Harvard Catalyst Profiles

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Marc D Normandin, Ph.D.

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Yale University School of MedicinePostdoctoral Fellowship2011Diagnostic Radiology
Purdue UniversityPh.D.2008Biomedical Engineering
University of Rhode IslandB.S.2003Biomedical Engineering
University of Rhode IslandB.S.2003Electrical Engineering

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P41EB022544 (EL FAKHRI, GEORGES) Jul 1, 2022 - Apr 30, 2027
    Center for Molecular Imaging Technology & Translation (CMITT)
    Role: Deputy Director
  2. P41EB022544 (NORMANDIN, MARC DAVID) Jul 1, 2022 - Apr 30, 2027
    TR&D3: Novel Imaging Agents & Physiological Modeling for Quantitative PET/MR
    Role: Principal Investigator
  3. R01AG076153 (EL FAKHRI, GEORGES) Feb 1, 2022 - Jan 31, 2027
    Methods for Quantitative Neuroimaging of Tau Burden in Pre-symptomatic AD
    Role: Co-Principal Investigator
  4. P41EB022544 (NORMANDIN, MARC DAVID) Sep 30, 2017 - Jun 30, 2022
    TR&D3: Pharmacokinetic and physiological modeling in simultaneous PET/MR
    Role: Principal Investigator
  5. R01EB017699 (NORMANDIN, MARC DAVID) Sep 22, 2014 - May 31, 2019
    PEG-like Multimodal Nanoprobes for Imaging Enhanced Permeability Retention
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Guehl NJ, Wooten DW, Yokell DL, Moon SH, Dhaynaut M, Katz S, Moody KA, Gharagouzloo C, Kas A, Johnson KA, Fakhri GE, Normandin MD. Correction to: Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [18F]MK6240 in human subjects. Eur J Nucl Med Mol Imaging. 2023 Jan 05. PMID: 36604327.
    Citations:    Fields:    
  2. Fu JF, Lois C, Sanchez J, Becker JA, Rubinstein ZB, Thibault E, Salvatore AN, Sari H, Farrell ME, Guehl NJ, Normandin MD, Fakhri GE, Johnson KA, Price JC. Kinetic evaluation and assessment of longitudinal changes in reference region and extracerebral [18F]MK-6240 PET uptake. J Cereb Blood Flow Metab. 2022 Nov 24; 271678X221142139. PMID: 36420769.
    Citations:    Fields:    
  3. Sun Y, Guehl NJ, Zhou YP, Takahashi K, Belov V, Dhaynaut M, Moon SH, El Fakhri G, Normandin MD, Brugarolas P. Radiochemical Synthesis and Evaluation of 3-[11C]Methyl-4-aminopyridine in Rodents and Nonhuman Primates for Imaging Potassium Channels in the CNS. ACS Chem Neurosci. 2022 12 07; 13(23):3342-3351. PMID: 36417797; PMCID: PMC9732819.
    Citations:    Fields:    Translation:Animals
  4. Brugarolas P, Wilks MQ, Noel J, Kaiser JA, Vesper DR, Ramos-Torres KM, Guehl NJ, Macdonald-Soccorso MT, Sun Y, Rice PA, Yokell DL, Lim R, Normandin MD, El Fakhri G. Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP. Eur J Nucl Med Mol Imaging. 2023 01; 50(2):344-351. PMID: 36197499; PMCID: PMC9816249.
    Citations:    Fields:    Translation:HumansAnimals
  5. Yuan G, Dhaynaut M, Guehl NJ, Neelamegam R, Moon SH, Qu X, Poutiainen P, Afshar S, Fakhri GE, Normandin MD, Brownell AL. PET imaging studies to investigate functional expression of mGluR2 using [11C]mG2P001. J Cereb Blood Flow Metab. 2023 Feb; 43(2):296-308. PMID: 36172629.
    Citations:    Fields:    
  6. Yuan G, Dhaynaut M, Guehl NJ, Afshar S, Huynh D, Moon SH, Iyengar SM, Jain MK, Pickett JE, Kang HJ, Ondrechen MJ, El Fakhri G, Normandin MD, Brownell AL. Design, Synthesis, and Characterization of [18F]mG2P026 as a High-Contrast PET Imaging Ligand for Metabotropic Glutamate Receptor 2. J Med Chem. 2022 07 28; 65(14):9939-9954. PMID: 35802702; PMCID: PMC9434700.
    Citations:    Fields:    Translation:Animals
  7. Ang YS, Cusin C, Petibon Y, Dillon DG, Breiger M, Belleau EL, Normandin M, Schroder H, Boyden S, Hayden E, Levine MT, Jahan A, Meyer AK, Kang MS, Brunner D, Gelda SE, Hooker J, El Fakhri G, Fava M, Pizzagalli DA. A multi-pronged investigation of option generation using depression, PET and modafinil. Brain. 2022 06 03; 145(5):1854-1865. PMID: 35150243; PMCID: PMC9166534.
    Citations:    Fields:    Translation:Humans
  8. Detmer FJ, Alpert NM, Moon SH, Dhaynaut M, Guerrero JL, Guehl NJ, Xing F, Brugarolas P, Shoup TM, Normandin MD, Pelletier-Galarneau M, El Fakhri G, Petibon Y. PET imaging of mitochondrial function in acute doxorubicin-induced cardiotoxicity: a proof-of-principle study. Sci Rep. 2022 04 12; 12(1):6122. PMID: 35414642; PMCID: PMC9005533.
