"Glutamate-Ammonia Ligase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and L-glutamine. It also acts more slowly on 4-methylene-L-glutamate. (From Enzyme Nomenclature, 1992) EC 6.3.1.2.
Concept/Terms
Glutamate-Ammonia Ligase- Glutamate-Ammonia Ligase
- Glutamate Ammonia Ligase
- Ligase, Glutamate-Ammonia
- Glutamate Ammonia Ligase (ADP)
- Glutamine Synthetase
- Synthetase, Glutamine
Below are MeSH descriptors whose meaning is more general than "Glutamate-Ammonia Ligase".
Below are MeSH descriptors whose meaning is more specific than "Glutamate-Ammonia Ligase".
This graph shows the total number of publications written about "Glutamate-Ammonia Ligase" by people in Harvard Catalyst Profiles by year, and whether "Glutamate-Ammonia Ligase" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 0 | 1 |
| 1997 | 2 | 1 | 3 |
| 1998 | 3 | 2 | 5 |
| 1999 | 1 | 2 | 3 |
| 2000 | 1 | 3 | 4 |
| 2001 | 2 | 0 | 2 |
| 2002 | 0 | 4 | 4 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 2 | 2 |
| 2020 | 1 | 2 | 3 |
| 2021 | 1 | 0 | 1 |
Below are the most recent publications written about "Glutamate-Ammonia Ligase" by people in Profiles.
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Glutamine synthetase in human carotid plaque macrophages associates with features of plaque vulnerability: An immunohistological study. Atherosclerosis. 2022 07; 352:18-26.
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Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. Proc Natl Acad Sci U S A. 2021 03 09; 118(10).
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Maternal separation with early weaning impairs neuron-glia integrity: non-invasive evaluation and substructure demonstration. Sci Rep. 2020 11 10; 10(1):19440.
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Association of the 1q25 Diabetes-Specific Coronary Heart Disease Locus With Alterations of the ?-Glutamyl Cycle and Increased Methylglyoxal Levels in Endothelial Cells. Diabetes. 2020 10; 69(10):2206-2216.
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Nodular Regenerative Hyperplasia: Expression Pattern of Glutamine Synthetase and a Potential Role for Hepatic Progenitor Cells. Appl Immunohistochem Mol Morphol. 2020 03; 28(3):243-248.
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GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay. Hum Mol Genet. 2019 01 01; 28(1):96-104.
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Ammonia modifies enteric neuromuscular transmission through glial ?-aminobutyric acid signaling. Am J Physiol Gastrointest Liver Physiol. 2017 Dec 01; 313(6):G570-G580.
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Additive neurogenesis supported by multiple stem cell populations mediates adult spinal cord development: A spatiotemporal statistical mapping analysis in a teleost model of indeterminate growth. Dev Neurobiol. 2017 11; 77(11):1269-1307.
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Correlation of exon 3 ß-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma. Mod Pathol. 2016 11; 29(11):1370-1380.
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Genetic Variant at the GLUL Locus Predicts All-Cause Mortality in Patients With Type 2 Diabetes. Diabetes. 2015 Jul; 64(7):2658-63.