Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

profileAnthony N. Hollenberg, M.D.

TitleProfessor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr, CLS 738
Division of Endocrinology, Diabetes and Metabolism
330 Brookline Ave
Boston MA 02215
Phone617/735-3268
Fax617/735-3323
vCardDownload vCard (login for email)

Collapse Mentoring 
Collapse current student opportunities
Available: 07/10/17, Expires: 07/01/19

The production of thyroid hormones by the thyroid gland is one of the most important avenues by which metabolism is regulated in humans. Our laboratory works on how the thyroid gland develops from embryonic stem cells and also on how the hormones themselves function. Students who participate in this project will have the opportunity to learn laboratory techniques to explore the thyroid field both in context of gland development and hormone action. No experience is required.

Collapse completed student projects
Targeting new biomarkers for thyroid hormone action
Summer, 06/09/14 - 08/15/14

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01DK105029     (HOLLENBERG, ANTHONY N)Dec 1, 2015 - Nov 30, 2019
NIH/NIDDK
Thyroid Follicular Cell Development in Mice and Humans
Role: Principal Investigator

R01DK098525     (HOLLENBERG, ANTHONY N)Sep 16, 2013 - Jul 31, 2018
NIH/NIDDK
New Targets of Thyroid Hormone Action
Role: Principal Investigator

R21DK091941     (HOLLENBERG, ANTHONY N)Jul 11, 2011 - Sep 14, 2013
NIH/NIDDK
Defining the thyroid hormone receptor Cistrome in vivo
Role: Principal Investigator

R01DK078090     (HOLLENBERG, ANTHONY N)Apr 10, 2007 - Mar 31, 2012
NIH/NIDDK
Negative regulation by thyroid hormone
Role: Principal Investigator

R01DK056123     (HOLLENBERG, ANTHONY N)Aug 15, 2000 - Apr 30, 2019
NIH/NIDDK
Corepressor regulation of nuclear receptor action
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Serra M, Alysandratos KD, Hawkins F, McCauley KB, Jacob A, Choi J, Caballero IS, Vedaie M, Kurmann AA, Ikonomou L, Hollenberg AN, Shannon JM, Kotton DN. Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification. Development. 2017 Nov 01; 144(21):3879-3893. PMID: 28947536.
    View in: PubMed
  2. Mendoza A, Astapova I, Shimizu H, Gallop MR, Al-Sowaimel L, MacGowan SMD, Bergmann T, Berg AH, Tenen DE, Jacobs C, Lyubetskaya A, Tsai L, Hollenberg AN. NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor. Proc Natl Acad Sci U S A. 2017 Oct 03; 114(40):E8458-E8467. PMID: 28923959.
    View in: PubMed
  3. Flamant F, Cheng SY, Hollenberg AN, Moeller LC, Samarut J, Wondisford FE, Yen PM, Refetoff S. Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature. Endocrinology. 2017 Jul 01; 158(7):2052-2057. PMID: 28472304.
    View in: PubMed
  4. Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab. 2017 Jun 06; 25(6):1320-1333.e5. PMID: 28591635.
    View in: PubMed
  5. Hawkins F, Kramer P, Jacob A, Driver I, Thomas DC, McCauley KB, Skvir N, Crane AM, Kurmann AA, Hollenberg AN, Nguyen S, Wong BG, Khalil AS, Huang SX, Guttentag S, Rock JR, Shannon JM, Davis BR, Kotton DN. Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells. J Clin Invest. 2017 Jun 01; 127(6):2277-2294. PMID: 28463226.
    View in: PubMed
  6. Vella KR, Hollenberg AN. The actions of thyroid hormone signaling in the nucleus. Mol Cell Endocrinol. 2017 Mar 10. PMID: 28286327.
    View in: PubMed
  7. Mendoza A, Hollenberg AN. New insights into thyroid hormone action. Pharmacol Ther. 2017 May; 173:135-145. PMID: 28174093.
