Harvard Catalyst Profiles

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Robert Anthony, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AI155662 (ANTHONY, ROBERT MCCULLOUGH) Apr 16, 2021 - Mar 31, 2026
    NIH
    Harnessing the anti-inflammatory activity of extracellular sialylation of IgG.
    Role: Principal Investigator
  2. R01AI153441 (ANTHONY, ROBERT MCCULLOUGH) Jul 1, 2020 - Jun 30, 2025
    NIH
    Examining IgG4 sialylation as a gain of function post-translation modification in IgG4-related diseases
    Role: Principal Investigator
  3. R21AI154930 (MAYADAS, TANYA N) Jun 3, 2020 - May 31, 2022
    NIH
    Glycoengineering IgA1 in IgA nephropathy
    Role: Co-Principal Investigator
  4. R01AI139669 (ANTHONY, ROBERT MCCULLOUGH) Jan 1, 2019 - Dec 31, 2023
    NIH
    Novel Roles of IgE Glycosylation in Anaphylaxis
    Role: Principal Investigator
  5. DP2AR068272 (ANTHONY, ROBERT MCCULLOUGH) Sep 30, 2014 - Jun 30, 2019
    NIH
    Glycoengineering In Vivo
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shin DS, Ratnapriya S, Cashin CN, Kuhn LF, Rahimi RA, Anthony RM, Moon JJ. Lung injury induces a polarized immune response by self antigen-specific Foxp3 + regulatory T cells. bioRxiv. 2023 Feb 10. PMID: 36798259; PMCID: PMC9934659.
    Citations:    
  2. Amatullah H, Fraschilla I, Digumarthi S, Huang J, Adiliaghdam F, Bonilla G, Wong LP, Rivard ME, Beauchamp C, Mercier V, Goyette P, Sadreyev RI, Anthony RM, Rioux JD, Jeffrey KL. Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases. Cell. 2022 08 18; 185(17):3232-3247.e18. PMID: 35952671; PMCID: PMC9442451.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  3. Vattepu R, Sneed SL, Anthony RM. Sialylation as an Important Regulator of Antibody Function. Front Immunol. 2022; 13:818736. PMID: 35464485; PMCID: PMC9021442.
    Citations: 5     Fields:    Translation:Humans
  4. McKitrick TR, Ackerman ME, Anthony RM, Bennett CS, Demetriou M, Hudalla GA, Ribbeck K, Ruhl S, Woo CM, Yang L, Zost SJ, Schnaar RL, Doering TL. The Crossroads of Glycoscience, Infection, and Immunology. Front Microbiol. 2021; 12:731008. PMID: 34646251; PMCID: PMC8504252.
    Citations:    
  5. Pagan JD, Vlamakis H, Gaca A, Xavier RJ, Anthony RM. Modulating T Follicular Cells In Vivo Enhances Antigen-Specific Humoral Immunity. J Immunol. 2021 06 01; 206(11):2583-2595. PMID: 34011521; PMCID: PMC8164984.
    Citations:    Fields:    Translation:AnimalsCells
  6. Shade KC, Conroy ME, Washburn N, Kitaoka M, Huynh DJ, Laprise E, Patil SU, Shreffler WG, Anthony RM. Sialylation of immunoglobulin E is a determinant of allergic pathogenicity. Nature. 2020 06; 582(7811):265-270. PMID: 32499653; PMCID: PMC7386252.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  7. Shade KT, Conroy ME, Anthony RM. IgE Glycosylation in Health and Disease. Curr Top Microbiol Immunol. 2019; 423:77-93. PMID: 30820668; PMCID: PMC6750212.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  8. Saggu G, Okubo K, Chen Y, Vattepu R, Tsuboi N, Rosetti F, Cullere X, Washburn N, Tahir S, Rosado AM, Holland SM, Anthony RM, Sen M, Zhu C, Mayadas TN. Cis interaction between sialylated Fc?RIIA and the aI-domain of Mac-1 limits antibody-mediated neutrophil recruitment. Nat Commun. 2018 11 29; 9(1):5058. PMID: 30498196.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  9. Sulka KB, Strle K, Crowley JT, Lochhead RB, Anthony R, Steere AC. Correlation of Lyme Disease-Associated IgG4 Autoantibodies With Synovial Pathology in Antibiotic-Refractory Lyme Arthritis. Arthritis Rheumatol. 2018 11; 70(11):1835-1846. PMID: 29790305; PMCID: PMC6203610.
