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Thomas E. Scammell, M.D.

Title
Institution
Department
Address
Phone

Biography
education and training
Univ. of Rochester, Rochester, NYBS1984Neuroscience
Univ. of Mass. Medical School, Worcester, MAMD1988Medicine
Univ. of Mass. Medical Center, Worcester, MA1990Medicine Resident
Univ. of California, San Francisco, CA1993Neurology Residency

Mentoring
current student opportunities
Neurobiology of narcolepsy [login at prompt]
Available: 10/01/23, Expires: 12/31/25

Narcolepsy is a common sleep disorder caused by loss of the orexin-producing neurons in the hypothalamus. The student will perform basic science research using mouse models of narcolepsy to identify the brain circuits that give rise to sleepiness and cataplexy. Techniques may include fiber photometry to track neuronal activity and levels of neurotransmitters, optogenetics, chemogenetics, sleep recordings in mice, and anatomic studies. Prior experience in basic animal research is helpful but not necessary. The mentor (Dr. Scammell) has an office next to the lab in the Center for Life Sciences and will meet with the student at least weekly.

completed student projects
Does REM Sleep Influence Cataplexy?
Summer, 05/20/10 - 08/31/10
Circadian Rhythms in Mice with Genetic Ablation of the Orexin Neurons
Summer, 07/01/05 - 09/01/05