    View in: PubMed
  8. Dame K, Cincotta S, Lang AH, Sanghrajka RM, Zhang L, Choi J, Kwok L, Wilson T, Kandula MM, Monti S, Hollenberg AN, Mehta P, Kotton DN, Ikonomou L. Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1. Stem Cell Reports. 2017 Feb 14; 8(2):216-225. PMID: 28162994.
    View in: PubMed
  9. Hollenberg AN, Choi J, Serra M, Kotton DN. Regenerative therapy for hypothyroidism: Mechanisms and possibilities. Mol Cell Endocrinol. 2017 Apr 15; 445:35-41. PMID: 27876515.
    View in: PubMed
  10. Sinha RA, Singh BK, Zhou J, Xie S, Farah BL, Lesmana R, Ohba K, Tripathi M, Ghosh S, Hollenberg AN, Yen PM. Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells. Autophagy. 2017 Jan 02; 13(1):169-186. PMID: 27846372.
    View in: PubMed
  11. Kyono Y, Subramani A, Ramadoss P, Hollenberg AN, Bonett RM, Denver RJ. Liganded Thyroid Hormone Receptors Transactivate the DNA Methyltransferase 3a Gene in Mouse Neuronal Cells. Endocrinology. 2016 Sep; 157(9):3647-57. PMID: 27387481; PMCID: PMC5007891 [Available on 09/01/17].
  12. Goldfarb Y, Kadouri N, Levi B, Sela A, Herzig Y, Cohen RN, Hollenberg AN, Abramson J. HDAC3 Is a Master Regulator of mTEC Development. Cell Rep. 2016 Apr 19; 15(3):651-665. PMID: 27068467.
    View in: PubMed
  13. Hollenberg AN. The Endocrine Society Centennial: The Thyroid Leads the Way. Endocrinology. 2016 Jan; 157(1):1-3. PMID: 26717469; PMCID: PMC4701885 [Available on 01/01/17].
  14. Kurmann AA, Serra M, Hawkins F, Rankin SA, Mori M, Astapova I, Ullas S, Lin S, Bilodeau M, Rossant J, Jean JC, Ikonomou L, Deterding RR, Shannon JM, Zorn AM, Hollenberg AN, Kotton DN. Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells. Cell Stem Cell. 2015 Nov 05; 17(5):527-42. PMID: 26593959; PMCID: PMC4666682 [Available on 11/05/16].
  15. Singh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Gauthier K, Yen PM. Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. J Biol Chem. 2016 Jan 01; 291(1):198-214. PMID: 26453307; PMCID: PMC4697156 [Available on 01/01/17].
  16. Castinetti F, Brinkmeier ML, Mortensen AH, Vella KR, Gergics P, Brue T, Hollenberg AN, Gan L, Camper SA. ISL1 Is Necessary for Maximal Thyrotrope Response to Hypothyroidism. Mol Endocrinol. 2015 Oct; 29(10):1510-21. PMID: 26296153; PMCID: PMC4588728 [Available on 10/01/16].
  17. Ng L, Cordas E, Wu X, Vella KR, Hollenberg AN, Forrest D. Age-Related Hearing Loss and Degeneration of Cochlear Hair Cells in Mice Lacking Thyroid Hormone Receptor ß1. Endocrinology. 2015 Oct; 156(10):3853-65. PMID: 26241124; PMCID: PMC4588828 [Available on 10/01/16].
  18. Petryk A, Kanakatti Shankar R, Giri N, Hollenberg AN, Rutter MM, Nathan B, Lodish M, Alter BP, Stratakis CA, Rose SR. Endocrine disorders in Fanconi anemia: recommendations for screening and treatment. J Clin Endocrinol Metab. 2015 Mar; 100(3):803-11. PMID: 25575015; PMCID: PMC4333044.
  19. Shimizu H, Astapova I, Ye F, Bilban M, Cohen RN, Hollenberg AN. NCoR1 and SMRT play unique roles in thyroid hormone action in vivo. Mol Cell Biol. 2015 Feb; 35(3):555-65. PMID: 25421714; PMCID: PMC4285426.