    Citations: 6     Fields:    Translation:HumansCells
  10. Jubair WK, Hendrickson JD, Severs EL, Schulz HM, Adhikari S, Ir D, Pagan JD, Anthony RM, Robertson CE, Frank DN, Banda NK, Kuhn KA. Modulation of Inflammatory Arthritis in Mice by Gut Microbiota Through Mucosal Inflammation and Autoantibody Generation. Arthritis Rheumatol. 2018 08; 70(8):1220-1233. PMID: 29534332; PMCID: PMC6105374.
    Citations: 50     Fields:    Translation:Animals
  11. Pagan JD, Kitaoka M, Anthony RM. Engineered Sialylation of Pathogenic Antibodies In Vivo Attenuates Autoimmune Disease. Cell. 2018 01 25; 172(3):564-577.e13. PMID: 29275858.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  12. Arlauckas SP, Garris CS, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ. In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy. Sci Transl Med. 2017 05 10; 9(389). PMID: 28490665; PMCID: PMC5734617.
    Citations: 257     Fields:    Translation:HumansAnimalsCells
  13. Mehta S, Cronkite DA, Basavappa M, Saunders TL, Adiliaghdam F, Amatullah H, Morrison SA, Pagan JD, Anthony RM, Tonnerre P, Lauer GM, Lee JC, Digumarthi S, Pantano L, Ho Sui SJ, Ji F, Sadreyev R, Zhou C, Mullen AC, Kumar V, Li Y, Wijmenga C, Xavier RJ, Means TK, Jeffrey KL. Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140. Sci Immunol. 2017 Mar 03; 2(9). PMID: 28783698.
    Citations: 28     Fields:    
  14. Azimi E, Reddy VB, Shade KC, Anthony RM, Talbot S, Pereira PJS, Lerner EA. Dual action of neurokinin-1 antagonists on Mas-related GPCRs. JCI Insight. 2016 Oct 06; 1(16):e89362. PMID: 27734033.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  15. Shade KT, Platzer B, Washburn N, Mani V, Bartsch YC, Conroy M, Pagan JD, Bosques C, Mempel TR, Fiebiger E, Anthony RM. A single glycan on IgE is indispensable for initiation of anaphylaxis. J Exp Med. 2015 Apr 06; 212(4):457-67. PMID: 25824821; PMCID: PMC4387292.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  16. Platzer B, Elpek KG, Cremasco V, Baker K, Stout MM, Schultz C, Dehlink E, Shade KC, Anthony RM, Blumberg RS, Turley SJ, Fiebiger E. IgE/FceRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses. Cell Rep. 2015 Mar 10; 10(9):1487-1495. PMID: 25753415; PMCID: PMC4559493.
    Citations: 29     Fields:    
  17. Anthony RM, Kobayashi T, Wermeling F, Ravetch JV. Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway. Nature. 2011 Jun 19; 475(7354):110-3. PMID: 21685887.
    Citations: 278     Fields:    Translation:HumansAnimalsCells
  18. Anthony RM, Nimmerjahn F. The role of differential IgG glycosylation in the interaction of antibodies with Fc?Rs in vivo. Curr Opin Organ Transplant. 2011 Feb; 16(1):7-14. PMID: 21150612.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  19. Cheong C, Matos I, Choi JH, Dandamudi DB, Shrestha E, Longhi MP, Jeffrey KL, Anthony RM, Kluger C, Nchinda G, Koh H, Rodriguez A, Idoyaga J, Pack M, Velinzon K, Park CG, Steinman RM. Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas. Cell. 2010 Oct 29; 143(3):416-29. PMID: 21029863.
    Citations: 299     Fields:    Translation:AnimalsCells
  20. Anthony RM, Ravetch JV. A novel role for the IgG Fc glycan: the anti-inflammatory activity of sialylated IgG Fcs. J Clin Immunol. 2010 May; 30 Suppl 1:S9-14. PMID: 20480216.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  21. Scheid JF, Mouquet H, Feldhahn N, Seaman MS, Velinzon K, Pietzsch J, Ott RG, Anthony RM, Zebroski H, Hurley A, Phogat A, Chakrabarti B, Li Y, Connors M, Pereyra F, Walker BD, Wardemann H, Ho D, Wyatt RT, Mascola JR, Ravetch JV, Nussenzweig MC. Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature. 2009 Apr 02; 458(7238):636-40. PMID: 19287373.
