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Robert Grant Rowe, M.D.,Ph.D.

Title
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Department
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Biography
University of Michigan, Ann ArborMD/PhD05/2011Medicine
Boston Children's Hospital06/2014Residency in pediatrics
Boston Children's Hospital/Dana-Farber Cancer Institute06/2017Fellowship in pediatric hematology/oncology

Overview
My laboratory is interested in studying normal hematopoietic development and understanding the factors that specify the juvenile blood forming system. We believe that this will lead to improved understanding of blood diseases that affect children.

Mentoring
Available: 11/13/19, Expires: 12/01/20

This is a ready made project with primary data on which to develop new findings. The overarching goal of the Rowe laboratory is to study the developmental changes that occur in hematopoiesis and their relevance to blood diseases. The student will learn mouse blood cell transplantation, flow cytometry, and cutting edge molecular tools such as CRISPR/Cas9, gene transfer, and next generation sequencing.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08DK114527 (ROWE, ROBERT GRANT) Jul 1, 2017 - Apr 30, 2022
    NIH/NIDDK
    Role of the Lin28b/let-7 axis in the maturation of hematopoietic progenitor cells
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rowe RG, Daley GQ. Induced pluripotent stem cells in disease modelling and drug discovery. Nat Rev Genet. 2019 07; 20(7):377-388. PMID: 30737492.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  2. Rowe RG, Lummertz da Rocha E, Sousa P, Missios P, Morse M, Marion W, Yermalovich A, Barragan J, Mathieu R, Jha DK, Fleming MD, North TE, Daley GQ. The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia. J Exp Med. 2019 03 04; 216(3):527-538. PMID: 30728174.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Stolla MC, Catherman SC, Kingsley PD, Rowe RG, Koniski AD, Fegan K, Vit L, McGrath KE, Daley GQ, Palis J. Lin28b regulates age-dependent differences in murine platelet function. Blood Adv. 2019 01 08; 3(1):72-82. PMID: 30622145.
    Citations: 2     Fields:    Translation:AnimalsCells
  4. Wang L, Rowe RG, Jaimes A, Yu C, Nam Y, Pearson DS, Zhang J, Xie X, Marion W, Heffron GJ, Daley GQ, Sliz P. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 06 05; 23(10):3091-3101. PMID: 29874593.
    Citations: 9     Fields:    Translation:HumansCells
  5. Lummertz da Rocha E, Rowe RG, Lundin V, Malleshaiah M, Jha DK, Rambo CR, Li H, North TE, Collins JJ, Daley GQ. Reconstruction of complex single-cell trajectories using CellRouter. Nat Commun. 2018 03 01; 9(1):892. PMID: 29497036.
    Citations: 8     Fields:    Translation:HumansCells
  6. Sugimura R, Jha DK, Han A, Soria-Valles C, da Rocha EL, Lu YF, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, Engelman AN, Snapper SB, Doulatov S, Daley GQ. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 2017 05 25; 545(7655):432-438. PMID: 28514439.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  7. Rowe RG, Wang LD, Coma S, Han A, Mathieu R, Pearson DS, Ross S, Sousa P, Nguyen PT, Rodriguez A, Wagers AJ, Daley GQ. Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis. J Exp Med. 2016 07 25; 213(8):1497-512. PMID: 27401346.
    Citations: 14     Fields:    Translation:AnimalsCells
  8. Rowe RG, Mandelbaum J, Zon LI, Daley GQ. Engineering Hematopoietic Stem Cells: Lessons from Development. Cell Stem Cell. 2016 06 02; 18(6):707-20. PMID: 27257760.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  9. Kim PG, Nakano H, Das PP, Chen MJ, Rowe RG, Chou SS, Ross SJ, Sakamoto KM, Zon LI, Schlaeger TM, Orkin SH, Nakano A, Daley GQ. Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence. J Exp Med. 2015 May 04; 212(5):633-48. PMID: 25870201.
    Citations: 22     Fields:    Translation:AnimalsCells
  10. Wang LD, Rao TN, Rowe RG, Nguyen PT, Sullivan JL, Pearson DS, Doulatov S, Wu L, Lindsley RC, Zhu H, DeAngelo DJ, Daley GQ, Wagers AJ. The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy. Leukemia. 2015 Jun; 29(6):1320-30. PMID: 25655194.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.