"Ubiquitin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
Concept/Terms
Ubiquitin- Ubiquitin
- HMG-20
- High Mobility Protein 20
- APF-1
- ATP-Dependent Proteolysis Factor 1
- ATP Dependent Proteolysis Factor 1
Below are MeSH descriptors whose meaning is more general than "Ubiquitin".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin".
This graph shows the total number of publications written about "Ubiquitin" by people in Harvard Catalyst Profiles by year, and whether "Ubiquitin" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 7 | 2 | 9 |
| 2002 | 15 | 21 | 36 |
| 2003 | 17 | 11 | 28 |
| 2004 | 15 | 23 | 38 |
| 2005 | 13 | 23 | 36 |
| 2006 | 17 | 23 | 40 |
| 2007 | 13 | 16 | 29 |
| 2008 | 13 | 10 | 23 |
| 2009 | 11 | 17 | 28 |
| 2010 | 17 | 13 | 30 |
| 2011 | 14 | 9 | 23 |
| 2012 | 7 | 14 | 21 |
| 2013 | 3 | 9 | 12 |
| 2014 | 8 | 8 | 16 |
| 2015 | 11 | 14 | 25 |
| 2016 | 12 | 15 | 27 |
| 2017 | 8 | 14 | 22 |
| 2018 | 10 | 11 | 21 |
| 2019 | 11 | 10 | 21 |
| 2020 | 11 | 8 | 19 |
| 2021 | 9 | 9 | 18 |
| 2022 | 13 | 4 | 17 |
| 2023 | 9 | 14 | 23 |
| 2024 | 1 | 6 | 7 |
Below are the most recent publications written about "Ubiquitin" by people in Profiles.
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Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation. Mol Cell. 2024 Apr 04; 84(7):1290-1303.e7.
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NEDD4L intramolecular interactions regulate its auto and substrate NaV1.5 ubiquitination. J Biol Chem. 2024 Mar; 300(3):105715.
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The E3 ligase SMURF1 stabilizes p27 via UbcH7 catalyzed K29-linked ubiquitin chains to promote cell migration SMURF1-UbcH7 K29 ubiquitination of p27 and cell migration. J Biol Chem. 2024 Mar; 300(3):105693.
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Integrating Clinical Cancer and PTM Proteomics Data Identifies a Mechanism of ACK1 Kinase Activation. Mol Cancer Res. 2024 Feb 01; 22(2):137-151.
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The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3. Proc Natl Acad Sci U S A. 2024 Feb 06; 121(6):e2312291121.
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UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4. Nat Struct Mol Biol. 2024 Feb; 31(2):351-363.
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RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation. Sci Rep. 2024 01 03; 14(1):346.
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A novel RNF125 variant associated with Tenorio syndrome alters ubiquitin chain binding. Clin Genet. 2024 03; 105(3):254-261.
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The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment. Dev Cell. 2023 Dec 04; 58(23):2666-2683.e9.
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Defining E3 ligase-substrate relationships through multiplex CRISPR screening. Nat Cell Biol. 2023 10; 25(10):1535-1545.