Methylenetetrahydrofolate Dehydrogenase (NADP)
"Methylenetetrahydrofolate Dehydrogenase (NADP)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
Below are MeSH descriptors whose meaning is more general than "Methylenetetrahydrofolate Dehydrogenase (NADP)".
Below are MeSH descriptors whose meaning is more specific than "Methylenetetrahydrofolate Dehydrogenase (NADP)".
This graph shows the total number of publications written about "Methylenetetrahydrofolate Dehydrogenase (NADP)" by people in Harvard Catalyst Profiles by year, and whether "Methylenetetrahydrofolate Dehydrogenase (NADP)" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 2 | 2 | 4 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
Below are the most recent publications written about "Methylenetetrahydrofolate Dehydrogenase (NADP)" by people in Profiles.
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Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation. Cell Metab. 2019 09 03; 30(3):539-555.e11.
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MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation. Nat Genet. 2019 06; 51(6):990-998.
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The importance of mitochondrial folate enzymes in human colorectal cancer. Oncol Rep. 2017 Jan; 37(1):417-425.
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mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science. 2016 Feb 12; 351(6274):728-733.
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Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study. Cancer. 2015 Oct 15; 121(20):3684-91.
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Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer. Nat Commun. 2014; 5:3128.
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Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk. Mol Nutr Food Res. 2013 Apr; 57(4):721-34.
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Maternal and infant gene-folate interactions and the risk of neural tube defects. Am J Med Genet A. 2012 Oct; 158A(10):2439-46.
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Understanding the complexity of homocysteine lowering with vitamins: the potential role of subgroup analyses. JAMA. 2011 Dec 21; 306(23):2610-1.
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Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study. BMC Med Genet. 2011 Nov 21; 12:150.