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Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion.
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Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion.
Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion. J Exp Med. 2019 11 04; 216(11):2635-2652.
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PubMed
subject areas
Animals
Cell Line, Tumor
Cells, Cultured
Cyclin-Dependent Kinases
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Glutathione
HEK293 Cells
Humans
Mice
Mice, Nude
Mutation
Neoplasms
NF-E2-Related Factor 2
Phenylenediamines
Pyrimidines
Tuberous Sclerosis
Xenograft Model Antitumor Assays
authors with profiles
Amin Nassar, M.D.
Heng Du, B.M.
Krinio Giannikou, Ph.D.
Hilaire Colletta Lam, Ph.D.
John M Asara, Ph.D.
David Joseph Kwiatkowski, M.D., Ph.D.
Elizabeth Petri Henske, M.D.
Yubao Wang, Ph.D.