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Last Name

profileDeborah Jane Wexler, M.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
AddressMassachusetts General Hospital
Medicine, GRB 740
55 Fruit St
Boston MA 02114
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R18DK102737     (WEXLER, DEBORAH J)Sep 15, 2014 - Jul 31, 2019
REAL HEALTH-Diabetes: REach Ahead for Lifestyle and Health-Diabetes
Role: Co-Principal Investigator

R03DK090196     (WEXLER, DEBORAH J)Jul 1, 2011 - Jun 30, 2013
Identifying Effective Treatment Strategies for Older Adults with Diabetes
Role: Principal Investigator

K23DK080228     (WEXLER, DEBORAH J)Sep 20, 2007 - Nov 30, 2012
Effective Inpatient Diabetes Management and the Transition to Outpatient Care
Role: Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Berkowitz SA, Karter AJ, Corbie-Smith G, Seligman HK, Ackroyd SA, Barnard LS, Atlas SJ, Wexler DJ. Food Insecurity, Food "Deserts," and Glycemic Control in Patients With Diabetes: A Longitudinal Analysis. Diabetes Care. 2018 Mar 19. PMID: 29555650.
    View in: PubMed
  2. Berkowitz SA, Eisenstat SA, Barnard LS, Wexler DJ. Multidisciplinary coordinated care for Type 2 diabetes: A qualitative analysis of patient perspectives. Prim Care Diabetes. 2018 Jan 31. PMID: 29397351.
    View in: PubMed
  3. Basu S, Raghavan S, Wexler DJ, Berkowitz SA. Characteristics Associated With Decreased or Increased Mortality Risk From Glycemic Therapy Among Patients With Type 2 Diabetes and High Cardiovascular Risk: Machine Learning Analysis of the ACCORD Trial. Diabetes Care. 2018 Mar; 41(3):604-612. PMID: 29279299.
    View in: PubMed
  4. Carter J, Ward C, Wexler D, Donelan K. The association between patient experience factors and likelihood of 30-day readmission: a prospective cohort study. BMJ Qual Saf. 2017 Nov 16. PMID: 29146680.
    View in: PubMed
  5. Berkowitz SA, Berkowitz TSZ, Meigs JB, Wexler DJ. Trends in food insecurity for adults with cardiometabolic disease in the United States: 2005-2012. PLoS One. 2017; 12(6):e0179172. PMID: 28591225.
    View in: PubMed
  6. Safren SA, Gonzalez JS, Wexler DJ, Psaros C, Delahanty LM, Blashill AJ, Margolina AI, Cagliero E. Erratum. A Randomized Controlled Trial of Cognitive Behavioral Therapy for Adherence and Depression (CBT-AD) in Patients With Uncontrolled Type 2 Diabetes. Diabetes Care 2014;37:625-633. Diabetes Care. 2016 06; 39(6):1065. PMID: 27222555.
    View in: PubMed
  7. Herman WH, Kalyani RR, Wexler DJ, Matthews DR, Inzucchi SE. Response to Comment on American Diabetes Association. Approaches to Glycemic Treatment. Sec. 7. In Standards of Medical Care in Diabetes-2016. Diabetes Care 2016;39(Suppl. 1):S52-S59. Diabetes Care. 2016 06; 39(6):e88-9. PMID: 27222560.
    View in: PubMed
  8. Eisenstat SA, Chang Y, Porneala BC, Geagan E, Wilkins G, Chase B, O'Keefe SM, Delahanty LM, Atlas SJ, Zai AH, Finn D, Weil E, Wexler DJ. Development and Implementation of a Collaborative Team Care Model for Effective Insulin Use in an Academic Medical Center Primary Care Network. Am J Med Qual. 2017 Jul/Aug; 32(4):397-405. PMID: 27259871.
    View in: PubMed
  9. DuBois CM, Millstein RA, Celano CM, Wexler DJ, Huffman JC. Feasibility and Acceptability of a Positive Psychological Intervention for Patients With Type 2 Diabetes. Prim Care Companion CNS Disord. 2016; 18(3). PMID: 27733954.
    View in: PubMed
  10. Leong A, Berkowitz SA, Triant VA, Porneala B, He W, Atlas SJ, Wexler DJ, Meigs JB. Hypoglycemia in Diabetes Mellitus as a Coronary Artery Disease Risk Factor in Patients at Elevated Vascular Risk. J Clin Endocrinol Metab. 2016 Feb; 101(2):659-68. PMID: 26672635; PMCID: PMC4880119 [Available on 02/01/17].
