"Teniposide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
Concept/Terms
Teniposide- Teniposide
- Demethyl Epipodophyllotoxin Thenylidine Glucoside
Vumon- Vumon
- Bristol-Myers Brand of Teniposide
- Bristol Myers Brand of Teniposide
- Bristol-Myers Squibb Brand of Teniposide
- Bristol Myers Squibb Brand of Teniposide
Below are MeSH descriptors whose meaning is more general than "Teniposide".
Below are MeSH descriptors whose meaning is more specific than "Teniposide".
This graph shows the total number of publications written about "Teniposide" by people in Harvard Catalyst Profiles by year, and whether "Teniposide" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1995 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
Below are the most recent publications written about "Teniposide" by people in Profiles.
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Pathologic risk-based adjuvant chemotherapy for unilateral retinoblastoma following enucleation. J Pediatr Hematol Oncol. 2014 Aug; 36(6):e335-40.
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[Chemotherapy in patients with refractory Ewing sarcoma]. Med Wieku Rozwoj. 2013 Apr-Jun; 17(2):117-25.
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Adenovirus-mediated transfer of siRNA against basic fibroblast growth factor mRNA enhances the sensitivity of glioblastoma cells to chemotherapy. Med Oncol. 2011 Mar; 28(1):24-30.
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The E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex - a potentially new drug target. PLoS One. 2009 Dec 01; 4(12):e8104.
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The addition of ifosfamide/etoposide to cisplatin/teniposide improves the survival of children with retinoblastoma and orbital involvement. J Pediatr Hematol Oncol. 2007 Oct; 29(10):700-4.
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Study of either ifosfamide or teniposide compared to a standard chemotherapy for extensive disease small cell lung cancer: an Eastern Cooperative Oncology Group randomized study (E1588). Lung Cancer. 2002 Sep; 37(3):311-8.
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Suppression of c-myc expression and c-Myc function in response to sustained DNA damage in MCF-7 breast tumor cells. Biochem Pharmacol. 2001 Sep 01; 62(5):593-602.
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Quality-of-life-adjusted survival analysis of interferon alfa-2b treatment for advanced follicular lymphoma: an aid to clinical decision making. J Clin Oncol. 1998 Jul; 16(7):2339-44.
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Genetic staging of unresectable or metastatic neuroblastoma in infants: a Pediatric Oncology Group study. J Natl Cancer Inst. 1997 Mar 05; 89(5):373-80.
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Phase II trial of gallium nitrate, amonafide and teniposide in metastatic non-small cell lung cancer. An Eastern Cooperative Oncology Group study (E2588). Invest New Drugs. 1995; 13(2):137-41.