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Epidemiology of atherosclerosis among older-age individuals with HIV in Uganda


We aim to measure the prevalence and correlates of cardiovascular and pulmonary disease surrogates among people living with HIV and age and gender-matched HIV-, population-based, uninfected controls in rural, sub-Saharan Africa.
• Our outcomes of interest will be: measures of atherosclerosis and pulmonary disease, including: 1) carotid intima-media thickness, 2) ankle-brachial index, 3) presence of q-waves on electrocardiogram; and 4) pulmonary function testing
• Our exposures of interest will be: traditional cardiovascular and pulmonary disease risk factors (age, gender, family history of cardiovascular disease, smoking history, diet, activity, body mass index, prevalence of diabetes, and prevalence of hypertension) and HIV-related risk factors (nadir CD4 count, ART duration, gut and plasma microbiome composition, and markers of both immune activation and systemic inflammation).

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.