome in a rabbit model. Fertil Steril. 2012 Aug; 98(2):496-502. PMID: 22698641.
    Citations: 1     Fields:    Translation:Animals
  47. Gillet JP, Calcagno AM, Varma S, Davidson B, Bunkholt Elstrand M, Ganapathi R, Kamat AA, Sood AK, Ambudkar SV, Seiden MV, Rueda BR, Gottesman MM. Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma. Clin Cancer Res. 2012 Jun 01; 18(11):3197-206. PMID: 22492981.
    Citations: 10     Fields:    Translation:Humans
  48. Panda B, Panda A, Ueda I, Abrahams VM, Norwitz ER, Stanic AK, Young BC, Ecker JL, Altfeld M, Shaw AC, Rueda BR. Dendritic cells in the circulation of women with preeclampsia demonstrate a pro-inflammatory bias secondary to dysregulation of TLR receptors. J Reprod Immunol. 2012 Jun; 94(2):210-5. PMID: 22440523.
    Citations: 7     Fields:    Translation:HumansCells
  49. Engler DA, Gupta S, Growdon WB, Drapkin RI, Nitta M, Sergent PA, Allred SF, Gross J, Deavers MT, Kuo WL, Karlan BY, Rueda BR, Orsulic S, Gershenson DM, Birrer MJ, Gray JW, Mohapatra G. Genome wide DNA copy number analysis of serous type ovarian carcinomas identifies genetic markers predictive of clinical outcome. PLoS One. 2012; 7(2):e30996. PMID: 22355333.
    Citations: 16     Fields:    Translation:Humans
  50. Burgos-Ojeda D, Rueda BR, Buckanovich RJ. Ovarian cancer stem cell markers: prognostic and therapeutic implications. Cancer Lett. 2012 Sep 01; 322(1):1-7. PMID: 22334034.
    Citations: 48     Fields:    Translation:HumansCells
  51. Broen JC, Bossini-Castillo L, van Bon L, Vonk MC, Knaapen H, Beretta L, Rueda B, Hesselstrand R, Herrick A, Worthington J, Hunzelman N, Denton CP, Fonseca C, Riemekasten G, Kiener HP, Scorza R, Simeón CP, Ortego-Centeno N, Gonzalez-Gay MA, Airò P, Coenen MJ, Martín J, Radstake TR. A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators. Arthritis Rheum. 2012 Jan; 64(1):264-71. PMID: 21905008.
    Citations: 23     Fields:    Translation:HumansCells
  52. McCann CK, Growdon WB, Kulkarni-Datar K, Curley MD, Friel AM, Proctor JL, Sheikh H, Deyneko I, Ferguson JA, Vathipadiekal V, Birrer MJ, Borger DR, Mohapatra G, Zukerberg LR, Foster R, Macdougall JR, Rueda BR. Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model. PLoS One. 2011; 6(11):e28077. PMID: 22140510.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  53. Gillet JP, Calcagno AM, Varma S, Marino M, Green LJ, Vora MI, Patel C, Orina JN, Eliseeva TA, Singal V, Padmanabhan R, Davidson B, Ganapathi R, Sood AK, Rueda BR, Ambudkar SV, Gottesman MM. Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18708-13. PMID: 22068913.
    Citations: 96     Fields:    Translation:HumansCells
  54. Sabatini ME, Guo L, Lynch MP, Doyle JO, Lee H, Rueda BR, Styer AK. Metformin therapy in a hyperandrogenic anovulatory mutant murine model with polycystic ovarian syndrome characteristics improves oocyte maturity during superovulation. J Ovarian Res. 2011 May 23; 4(1):8. PMID: 21605417.
    Citations: 5     Fields:    
  55. Konstantinopoulos PA, Cannistra SA, Fountzilas H, Culhane A, Pillay K, Rueda B, Cramer D, Seiden M, Birrer M, Coukos G, Zhang L, Quackenbush J, Spentzos D. Integrated analysis of multiple microarray datasets identifies a reproducible survival predictor in ovarian cancer. PLoS One. 2011 Mar 29; 6(3):e18202. PMID: 21479231.