  11. Basnet KM, Bentley-Lewis R, Wexler DJ, Kilic F, Roberts DJ. Prevalence of Intervillous Thrombi Is Increased in Placentas from Pregnancies Complicated by Diabetes. Pediatr Dev Pathol. 2016 Nov/Dec; 19(6):502-505. PMID: 26669929.
    View in: PubMed
  12. Huynh J, Yamada J, Beauharnais C, Wenger JB, Thadhani RI, Wexler D, Roberts DJ, Bentley-Lewis R. Type 1, type 2 and gestational diabetes mellitus differentially impact placental pathologic characteristics of uteroplacental malperfusion. Placenta. 2015 Oct; 36(10):1161-6. PMID: 26303757; PMCID: PMC4609602 [Available on 10/01/16].
  13. Delahanty LM, Dalton KM, Porneala B, Chang Y, Goldman VM, Levy D, Nathan DM, Wexler DJ. Improving diabetes outcomes through lifestyle change--A randomized controlled trial. Obesity (Silver Spring). 2015 Sep; 23(9):1792-9. PMID: 26260043.
    View in: PubMed
  14. Huffman JC, DuBois CM, Millstein RA, Celano CM, Wexler D. Positive Psychological Interventions for Patients with Type 2 Diabetes: Rationale, Theoretical Model, and Intervention Development. J Diabetes Res. 2015; 2015:428349. PMID: 26064980; PMCID: PMC4442018.
  15. Walford GA, Colomo N, Todd JN, Billings LK, Fernandez M, Chamarthi B, Warner AS, Davis J, Littleton KR, Hernandez AM, Fanelli RR, Lanier A, Barbato C, Ackerman RJ, Khan SQ, Bui R, Garber L, Stolerman ES, Moore AF, Huang C, Kaur V, Harden M, Taylor A, Chen L, Manning AK, Huang P, Wexler D, McCarthy RM, Lo J, Thomas MK, Grant RW, Goldfine A, Hudson MS, Florez JC. The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for type 2 diabetes. PLoS One. 2015; 10(3):e0121553. PMID: 25812009; PMCID: PMC4374872.
  16. Berkowitz SA, Meigs JB, DeWalt D, Seligman HK, Barnard LS, Bright OJ, Schow M, Atlas SJ, Wexler DJ. Material need insecurities, control of diabetes mellitus, and use of health care resources: results of the Measuring Economic Insecurity in Diabetes study. JAMA Intern Med. 2015 Feb; 175(2):257-65. PMID: 25545780; PMCID: PMC4484589.
  17. Barnard LS, Wexler DJ, DeWalt D, Berkowitz SA. Material need support interventions for diabetes prevention and control: a systematic review. Curr Diab Rep. 2015 Feb; 15(2):574. PMID: 25620406.
    View in: PubMed
  18. Wei NJ, Nathan DM, Wexler DJ. Glycemic control after hospital discharge in insulin-treated type 2 diabetes: a randomized pilot study of daily remote glucose monitoring. Endocr Pract. 2015 Feb; 21(2):115-21. PMID: 25148814; PMCID: PMC4670560.
  19. Grant RW, Huang ES, Wexler DJ, Laiteerapong N, Warton ME, Moffet HH, Karter AJ. Patients who self-monitor blood glucose and their unused testing results. Am J Manag Care. 2015 Feb 01; 21(2):e119-29. PMID: 25880487; PMCID: PMC4430190.
  20. Berkowitz SA, Atlas SJ, Grant RW, Wexler DJ. Individualizing HbA1c targets for patients with diabetes: impact of an automated algorithm within a primary care network. Diabet Med. 2014 Jul; 31(7):839-46. PMID: 24606323; PMCID: PMC4425735.
  21. Ackroyd SA, Wexler DJ. Effectiveness of diabetes interventions in the patient-centered medical home. Curr Diab Rep. 2014 Mar; 14(3):471. PMID: 24477830; PMCID: PMC3958937.
  22. Lim S, Kim KM, Kim MJ, Woo SJ, Choi SH, Park KS, Jang HC, Meigs JB, Wexler DJ. The association of maximum body weight on the development of type 2 diabetes and microvascular complications: MAXWEL study. PLoS One. 2013; 8(12):e80525. PMID: 24324607; PMCID: PMC3851456.