  20. Astapova I, Ramadoss P, Costa-e-Sousa RH, Ye F, Holtz KA, Li Y, Niepel MW, Cohen DE, Hollenberg AN. Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRß1-governed pathway. J Clin Invest. 2014 May; 124(5):1976-86. PMID: 24713658; PMCID: PMC4001554.
  21. Domouzoglou EM, Fisher FM, Astapova I, Fox EC, Kharitonenkov A, Flier JS, Hollenberg AN, Maratos-Flier E. Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo. Endocrinology. 2014 May; 155(5):2031-40. PMID: 24564398; PMCID: PMC3990851.
  22. Vella KR, Ramadoss P, Costa-E-Sousa RH, Astapova I, Ye FD, Holtz KA, Harris JC, Hollenberg AN. Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors. Mol Cell Biol. 2014 May; 34(9):1564-75. PMID: 24550004; PMCID: PMC3993596.
  23. Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Horm Behav. 2014 Feb; 65(2):190-3. PMID: 24289987.
    View in: PubMed
  24. Ramadoss P, Abraham BJ, Tsai L, Zhou Y, Costa-e-Sousa RH, Ye F, Bilban M, Zhao K, Hollenberg AN. Novel mechanism of positive versus negative regulation by thyroid hormone receptor ß1 (TRß1) identified by genome-wide profiling of binding sites in mouse liver. J Biol Chem. 2014 Jan 17; 289(3):1313-28. PMID: 24288132; PMCID: PMC3894317.
  25. Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich, et al. Front Neuroendocrinol. 2014 Jan; 35(1):2-5. PMID: 24268499.
    View in: PubMed
  26. Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Andrology. 2013 Nov; 1(6):802-5. PMID: 24166945.
    View in: PubMed
  27. Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Eur J Endocrinol. 2013 Dec; 169(6):E1-4. PMID: 24057478.
    View in: PubMed
  28. Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Horm Res Paediatr. 2013; 80(5):305-8. PMID: 24107550.
    View in: PubMed
  29. Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Endocrinology. 2013 Nov; 154(11):3957-60. PMID: 24048095.
    View in: PubMed
  30. Fozzatti L, Kim DW, Park JW, Willingham MC, Hollenberg AN, Cheng SY. Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor a. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):7850-5. PMID: 23610395; PMCID: PMC3651436.
  31. Chiappini F, Ramadoss P, Vella KR, Cunha LL, Ye FD, Stuart RC, Nillni EA, Hollenberg AN. Family members CREB and CREM control thyrotropin-releasing hormone (TRH) expression in the hypothalamus. Mol Cell Endocrinol. 2013 Jan 05; 365(1):84-94. PMID: 23000398; PMCID: PMC3572472.
  32. Costa-e-Sousa RH, Astapova I, Ye F, Wondisford FE, Hollenberg AN. The thyroid axis is regulated by NCoR1 via its actions in the pituitary. Endocrinology. 2012 Oct; 153(10):5049-57. PMID: 22878400; PMCID: PMC3512014.
  33. Astapova I, Hollenberg AN. The in vivo role of nuclear receptor corepressors in thyroid hormone action. Biochim Biophys Acta. 2013 Jul; 1830(7):3876-81. PMID: 22801336; PMCID: PMC3529203.
  34. Costa-e-Sousa RH, Hollenberg AN. Minireview: The neural regulation of the hypothalamic-pituitary-thyroid axis. Endocrinology. 2012 Sep; 153(9):4128-35. PMID: 22759379; PMCID: PMC3423621.
  35. Hollenberg AN. Metabolic health and nuclear-receptor sensitivity. N Engl J Med. 2012 Apr 05; 366(14):1345-7. PMID: 22475600.
    View in: PubMed
  36. Li J, Paulson JM, Ye FD, Sung M, Hollenberg AN, Rutkove SB. Reducing systemic hypermetabolism by inducing hypothyroidism does not prolong survival in the SOD1-G93A mouse. Amyotroph Lateral Scler. 2012 Jun; 13(4):372-7. PMID: 22424124.
