Harvard Catalyst Profiles

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Buthionine Sulfoximine

"Buthionine Sulfoximine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)


This graph shows the total number of publications written about "Buthionine Sulfoximine" by people in Harvard Catalyst Profiles by year, and whether "Buthionine Sulfoximine" was a major or minor topic of these publication.
Bar chart showing 16 publications over 11 distinct years, with a maximum of 2 publications in 1989 and 1991 and 1998 and 2013 and 2016
To see the data from this visualization as text, click here.
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.