  23. Celano CM, Beale EE, Moore SV, Wexler DJ, Huffman JC. Positive psychological characteristics in diabetes: a review. Curr Diab Rep. 2013 Dec; 13(6):917-29. PMID: 24048687.
    View in: PubMed
  24. Safren SA, Gonzalez JS, Wexler DJ, Psaros C, Delahanty LM, Blashill AJ, Margolina AI, Cagliero E. A randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) in patients with uncontrolled type 2 diabetes. Diabetes Care. 2014; 37(3):625-33. PMID: 24170758; PMCID: PMC3931377.
  25. Berkowitz SA, Meigs JB, Wexler DJ. Age at type 2 diabetes onset and glycaemic control: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2010. Diabetologia. 2013 Dec; 56(12):2593-600. PMID: 23995472; PMCID: PMC3818392.
  26. Faje AT, Nachtigall L, Wexler D, Miller KK, Klibanski A, Makimura H. Central diabetes insipidus: a previously unreported side effect of temozolomide. J Clin Endocrinol Metab. 2013 Oct; 98(10):3926-31. PMID: 23928668; PMCID: PMC3790614.
  27. Draznin B, Gilden J, Golden SH, Inzucchi SE, Baldwin D, Bode BW, Boord JB, Braithwaite SS, Cagliero E, Dungan KM, Falciglia M, Figaro MK, Hirsch IB, Klonoff D, Korytkowski MT, Kosiborod M, Lien LF, Magee MF, Masharani U, Maynard G, McDonnell ME, Moghissi ES, Rasouli N, Rubin DJ, Rushakoff RJ, Sadhu AR, Schwartz S, Seley JJ, Umpierrez GE, Vigersky RA, Low CC, Wexler DJ. Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action. Diabetes Care. 2013 Jul; 36(7):1807-14. PMID: 23801791; PMCID: PMC3687296.
  28. Berkowitz SA, Baggett TP, Wexler DJ, Huskey KW, Wee CC. Food insecurity and metabolic control among U.S. adults with diabetes. Diabetes Care. 2013 Oct; 36(10):3093-9. PMID: 23757436; PMCID: PMC3781549.
  29. Nathan DM, Buse JB, Kahn SE, Krause-Steinrauf H, Larkin ME, Staten M, Wexler D, Lachin JM. Rationale and design of the glycemia reduction approaches in diabetes: a comparative effectiveness study (GRADE). Diabetes Care. 2013 Aug; 36(8):2254-61. PMID: 23690531; PMCID: PMC3714493.
  30. Carper MM, Traeger L, Gonzalez JS, Wexler DJ, Psaros C, Safren SA. The differential associations of depression and diabetes distress with quality of life domains in type 2 diabetes. J Behav Med. 2014 Jun; 37(3):501-10. PMID: 23515932; PMCID: PMC3758402.
  31. Wei NJ, Wexler DJ, Nathan DM, Grant RW. Intensification of diabetes medication and risk for 30-day readmission. Diabet Med. 2013 Feb; 30(2):e56-62. PMID: 23126686; PMCID: PMC3552066.
  32. Gonzalez JS, Schneider HE, Wexler DJ, Psaros C, Delahanty LM, Cagliero E, Safren SA. Validity of medication adherence self-reports in adults with type 2 diabetes. Diabetes Care. 2013 Apr; 36(4):831-7. PMID: 23204245; PMCID: PMC3609536.
  33. Grant RW, Wexler DJ. Lower blood pressure associated with higher mortality in retrospective study of patients with newly diagnosed type 2 diabetes. Evid Based Med. 2013 Aug; 18(4):e35. PMID: 23173154.
    View in: PubMed
  34. Wei NJ, Wexler DJ. Perioperative Glucose Management. Hosp Med Clin. 2012 Oct 01; 1(4):e508-e519. PMID: 23275895.
    View in: PubMed
  35. Wexler DJ, Beauharnais CC, Regan S, Nathan DM, Cagliero E, Larkin ME. Impact of inpatient diabetes management, education, and improved discharge transition on glycemic control 12 months after discharge. Diabetes Res Clin Pract. 2012 Nov; 98(2):249-56. PMID: 23036785; PMCID: PMC3514591.
  36. Wei NJ, Grant RW, Nathan DM, Wexler DJ. Effect of hospital admission on glycemic control 1 year after discharge. Endocr Pract. 2012 Jul-Aug; 18(4):456-63. PMID: 22805110; PMCID: PMC3746561.
