"Spheroids, Cellular" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Spherical, heterogeneous aggregates of proliferating, quiescent, and necrotic cells in culture that retain three-dimensional architecture and tissue-specific functions. The ability to form spheroids is a characteristic trait of CULTURED TUMOR CELLS derived from solid TUMORS. Cells from normal tissues can also form spheroids. They represent an in-vitro model for studies of the biology of both normal and malignant cells. (From Bjerkvig, Spheroid Culture in Cancer Research, 1992, p4)
Concept/Terms
Spheroids, Cellular- Spheroids, Cellular
- Cellular Spheroid
- Cellular Spheroids
- Spheroid, Cellular
- Multicellular Spheroids
- Multicellular Spheroid
- Spheroid, Multicellular
- Spheroids, Multicellular
Below are MeSH descriptors whose meaning is more general than "Spheroids, Cellular".
Below are MeSH descriptors whose meaning is more specific than "Spheroids, Cellular".
This graph shows the total number of publications written about "Spheroids, Cellular" by people in Harvard Catalyst Profiles by year, and whether "Spheroids, Cellular" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 1 | 2 |
| 2002 | 1 | 3 | 4 |
| 2003 | 1 | 1 | 2 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 4 | 4 |
| 2007 | 2 | 4 | 6 |
| 2008 | 3 | 7 | 10 |
| 2009 | 1 | 3 | 4 |
| 2010 | 2 | 6 | 8 |
| 2011 | 2 | 1 | 3 |
| 2012 | 1 | 6 | 7 |
| 2013 | 0 | 10 | 10 |
| 2014 | 3 | 6 | 9 |
| 2015 | 1 | 11 | 12 |
| 2016 | 5 | 13 | 18 |
| 2017 | 5 | 13 | 18 |
| 2018 | 3 | 11 | 14 |
| 2019 | 6 | 12 | 18 |
| 2020 | 6 | 8 | 14 |
| 2021 | 6 | 8 | 14 |
| 2022 | 2 | 1 | 3 |
| 2023 | 0 | 2 | 2 |
Below are the most recent publications written about "Spheroids, Cellular" by people in Profiles.
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The response and resistance to drugs in ovarian cancer cell lines in 2D monolayers and 3D spheroids. Biomed Pharmacother. 2023 Sep; 165:115152.
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Targeting TBK1 to overcome resistance to cancer immunotherapy. Nature. 2023 03; 615(7950):158-167.
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New Strategy for Promoting Vascularization in Tumor Spheroids in a Microfluidic Assay. Adv Healthc Mater. 2023 06; 12(14):e2201784.
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Culture of cancer spheroids and evaluation of anti-cancer drugs in 3D-printed miniaturized continuous stirred tank reactors (mCSTRs). Biofabrication. 2022 04 21; 14(3).
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Automated Assessment of Cancer Drug Efficacy On Breast Tumor Spheroids in Aggrewell™400 Plates Using Image Cytometry. J Fluoresc. 2022 Mar; 32(2):521-531.
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Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis. Life Sci Alliance. 2022 03; 5(3).
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A machine learning pipeline revealing heterogeneous responses to drug perturbations on vascular smooth muscle cell spheroid morphology and formation. Sci Rep. 2021 12 02; 11(1):23285.
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NF-?B suppression synergizes with E7386, an inhibitor of CBP/ß-catenin interaction, to block proliferation of patient-derived colon cancer spheroids. Biochem Biophys Res Commun. 2022 01 01; 586:93-99.
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GLRX3, a novel cancer stem cell-related secretory biomarker of pancreatic ductal adenocarcinoma. BMC Cancer. 2021 Nov 18; 21(1):1241.
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Optimizing the Design of Blood-Brain Barrier-Penetrating Polymer-Lipid-Hybrid Nanoparticles for Delivering Anticancer Drugs to Glioblastoma. Pharm Res. 2021 Nov; 38(11):1897-1914.