    Citations:    Fields:    Translation:AnimalsCells
  9. Yuan G, Dhaynaut M, Lan Y, Guehl NJ, Huynh D, Iyengar SM, Afshar S, Jain MK, Pickett JE, Kang HJ, Wang H, Moon SH, Ondrechen MJ, Wang C, Shoup TM, El Fakhri G, Normandin MD, Brownell AL. Synthesis and Characterization of 5-(2-Fluoro-4-[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2. J Med Chem. 2022 02 10; 65(3):2593-2609. PMID: 35089713; PMCID: PMC9434702.
    Citations:    Fields:    Translation:Animals
  10. Dhaynaut M, Sprugnoli G, Cappon D, Macone J, Sanchez JS, Normandin MD, Guehl NJ, Koch G, Paciorek R, Connor A, Press D, Johnson K, Pascual-Leone A, El Fakhri G, Santarnecchi E. Impact of 40?Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer's Disease: A Case Series. J Alzheimers Dis. 2022; 85(4):1667-1676. PMID: 34958021; PMCID: PMC9023125.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  11. Wu X, Daniel Ulumben A, Long S, Katagiri W, Wilks MQ, Yuan H, Cortese B, Yang C, Kashiwagi S, Choi HS, Normandin MD, El Fakhri G, Zaman RT. Near-Infrared Fluorescence Imaging of Carotid Plaques in an Atherosclerotic Murine Model. Biomolecules. 2021 11 24; 11(12). PMID: 34944397; PMCID: PMC8698491.
    Citations:    Fields:    Translation:HumansAnimalsCells
  12. Jacobs HIL, Becker JA, Kwong K, Engels-Domínguez N, Prokopiou PC, Papp KV, Properzi M, Hampton OL, d'Oleire Uquillas F, Sanchez JS, Rentz DM, El Fakhri G, Normandin MD, Price JC, Bennett DA, Sperling RA, Johnson KA. In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline. Sci Transl Med. 2021 Sep 22; 13(612):eabj2511. PMID: 34550726; PMCID: PMC8641759.
    Citations: 14     Fields:    Translation:Humans
  13. Leaston J, Ferris CF, Kulkarni P, Chandramohan D, van de Ven AL, Qiao J, Timms L, Sepulcre J, El Fakhri G, Ma C, Normandin MD, Gharagouzloo C. Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities. PLoS One. 2021; 16(8):e0256749. PMID: 34449808.
    Citations: 1     Fields:    Translation:HumansAnimals
  14. Mody M, Petibon Y, Han P, Kuruppu D, Ma C, Yokell D, Neelamegam R, Normandin MD, Fakhri GE, Brownell AL. In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker. Sci Rep. 2021 08 05; 11(1):15897. PMID: 34354107; PMCID: PMC8342610.
    Citations: 6     Fields:    Translation:Humans
  15. Pelletier-Galarneau M, Detmer FJ, Petibon Y, Normandin M, Ma C, Alpert NM, El Fakhri G. Quantification of Myocardial Mitochondrial Membrane Potential Using PET. Curr Cardiol Rep. 2021 05 10; 23(6):70. PMID: 33970353; PMCID: PMC8443083.
    Citations: 2     Fields:    Translation:HumansAnimals
  16. Bouziri H, Pepin CM, Koua K, Benhouria M, Paulin C, Ouyang J, Normandin M, Pratte JF, El Fakhri G, Lecomte R, Fontaine R. Investigation of a Model-based Time-over-threshold Technique for Phoswich Crystal Discrimination. IEEE Trans Radiat Plasma Med Sci. 2022 Apr; 6(4):393-403. PMID: 35372739; PMCID: PMC8974315.
  17. Yuan G, Guehl NJ, Zheng B, Qu X, Moon SH, Dhaynaut M, Shoup TM, Afshar S, Kang HJ, Zhang Z, El Fakhri G, Normandin MD, Brownell AL. Synthesis and Characterization of [18F]JNJ-46356479 as the First 18F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2. Mol Imaging Biol. 2021 08; 23(4):527-536. PMID: 33559035; PMCID: PMC8277681.
    Citations: 1     Fields:    Translation:Animals
  18. Guehl NJ, Neelamegam R, Zhou YP, Moon SH, Dhaynaut M, El Fakhri G, Normandin MD, Brugarolas P. Radiochemical Synthesis and Evaluation in Non-Human Primates of 3-[11C]methoxy-4-aminopyridine: A Novel PET Tracer for Imaging Potassium Channels in the CNS. ACS Chem Neurosci. 2021 02 17; 12(4):756-765. PMID: 33539063; PMCID: PMC8060895.
    Citations: 2     Fields:    Translation:Animals
  19. Sanchez JS, Becker JA, Jacobs HIL, Hanseeuw BJ, Jiang S, Schultz AP, Properzi MJ, Katz SR, Beiser A, Satizabal CL, O'Donnell A, DeCarli C, Killiany R, El Fakhri G, Normandin MD, Gómez-Isla T, Quiroz YT, Rentz DM, Sperling RA, Seshadri S, Augustinack J, Price JC, Johnson KA. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography. Sci Transl Med. 2021 01 20; 13(577). PMID: 33472953; PMCID: PMC7978042.