  37. Grant RW, Wexler DJ, Ashburner JM, Hong CS, Atlas SJ. Characteristics of "complex" patients with type 2 diabetes mellitus according to their primary care physicians. Arch Intern Med. 2012 May 28; 172(10):821-3. PMID: 22636827.
    View in: PubMed
  38. Wexler DJ, Porneala B, Chang Y, Huang ES, Huffman JC, Grant RW. Diabetes differentially affects depression and self-rated health by age in the U.S. Diabetes Care. 2012 Jul; 35(7):1575-7. PMID: 22611066; PMCID: PMC3379579.
  39. Wexler DJ, Lee TH. Taking AIM at a moving target: the challenge of improving on high-performance care. Circulation. 2012 Jun 12; 125(23):2812-4. PMID: 22570369.
    View in: PubMed
  40. Grant RW, Wexler DJ. Personalized medicine in Type 2 diabetes: what does the future hold? Diabetes Manag (Lond). 2012 May; 2(3):199-204. PMID: 23814613.
    View in: PubMed
  41. Beauharnais CC, Roberts DJ, Wexler DJ. High rate of placental infarcts in type 2 compared with type 1 diabetes. J Clin Endocrinol Metab. 2012 Jul; 97(7):E1160-4. PMID: 22492874; PMCID: PMC3387400.
  42. Beauharnais CC, Larkin ME, Zai AH, Boykin EC, Luttrell J, Wexler DJ. Efficacy and cost-effectiveness of an automated screening algorithm in an inpatient clinical trial. Clin Trials. 2012 Apr; 9(2):198-203. PMID: 22308560.
    View in: PubMed
  43. Wei NJ, Wexler DJ. Basal-bolus insulin protocols enter the computer age. Curr Diab Rep. 2012 Feb; 12(1):119-26. PMID: 22015856; PMCID: PMC3253986.
  44. Sha S, Devineni D, Ghosh A, Polidori D, Chien S, Wexler D, Shalayda K, Demarest K, Rothenberg P. Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects. Diabetes Obes Metab. 2011 Jul; 13(7):669-72. PMID: 21457428.
    View in: PubMed
  45. Wexler DJ, Grant RW. Intensive dietary advice significantly improves HbA(1c) in patients with type II diabetes who remain hyperglycaemic despite optimised drug treatment. Evid Based Med. 2010 Dec; 15(6):179-80. PMID: 20861408.
    View in: PubMed
  46. Wexler DJ, Shrader P, Burns SM, Cagliero E. Effectiveness of a computerized insulin order template in general medical inpatients with type 2 diabetes: a cluster randomized trial. Diabetes Care. 2010 Oct; 33(10):2181-3. PMID: 20664017; PMCID: PMC2945157.
  47. Lee CC, Sharp SJ, Wexler DJ, Adler AI. Dietary intake of eicosapentaenoic and docosahexaenoic acid and diabetic nephropathy: cohort analysis of the diabetes control and complications trial. Diabetes Care. 2010 Jul; 33(7):1454-6. PMID: 20357378; PMCID: PMC2890339.
  48. Grant RW, Wexler DJ. Loss-of-function CYP2C9 variants: finding the correct clinical role for Type 2 diabetes pharmacogenetic testing. Expert Rev Cardiovasc Ther. 2010 Mar; 8(3):339-43. PMID: 20222813; PMCID: PMC2852129.
  49. Park L, Wexler D. Update in diabetes and cardiovascular disease: synthesizing the evidence from recent trials of glycemic control to prevent cardiovascular disease. Curr Opin Lipidol. 2010 Feb; 21(1):8-14. PMID: 19829110; PMCID: PMC2871337.
  50. Cole A, Nathan DM, Savaria-Porter E, Copeland P, Turchin A, Brunt M, Zusman R, Barrett JA, Wexler D, Case E, McMahon GT, Mort E. An algorithm for the care of type 2 diabetes. Crit Pathw Cardiol. 2009 Dec; 8(4):156-65. PMID: 19952550.
    View in: PubMed
  51. Delahanty LM, Nathan DM, Lachin JM, Hu FB, Cleary PA, Ziegler GK, Wylie-Rosett J, Wexler DJ. Association of diet with glycated hemoglobin during intensive treatment of type 1 diabetes in the Diabetes Control and Complications Trial. Am J Clin Nutr. 2009 Feb; 89(2):518-24. PMID: 19106241; PMCID: PMC2647518.
