Granulocyte-Macrophage Colony-Stimulating Factor
"Granulocyte-Macrophage Colony-Stimulating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
MeSH Number(s)
D12.644.276.374.410.240.375
D12.776.395.240.300
D12.776.467.374.410.240.375
D23.529.374.410.240.375
Concept/Terms
Granulocyte-Macrophage Colony-Stimulating Factor- Granulocyte-Macrophage Colony-Stimulating Factor
- Granulocyte Macrophage Colony Stimulating Factor
- CSF-2
- Tumor-Cell Human GM Colony-Stimulating Factor
- Tumor Cell Human GM Colony Stimulating Factor
- GM-CSF
- Histamine-Producing Cell-Stimulating Factor
- Cell-Stimulating Factor, Histamine-Producing
- Histamine Producing Cell Stimulating Factor
- TC-GM-CSF
- Colony-Stimulating Factor, Granulocyte-Macrophage
- Colony Stimulating Factor, Granulocyte Macrophage
- CSF-GM
Below are MeSH descriptors whose meaning is more general than "Granulocyte-Macrophage Colony-Stimulating Factor".
Below are MeSH descriptors whose meaning is more specific than "Granulocyte-Macrophage Colony-Stimulating Factor".
This graph shows the total number of publications written about "Granulocyte-Macrophage Colony-Stimulating Factor" by people in Harvard Catalyst Profiles by year, and whether "Granulocyte-Macrophage Colony-Stimulating Factor" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 18 | 16 | 34 |
| 1992 | 9 | 14 | 23 |
| 1993 | 15 | 8 | 23 |
| 1994 | 15 | 12 | 27 |
| 1995 | 10 | 13 | 23 |
| 1996 | 14 | 20 | 34 |
| 1997 | 15 | 6 | 21 |
| 1998 | 7 | 10 | 17 |
| 1999 | 12 | 9 | 21 |
| 2000 | 8 | 7 | 15 |
| 2001 | 7 | 8 | 15 |
| 2002 | 11 | 10 | 21 |
| 2003 | 7 | 11 | 18 |
| 2004 | 4 | 8 | 12 |
| 2005 | 5 | 4 | 9 |
| 2006 | 6 | 9 | 15 |
| 2007 | 4 | 2 | 6 |
| 2008 | 4 | 9 | 13 |
| 2009 | 10 | 4 | 14 |
| 2010 | 9 | 10 | 19 |
| 2011 | 6 | 13 | 19 |
| 2012 | 3 | 7 | 10 |
| 2013 | 1 | 12 | 13 |
| 2014 | 7 | 12 | 19 |
| 2015 | 8 | 14 | 22 |
| 2016 | 10 | 7 | 17 |
| 2017 | 3 | 4 | 7 |
| 2018 | 3 | 3 | 6 |
| 2019 | 7 | 7 | 14 |
| 2020 | 2 | 6 | 8 |
| 2021 | 2 | 2 | 4 |
Below are the most recent publications written about "Granulocyte-Macrophage Colony-Stimulating Factor" by people in Profiles.
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The Conversion of Human Tissue-Like Inflammatory Monocytes Into Macrophages. Curr Protoc. 2021 Mar; 1(3):e74.
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Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis. Nat Commun. 2021 02 15; 12(1):1032.
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Subgroup analysis of nelipepimut-S plus GM-CSF combined with trastuzumab versus trastuzumab alone to prevent recurrences in patients with high-risk, HER2 low-expressing breast cancer. Clin Immunol. 2021 04; 225:108679.
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Clinical Benefit of Lenzilumab in Cases of Coronavirus Disease 2019. Mayo Clin Proc. 2021 03; 96(3):817.
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Migration-induced cell shattering due to DOCK8 deficiency causes a type 2-biased helper T cell response. Nat Immunol. 2020 12; 21(12):1528-1539.
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Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis. N Engl J Med. 2020 10 22; 383(17):1635-1644.
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Phase 1 study of lenzilumab, a recombinant anti-human GM-CSF antibody, for chronic myelomonocytic leukemia. Blood. 2020 08 13; 136(7):909-913.
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Biomaterials as Local Niches for Immunomodulation. Acc Chem Res. 2020 09 15; 53(9):1749-1760.
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Irinotecan, Temozolomide, and Dinutuximab With GM-CSF in Children With Refractory or Relapsed Neuroblastoma: A Report From the Children's Oncology Group. J Clin Oncol. 2020 07 01; 38(19):2160-2169.
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Neutrophil swarming delays the growth of clusters of pathogenic fungi. Nat Commun. 2020 04 27; 11(1):2031.