    Citations: 13     Fields:    Translation:HumansCells
  56. Curley MD, Garrett LA, Schorge JO, Foster R, Rueda BR. Evidence for cancer stem cells contributing to the pathogenesis of ovarian cancer. Front Biosci (Landmark Ed). 2011 Jan 01; 16:368-92. PMID: 21196176.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  57. Groeneweg JW, White YA, Kokel D, Peterson RT, Zukerberg LR, Berin I, Rueda BR, Wood AW. cables1 is required for embryonic neural development: molecular, cellular, and behavioral evidence from the zebrafish. Mol Reprod Dev. 2011 Jan; 78(1):22-32. PMID: 21268180.
    Citations: 1     Fields:    Translation:Animals
  58. Growdon WB, Roussel BN, Scialabba VL, Foster R, Dias-Santagata D, Iafrate AJ, Ellisen LW, Tambouret RH, Rueda BR, Borger DR. Tissue-specific signatures of activating PIK3CA and RAS mutations in carcinosarcomas of gynecologic origin. Gynecol Oncol. 2011 Apr; 121(1):212-7. PMID: 21168197.
    Citations: 8     Fields:    Translation:Humans
  59. Friel AM, Zhang L, Curley MD, Therrien VA, Sergent PA, Belden SE, Borger DR, Mohapatra G, Zukerberg LR, Foster R, Rueda BR. Epigenetic regulation of CD133 and tumorigenicity of CD133 positive and negative endometrial cancer cells. Reprod Biol Endocrinol. 2010 Dec 01; 8:147. PMID: 21122138.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  60. Sullivan BT, Cherry JA, Sakamoto H, Henkes LE, Townson DH, Rueda BR. Cytokeratin 18 expression inhibits cytokine-induced death of cervical cancer cells. Int J Gynecol Cancer. 2010 Dec; 20(9):1474-81. PMID: 21119362.
    Citations: 6     Fields:    Translation:HumansCells
  61. Cramer DW, Vitonis AF, Welch WR, Terry KL, Goodman A, Rueda BR, Berkowitz RS. Correlates of the preoperative level of CA125 at presentation of ovarian cancer. Gynecol Oncol. 2010 Dec; 119(3):462-8. PMID: 20850174.
    Citations: 9     Fields:    Translation:Humans
  62. Ibrahim N, He L, Leong CO, Xing D, Karlan BY, Swisher EM, Rueda BR, Orsulic S, Ellisen LW. BRCA1-associated epigenetic regulation of p73 mediates an effector pathway for chemosensitivity in ovarian carcinoma. Cancer Res. 2010 Sep 15; 70(18):7155-65. PMID: 20807817.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  63. Wang N, Guo L, Rueda BR, Tilly JL. Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress. EMBO Rep. 2010 Aug; 11(8):633-9. PMID: 20559324.
    Citations: 7     Fields:    Translation:AnimalsCells
  64. Friel AM, Growdon WB, McCann CK, Olawaiye AB, Munro EG, Schorge JO, Castrillon DH, Broaddus RR, Rueda BR. Mouse models of uterine corpus tumors: clinical significance and utility. Front Biosci (Elite Ed). 2010 Jun 01; 2:882-905. PMID: 20515761.
    Citations: 8     Fields:    Translation:Animals
  65. Rueda BR, Tilly JL, Schorge JO. Surgical debulking before or after chemotherapy: stemming the tide on ovarian cancer recurrence. Onkologie. 2010; 33(6):286-7. PMID: 20523089.
    Citations:    Fields:    Translation:Humans
  66. Arvisais E, Hou X, Wyatt TA, Shirasuna K, Bollwein H, Miyamoto A, Hansen TR, Rueda BR, Davis JS. Prostaglandin F2alpha represses IGF-I-stimulated IRS1/phosphatidylinositol-3-kinase/AKT signaling in the corpus luteum: role of ERK and P70 ribosomal S6 kinase. Mol Endocrinol. 2010 Mar; 24(3):632-43. PMID: 20160123.