  52. Gonzalez JS, Safren SA, Delahanty LM, Cagliero E, Wexler DJ, Meigs JB, Grant RW. Symptoms of depression prospectively predict poorer self-care in patients with Type 2 diabetes. Diabet Med. 2008 Sep; 25(9):1102-7. PMID: 19183315; PMCID: PMC2635490.
  53. Wexler DJ, Nathan DM, Grant RW, Regan S, Van Leuvan AL, Cagliero E. Prevalence of elevated hemoglobin A1c among patients admitted to the hospital without a diagnosis of diabetes. J Clin Endocrinol Metab. 2008 Nov; 93(11):4238-44. PMID: 18697862; PMCID: PMC2582564.
  54. Wexler DJ, Cagliero E. Inpatient diabetes management in non-ICU settings: evidence and strategies. Curr Diabetes Rev. 2007 Nov; 3(4):239-43. PMID: 18220680.
    View in: PubMed
  55. Wexler DJ. Inpatient diabetes management in general medical and surgical settings: evidence and update. Expert Rev Pharmacoecon Outcomes Res. 2007 Oct; 7(5):491-502. PMID: 20528394.
    View in: PubMed
  56. Gonzalez JS, Safren SA, Cagliero E, Wexler DJ, Delahanty L, Wittenberg E, Blais MA, Meigs JB, Grant RW. Depression, self-care, and medication adherence in type 2 diabetes: relationships across the full range of symptom severity. Diabetes Care. 2007 Sep; 30(9):2222-7. PMID: 17536067; PMCID: PMC4440862.
  57. Grant RW, Wexler DJ, Watson AJ, Lester WT, Cagliero E, Campbell EG, Nathan DM. How doctors choose medications to treat type 2 diabetes: a national survey of specialists and academic generalists. Diabetes Care. 2007 Jun; 30(6):1448-53. PMID: 17337497; PMCID: PMC3829641.
  58. Wexler DJ, Meigs JB, Cagliero E, Nathan DM, Grant RW. Prevalence of hyper- and hypoglycemia among inpatients with diabetes: a national survey of 44 U.S. hospitals. Diabetes Care. 2007 Feb; 30(2):367-9. PMID: 17259511.
    View in: PubMed
  59. Delahanty LM, Grant RW, Wittenberg E, Bosch JL, Wexler DJ, Cagliero E, Meigs JB. Association of diabetes-related emotional distress with diabetes treatment in primary care patients with Type 2 diabetes. Diabet Med. 2007 Jan; 24(1):48-54. PMID: 17227324.
    View in: PubMed
  60. Wexler DJ. Low risk of depression in diabetes? Would that it were so. CMAJ. 2006 Jul 04; 175(1):47. PMID: 16818908; PMCID: PMC1482763.
  61. Wexler DJ, Grant RW, Wittenberg E, Bosch JL, Cagliero E, Delahanty L, Blais MA, Meigs JB. Correlates of health-related quality of life in type 2 diabetes. Diabetologia. 2006 Jul; 49(7):1489-97. PMID: 16752167.
    View in: PubMed
  62. Wexler DJ, Hu FB, Manson JE, Rifai N, Meigs JB. Mediating effects of inflammatory biomarkers on insulin resistance associated with obesity. Obes Res. 2005 Oct; 13(10):1772-83. PMID: 16286525.
    View in: PubMed
  63. Wexler DJ, Grant RW, Meigs JB, Nathan DM, Cagliero E. Sex disparities in treatment of cardiac risk factors in patients with type 2 diabetes. Diabetes Care. 2005 Mar; 28(3):514-20. PMID: 15735180.
    View in: PubMed
  64. Wexler DJ, Pallais JC, Bringhurst, R. Endocrinology. Pocket Medicine, Ed. Sabatine, MS. 2002.
  65. Wexler DJ, Chen J, Smith GL, Radford MJ, Yaari S, Bradford WD, Krumholz HM. Predictors of costs of caring for elderly patients discharged with heart failure. Am Heart J. 2001 Aug; 142(2):350-7. PMID: 11479477.
    View in: PubMed
  66. Wexler D. Can Canada afford type of care afforded to MP? CMAJ. 1996 Aug 15; 155(4):367. PMID: 8801007; PMCID: PMC1488042.
    View in: PubMed
    View in: PubMed
  69. LEIDERMAN H, MENDELSON JH, WEXLER D, SOLOMON P. Sensory deprivation; clinical aspects. AMA Arch Intern Med. 1958 Feb; 101(2):389-96. PMID: 13497341.
    View in: PubMed
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