Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Superantigens

"Superantigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.


This graph shows the total number of publications written about "Superantigens" by people in Harvard Catalyst Profiles by year, and whether "Superantigens" was a major or minor topic of these publication.
Bar chart showing 95 publications over 26 distinct years, with a maximum of 13 publications in 1994
To see the data from this visualization as text, click here.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.