Harvard Catalyst Profiles

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Tomohiko Kawate, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Johnson EO, Office E, Kawate T, Orzechowski M, Hung DT. Large-Scale Chemical-Genetic Strategy Enables the Design of Antimicrobial Combination Chemotherapy in Mycobacteria. ACS Infect Dis. 2020 01 10; 6(1):56-63. PMID: 31721551.
    Citations: 4     Fields:    Translation:Cells
  2. Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas AJ, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski RM, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes. Nature. 2019 07; 571(7763):72-78. PMID: 31217586.
    Citations: 34     Fields:    Translation:Cells
  3. Grant SS, Wellington S, Kawate T, Desjardins CA, Silvis MR, Wivagg C, Thompson M, Gordon K, Kazyanskaya E, Nietupski R, Haseley N, Iwase N, Earl AM, Fitzgerald M, Hung DT. Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors. Cell Chem Biol. 2016 06 23; 23(6):666-77. PMID: 27321573.
    Citations: 15     Fields:    Translation:Cells
  4. Kawate T, Iwase N, Shimizu M, Stanley SA, Wellington S, Kazyanskaya E, Hung DT. Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32. Bioorg Med Chem Lett. 2013 Nov 15; 23(22):6052-9. PMID: 24103299.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  5. Grant SS, Kawate T, Nag PP, Silvis MR, Gordon K, Stanley SA, Kazyanskaya E, Nietupski R, Golas A, Fitzgerald M, Cho S, Franzblau SG, Hung DT. Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model. ACS Chem Biol. 2013 Oct 18; 8(10):2224-34. PMID: 23898841.
    Citations: 32     Fields:    Translation:Cells
  6. Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Grant SS, Rubin EJ, Hung DT. Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):11565-70. PMID: 23798446.
    Citations: 34     Fields:    Translation:AnimalsCells
  7. Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat Chem Biol. 2013 Jun; 9(6):398-405. PMID: 23603659.
    Citations: 43     Fields:    Translation:AnimalsCells
  8. Stanley SA, Grant SS, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol. 2012 Aug 17; 7(8):1377-84. PMID: 22577943.
    Citations: 108     Fields:    Translation:Cells
  9. Zhou L, Kawate T, Liu X, Kim YB, Zhao Y, Feng G, Banerji J, Nash H, Whitehurst C, Jindal S, Siddiqui A, Seed B, Wolfe JL. STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells. Bioorg Med Chem. 2012 Jan 15; 20(2):750-8. PMID: 22217933.
    Citations: 10     Fields:    Translation:HumansCells
  10. Kawate T, Allerson CR, Wolfe JL. Regioselective syntheses of 7-nitro-7-deazapurine nucleosides and nucleotides for efficient PCR incorporation. Org Lett. 2005 Sep 01; 7(18):3865-8. PMID: 16119918.
    Citations: 6     Fields:    Translation:Cells
  11. Wolfe JL, Kawate T. Synthesis and polymerase incorporation of 5'-amino-2',5'-dideoxy-5'-N-triphosphate nucleotides. Curr Protoc Nucleic Acid Chem. 2004 Oct; Chapter 13:Unit 13.3. PMID: 18428923.
    Citations:    Fields:    
  12. Wolfe JL, Wang BH, Kawate T, Stanton VP. Sequence-specific dinucleotide cleavage promoted by synergistic interactions between neighboring modified nucleotides in DNA. J Am Chem Soc. 2003 Sep 03; 125(35):10500-1. PMID: 12940715.
    Citations: 2     Fields:    Translation:HumansCells
  13. Wolfe JL, Kawate T, Belenky A, Stanton V. Synthesis and polymerase incorporation of 5'-amino-2',5'-dideoxy-5'-N-triphosphate nucleotides. Nucleic Acids Res. 2002 Sep 01; 30(17):3739-47. PMID: 12202759.
    Citations: 7     Fields:    Translation:Cells
  14. Wolfe JL, Kawate T, Sarracino DA, Zillmann M, Olson J, Stanton VP, Verdine GL. A genotyping strategy based on incorporation and cleavage of chemically modified nucleotides. Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):11073-8. PMID: 12169663.
    Citations: 3     Fields:    Translation:HumansCells
  15. Yamada H, Kawate T, Nishida A, Nakagawa M. Asymmetric Addition of Alkyllithium to Chiral Imines: alpha-Naphthylethyl Group as a Chiral Auxiliary. J Org Chem. 1999 Nov 26; 64(24):8821-8828. PMID: 11674785.
    Citations: 4     Fields:    
  16. Yamada H, Kawate T, Matsumizu M, Nishida A, Yamaguchi K, Nakagawa M. Chiral Lewis Acid-Mediated Enantioselective Pictet-Spengler Reaction of N(b)-Hydroxytryptamine with Aldehydes. J Org Chem. 1998 Sep 04; 63(18):6348-6354. PMID: 11672269.
    Citations: 8     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.