Amy O'Connell, M.D.,Ph.D.
Assistant Professor of Pediatrics
Boston Children's Hospital
300 Longwood Ave
Boston MA 02115
|Merrimack College, North Andover, MA||B.S.||2002||Biochemistry|
|Jefferson Medical College/Thomas Jefferson University, Philadelphia, PA||M.D./Ph.D.||2009||Immunology|
|University of Vermont, Burlington, VT||Residency||2012||Pediatrics|
|Boston Children's Hospital, Boston, MA||Fellowship||2014||Allergy/Immunology|
|Boston Children's Hospital, Boston, MA||Fellowship||2017||Neonatology|
Dr. O'Connell has a history of research in immunology and the molecular characterization of oprhan diseases. Her current projects include:
1. Determining the importance of Wnt2b for intestinal health
2. Examining the role of cellular and molecular developmental changes of the intestine in susceptibility to necrotizing enterocolitis.
3. Assessing whether immune receptor repertoire analysis can improve immunodeficiency screening in premature infants.
Available: 01/10/22, Expires: 03/01/24
Our lab studies intestinal and immune development with a focus on premature infants. We have also characterized several novel genetic diseases and use these to help understand normal development. Current projects in the lab include: 1. Understanding how loss of Wnt2b causes decreased intestinal stem cells. 2. Developing an organoid model for necrotizing enterocolitis (NEC), a deadly intestinal disease in premature infants. 3. Developing a novel organoid system to model tissue resident immune cells in the intestine. 4. Characterizing additional novel orphan diseases, particularly those affecting the immune system and/or intestine. 5. Studying developmental changes that make a premature baby susceptible to NEC.
Available: 12/01/22, Expires: 12/31/23
Our lab is becoming more interested in clinical usefulness of intravenous immunoglobulin (IVIG) for a variety of autoimmune conditions. IVIG is used in the neonatal intensive care unit (NICU) for autoimmune hemolytic disease, neonatal thrombocytopenia, and other situations, however, its mechanism of action is not well understood. In this first step project we would like review clinical cases where IVIG was used in the Harvard Longwood area NICUs in order to get a better sense of case numbers to plan for a prospective clinical trial. This project is very doable for a student project in a reasonable time frame.
The research activities and funding listed below are automatically derived from
NIH ExPORTER and other sources, which might result in incorrect or missing items.
to make corrections and additions.
Jul 1, 2022 - Jun 20, 2024
Harvard Digestive Disease Center
Examining the role of canonical Wnts in NEC
Role Description: Pilot & Feasibility Award
Jul 1, 2020 - Jun 30, 2022
Boston Children's Hospital Office of Faculty Development
Wnt2b in Susceptibility to Necrotizing Enterocolitis (NEC)
Role Description: Examining whether Wnt2b-producing telocytes are protective against NEC
Jul 1, 2020 - Jun 30, 2022
Manton Center for Orphan Disease Research Innovation Fund
Primary and Secondary Immunodeficiency Disorders in Extremely Premature Infants
Role Description: Assessing a test to increase specificity of SCID newborn screening in extremely premature infants and characterizing a novel immune disorder in premature infants.
Jan 11, 2020 - Dec 31, 2024
The Role of Wnt2b in Small Intestinal Health
Role Description: Determining why Wnt2b is required for human intestinal health.
Mar 1, 2019 - Feb 28, 2023
MSC Exosome Treatment for BPD: Impact on Immunity and Lung Development
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