Douglas Kwon, M.D.,Ph.D.
|Title||Assistant Professor of Medicine|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
Ragon Institute of MGH, MIT, and Harvard
400 Technology Square, Room 892
Cambridge MA 02139
||Young Investigator Award|
2016||Career Award for Medical Scientists|
||Maxwell Finland Research Award|
My current research focuses on the investigation of immune responses against HIV at mucosal surfaces. The vast majority of HIV is transmitted following exposure to virus at a mucosal site. Mucosal tissues, particularly gut associated lymphoid tissue (GALT), also represents the main compartment of viral replication and the largest reservoir of latently infected cells. Despite this, HIV pathogenesis has primarily been studied in the most accessible compartment- the peripheral blood. However, only 2-3% of all lymphocytes reside in the blood- a small minority relative to the 70-90% of the body’s T and B cells that reside within mucosal tissues. One of the bottlenecks to obtaining a deeper understanding of immune responses against HIV at mucosal sites is the inherently small amount of material that can be obtained from mucosal sampling. We are therefore utilizing new cutting-edge technologies developed in conjunction with our collaborators at the Massachusetts Institute of Technology to simultaneously capture multiple measures of HIV-specific immune responses using small numbers of cells. Using these methodologies we have begun to map mucosal immune responses in the GALT and female reproductive tract at a level of resolution that has not been previously possible with existing technologies.
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