    Citations: 9     Fields:    Translation:AnimalsCells
  67. Curley MD, Therrien VA, Cummings CL, Sergent PA, Koulouris CR, Friel AM, Roberts DJ, Seiden MV, Scadden DT, Rueda BR, Foster R. CD133 expression defines a tumor initiating cell population in primary human ovarian cancer. Stem Cells. 2009 Dec; 27(12):2875-83. PMID: 19816957.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  68. Lee HJ, Elmoazzen H, Wright D, Biggers J, Rueda BR, Heo YS, Toner M, Toth TL. Ultra-rapid vitrification of mouse oocytes in low cryoprotectant concentrations. Reprod Biomed Online. 2010 Feb; 20(2):201-8. PMID: 20113958.
    Citations: 10     Fields:    Translation:AnimalsCells
  69. Hubbard SA, Friel AM, Kumar B, Zhang L, Rueda BR, Gargett CE. Evidence for cancer stem cells in human endometrial carcinoma. Cancer Res. 2009 Nov 01; 69(21):8241-8. PMID: 19843861.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  70. Rene Gonzalez R, Watters A, Xu Y, Singh UP, Mann DR, Rueda BR, Penichet ML. Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer. Breast Cancer Res. 2009; 11(3):R36. PMID: 19531256.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  71. Tanwar PS, Lee HJ, Zhang L, Zukerberg LR, Taketo MM, Rueda BR, Teixeira JM. Constitutive activation of Beta-catenin in uterine stroma and smooth muscle leads to the development of mesenchymal tumors in mice. Biol Reprod. 2009 Sep; 81(3):545-52. PMID: 19403928.
    Citations: 40     Fields:    Translation:AnimalsCells
  72. Munro EG, Jain M, Oliva E, Kamal N, Lele SM, Lynch MP, Guo L, Fu K, Sharma P, Remmenga S, Growdon WB, Davis JS, Rueda BR, Batra SK. Upregulation of MUC4 in cervical squamous cell carcinoma: pathologic significance. Int J Gynecol Pathol. 2009 Mar; 28(2):127-33. PMID: 19188823.
    Citations: 9     Fields:    Translation:HumansCells
  73. Imamura T, Kikuchi H, Herraiz MT, Park DY, Mizukami Y, Mino-Kenduson M, Lynch MP, Rueda BR, Benita Y, Xavier RJ, Chung DC. HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer. 2009 Feb 15; 124(4):763-71. PMID: 19030186.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  74. Carino C, Olawaiye AB, Cherfils S, Serikawa T, Lynch MP, Rueda BR, Gonzalez RR. Leptin regulation of proangiogenic molecules in benign and cancerous endometrial cells. Int J Cancer. 2008 Dec 15; 123(12):2782-90. PMID: 18798554.
    Citations: 31     Fields:    Translation:HumansCells
  75. Growdon WB, Boisvert SL, Akhavanfard S, Oliva E, Dias-Santagata DC, Kojiro S, Horowitz NS, Iafrate AJ, Borger DR, Rueda BR. Decreased survival in EGFR gene amplified vulvar carcinoma. Gynecol Oncol. 2008 Nov; 111(2):289-97. PMID: 18768215.
    Citations: 11     Fields:    Translation:HumansCells
  76. Tilly JL, Niikura Y, Rueda BR. The current status of evidence for and against postnatal oogenesis in mammals: a case of ovarian optimism versus pessimism? Biol Reprod. 2009 Jan; 80(1):2-12. PMID: 18753611.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  77. Olawaiye AB, Rauh-Hain JA, Withiam-Leitch M, Rueda B, Goodman A, del Carmen MG. Utility of pre-operative serum CA-125 in the management of uterine papillary serous carcinoma. Gynecol Oncol. 2008 Sep; 110(3):293-8. PMID: 18644620.
    Citations: 4     Fields:    Translation:Humans
  78. Tilly JL, Rueda BR. Minireview: stem cell contribution to ovarian development, function, and disease. Endocrinology. 2008 Sep; 149(9):4307-11. PMID: 18556344.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  79. Henkes LE, Sullivan BT, Lynch MP, Kolesnick R, Arsenault D, Puder M, Davis JS, Rueda BR. Acid sphingomyelinase involvement in tumor necrosis factor alpha-regulated vascular and steroid disruption during luteolysis in vivo. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7670-5. PMID: 18505843.