    Citations: 27     Fields:    Translation:Humans
  20. Shoup TM, Griciuc A, Normandin MD, Quinti L, Walsh LV, Dhaynaut M, Moon SH, Guehl NJ, Brugarolas P, Elmaleh DR, Fakhri GE, Tanzi RE. Evaluation of Fluorinated Cromolyn Derivatives as Potential Therapeutics for Alzheimer's Disease. J Alzheimers Dis. 2021; 80(2):775-786. PMID: 33579853.
    Citations: 3     Fields:    Translation:AnimalsCells
  21. Gholami YH, Yuan H, Wilks MQ, Josephson L, El Fakhri G, Normandin MD, Kuncic Z. Positron annihilation localization by nanoscale magnetization. Sci Rep. 2020 11 20; 10(1):20262. PMID: 33219274.
    Citations: 1     Fields:    Translation:Humans
  22. Kim K, Guehl NJ, Gong K, Moon S-H, El Fakhri G, Normandin MD, Li Q. Penalized Parametric PET Imaging Estimation Using Local Linear Fitting. IEEE Trans Rad Plas Med Sci. 2020; 6(4):750-758.
  23. Guehl NJ, Ramos-Torres KM, Linnman C, Moon SH, Dhaynaut M, Wilks MQ, Han PK, Ma C, Neelamegam R, Zhou YP, Popko B, Correia JA, Reich DS, Fakhri GE, Herscovitch P, Normandin MD, Brugarolas P. Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques. J Cereb Blood Flow Metab. 2021 07; 41(7):1721-1733. PMID: 33090071; PMCID: PMC8221756.
    Citations: 4     Fields:    Translation:Animals
  24. Pelletier-Galarneau M, Petibon Y, Ma C, Han P, Kim SJW, Detmer FJ, Yokell D, Guehl N, Normandin M, El Fakhri G, Alpert NM. In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study. Eur J Nucl Med Mol Imaging. 2021 02; 48(2):414-420. PMID: 32719915; PMCID: PMC7839097.
    Citations: 5     Fields:    Translation:Humans
  25. Ramos-Torres KM, Zhou YP, Yang BY, Guehl NJ, Sung-Hyun M, Telu S, Normandin MD, Pike VW, Brugarolas P. Syntheses of [11C]2- and [11C]3-trifluoromethyl-4-aminopyridine: potential PET radioligands for demyelinating diseases. RSC Med Chem. 2020 Oct 01; 11(10):1161-1167. PMID: 33479620.
    Citations: 1     
  26. Ramos-Torres KM, Zhou Y-P, Yang B-Y, Guehl NJ, Moon S-H, Telu S, Normandin MD, Pike VW, Brugarolas P. Syntheses of [11C]2- and [11C]3-trifluoromethyl-4-aminopyridine: potential PET radioligands for demyelinating diseases. RSC Med Chem. 2020; (11):1161-1167.
  27. Petibon Y, Alpert NM, Ouyang J, Pizzagalli DA, Cusin C, Fava M, El Fakhri G, Normandin MD. PET imaging of neurotransmission using direct parametric reconstruction. Neuroimage. 2020 11 01; 221:117154. PMID: 32679252.
    Citations: 1     Fields:    Translation:HumansCells
  28. Alpert NM, Pelletier-Galarneau M, Petibon Y, Normandin MD, El Fakhri G. In vivo quantification of mitochondrial membrane potential. Nature. 2020 07; 583(7815):E17-E18. PMID: 32641811.
    Citations: 1     Fields:    Translation:Cells
  29. Guehl NJ, Wooten DW, El Fakhri G, Normandin MD. Reply to: Fitting of late dynamic [18F]MK6240 PET scans for in vivo tau quantification. Eur J Nucl Med Mol Imaging. 2020 12; 47(13):2947-2949. PMID: 32556399.
    Citations:    Fields:    Translation:Humans
  30. Alpert NM, Pelletier-Galarneau M, Kim SJW, Petibon Y, Sun T, Ramos-Torres KM, Normandin MD, El Fakhri G. In-vivo Imaging of Mitochondrial Depolarization of Myocardium With Positron Emission Tomography and a Proton Gradient Uncoupler. Front Physiol. 2020; 11:491. PMID: 32499721; PMCID: PMC7243673.
    Citations: 2     
  31. Sung Y, Tetrault MA, Takahashi K, Ouyang J, Pratx G, Fakhri GE, Normandin MD. Dependence of fluorodeoxyglucose (FDG) uptake on cell cycle and dry mass: a single-cell study using a multi-modal radiography platform. Sci Rep. 2020 03 09; 10(1):4280. PMID: 32152343.
    Citations: 2     Fields:    Translation:HumansCells
  32. Gholami YH, Yuan H, Wilks MQ, Maschmeyer R, Normandin MD, Josephson L, El Fakhri G, Kuncic Z. A Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging. Int J Nanomedicine. 2020; 15:1253-1266. PMID: 32161456; PMCID: PMC7049573.
    Citations: 4     Fields:    Translation:Humans
  33. Guehl NJ, Pelletier-Galarneau M, Wooten DW, Guerrero JL, Kas A, Normandin MD, Fakhri GE, Alpert NM. Preclinical Validation of a Single-Scan Rest/Stress Imaging Technique for 13N-Ammonia Positron Emission Tomography Cardiac Perfusion Studies. Circ Cardiovasc Imaging. 2020 01; 13(1):e009407. PMID: 31959009.