    View in: PubMed
  37. Vella KR, Ramadoss P, Lam FS, Harris JC, Ye FD, Same PD, O'Neill NF, Maratos-Flier E, Hollenberg AN. NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways. Cell Metab. 2011 Dec 07; 14(6):780-90. PMID: 22100407; PMCID: PMC3261758.
  38. Fozzatti L, Lu C, Kim DW, Park JW, Astapova I, Gavrilova O, Willingham MC, Hollenberg AN, Cheng SY. Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1). Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17462-7. PMID: 21987803; PMCID: PMC3198316.
  39. Castinetti F, Brinkmeier ML, Gordon DF, Vella KR, Kerr JM, Mortensen AH, Hollenberg A, Brue T, Ridgway EC, Camper SA. PITX2 AND PITX1 regulate thyrotroph function and response to hypothyroidism. Mol Endocrinol. 2011 Nov; 25(11):1950-60. PMID: 21964592; PMCID: PMC3386545.
  40. Astapova I, Vella KR, Ramadoss P, Holtz KA, Rodwin BA, Liao XH, Weiss RE, Rosenberg MA, Rosenzweig A, Hollenberg AN. The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis. Mol Endocrinol. 2011 Feb; 25(2):212-24. PMID: 21239618; PMCID: PMC3386544.
  41. Chiappini F, Cunha LL, Harris JC, Hollenberg AN. Lack of cAMP-response element-binding protein 1 in the hypothalamus causes obesity. J Biol Chem. 2011 Mar 11; 286(10):8094-105. PMID: 21209091; PMCID: PMC3048696.
  42. Ghamari-Langroudi M, Vella KR, Srisai D, Sugrue ML, Hollenberg AN, Cone RD. Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity. Mol Endocrinol. 2010 Dec; 24(12):2366-81. PMID: 20943814; PMCID: PMC2999480.
  43. Perello M, Cakir I, Cyr NE, Romero A, Stuart RC, Chiappini F, Hollenberg AN, Nillni EA. Maintenance of the thyroid axis during diet-induced obesity in rodents is controlled at the central level. Am J Physiol Endocrinol Metab. 2010 Dec; 299(6):E976-89. PMID: 20858755; PMCID: PMC3006258.
  44. Ramadoss P, Chiappini F, Bilban M, Hollenberg AN. Regulation of hepatic six transmembrane epithelial antigen of prostate 4 (STEAP4) expression by STAT3 and CCAAT/enhancer-binding protein alpha. J Biol Chem. 2010 May 28; 285(22):16453-66. PMID: 20304921; PMCID: PMC2878015.
  45. Adams AC, Astapova I, Fisher FM, Badman MK, Kurgansky KE, Flier JS, Hollenberg AN, Maratos-Flier E. Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner. J Biol Chem. 2010 May 07; 285(19):14078-82. PMID: 20236931; PMCID: PMC2863226.
  46. Sugrue ML, Vella KR, Morales C, Lopez ME, Hollenberg AN. The thyrotropin-releasing hormone gene is regulated by thyroid hormone at the level of transcription in vivo. Endocrinology. 2010 Feb; 151(2):793-801. PMID: 20032051; PMCID: PMC2817611.
  47. Levine RJ, Vatten LJ, Horowitz GL, Qian C, Romundstad PR, Yu KF, Hollenberg AN, Hellevik AI, Asvold BO, Karumanchi SA. Pre-eclampsia, soluble fms-like tyrosine kinase 1, and the risk of reduced thyroid function: nested case-control and population based study. BMJ. 2009 Nov 17; 339:b4336. PMID: 19920004; PMCID: PMC2778749.
  48. Vella KR, Hollenberg AN. The ups and downs of thyrotropin-releasing hormone. Endocrinology. 2009 May; 150(5):2021-3. PMID: 19383877; PMCID: PMC2671896.
  49. Astapova I, Dordek MF, Hollenberg AN. The thyroid hormone receptor recruits NCoR via widely spaced receptor-interacting domains. Mol Cell Endocrinol. 2009 Aug 13; 307(1-2):83-8. PMID: 19524130.
