Amy O'Connell, M.D.,Ph.D.
Assistant Professor of Pediatrics
Boston Children's Hospital
300 Longwood Ave
Boston MA 02115
|Merrimack College, North Andover, MA||B.S.||2002||Biochemistry|
|Jefferson Medical College/Thomas Jefferson University, Philadelphia, PA||M.D./Ph.D.||2009||Immunology|
|University of Vermont, Burlington, VT||Residency||2012||Pediatrics|
|Boston Children's Hospital, Boston, MA||Fellowship||2014||Allergy/Immunology|
|Boston Children's Hospital, Boston, MA||Fellowship||2017||Neonatology|
Dr. O'Connell has a history of research in immunology and the molecular characterization of oprhan diseases. Her current projects include:
1. Determining the importance of Wnt2b for intestinal health
2. Examining the role of cellular and molecular developmental changes of the intestine in susceptibility to necrotizing enterocolitis.
3. Assessing whether immune receptor repertoire analysis can improve immunodeficiency screening in premature infants.
Available: 10/15/20, Expires: 06/30/21
This project could be 4mos-1yr depending on the needs of the student. My lab is investigating early intestinal development, and we think that fluctuations in the level of Wnt2b-secreting intestinal cells may correlate with the development of the deadly intestinal disease necrotizing enterocolitis (NEC) in premature babies. No prior wet lab experience is necessary, but willingness to work with mouse models is preferred. The project can be somewhat tailored to the student but would involve either cell culture or models of intestinal injury in young mice.
Available: 03/01/21, Expires: 06/30/21
This project involves using bioinformatics approaches to process T cell receptor repertoire sequencing data from premature infants and control neonates. We are looking at two questions with this dataset: 1. whether a subset of extremely premature infants develops abnormal T cell diversity and 2. whether T cell receptor repertoire sequencing can be used to improve newborn screening for severe combined immunodeficiency (SCID).
Interested students could spend 3 months on this project. Previous knowledge of programming in R is required. Good potential for a first author publication.
The research activities and funding listed below are automatically derived from
NIH ExPORTER and other sources, which might result in incorrect or missing items.
to make corrections and additions.
Jul 1, 2020 - Jun 30, 2022
Manton Center for Orphan Disease Research Innovation Fund
Primary and Secondary Immunodeficiency Disorders in Extremely Premature Infants
Role Description: Assessing a test to increase specificity of SCID newborn screening in extremely premature infants and characterizing a novel immune disorder in premature infants.
Jul 1, 2020 - Jun 30, 2022
Boston Children's Hospital Office of Faculty Development
Wnt2b in Susceptibility to Necrotizing Enterocolitis (NEC)
Role Description: Examining whether Wnt2b-producing telocytes are protective against NEC
Jan 11, 2020 - Dec 31, 2024
The Role of Wnt2b in Small Intestinal Health
Role Description: Determining why Wnt2b is required for human intestinal health.
Oct 1, 2017 - Sep 30, 2019
Wnt2b in Intestinal Homeostasis
Role Description: The goal of this project is to clarify the requirement for Wnt2b in intestinal homeostasis in humans. We hypothesize that absence of Wnt2b leads to decreased transcription of beta-catenin target genes, resulting in a diminished crypt-based columnar intestinal stem cell (CBC iSC) pool and inflammatory dysregulation.
Role: Primary Investigator
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