    Citations: 1     Fields:    Translation:Animals
  34. Gholami YH, Josephson L, Akam EA, Caravan P, Wilks MQ, Pan XZ, Maschmeyer R, Kolnick A, El Fakhri G, Normandin MD, Kuncic Z, Yuan H. A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes. Int J Nanomedicine. 2020; 15:31-47. PMID: 32021163; PMCID: PMC6954846.
    Citations: 3     Fields:    
  35. Pizzagalli DA, Berretta S, Wooten D, Goer F, Pilobello KT, Kumar P, Murray L, Beltzer M, Boyer-Boiteau A, Alpert N, El Fakhri G, Mechawar N, Vitaliano G, Turecki G, Normandin M. Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder: In Vivo Positron Emission Tomography and Postmortem Evidence. JAMA Psychiatry. 2019 08 01; 76(8):854-861. PMID: 31042280; PMCID: PMC6495358.
    Citations: 12     Fields:    Translation:Humans
  36. Guehl NJ, Wooten DW, Yokell DL, Moon SH, Dhaynaut M, Katz S, Moody KA, Gharagouzloo C, Kas A, Johnson KA, El Fakhri G, Normandin MD. Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [18F]MK6240 in human subjects. Eur J Nucl Med Mol Imaging. 2019 Sep; 46(10):2099-2111. PMID: 31332496; PMCID: PMC6709592.
    Citations: 12     Fields:    Translation:Humans
  37. Lan Y, Bai P, Chen Z, Neelamegam R, Placzek MS, Wang H, Fiedler SA, Yang J, Yuan G, Qu X, Schmidt HR, Song J, Normandin MD, Ran C, Wang C. Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET). Acta Pharm Sin B. 2019 Nov; 9(6):1204-1215. PMID: 31867166; PMCID: PMC6900558.
    Citations: 7     
  38. Aguero C, Dhaynaut M, Normandin MD, Amaral AC, Guehl NJ, Neelamegam R, Marquie M, Johnson KA, El Fakhri G, Frosch MP, Gomez-Isla T. Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue. Acta Neuropathol Commun. 2019 03 11; 7(1):37. PMID: 30857558; PMCID: PMC6410510.
    Citations: 35     Fields:    Translation:Humans
  39. Kaiser RH, Treadway MT, Wooten DW, Kumar P, Goer F, Murray L, Beltzer M, Pechtel P, Whitton A, Cohen AL, Alpert NM, El Fakhri G, Normandin MD, Pizzagalli DA. Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation. Cereb Cortex. 2018 12 01; 28(12):4281-4290. PMID: 29121332; PMCID: PMC6454484.
    Citations: 25     Fields:    Translation:Humans
  40. Verwer EE, Kavanagh TR, Mischler WJ, Feng Y, Takahashi K, Wang S, Shoup TM, Neelamegam R, Yang J, Guehl NJ, Ran C, Massefski W, Cui Y, El-Chemaly S, Sadow PM, Oldham WM, Kijewski MF, El Fakhri G, Normandin MD, Priolo C. [18F]Fluorocholine and [18F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM. Clin Cancer Res. 2018 12 01; 24(23):5925-5938. PMID: 30054282; PMCID: PMC6816044.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  41. Yuan H, Wilks MQ, Normandin MD, El Fakhri G, Kaittanis C, Josephson L. Heat-induced radiolabeling and fluorescence labeling of Feraheme nanoparticles for PET/SPECT imaging and flow cytometry. Nat Protoc. 2018 02; 13(2):392-412. PMID: 29370158.
    Citations: 18     Fields:    Translation:HumansAnimals
  42. Alpert NM, Guehl N, Ptaszek L, Pelletier-Galarneau M, Ruskin J, Mansour MC, Wooten D, Ma C, Takahashi K, Zhou Y, Shoup TM, Normandin MD, El Fakhri G. Quantitative in vivo mapping of myocardial mitochondrial membrane potential. PLoS One. 2018; 13(1):e0190968. PMID: 29338024.
    Citations: 13     Fields:    Translation:Animals
  43. Marquié M, Verwer EE, Meltzer AC, Kim SJW, Agüero C, Gonzalez J, Makaretz SJ, Siao Tick Chong M, Ramanan P, Amaral AC, Normandin MD, Vanderburg CR, Gomperts SN, Johnson KA, Frosch MP, Gómez-Isla T. Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson's case. Acta Neuropathol Commun. 2017 10 19; 5(1):75. PMID: 29047416.
    Citations: 46     Fields:    Translation:Humans
  44. Sîrbulescu RF, Boehm CK, Soon E, Wilks MQ, Ilies I, Yuan H, Maxner B, Chronos N, Kaittanis C, Normandin MD, El Fakhri G, Orgill DP, Sluder AE, Poznansky MC. Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions. Wound Repair Regen. 2017 09; 25(5):774-791. PMID: 28922523.