    Citations: 547     Fields:    Translation:HumansCells
  22. Anthony RM, Wermeling F, Karlsson MC, Ravetch JV. Identification of a receptor required for the anti-inflammatory activity of IVIG. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19571-8. PMID: 19036920.
    Citations: 235     Fields:    Translation:HumansAnimalsCells
  23. Anthony RM, Nimmerjahn F, Ashline DJ, Reinhold VN, Paulson JC, Ravetch JV. Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc. Science. 2008 Apr 18; 320(5874):373-6. PMID: 18420934.
    Citations: 340     Fields:    Translation:HumansAnimalsCells
  24. Anthony RM, Rutitzky LI, Urban JF, Stadecker MJ, Gause WC. Protective immune mechanisms in helminth infection. Nat Rev Immunol. 2007 Dec; 7(12):975-87. PMID: 18007680.
    Citations: 406     Fields:    Translation:HumansAnimalsCells
  25. Norris HH, Peterson ME, Stebbins CC, McConchie BW, Bundoc VG, Trivedi S, Hodges MG, Anthony RM, Urban JF, Long EO, Keane-Myers AM. Inhibitory receptor gp49B regulates eosinophil infiltration during allergic inflammation. J Leukoc Biol. 2007 Dec; 82(6):1531-41. PMID: 17761953.
    Citations: 8     Fields:    Translation:AnimalsCells
  26. Kreider T, Anthony RM, Urban JF, Gause WC. Alternatively activated macrophages in helminth infections. Curr Opin Immunol. 2007 Aug; 19(4):448-53. PMID: 17702561; PMCID: PMC2000338.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  27. Urban JF, Steenhard NR, Solano-Aguilar GI, Dawson HD, Iweala OI, Nagler CR, Noland GS, Kumar N, Anthony RM, Shea-Donohue T, Weinstock J, Gause WC. Infection with parasitic nematodes confounds vaccination efficacy. Vet Parasitol. 2007 Aug 19; 148(1):14-20. PMID: 17587500; PMCID: PMC1959410.
    Citations: 38     Fields:    Translation:Animals
  28. Nimmerjahn F, Anthony RM, Ravetch JV. Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity. Proc Natl Acad Sci U S A. 2007 May 15; 104(20):8433-7. PMID: 17485663; PMCID: PMC1895967.
    Citations: 97     Fields:    Translation:AnimalsCells
  29. Anthony RM, Urban JF, Alem F, Hamed HA, Rozo CT, Boucher JL, Van Rooijen N, Gause WC. Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat Med. 2006 Aug; 12(8):955-60. PMID: 16892038; PMCID: PMC1955764.
    Citations: 270     Fields:    Translation:AnimalsCells
  30. Liu Z, Liu Q, Hamed H, Anthony RM, Foster A, Finkelman FD, Urban JF, Gause WC. IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites. J Immunol. 2005 Feb 15; 174(4):2242-9. PMID: 15699158; PMCID: PMC1978543.
    Citations: 23     Fields:    Translation:AnimalsCells
  31. Morimoto M, Morimoto M, Whitmire J, Xiao S, Anthony RM, Mirakami H, Star RA, Urban JF, Gause WC. Peripheral CD4 T cells rapidly accumulate at the host: parasite interface during an inflammatory Th2 memory response. J Immunol. 2004 Feb 15; 172(4):2424-30. PMID: 14764713.
    Citations: 38     Fields:    Translation:AnimalsCells
  32. Florens L, Washburn MP, Raine JD, Anthony RM, Grainger M, Haynes JD, Moch JK, Muster N, Sacci JB, Tabb DL, Witney AA, Wolters D, Wu Y, Gardner MJ, Holder AA, Sinden RE, Yates JR, Carucci DJ. A proteomic view of the Plasmodium falciparum life cycle. Nature. 2002 Oct 03; 419(6906):520-6. PMID: 12368866.
    Citations: 455     Fields:    Translation:HumansAnimalsCells
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© 2023 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.