    View in: PubMed
  50. Ramadoss P, Unger-Smith NE, Lam FS, Hollenberg AN. STAT3 targets the regulatory regions of gluconeogenic genes in vivo. Mol Endocrinol. 2009 Jun; 23(6):827-37. PMID: 19264844.
    View in: PubMed
  51. Astapova I, Lee LJ, Morales C, Tauber S, Bilban M, Hollenberg AN. The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19544-9. PMID: 19052228; PMCID: PMC2614797.
  52. Hodgson MC, Shen HC, Hollenberg AN, Balk SP. Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor. Mol Cancer Ther. 2008 Oct; 7(10):3187-94. PMID: 18852122; PMCID: PMC2587007.
  53. Hollenberg AN, Forrest D. The thyroid and metabolism: the action continues. Cell Metab. 2008 Jul; 8(1):10-2. PMID: 18590688.
    View in: PubMed
  54. Hollenberg AN. The role of the thyrotropin-releasing hormone (TRH) neuron as a metabolic sensor. Thyroid. 2008 Feb; 18(2):131-9. PMID: 18279013.
    View in: PubMed
  55. Hodgson MC, Astapova I, Hollenberg AN, Balk SP. Activity of androgen receptor antagonist bicalutamide in prostate cancer cells is independent of NCoR and SMRT corepressors. Cancer Res. 2007 Sep 01; 67(17):8388-95. PMID: 17804755.
    View in: PubMed
  56. Blumberg JM, Tzameli I, Astapova I, Lam FS, Flier JS, Hollenberg AN. Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. J Biol Chem. 2006 Apr 21; 281(16):11205-13. PMID: 16467308.
    View in: PubMed
  57. Kishi T, Aschkenasi CJ, Choi BJ, Lopez ME, Lee CE, Liu H, Hollenberg AN, Friedman JM, Elmquist JK. Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor. J Comp Neurol. 2005 Feb 14; 482(3):217-43. PMID: 15690487.
    View in: PubMed
  58. Hodgson MC, Astapova I, Cheng S, Lee LJ, Verhoeven MC, Choi E, Balk SP, Hollenberg AN. The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists. J Biol Chem. 2005 Feb 25; 280(8):6511-9. PMID: 15598662.
    View in: PubMed
  59. Masiello D, Chen SY, Xu Y, Verhoeven MC, Choi E, Hollenberg AN, Balk SP. Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells. Mol Endocrinol. 2004 Oct; 18(10):2388-401. PMID: 15256534.
    View in: PubMed
  60. Tzameli I, Fang H, Ollero M, Shi H, Hamm JK, Kievit P, Hollenberg AN, Flier JS. Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes. J Biol Chem. 2004 Aug 20; 279(34):36093-102. PMID: 15190061.
    View in: PubMed
  61. Bachman ES, Hampton TG, Dhillon H, Amende I, Wang J, Morgan JP, Hollenberg AN. The metabolic and cardiovascular effects of hyperthyroidism are largely independent of beta-adrenergic stimulation. Endocrinology. 2004 Jun; 145(6):2767-74. PMID: 15016719.
    View in: PubMed
  62. Guo F, Bakal K, Minokoshi Y, Hollenberg AN. Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo. Endocrinology. 2004 May; 145(5):2221-7. PMID: 14764630.
    View in: PubMed
  63. Valli-Jaakola K, Lipsanen-Nyman M, Oksanen L, Hollenberg AN, Kontula K, Bjørbaek C, Schalin-Jäntti C. Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults. J Clin Endocrinol Metab. 2004 Feb; 89(2):940-5. PMID: 14764818.
    View in: PubMed
  64. Shattuck TM, Kim TS, Costa J, Yandell DW, Imanishi Y, Palanisamy N, Gaz RD, Shoback D, Clark OH, Monchik JM, Wierman ME, Hollenberg A, Tojo K, Chaganti RS, Arnold A. Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma. Clin Endocrinol (Oxf). 2003 Aug; 59(2):180-9. PMID: 12864795.