    Citations: 36     Fields:    Translation:AnimalsCells
  45. Albrecht DS, Normandin MD, Shcherbinin S, Wooten DW, Schwarz AJ, Zürcher NR, Barth VN, Guehl NJ, Akeju O, Atassi N, Veronese M, Turkheimer F, Hooker JM, Loggia ML. Pseudoreference Regions for Glial Imaging with 11C-PBR28: Investigation in 2 Clinical Cohorts. J Nucl Med. 2018 01; 59(1):107-114. PMID: 28818984; PMCID: PMC5750517.
    Citations: 14     Fields:    Translation:HumansCells
  46. Guehl NJ, Normandin MD, Wooten DW, Rozen G, Ruskin JN, Shoup TM, Woo J, Ptaszek LM, Fakhri GE, Alpert NM. Rapid computation of single PET scan rest-stress myocardial blood flow parametric images by table look up. Med Phys. 2017 Sep; 44(9):4643-4651. PMID: 28594441; PMCID: PMC5603217.
    Citations: 1     Fields:    Translation:HumansAnimals
  47. Marquié M, Siao Tick Chong M, Antón-Fernández A, Verwer EE, Sáez-Calveras N, Meltzer AC, Ramanan P, Amaral AC, Gonzalez J, Normandin MD, Frosch MP, Gómez-Isla T. [F-18]-AV-1451 binding correlates with postmortem neurofibrillary tangle Braak staging. Acta Neuropathol. 2017 Oct; 134(4):619-628. PMID: 28612291; PMCID: PMC5772971.
    Citations: 44     Fields:    Translation:HumansCells
  48. Collier TL, Normandin MD, Stephenson NA, Livni E, Liang SH, Wooten DW, Esfahani SA, Stabin MG, Mahmood U, Chen J, Wang W, Maresca K, Waterhouse RN, El Fakhri G, Richardson P, Vasdev N. Synthesis and preliminary PET imaging of 11C and 18F isotopologues of the ROS1/ALK inhibitor lorlatinib. Nat Commun. 2017 06 08; 8:15761. PMID: 28594000; PMCID: PMC5472746.
    Citations: 14     Fields:    Translation:HumansAnimals
  49. Guehl NJ, Normandin MD, Wooten DW, Rozen G, Sitek A, Ruskin J, Shoup TM, Ptaszek LM, El Fakhri G, Alpert NM. Single-scan rest/stress imaging: validation in a porcine model with 18F-Flurpiridaz. Eur J Nucl Med Mol Imaging. 2017 Aug; 44(9):1538-1546. PMID: 28365789.
    Citations: 8     Fields:    Translation:Animals
  50. Guehl NJ**, Normandin MD**, Wooten DW, Rozen G, Sitek A, Ruskin J, Shoup TM, Ptaszek, El Fakhri G, Alpert NM (**contributed equally). Single-scan rest/stress imaging: validation in a porcine model with 18F-Flurpiridaz. Eur J Nucl Med Mol Imaging. 2017; (in press). View Publication.
  51. Yuan H, Wilks MQ, El Fakhri G, Normandin MD, Kaittanis C, Josephson L. Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials. PLoS One. 2017; 12(2):e0172722. PMID: 28225818; PMCID: PMC5321420.
    Citations: 12     Fields:    
  52. Marquié M, Normandin MD, Meltzer AC, Siao Tick Chong M, Andrea NV, Antón-Fernández A, Klunk WE, Mathis CA, Ikonomovic MD, Debnath M, Bien EA, Vanderburg CR, Costantino I, Makaretz S, DeVos SL, Oakley DH, Gomperts SN, Growdon JH, Domoto-Reilly K, Lucente D, Dickerson BC, Frosch MP, Hyman BT, Johnson KA, Gómez-Isla T. Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies. Ann Neurol. 2017 Jan; 81(1):117-128. PMID: 27997036; PMCID: PMC5319193.
    Citations: 96     Fields:    Translation:Humans
  53. Collier TL, Maresca KP, Normandin MD, Richardson P, McCarthy TJ, Liang SH, Waterhouse RN, Vasdev N. Brain Penetration of the ROS1/ALK Inhibitor Lorlatinib Confirmed by PET. Mol Imaging. 2017 Jan-Dec; 16:1536012117736669. PMID: 29067878; PMCID: PMC5661750.
    Citations: 5     Fields:    Translation:HumansAnimals
  54. Petibon Y, Guehl NJ, Reese TG, Ebrahimi B, Normandin MD, Shoup TM, Alpert NM, El Fakhri G, Ouyang J. Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR. Phys Med Biol. 2017 01 21; 62(2):326-343. PMID: 27997375.
    Citations: 14     Fields:    Translation:Animals
  55. Wooten DW, Guehl NJ, Verwer EE, Shoup TM, Yokell DL, Zubcevik N, Vasdev N, Zafonte RD, Johnson KA, El Fakhri G, Normandin MD. Pharmacokinetic Evaluation of the Tau PET Radiotracer 18F-T807 (18F-AV-1451) in Human Subjects. J Nucl Med. 2017 Mar; 58(3):484-491. PMID: 27660144; PMCID: PMC5334185.
