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Nestor Uribe-Patarroyo, Ph.D.


I am an Assistant Professor at Harvard Medical School and the Wellman Center for Photomedicine at Massachusetts General Hospital, and a faculty member of the Center for Biomedical OCT Research and Translation (CBORT, https://octresearch.org/). I am a physicist by training (Universidad del Valle, Colombia), and received my PhD in Advanced Optics (Universidad Complutense de Madrid, Spain). Before joining Wellman, I worked on optical instrumentation for space science missions and quantum optics. I am a PI with major NIH funding and also manage three sub-projects from the Department of Defense/Air Force Office of Scientific Research. My research is focused on the development of functional imaging and enhanced endogenous contrast in OCT for diagnostics and guided therapy.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EB033306 (URIBE-PATARROYO, NESTOR)) Aug 1, 2022 - Apr 30, 2026
    Intravascular microstructural, chemical and biomechanical characterization of coronary plaques
    Role Description: The most prevalent type of heart disease is caused by atherosclerosis, the thickening of the vessel wall and creation of atherosclerotic plaque. In this project, we will develop an imaging tool for the compre- hensive assessment of atherosclerotic plaque composition and vulnerability, with a clear pathway for translation into the clinical environment to enable the determination of the optimal treatment strategy in individual patients.
    Role: Principal investigator
  2. P41EB015903 (BOUMA, BRETT) Jul 1, 2022 - Mar 31, 2027
    Center for Biomedical OCT Research and Translation. TRD1: Functional Imaging
    Role Description: The proposed NCBIB will develop and provide broad access to powerful new microscopic imaging tools for biological and clinical research. These instruments will open new avenues of biomedical research and may enable the identification of new methods for diagnosis, provide new insights into disease or disease progression, or lead to the formulation of new therapeutic strategies or drug targets.
    Role: Project Co-Lead
  3. Collaborative Research Travel Grant (URIBE-PATARROYO, NESTOR) Jun 1, 2018 - Dec 31, 2019
    Burroughs Wellcome Fund
    OCT velocimetry for quantifying corneal biomechanics
    Role: Principal Investigator
  4. K25EB024595 (URIBE-PATARROYO, NESTOR) Aug 1, 2017 - May 31, 2022
    Blood flow-based guidance and diagnostics using OCT
    Role Description: Coronary artery disease (CAD) and visual disorders like diabetic retinopathy, macular degeneration and glaucoma are among the leading causes of mortality and morbidity in the US, and are diagnosed using the qualitative assessment of blood flow using invasive dye contrast techniques. This project develops a fully validated flowmetry technique to guide CAD treatment and to provide early eye disease diagnosis, with the potential to extend into a wide range of clinical applications, meeting the large demand for accurate blood flowmetry in healthcare.
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Cannon TM, Bouma BE, Uribe-Patarroyo N. Layer-based, depth-resolved computation of attenuation coefficients and backscattering fractions in tissue using optical coherence tomography. Biomed Opt Express. 2021 Aug 01; 12(8):5037-5056. PMID: 34513241; PMCID: PMC8407832.
    Citations: 1     
  2. Ruiz-Lopera S, Restrepo R, Cuartas-Vélez C, Bouma BE, Uribe-Patarroyo N. Computational adaptive optics in phase-unstable optical coherence tomography. Opt Lett. 2020 Nov 01; 45(21):5982-5985. PMID: 33137049.
    Citations: 1     Fields:    
  3. Braaf B, Donner S, Uribe-Patarroyo N, Bouma BE, Vakoc BJ. A Neural Network Approach to Quantify Blood Flow from Retinal OCT Intensity Time-Series Measurements. Sci Rep. 2020 06 15; 10(1):9611. PMID: 32541887.
    Citations: 1     Fields:    Translation:Humans
  4. Maltais-Tariant R, Boudoux C, Uribe-Patarroyo N. Real-time co-localized OCT surveillance of laser therapy using motion corrected speckle decorrelation. Biomed Opt Express. 2020 Jun 01; 11(6):2925-2950. PMID: 32637233.
    Citations: 2     
  5. Uribe-Patarroyo N, Post AL, Ruiz-Lopera S, Faber DJ, Bouma BE. Noise and bias in optical coherence tomography intensity signal decorrelation. OSA Contin. 2020 Apr 15; 3(4):709-741. PMID: 34085035.