    Citations: 11     Fields:    Translation:Animals
  80. Cherry JA, Hou X, Rueda BR, Davis JS, Townson DH. Microvascular endothelial cells of the bovine corpus luteum: a comparative examination of the estrous cycle and pregnancy. J Reprod Dev. 2008 Jun; 54(3):183-91. PMID: 18296866.
    Citations: 1     Fields:    Translation:AnimalsCells
  81. Sakamoto H, Friel AM, Wood AW, Guo L, Ilic A, Seiden MV, Chung DC, Lynch MP, Serikawa T, Munro E, Oliva E, Orsulic S, Kirley SD, Foster R, Zukerberg LR, Rueda BR. Mechanisms of Cables 1 gene inactivation in human ovarian cancer development. Cancer Biol Ther. 2008 Feb; 7(2):180-88. PMID: 18059193.
    Citations: 8     Fields:    Translation:HumansCells
  82. Park DY, Sakamoto H, Kirley SD, Ogino S, Kawasaki T, Kwon E, Mino-Kenudson M, Lauwers GY, Chung DC, Rueda BR, Zukerberg LR. The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer. Am J Pathol. 2007 Nov; 171(5):1509-19. PMID: 17982127.
    Citations: 12     Fields:    Translation:HumansCells
  83. Styer AK, Sullivan BT, Puder M, Arsenault D, Petrozza JC, Serikawa T, Chang S, Hasan T, Gonzalez RR, Rueda BR. Ablation of leptin signaling disrupts the establishment, development, and maintenance of endometriosis-like lesions in a murine model. Endocrinology. 2008 Feb; 149(2):506-14. PMID: 17962343.
    Citations: 20     Fields:    Translation:AnimalsCells
  84. Friel AM, Sergent PA, Patnaude C, Szotek PP, Oliva E, Scadden DT, Seiden MV, Foster R, Rueda BR. Functional analyses of the cancer stem cell-like properties of human endometrial tumor initiating cells. Cell Cycle. 2008 Jan 15; 7(2):242-9. PMID: 18256549.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  85. Hou X, Arvisais EW, Jiang C, Chen DB, Roy SK, Pate JL, Hansen TR, Rueda BR, Davis JS. Prostaglandin F2alpha stimulates the expression and secretion of transforming growth factor B1 via induction of the early growth response 1 gene (EGR1) in the bovine corpus luteum. Mol Endocrinol. 2008 Feb; 22(2):403-14. PMID: 17916653.
    Citations: 13     Fields:    Translation:AnimalsCells
  86. Lee HJ, Sakamoto H, Luo H, Skaznik-Wikiel ME, Friel AM, Niikura T, Tilly JC, Niikura Y, Klein R, Styer AK, Zukerberg LR, Tilly JL, Rueda BR. Loss of CABLES1, a cyclin-dependent kinase-interacting protein that inhibits cell cycle progression, results in germline expansion at the expense of oocyte quality in adult female mice. Cell Cycle. 2007 Nov 01; 6(21):2678-84. PMID: 17912041.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  87. Gonzalez-Gay MA, Rueda B, Vilchez JR, Lopez-Nevot MA, Robledo G, Ruiz MP, Fernández O, Garcia-Porrua C, Gonzalez-Escribano MF, Martín J. Contribution of MHC class I region to genetic susceptibility for giant cell arteritis. Rheumatology (Oxford). 2007 Mar; 46(3):431-4. PMID: 17003171.
    Citations: 11     Fields:    Translation:HumansCells
  88. Gonzalez RR, Cherfils S, Escobar M, Yoo JH, Carino C, Styer AK, Sullivan BT, Sakamoto H, Olawaiye A, Serikawa T, Lynch MP, Rueda BR. Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2). J Biol Chem. 2006 Sep 08; 281(36):26320-8. PMID: 16825198.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  89. Olawaiye AB, Sakamoto H, Serikawa T, Friel A, Kiyama R, Inoue A, Drapkin R, Foster R, Gonzalez RR, Rueda BR. Defining the mechanisms by which leptin stimulates proliferation of ovarian cancer cells. J Clin Oncol. 2006 Jun 20; 24(18_suppl):15017. PMID: 27954731.