    Citations: 38     Fields:    Translation:Humans
  56. Liang SH, Chen JM, Normandin MD, Chang JS, Chang GC, Taylor CK, Trapa P, Plummer MS, Para KS, Conn EL, Lopresti-Morrow L, Lanyon LF, Cook JM, Richter KE, Nolan CE, Schachter JB, Janat F, Che Y, Shanmugasundaram V, Lefker BA, Enerson BE, Livni E, Wang L, Guehl NJ, Patnaik D, Wagner FF, Perlis R, Holson EB, Haggarty SJ, El Fakhri G, Kurumbail RG, Vasdev N. Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angew Chem Int Ed Engl. 2016 08 08; 55(33):9601-5. PMID: 27355874; PMCID: PMC4983481.
    Citations: 23     Fields:    Translation:HumansCells
  57. Zhu W, Ouyang J, Rakvongthai Y, Guehl NJ, Wooten DW, El Fakhri G, Normandin MD, Fan Y. A Bayesian spatial temporal mixtures approach to kinetic parametric images in dynamic positron emission tomography. Med Phys. 2016 Mar; 43(3):1222-34. PMID: 26936707.
    Citations: 3     Fields:    Translation:Animals
  58. Yoder KK, Albrecht DS, Dzemidzic M, Normandin MD, Federici LM, Graves T, Herring CM, Hile KL, Walters JW, Liang T, Plawecki MH, O'Connor S, Kareken DA. Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics. Drug Alcohol Depend. 2016 Mar 01; 160:163-9. PMID: 26832934.
    Citations: 23     Fields:    Translation:Humans
  59. D'Souza DC, Cortes-Briones JA, Ranganathan M, Thurnauer H, Creatura G, Surti T, Planeta B, Neumeister A, Pittman B, Normandin M, Kapinos M, Ropchan J, Huang Y, Carson RE, Skosnik PD. Rapid Changes in CB1 Receptor Availability in Cannabis Dependent Males after Abstinence from Cannabis. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Jan 01; 1(1):60-67. PMID: 26858993.
    Citations: 39     Fields:    
  60. Grogg KS, Toole T, Ouyang J, Zhu X, Normandin MD, Li Q, Johnson K, Alpert NM, El Fakhri G. National Electrical Manufacturers Association and Clinical Evaluation of a Novel Brain PET/CT Scanner. J Nucl Med. 2016 Apr; 57(4):646-52. PMID: 26697961; PMCID: PMC4818715.
    Citations: 10     Fields:    Translation:HumansAnimals
  61. D'Souza DC, Cortes-Briones JA, Ranganathan M, Thurnauer H, Creatura G, Surti T, Planeta B, Neumeister A, Pittman B, Normandin MD, Kapinos M, Ropchan J, Huang Y, Carson RE, Skosnik PD. Rapid Changes in Cannabinoid 1 Receptor Availability in Cannabis-Dependent Male Subjects After Abstinence From Cannabis. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Jan; 1(1):60-67. PMID: 29560896.
    Citations: 21     Fields:    
  62. Marquié M, Normandin MD, Vanderburg CR, Costantino IM, Bien EA, Rycyna LG, Klunk WE, Mathis CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA, Frosch MP, Hyman BT, Gómez-Isla T. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Ann Neurol. 2015 Nov; 78(5):787-800. PMID: 26344059; PMCID: PMC4900162.
    Citations: 298     Fields:    Translation:HumansCells
  63. Normandin MD, Yuan H, Wilks MQ, Chen HH, Kinsella JM, Cho H, Guehl NJ, Absi-Halabi N, Hosseini SM, El Fakhri G, Sosnovik DE, Josephson L. Heat-Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET. Angew Chem Int Ed Engl. 2015 Oct 26; 54(44):13002-6. PMID: 26368132; PMCID: PMC4754124.
    Citations: 16     Fields:    Translation:AnimalsCells
  64. Wilks MQ, Normandin MD, Yuan H, Cho H, Guo Y, Herisson F, Ayata C, Wooten DW, El Fakhri G, Josephson L. Imaging PEG-like nanoprobes in tumor, transient ischemia, and inflammatory disease models. Bioconjug Chem. 2015 Jun 17; 26(6):1061-9. PMID: 25971846; PMCID: PMC5378316.
    Citations: 3     Fields:    Translation:AnimalsCells
  65. Wilks MQ**, Normandin MD**, Yuan H, Cho H, Guo Y, Herrison F, Ayata C, Wooten DW, El Fakhri G, Josephson L (**contributed equally). Imaging PEG-Like Nanoprobes in Tumor, Transient Ischemia, and Inflammatory Disease Models. Bioconjug Chem. 2015; 26(6):1061-9. View Publication.
  66. Normandin MD, Zheng MQ, Lin KS, Mason NS, Lin SF, Ropchan J, Labaree D, Henry S, Williams WA, Carson RE, Neumeister A, Huang Y. Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: assessment of kinetic analysis methods, test-retest reproducibility, and gender differences. J Cereb Blood Flow Metab. 2015 Aug; 35(8):1313-22. PMID: 25833345; PMCID: PMC4528005.
    Citations: 27     Fields:    Translation:HumansCTClinical Trials
  67. Grogg K, Alpert NM, Zhu X, Min CH, Testa M, Winey B, Normandin MD, Shih HA, Paganetti H, Bortfeld T, El Fakhri G. Mapping (15)O production rate for proton therapy verification. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):453-9. PMID: 25817530; PMCID: PMC4431894.