    Citations: 1     
  6. Ferris NG, Cannon TM, Villiger M, Bouma BE, Uribe-Patarroyo N. Forward multiple scattering dominates speckle decorrelation in whole-blood flowmetry using optical coherence tomography. Biomed Opt Express. 2020 Apr 01; 11(4):1947-1966. PMID: 32341859.
    Citations: 4     
  7. Lo WCY, Uribe-Patarroyo N, Hoebel K, Beaudette K, Villiger M, Nishioka NS, Vakoc BJ, Bouma BE. Balloon catheter-based radiofrequency ablation monitoring in porcine esophagus using optical coherence tomography. Biomed Opt Express. 2019 Apr 01; 10(4):2067-2089. PMID: 31086717; PMCID: PMC6484999.
    Citations: 4     
  8. Braaf B, Gräfe MGO, Uribe-Patarroyo N, Bouma BE, Vakoc BJ, de Boer JF, Donner S, Weichsel J. OCT-Based Velocimetry for Blood Flow Quantification. High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics. 2019. View Publication.
  9. Cuartas-Vélez C, Restrepo R, Bouma BE, Uribe-Patarroyo N. Volumetric non-local-means based speckle reduction for optical coherence tomography. Biomed Opt Express. 2018 Jul 01; 9(7):3354-3372. PMID: 29984102; PMCID: PMC6033569.
    Citations: 8     
  10. Uribe-Patarroyo N, Kassani SH, Villiger M, Bouma BE. Robust wavenumber and dispersion calibration for Fourier-domain optical coherence tomography. Opt Express. 2018 Apr 02; 26(7):9081-9094. PMID: 29715866.
    Citations: 9     Fields:    
  11. Kassani SH, Villiger M, Uribe-Patarroyo N, Jun C, Khazaeinezhad R, Lippok N, Bouma BE. Extended bandwidth wavelength swept laser source for high resolution optical frequency domain imaging. Opt Express. 2017 Apr 03; 25(7):8255-8266. PMID: 28380940.
    Citations: 3     Fields:    Translation:HumansAnimals
  12. Lo WC, Uribe-Patarroyo N, Nam AS, Villiger M, Vakoc BJ, Bouma BE. Laser thermal therapy monitoring using complex differential variance in optical coherence tomography. J Biophotonics. 2017 01; 10(1):84-91. PMID: 27623742; PMCID: PMC5243231.
    Citations: 8     Fields:    Translation:Animals
  13. Uribe-Patarroyo N, Bouma BE. Velocity gradients in spatially resolved laser Doppler flowmetry and dynamic light scattering with confocal and coherence gating. Phys Rev E. 2016 Aug; 94(2-1):022604. PMID: 27627357.
    Citations: 11     Fields:    
  14. Soldevila F, Clemente P, Tajahuerce E, Uribe-Patarroyo N, Andrés P, Lancis J. Computational imaging with a balanced detector. Sci Rep. 2016 06 29; 6:29181. PMID: 27353733.
    Citations: 3     Fields:    
  15. Echeverri-Chacón S, Restrepo R, Cuartas-Vélez C, Uribe-Patarroyo N. Vortex-enhanced coherent-illumination phase diversity for phase retrieval in coherent imaging systems. Opt Lett. 2016 Apr 15; 41(8):1817-20. PMID: 27082353.
    Citations:    Fields:    
  16. Uribe-Patarroyo N, Bouma BE. Rotational distortion correction in endoscopic optical coherence tomography based on speckle decorrelation. Opt Lett. 2015 Dec 01; 40(23):5518-21. PMID: 26625040.
    Citations: 22     Fields:    
  17. Uribe-Patarroyo N, Villiger M, Bouma BE. Quantitative technique for robust and noise-tolerant speed measurements based on speckle decorrelation in optical coherence tomography. Opt Express. 2014 Oct 06; 22(20):24411-29. PMID: 25322018.
    Citations: 20     Fields:    
  18. Baac HW, Uribe-Patarroyo N, Bouma BE. High-energy pulsed Raman fiber laser for biological tissue coagulation. Opt Express. 2014 Mar 24; 22(6):7113-23. PMID: 24664059.
    Citations: 3     Fields:    Translation:Animals
  19. Uribe-Patarroyo N, Fraine A, Simon DS, Minaeva O, Sergienko AV. Object identification using correlated orbital angular momentum states. Phys Rev Lett. 2013 Jan 25; 110(4):043601. PMID: 25166163.
    Citations: 9     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.