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. P01HL149630 (SAPER, CLIFFORD B) Jul 1, 2020 - Jun 30, 2025
    NIH
    Mechanisms of sleep and sleep apnea
    Role: Co-Investigator
  2. U54AG062322 (JOFFE, HADINE) Jun 1, 2020 - May 31, 2025
    NIH
    Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes
    Role: Co-Investigator
  3. R01NS106032 (SCAMMELL, THOMAS E) Jul 1, 2018 - Apr 30, 2022
    NIH
    Mechanisms of Cataplexy
    Role: Principal Investigator
  4. P01HL095491 (SAPER, CLIFFORD B) Apr 1, 2009 - May 31, 2021
    NIH
    Mechanisms of Arousal in Sleep Apnea
    Role: Co-Principal Investigator
  5. R01MH062589 (SCAMMELL, THOMAS EMERY) Aug 15, 2001 - Apr 30, 2007
    NIH
    Circadian and Aminergic Regulation of Orexin Neurons
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 158 total Publications Show all
  1. Korkutata M, De Luca R, Fitzgerald B, Khanday MA, Arrigoni E, Scammell TE. Afferent Projections to the Calca/CGRP-Expressing Parabrachial Neurons in Mice. J Comp Neurol. 2025 Jan; 533(1):e70018. PMID: 39801453; PMCID: PMC11777123.
    Citations:
    Fields: NeuNeurology
  2. Davidson RD, Blattner M, Scammell TE, Zhou ES. The impact of idiopathic hypersomnia on the social lives of young adults. Sleep Health. 2024 Dec 31. PMID: 39743439.
    Citations:
    Fields: PsyPsychophysiology
  3. Blattner MS, Scammell TE. What is cataplexy? Sleep. 2024 Nov 08; 47(11). PMID: 37788645.
    Citations:
    Fields: PsyPsychophysiology
  4. Di Marco T, Djonlagic I, Dauvilliers Y, Sadeghi K, Little D, Datta AN, Hubbard J, Hajak G, Krystal A, Olivieri A, Parrino L, Puryear CB, Zammit G, Donoghue J, Scammell TE. Effect of daridorexant on sleep architecture in patients with chronic insomnia disorder: a pooled post hoc analysis of two randomized phase 3 clinical studies. Sleep. 2024 Nov 08; 47(11). PMID: 38644625; PMCID: PMC11543623.
    Citations:
    Fields: PsyPsychophysiologyTranslation:HumansCTClinical Trials
  5. Maski K, Heckler G, Worhach J, Mylonas D, Wang G, Szilagyi K, Zhang B, Diniz Behn C, Scammell TE, Stickgold R. Impaired Sleep-Dependent Memory Consolidation in Pediatric Narcolepsy Type 1. Sleep. 2024 Oct 18. PMID: 39420719.
    Citations:
    Fields: PsyPsychophysiology
  6. Heckler G, Worhach J, Wang G, Szilagyi K, Zhang B, Behn CD, Scammell T, Maski K. Characterizing disrupted nighttime sleep and associated functional outcomes in youth with narcolepsy type 1. J Clin Sleep Med. 2024 Oct 17. PMID: 39415540.
    Citations:
    Fields: NeuNeurologyPsyPsychophysiology
  7. Cano CA, Harel BT, Scammell TE. Impaired cognition in narcolepsy: clinical and neurobiological perspectives. Sleep. 2024 Sep 09; 47(9). PMID: 38943485.
    Citations:
    Fields: PsyPsychophysiologyTranslation:HumansAnimals
  8. Kwon Y, Gami AS, Javaheri S, Pressman GS, Scammell TE, Surkin LA, Zee PC. Cardiovascular Risks in People With Narcolepsy: Expert Panel Consensus Recommendations. J Am Heart Assoc. 2024 Aug 20; 13(16):e035168. PMID: 39119988.
    Citations:
    Fields: CarCardiologyVasVascular DiseasesTranslation:Humans
  9. Harel BT, Gattuso JJ, Latzman RD, Maruff P, Scammell TE, Plazzi G. The nature and magnitude of cognitive impairment in narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia: a meta-analysis. Sleep Adv. 2024; 5(1):zpae043. PMID: 39036743; PMCID: PMC11258808.
    Citations:
  10. Di Marco T, Scammell TE, Sadeghi K, Datta AN, Little D, Tjiptarto N, Djonlagic I, Olivieri A, Zammit G, Krystal A, Pathmanathan J, Donoghue J, Hubbard J, Dauvilliers Y. Hyperarousal features in the sleep architecture of individuals with and without insomnia. J Sleep Res. 2025 Feb; 34(1):e14256. PMID: 38853521; PMCID: PMC11744246.
    Citations:
    Fields: PsyPsychophysiology
  11. Korkutata M, De Luca R, Fitzgerald B, Arrigoni E, Scammell TE. Afferent projections to the Calca /CGRP-expressing parabrachial neurons in mice. bioRxiv. 2024 May 08. PMID: 38766214; PMCID: PMC11100666.
    Citations:
  12. Alexandre C, Miracca G, Holanda VD, Sharma A, Kourbanova K, Ferreira A, Bicca MA, Zeng X, Nassar VA, Lee S, Kaur S, Sarma SV, Sacré P, Scammell TE, Woolf CJ, Latremoliere A. Nociceptor spontaneous activity is responsible for fragmenting non-rapid eye movement sleep in mouse models of neuropathic pain. Sci Transl Med. 2024 Apr 17; 16(743):eadg3036. PMID: 38630850; PMCID: PMC11106840.