    Citations: 4     Fields:    Translation:AnimalsCells
  68. Yoder KK, Territo PR, Hutchins GD, Hannestad J, Morris ED, Gallezot JD, Normandin MD, Cosgrove KP. Comparison of standardized uptake values with volume of distribution for quantitation of [(11)C]PBR28 brain uptake. Nucl Med Biol. 2015 Mar; 42(3):305-8. PMID: 25487553; PMCID: PMC4329090.
    Citations: 10     Fields:    Translation:AnimalsCells
  69. Liang SH, Yokell DL, Normandin MD, Rice PA, Jackson RN, Shoup TM, Brady TJ, Fakhri GE, Collier TL, Vasdev N. First Human Use of a Radiopharmaceutical Prepared by Continuous-Flow Microfluidic Radiofluorination: Proof of Concept with the Tau Imaging Agent [18F]T807. Mol Imaging. 2014 Oct 01; 13(8):7290201400025. PMID: 28650281.
  70. Wooten DW, Hillmer AT, Murali D, Barnhart TE, Thio JP, Bajwa AK, Bonab AA, Normandin MD, Schneider ML, Mukherjee J, Christian BT. Initial in vivo PET imaging of 5-HT1A receptors with 3-[(18)F]mefway. Am J Nucl Med Mol Imaging. 2014; 4(5):483-9. PMID: 25143866.
    Citations: 2     
  71. Shoup TM, McCauley JP, Lee DF, Chen R, Normandin MD, Bonab AA, El Fakhri G, Vasdev N. Synthesis of the dopamine D2/D3 receptor agonist (+)-PHNO via a supercritical fluid chromatography: Preliminary PET imaging study with [3-11C]-(+)PHNO. Tetrahedron Letters. 2014; 3(55):682-685. View Publication.
  72. Huang C, Ackerman JL, Petibon Y, Normandin MD, Brady TJ, El Fakhri G, Ouyang J. Motion compensation for brain PET imaging using wireless MR active markers in simultaneous PET-MR: phantom and non-human primate studies. Neuroimage. 2014 May 01; 91:129-37. PMID: 24418501.
    Citations: 15     Fields:    Translation:HumansAnimals
  73. Liang SH, Yokell DL, Normandin MD, Rice PA, Jackson RN, Shoup TM, Brady TJ, El Fakhri G, Collier TL, Vasdev N. First human use of a radiopharmaceutical prepared by continuous-flow microfluidic radiofluorination: proof of concept with the tau imaging agent [18F]T807. Mol Imaging. 2014; 13. PMID: 25248283.
    Citations: 11     Fields:    Translation:Humans
  74. Neumeister A, Normandin MD, Pietrzak RH, Piomelli D, Zheng MQ, Gujarro-Anton A, Potenza MN, Bailey CR, Lin SF, Najafzadeh S, Ropchan J, Henry S, Corsi-Travali S, Carson RE, Huang Y. Increased OMAR MA1 DV in PTSD. Mol Psychiatry. 2013 Sep; 18(9):953. PMID: 23969378.
  75. Morris ED, Kim SJ, Sullivan JM, Wang S, Normandin MD, Constantinescu CC, Cosgrove KP. Creating dynamic images of short-lived dopamine fluctuations with lp-ntPET: dopamine movies of cigarette smoking. J Vis Exp. 2013 Aug 06; (78). PMID: 23963311.
    Citations: 12     Fields:    Translation:Humans
  76. Sander CY, Hooker JM, Catana C, Normandin MD, Alpert NM, Knudsen GM, Vanduffel W, Rosen BR, Mandeville JB. Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):11169-74. PMID: 23723346.
    Citations: 55     Fields:    Translation:Animals
  77. Neumeister A, Normandin MD, Pietrzak RH, Piomelli D, Zheng MQ, Gujarro-Anton A, Potenza MN, Bailey CR, Lin SF, Najafzadeh S, Ropchan J, Henry S, Corsi-Travali S, Carson RE, Huang Y. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. Mol Psychiatry. 2013 Sep; 18(9):1034-40. PMID: 23670490.
    Citations: 125     Fields:    Translation:Humans
  78. Mandeville JB, Sander CYM, Jenkins BG, Hooker JM, Catana C, Vanduffel W, Alpert NM, Rosen BR, Normandin MD. A receptor-based model for dopamine-induced fMRI signal. Neuroimage. 2013 Jul 15; 75:46-57. PMID: 23466936.
    Citations: 30     Fields:    Translation:HumansAnimals
  79. Normandin MD, Petersen KF, Ding YS, Lin SF, Naik S, Fowles K, Skovronsky DM, Herold KC, McCarthy TJ, Calle RA, Carson RE, Treadway JL, Cline GW. In vivo imaging of endogenous pancreatic ß-cell mass in healthy and type 1 diabetic subjects using 18F-fluoropropyl-dihydrotetrabenazine and PET. J Nucl Med. 2012 Jun; 53(6):908-16. PMID: 22573821.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  80. Neumeister A, Normandin MD, Murrough JW, Henry S, Bailey CR, Luckenbaugh DA, Tuit K, Zheng MQ, Galatzer-Levy IR, Sinha R, Carson RE, Potenza MN, Huang Y. Positron emission tomography shows elevated cannabinoid CB1 receptor binding in men with alcohol dependence. Alcohol Clin Exp Res. 2012 Dec; 36(12):2104-9. PMID: 22551199.