    View in: PubMed
  65. Monden T, Yamada M, Ishii S, Hosoya T, Satoh T, Wondisford FE, Hollenberg AN, Mori M. Leucine at codon 428 in the ninth heptad of thyroid hormone receptor beta1 is necessary for interactions with the transcriptional cofactors and functions regardless of dimer formations. Thyroid. 2003 May; 13(5):427-35. PMID: 12855009.
    View in: PubMed
  66. Yohrling GJ, Farrell LA, Hollenberg AN, Cha JH. Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation. Mol Cell Neurosci. 2003 May; 23(1):28-38. PMID: 12799135.
    View in: PubMed
  67. Münzberg H, Huo L, Nillni EA, Hollenberg AN, Bjørbaek C. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology. 2003 May; 144(5):2121-31. PMID: 12697721.
    View in: PubMed
  68. Yamamoto H, Kishi T, Lee CE, Choi BJ, Fang H, Hollenberg AN, Drucker DJ, Elmquist JK. Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. J Neurosci. 2003 Apr 01; 23(7):2939-46. PMID: 12684481.
    View in: PubMed
  69. Meng X, Yang YF, Cao X, Govindan MV, Shuen M, Hollenberg AN, Mymryk JS, Walfish PG. Cellular context of coregulator and adaptor proteins regulates human adenovirus 5 early region 1A-dependent gene activation by the thyroid hormone receptor. Mol Endocrinol. 2003 Jun; 17(6):1095-105. PMID: 12637585.
    View in: PubMed
  70. Makowski A, Brzostek S, Cohen RN, Hollenberg AN. Determination of nuclear receptor corepressor interactions with the thyroid hormone receptor. Mol Endocrinol. 2003 Feb; 17(2):273-86. PMID: 12554754.
    View in: PubMed
  71. Shibusawa N, Hollenberg AN, Wondisford FE. Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation. J Biol Chem. 2003 Jan 10; 278(2):732-8. PMID: 12419821.
    View in: PubMed
  72. Yamamoto H, Lee CE, Marcus JN, Williams TD, Overton JM, Lopez ME, Hollenberg AN, Baggio L, Saper CB, Drucker DJ, Elmquist JK. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J Clin Invest. 2002 Jul; 110(1):43-52. PMID: 12093887; PMCID: PMC151031.
  73. Cheng S, Brzostek S, Lee SR, Hollenberg AN, Balk SP. Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor. Mol Endocrinol. 2002 Jul; 16(7):1492-501. PMID: 12089345.
    View in: PubMed
  74. Bjørbaek C, Hollenberg AN. Leptin and melanocortin signaling in the hypothalamus. Vitam Horm. 2002; 65:281-311. PMID: 12481551.
    View in: PubMed
  75. Cohen RN, Brzostek S, Kim B, Chorev M, Wondisford FE, Hollenberg AN. The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains. Mol Endocrinol. 2001 Jul; 15(7):1049-61. PMID: 11435607.
    View in: PubMed
  76. Li AW, Morash B, Hollenberg AN, Ur E, Wilkinson M, Murphy PR. Transcriptional regulation of the leptin gene promoter in rat GH3 pituitary and C6 glioma cells. Mol Cell Endocrinol. 2001 May 15; 176(1-2):57-65. PMID: 11369443.
    View in: PubMed
  77. Harris M, Aschkenasi C, Elias CF, Chandrankunnel A, Nillni EA, Bjøorbaek C, Elmquist JK, Flier JS, Hollenberg AN. Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest. 2001 Jan; 107(1):111-20. PMID: 11134186; PMCID: PMC198547.
  78. Nillni EA, Vaslet C, Harris M, Hollenberg A, Bjørbak C, Flier JS. Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways. J Biol Chem. 2000 Nov 17; 275(46):36124-33. PMID: 10967095.
    View in: PubMed
  79. Hashimoto K, Zanger K, Hollenberg AN, Cohen LE, Radovick S, Wondisford FE. cAMP response element-binding protein-binding protein mediates thyrotropin-releasing hormone signaling on thyrotropin subunit genes. J Biol Chem. 2000 Oct 27; 275(43):33365-72. PMID: 10931853.