    Citations: 2
    Fields: MedMedicine (General)SciScienceTranslation:HumansAnimalsCells
  13. Balmuth EA, Scammell TE. Harriet Tubman's Hypersomnia: Insights from Historical and Medical Perspectives. J Gen Intern Med. 2023 Dec; 38(16):3621-3627. PMID: 37740167; PMCID: PMC10713879.
    Citations:
    Fields: IntInternal MedicineTranslation:Humans
  14. Dauvilliers Y, Mignot E, Del Río Villegas R, Du Y, Hanson E, Inoue Y, Kadali H, Koundourakis E, Meyer S, Rogers R, Scammell TE, Sheikh SI, Swick T, Szakács Z, von Rosenstiel P, Wu J, Zeitz H, Murthy NV, Plazzi G, von Hehn C. Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1. N Engl J Med. 2023 Jul 27; 389(4):309-321. PMID: 37494485.
    Citations: 6
    Fields: MedMedicine (General)Translation:HumansCTClinical Trials
  15. Di Marco T, Scammell TE, Meinel M, Seboek Kinter D, Datta AN, Zammit G, Dauvilliers Y. Number, Duration, and Distribution of Wake Bouts in Patients with Insomnia Disorder: Effect of Daridorexant and Zolpidem. CNS Drugs. 2023 07; 37(7):639-653. PMID: 37477771; PMCID: PMC10374812.
    Citations: 1
    Fields: DruDrug TherapyNeuNeurologyPhaPharmacologyTranslation:HumansCTClinical Trials
  16. Kroeger D, Thundercliffe J, Phung A, De Luca R, Geraci C, Bragg S, McCafferty KJ, Bandaru SS, Arrigoni E, Scammell TE. Glutamatergic pedunculopontine tegmental neurons control wakefulness and locomotion via distinct axonal projections. Sleep. 2022 Dec 12; 45(12). PMID: 36170177; PMCID: PMC9742893.
    Citations: 2
    Fields: PsyPsychophysiologyTranslation:AnimalsCells
  17. Davidson RD, Biddle K, Nassan M, Scammell TE, Zhou ES. The impact of narcolepsy on social relationships in young adults. J Clin Sleep Med. 2022 12 01; 18(12):2751-2761. PMID: 35946418; PMCID: PMC9713907.
    Citations: 3
    Fields: NeuNeurologyPsyPsychophysiologyTranslation:Humans
  18. Dauvilliers Y, Bogan RK, Arnulf I, Scammell TE, St Louis EK, Thorpy MJ. Clinical considerations for the diagnosis of idiopathic hypersomnia. Sleep Med Rev. 2022 12; 66:101709. PMID: 36401976.
    Citations: 13
    Fields: NeuNeurologyPsyPsychophysiologyTranslation:Humans
  19. Scammell TE, Saper CB. Major advances in sleep neurology: 2002-22. Lancet Neurol. 2022 08; 21(8):678-680. PMID: 35841898.
    Citations: 2
    Fields: NeuNeurologyTranslation:Humans
  20. De Luca R, Nardone S, Grace KP, Venner A, Cristofolini M, Bandaru SS, Sohn LT, Kong D, Mochizuki T, Viberti B, Zhu L, Zito A, Scammell TE, Saper CB, Lowell BB, Fuller PM, Arrigoni E. Orexin neurons inhibit sleep to promote arousal. Nat Commun. 2022 07 18; 13(1):4163. PMID: 35851580; PMCID: PMC9293990.
    Citations: 26
    Fields: BioBiologySciScienceTranslation:HumansAnimalsCells
  21. Burgess CR, Scammell TE. Catching Up on REMs. N Engl J Med. 2022 05 19; 386(20):1950-1952. PMID: 35584160.
    Citations: 1
    Fields: MedMedicine (General)
  22. Shi SQ, Mahoney CE, Houdek P, Zhao W, Anderson MP, Zhuo X, Beaudet A, Sumova A, Scammell TE, Johnson CH. Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase Ube3a. Front Behav Neurosci. 2022; 16:837523. PMID: 35401134; PMCID: PMC8989470.
    Citations: 4
  23. Maski K, Worhach J, Steinhart E, Boduch M, Morse AM, Strunc M, Scammell T, Owens J, Jesteadt L, Crisp C, Williams D, Sideridis G. Development and Validation of the Pediatric Hypersomnolence Survey. Neurology. 2022 05 10; 98(19):e1964-e1975. PMID: 35314496; PMCID: PMC9141629.
    Citations: 1
    Fields: NeuNeurologyTranslation:Humans
  24. Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC, Hausen AC. Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nat Commun. 2021 09 02; 12(1):5249. PMID: 34475397; PMCID: PMC8413382.
    Citations: 13
    Fields: BioBiologySciScienceTranslation:AnimalsCells
  25. Maski KP, Colclasure A, Little E, Steinhart E, Scammell TE, Navidi W, Diniz Behn C. Stability of nocturnal wake and sleep stages defines central nervous system disorders of hypersomnolence. Sleep. 2021 07 09; 44(7). PMID: 33512510; PMCID: PMC8564004.
    Citations: 12
    Fields: PsyPsychophysiologyTranslation:Humans
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© 2025 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.