    Citations:    
  90. Mizukami Y, Jo WS, Duerr EM, Gala M, Li J, Zhang X, Zimmer MA, Iliopoulos O, Zukerberg LR, Kohgo Y, Lynch MP, Rueda BR, Chung DC. Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells. Nat Med. 2005 Sep; 11(9):992-7. PMID: 16127434.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  91. Kirley SD, Rueda BR, Chung DC, Zukerberg LR. Increased growth rate, delayed senescense and decreased serum dependence characterize cables-deficient cells. Cancer Biol Ther. 2005 Jun; 4(6):654-8. PMID: 15908791.
    Citations: 7     Fields:    Translation:AnimalsCells
  92. Liptak AR, Sullivan BT, Henkes LE, Wijayagunawardane MP, Miyamoto A, Davis JS, Rueda BR, Townson DH. Cooperative expression of monocyte chemoattractant protein 1 within the bovine corpus luteum: evidence of immune cell-endothelial cell interactions in a coculture system. Biol Reprod. 2005 May; 72(5):1169-76. PMID: 15659710.
    Citations: 7     Fields:    Translation:AnimalsCells
  93. DeBernardo RL, Littell RD, Luo H, Duska LR, Oliva E, Kirley SD, Lynch MP, Zukerberg LR, Rueda BR. Defining the extent of cables loss in endometrial cancer subtypes and its effectiveness as an inhibitor of cell proliferation in malignant endometrial cells in vitro and in vivo. Cancer Biol Ther. 2005 Jan; 4(1):103-7. PMID: 15662117.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  94. Renaud EJ, MacLaughlin DT, Oliva E, Rueda BR, Donahoe PK. Endometrial cancer is a receptor-mediated target for Mullerian Inhibiting Substance. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):111-6. PMID: 15618407.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  95. Ramos MP, Rueda BR, Leavis PC, Gonzalez RR. Leptin serves as an upstream activator of an obligatory signaling cascade in the embryo-implantation process. Endocrinology. 2005 Feb; 146(2):694-701. PMID: 15539553.
    Citations: 15     Fields:    Translation:AnimalsCells
  96. Moriyama T, Littell RD, Debernardo R, Oliva E, Lynch MP, Rueda BR, Duska LR. BAG-1 expression in normal and neoplastic endometrium. Gynecol Oncol. 2004 Aug; 94(2):289-95. PMID: 15297164.
    Citations: 1     Fields:    Translation:Humans
  97. Rueda B, López-Nevot MA, Ruiz MP, Ortega E, Maldonado J, López M, Martín J. CA microsatellite polymorphism of the nuclear factor kappa B1 gene in celiac disease. Eur J Immunogenet. 2004 Jun; 31(3):129-32. PMID: 15182326.
    Citations:    Fields:    Translation:HumansCells
  98. Gonzalez RR, Rueda BR, Ramos MP, Littell RD, Glasser S, Leavis PC. Leptin-induced increase in leukemia inhibitory factor and its receptor by human endometrium is partially mediated by interleukin 1 receptor signaling. Endocrinology. 2004 Aug; 145(8):3850-7. PMID: 15142989.
    Citations: 13     Fields:    Translation:HumansCells
  99. Zukerberg LR, DeBernardo RL, Kirley SD, D'Apuzzo M, Lynch MP, Littell RD, Duska LR, Boring L, Rueda BR. Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer. Cancer Res. 2004 Jan 01; 64(1):202-8. PMID: 14729625.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  100. Davis JS, Rueda BR, Spanel-Borowski K. Microvascular endothelial cells of the corpus luteum. Reprod Biol Endocrinol. 2003 Nov 10; 1:89. PMID: 14613535.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  101. Henkes LE, Davis JS, Rueda BR. Mutant mouse models and their contribution to our knowledge of corpus luteum development, function and regression. Reprod Biol Endocrinol. 2003 Nov 10; 1:87. PMID: 14613537.
    Citations: 4     Fields:    Translation:Animals
  102. Dong Q, Kirley S, Rueda B, Zhao C, Zukerberg L, Oliva E. Loss of cables, a novel gene on chromosome 18q, in ovarian cancer. Mod Pathol. 2003 Sep; 16(9):863-8. PMID: 13679449.