    View in: PubMed
  80. Cohen RN, Putney A, Wondisford FE, Hollenberg AN. The nuclear corepressors recognize distinct nuclear receptor complexes. Mol Endocrinol. 2000 Jun; 14(6):900-14. PMID: 10847591.
    View in: PubMed
  81. Flier JS, Harris M, Hollenberg AN. Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring. J Clin Invest. 2000 Apr; 105(7):859-61. PMID: 10749565; PMCID: PMC377492.
  82. Oberste-Berghaus C, Zanger K, Hashimoto K, Cohen RN, Hollenberg AN, Wondisford FE. Thyroid hormone-independent interaction between the thyroid hormone receptor beta2 amino terminus and coactivators. J Biol Chem. 2000 Jan 21; 275(3):1787-92. PMID: 10636876.
    View in: PubMed
  83. Flier JS, Hollenberg AN. ADD-1 provides major new insight into the mechanism of insulin action. Proc Natl Acad Sci U S A. 1999 Dec 07; 96(25):14191-2. PMID: 10588675; PMCID: PMC33942.
  84. Monden T, Kishi M, Hosoya T, Satoh T, Wondisford FE, Hollenberg AN, Yamada M, Mori M. p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers. Mol Endocrinol. 1999 Oct; 13(10):1695-703. PMID: 10517671.
    View in: PubMed
  85. Safer JD, Cohen RN, Hollenberg AN, Wondisford FE. Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone. J Biol Chem. 1998 Nov 13; 273(46):30175-82. PMID: 9804773.
    View in: PubMed
  86. Cohen RN, Wondisford FE, Hollenberg AN. Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements. Mol Endocrinol. 1998 Oct; 12(10):1567-81. PMID: 9773980.
    View in: PubMed
  87. Monden T, Wondisford FE, Hollenberg AN. Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein. J Biol Chem. 1997 Nov 21; 272(47):29834-41. PMID: 9368056.
    View in: PubMed
  88. Langlois MF, Zanger K, Monden T, Safer JD, Hollenberg AN, Wondisford FE. A unique role of the beta-2 thyroid hormone receptor isoform in negative regulation by thyroid hormone. Mapping of a novel amino-terminal domain important for ligand-independent activation. J Biol Chem. 1997 Oct 03; 272(40):24927-33. PMID: 9312095.
    View in: PubMed
  89. Werman A, Hollenberg A, Solanes G, Bjorbaek C, Vidal-Puig AJ, Flier JS. Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin. J Biol Chem. 1997 Aug 08; 272(32):20230-5. PMID: 9242701.
    View in: PubMed
  90. Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM, Lowell BB. Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter. J Biol Chem. 1997 Feb 21; 272(8):5283-90. PMID: 9030601.
    View in: PubMed
  91. Safer JD, Langlois MF, Cohen R, Monden T, John-Hope D, Madura J, Hollenberg AN, Wondisford FE. Isoform variable action among thyroid hormone receptor mutants provides insight into pituitary resistance to thyroid hormone. Mol Endocrinol. 1997 Jan; 11(1):16-26. PMID: 8994184.
    View in: PubMed
  92. Hollenberg AN, Monden T, Madura JP, Lee K, Wondisford FE. Function of nuclear co-repressor protein on thyroid hormone response elements is regulated by the receptor A/B domain. J Biol Chem. 1996 Nov 08; 271(45):28516-20. PMID: 8910480.
    View in: PubMed
  93. Medeiros-Neto G, Herodotou DT, Rajan S, Kommareddi S, de Lacerda L, Sandrini R, Boguszewski MC, Hollenberg AN, Radovick S, Wondisford FE. A circulating, biologically inactive thyrotropin caused by a mutation in the beta subunit gene. J Clin Invest. 1996 Mar 01; 97(5):1250-6. PMID: 8636437; PMCID: PMC507178.
