Iain A. Drummond, PH.D.
|Title||Associate Professor of Medicine|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
Renal Unit - CNY 8
149 13th Street
Charlestown MA 02129
Available: 07/06/11, Expires: 09/30/15
Genetically defined human disease gene loci may contain many genes and although sequencing can identify mutations, whether these are pathogenic or simply polymorphisms can be difficult to determine for a novel gene. Through collaboration with labs cloning human kidney disease genes, the Student would learn linkage analysis and test candidate gene function in vivo in zebrafish using antisense gene knockdown, mRNA rescue and cell biological phenotyping approaches. Knockdown provides an efficient initial screen for gene function that could be followed up in a more extended study using targeted mutation approaches in zebrafish.
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