    Citations: 6     Fields:    Translation:HumansCells
  103. Fanzo JC, Lynch MP, Phee H, Hyer M, Cremesti A, Grassme H, Norris JS, Coggeshall KM, Rueda BR, Pernis AB, Kolesnick R, Gulbins E. CD95 rapidly clusters in cells of diverse origins. Cancer Biol Ther. 2003 Jul-Aug; 2(4):392-5. PMID: 14508111.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  104. Carambula SF, Pru JK, Lynch MP, Matikainen T, Gonçalves PB, Flavell RA, Tilly JL, Rueda BR. Prostaglandin F2alpha- and FAS-activating antibody-induced regression of the corpus luteum involves caspase-8 and is defective in caspase-3 deficient mice. Reprod Biol Endocrinol. 2003 Feb 11; 1:15. PMID: 12657159.
    Citations: 10     Fields:    Translation:AnimalsCells
  105. Pru JK, Lynch MP, Davis JS, Rueda BR. Signaling mechanisms in tumor necrosis factor alpha-induced death of microvascular endothelial cells of the corpus luteum. Reprod Biol Endocrinol. 2003 Feb 11; 1:17. PMID: 12646059.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  106. Pru JK, Hendry IR, Davis JS, Rueda BR. Soluble Fas ligand activates the sphingomyelin pathway and induces apoptosis in luteal steroidogenic cells independently of stress-activated p38(MAPK). Endocrinology. 2002 Nov; 143(11):4350-7. PMID: 12399431.
    Citations: 8     Fields:    Translation:AnimalsCells
  107. Davis JS, Rueda BR. The corpus luteum: an ovarian structure with maternal instincts and suicidal tendencies. Front Biosci. 2002 Sep 01; 7:d1949-78. PMID: 12161347.
    Citations: 34     Fields:    Translation:AnimalsCells
  108. Cavicchio VA, Pru JK, Davis BS, Davis JS, Rueda BR, Townson DH. Secretion of monocyte chemoattractant protein-1 by endothelial cells of the bovine corpus luteum: regulation by cytokines but not prostaglandin F2alpha. Endocrinology. 2002 Sep; 143(9):3582-9. PMID: 12193574.
    Citations: 13     Fields:    Translation:AnimalsCells
  109. Carambula SF, Matikainen T, Lynch MP, Flavell RA, Gonçalves PB, Tilly JL, Rueda BR. Caspase-3 is a pivotal mediator of apoptosis during regression of the ovarian corpus luteum. Endocrinology. 2002 Apr; 143(4):1495-501. PMID: 11897708.
    Citations: 18     Fields:    Translation:Animals
  110. Carambula SF, Matikainen T, Lynch MP, Flavell RA, Dias Gonc Alves PB, Tilly JL, Rueda BR. Caspase-3 Is a Pivotal Mediator of Apoptosis during Regression of the Ovarian Corpus Luteum. Endocrinology. 2002 Apr 01; 143(4):1495-1501. PMID: 28201471.
    Citations:    
  111. Duska LR, Garrett A, Rueda BR, Haas J, Chang Y, Fuller AF. Endometrial cancer in women 40 years old or younger. Gynecol Oncol. 2001 Nov; 83(2):388-93. PMID: 11606102.
    Citations: 31     Fields:    Translation:Humans
  112. Matikainen T, Perez GI, Zheng TS, Kluzak TR, Rueda BR, Flavell RA, Tilly JL. Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary. Endocrinology. 2001 Jun; 142(6):2468-80. PMID: 11356696.
    Citations: 27     Fields:    Translation:AnimalsCells
  113. Suter J, Hendry IR, Ndjountche L, Obholz K, Pru JK, Davis JS, Rueda BR. Mediators of interferon gamma-initiated signaling in bovine luteal cells. Biol Reprod. 2001 May; 64(5):1481-6. PMID: 11319155.
    Citations: 3     Fields:    Translation:AnimalsCells
  114. Pru JK, Rueda BR, Austin KJ, Thatcher WW, Guzeloglu A, Hansen TR. Interferon-tau suppresses prostaglandin F2alpha secretion independently of the mitogen-activated protein kinase and nuclear factor kappa B pathways. Biol Reprod. 2001 Mar; 64(3):965-73. PMID: 11207214.