  94. Hollenberg AN, Monden T, Wondisford FE. Ligand-independent and -dependent functions of thyroid hormone receptor isoforms depend upon their distinct amino termini. J Biol Chem. 1995 Jun 16; 270(24):14274-80. PMID: 7782283.
    View in: PubMed
  95. Hollenberg AN, Monden T, Flynn TR, Boers ME, Cohen O, Wondisford FE. The human thyrotropin-releasing hormone gene is regulated by thyroid hormone through two distinct classes of negative thyroid hormone response elements. Mol Endocrinol. 1995 May; 9(5):540-50. PMID: 7565802.
    View in: PubMed
  96. Flynn TR, Hollenberg AN, Cohen O, Menke JB, Usala SJ, Tollin S, Hegarty MK, Wondisford FE. A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone inhibition. J Biol Chem. 1994 Dec 30; 269(52):32713-6. PMID: 7528740.
    View in: PubMed
  97. Pestell RG, Hollenberg AN, Albanese C, Jameson JL. c-Jun represses transcription of the human chorionic gonadotropin alpha and beta genes through distinct types of CREs. J Biol Chem. 1994 Dec 09; 269(49):31090-6. PMID: 7983049.
    View in: PubMed
  98. Hollenberg AN, Pestell RG, Albanese C, Boers ME, Jameson JL. Multiple promoter elements in the human chorionic gonadotropin beta subunit genes distinguish their expression from the luteinizing hormone beta gene. Mol Cell Endocrinol. 1994 Dec; 106(1-2):111-9. PMID: 7534731.
    View in: PubMed
  99. Bauer-Dantoin AC, Hollenberg AN, Jameson JL. Dynamic regulation of gonadotropin-releasing hormone receptor mRNA levels in the anterior pituitary gland during the rat estrous cycle. Endocrinology. 1993 Oct; 133(4):1911-4. PMID: 8404635.
    View in: PubMed
  100. Jameson JL, Hollenberg AN. Regulation of chorionic gonadotropin gene expression. Endocr Rev. 1993 Apr; 14(2):203-21. PMID: 8325253.
    View in: PubMed
  101. Jameson JL, Hollenberg AN. Recent advances in studies of the molecular basis of endocrine disease. Horm Metab Res. 1992 May; 24(5):201-9. PMID: 1398458.
    View in: PubMed
  102. Hollenberg AN, Arnold A. Hypercalcemia with low-normal serum intact PTH: a novel presentation of primary hyperparathyroidism. Am J Med. 1991 Nov; 91(5):547-8. PMID: 1951417.
    View in: PubMed
  103. Jameson L, Chin WW, Hollenberg AN, Chang AS, Habener JF. The gene encoding the beta-subunit of rat luteinizing hormone. Analysis of gene structure and evolution of nucleotide sequence. J Biol Chem. 1984 Dec 25; 259(24):15474-80. PMID: 6096374.
    View in: PubMed
  104. HOLLENBERG A. [Drug evaluation and allergy]. Allg Homoopath Ztg. 1961 Jun; 206:339-49. PMID: 13715327.
    View in: PubMed
  105. HOLLENBERG A. Ainhum. J Natl Assoc Chirop. 1956 Oct; 46(10):697. PMID: 13377158.
    View in: PubMed
  106. HOLLENBERG A. The role of proteins in the management of diabetes. Manit Med Rev. 1947 Aug; 27(8):471. PMID: 20255823.
    View in: PubMed
  107. HOLLENBERG A. The Manitoba Medical Service. J Can Dent Assoc (Tor). 1945 Dec; 11:555-7. PMID: 21007016.
    View in: PubMed
  108. Hollenberg A. Manitoba Medical Service. Can Med Assoc J. 1945 Sep; 53(3):289-90. PMID: 20323559.
    View in: PubMed
  109. Hollenberg A. Diuresis and the Newer Diuretics-Ammonium Chloride and Novasurol. Can Med Assoc J. 1926 Nov; 16(11):1343-6. PMID: 20316028.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Hollenberg's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
_
Co-Authors Expand Description
_
Similar People Expand Description
_
Same Department Expand Description
Physical Neighbors Expand Description
_