    Citations: 23     Fields:    Translation:Humans
  81. Normandin MD, Koeppe RA, Morris ED. Selection of weighting factors for quantification of PET radioligand binding using simplified reference tissue models with noisy input functions. Phys Med Biol. 2012 Feb 07; 57(3):609-29. PMID: 22241524.
    Citations: 2     Fields:    Translation:Humans
  82. Wang Y, Lim K, Normandin M, Zhao X, Cline GW, Ding YS. Synthesis and evaluation of [18F]exendin (9-39) as a potential biomarker to measure pancreatic ß-cell mass. Nucl Med Biol. 2012 Feb; 39(2):167-76. PMID: 22033026.
    Citations: 23     Fields:    Translation:AnimalsCells
  83. Normandin MD, Schiffer WK, Morris ED. A linear model for estimation of neurotransmitter response profiles from dynamic PET data. Neuroimage. 2012 Feb 01; 59(3):2689-99. PMID: 21767654.
    Citations: 38     Fields:    Translation:AnimalsCells
  84. Anand A, Barkay G, Dzemidzic M, Albrecht D, Karne H, Zheng QH, Hutchins GD, Normandin MD, Yoder KK. Striatal dopamine transporter availability in unmedicated bipolar disorder. Bipolar Disord. 2011 Jun; 13(4):406-13. PMID: 21843280.
    Citations: 41     Fields:    Translation:Humans
  85. Sullivan JM, Risacher SL, Normandin MD, Yoder KK, Froehlich JC, Morris ED. Imaging of alcohol-induced dopamine release in rats:preliminary findings with [(11) C]raclopride PET. Synapse. 2011 Sep; 65(9):929-37. PMID: 21308803.
    Citations: 2     Fields:    Translation:AnimalsCells
  86. Singhal T, Ding YS, Weinzimmer D, Normandin MD, Labaree D, Ropchan J, Nabulsi N, Lin SF, Skaddan MB, Soeller WC, Huang Y, Carson RE, Treadway JL, Cline GW. Pancreatic beta cell mass PET imaging and quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in rodent models of diabetes. Mol Imaging Biol. 2011 Oct; 13(5):973-84. PMID: 20824509.
    Citations: 36     Fields:    Translation:Animals
  87. Morris ED, Constantinescu CC, Sullivan JM, Normandin MD, Christopher LA. Noninvasive visualization of human dopamine dynamics from PET images. Neuroimage. 2010 May 15; 51(1):135-44. PMID: 20056162.
    Citations: 8     Fields:    Translation:Humans
  88. Yoder KK, Morris ED, Constantinescu CC, Cheng TE, Normandin MD, O'Connor SJ, Kareken DA. When what you see isn't what you get: alcohol cues, alcohol administration, prediction error, and human striatal dopamine. Alcohol Clin Exp Res. 2009 Jan; 33(1):139-49. PMID: 18976347; PMCID: PMC2905874.
    Citations: 34     Fields:    Translation:Humans
  89. Cheng TE, Yoder KK, Normandin MD, Risacher SL, Converse AK, Hampel JA, Miller MA, Morris ED. A rat head holder for simultaneous scanning of two rats in small animal PET scanners: design, construction, feasibility testing and kinetic validation. J Neurosci Methods. 2009 Jan 15; 176(1):24-33. PMID: 18824025; PMCID: PMC3725621.
    Citations: 7     Fields:    Translation:Animals
  90. Constantinescu CC, Yoder KK, Kareken DA, Bouman CA, O'Connor SJ, Normandin MD, Morris ED. Estimation from PET data of transient changes in dopamine concentration induced by alcohol: support for a non-parametric signal estimation method. Phys Med Biol. 2008 Mar 07; 53(5):1353-67. PMID: 18296766.
    Citations: 5     Fields:    Translation:Humans
  91. Morris ED, Normandin MD, Schiffer WK. Initial comparison of ntPET with microdialysis measurements of methamphetamine-induced dopamine release in rats: support for estimation of dopamine curves from PET data. Mol Imaging Biol. 2008 Mar-Apr; 10(2):67-73. PMID: 18176804.
    Citations: 10     Fields:    Translation:Animals
  92. Normandin MD, Morris ED. Estimating neurotransmitter kinetics with ntPET: a simulation study of temporal precision and effects of biased data. Neuroimage. 2008 Feb 01; 39(3):1162-79. PMID: 18023364.
    Citations: 14     Fields:    Translation:Humans
  93. Yoder KK, Constantinescu CC, Kareken DA, Normandin MD, Cheng TE, O'Connor SJ, Morris ED. Heterogeneous effects of alcohol on dopamine release in the striatum: a PET study. Alcohol Clin Exp Res. 2007 Jun; 31(6):965-73. PMID: 17428296.
    Citations: 32     Fields:    Translation:Humans
  94. Normandin MD, Morris ED. Temporal resolution of ntPET using either arterial or reference region-derived plasma input functions. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:2005-8. PMID: 17946491.
    Citations: 4     Fields:    Translation:Humans
  95. Morris ED, Yoder KK, Wang C, Normandin MD, Zheng QH, Mock B, Muzic RF, Froehlich JC. ntPET: a new application of PET imaging for characterizing the kinetics of endogenous neurotransmitter release. Mol Imaging. 2005 Oct-Dec; 4(4):473-89. PMID: 16285909.
    Citations: 23     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.