    Citations: 2     Fields:    Translation:AnimalsCells
  115. Westfall SD, Hendry IR, Obholz KL, Rueda BR, Davis JS. Putative role of the phosphatidylinositol 3-kinase-Akt signaling pathway in the survival of granulosa cells. Endocrine. 2000 Jun; 12(3):315-21. PMID: 10963053.
    Citations: 4     Fields:    Translation:AnimalsCells
  116. Rueda BR, Hendry IR, Ndjountche L, Suter J, Davis JS. Stress-induced mitogen-activated protein kinase signaling in the corpus luteum. Mol Cell Endocrinol. 2000 Jun; 164(1-2):59-67. PMID: 11026558.
    Citations: 5     Fields:    Translation:AnimalsCells
  117. Rueda BR, Hendry IR, Hendry III WJ, Stormshak F, Slayden OD, Davis JS. Decreased progesterone levels and progesterone receptor antagonists promote apoptotic cell death in bovine luteal cells. Biol Reprod. 2000 Feb; 62(2):269-76. PMID: 10642562.
    Citations: 15     Fields:    Translation:Animals
  118. Mamluk R, Levy N, Rueda B, Davis JS, Meidan R. Characterization and regulation of type A endothelin receptor gene expression in bovine luteal cell types. Endocrinology. 1999 May; 140(5):2110-6. PMID: 10218961.
    Citations: 3     Fields:    Translation:AnimalsCells
  119. Rueda BR, Hendry IR, Tilly JL, Hamernik DL. Accumulation of caspase-3 messenger ribonucleic acid and induction of caspase activity in the ovine corpus luteum following prostaglandin F2alpha treatment in vivo. Biol Reprod. 1999 May; 60(5):1087-92. PMID: 10208968.
    Citations: 6     Fields:    Translation:HumansAnimals
  120. Hoyer PB, Marion SL, Stine I, Rueda BR, Hamernik DL, Regan JW, Wise ME. Ovine prostaglandin F2alpha receptor: steroid influence on steady-state levels of luteal mRNA. Endocrine. 1999 Apr; 10(2):105-11. PMID: 10451218.
    Citations: 1     Fields:    Translation:Animals
  121. Rueda BR, Tilly KI, Botros IW, Jolly PD, Hansen TR, Hoyer PB, Tilly JL. Increased bax and interleukin-1beta-converting enzyme messenger ribonucleic acid levels coincide with apoptosis in the bovine corpus luteum during structural regression. Biol Reprod. 1997 Jan; 56(1):186-93. PMID: 9002648.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  122. Rueda BR, Botros IW, Pierce KL, Regan JW, Hoyer PB. Comparison of mRNA levels for the PGF(2a) receptor (FP) during luteolysis and early pregnancy in the ovine corpus luteum. Endocrine. 1995 Nov; 3(11):781-7. PMID: 21153121.
    Citations: 1     Fields:    
  123. Graves PE, Pierce KL, Bailey TJ, Rueda BR, Gil DW, Woodward DF, Yool AJ, Hoyer PB, Regan JW. Cloning of a receptor for prostaglandin F2 alpha from the ovine corpus luteum. Endocrinology. 1995 Aug; 136(8):3430-6. PMID: 7628379.
    Citations: 2     Fields:    Translation:AnimalsCells
  124. Rueda BR, Tilly KI, Hansen TR, Hoyer PB, Tilly JL. Expression of superoxide dismutase, catalase and glutathione peroxidase in the bovine corpus luteum: evidence supporting a role for oxidative stress in luteolysis. Endocrine. 1995 Mar; 3(3):227-32. PMID: 21153199.
    Citations: 7     Fields:    
  125. Rueda BR, Wegner JA, Marion SL, Wahlen DD, Hoyer PB. Internucleosomal DNA fragmentation in ovine luteal tissue associated with luteolysis: in vivo and in vitro analyses. Biol Reprod. 1995 Feb; 52(2):305-12. PMID: 7711200.
    Citations: 11     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.