Sandro Santagata, Ph.D., M.D.
|Title||Assistant Professor of Pathology|
|Institution||Brigham and Women's Hospital|
|Address||Brigham and Women's Hospital|
HMS Department of Pathology, BTM 8002P
60 Fenwood Rd
Boston MA 02115
(login for email)
Stress Responses in Cancer Development and Progression:
We focus on understanding a fundamental challenge in tumor biology: how tumor cells develop their most aggressive behaviors and the mechanisms that they use to resist even the most sophisticated therapeutic regimens. One biological program that we focus on in this area is a potent adaptive mechanism: what has been classically called the heat shock response. So powerful is this program that it is used by even single cell organisms to survive scorching heat waves and other caustic environmental challenges. Our work has revealed that highly aggressive tumors across a broad range of tumor types co-opt the activity of heat shock factor 1 (HSF1), the dominant transcriptional regulator of this ancient survival program. The HSF1 transcriptional program differs when activated in cancer versus when it is activated in heat shock – how are the programs different, how are the programs regulated, how are tumor adaptive responses conscripted in cancer, how can the HSF1 program be modulated for therapeutic benefit. We use chemical and genetic approaches to address these questions in a range of cancer types including the most aggressive forms of cancer - melanoma and those of the brain, pancreas, ovary, breast and lung.
Molecular Genetics of Brain Tumors:
As molecular pathologists, we are eager to determine the molecular drivers of brain tumors and viable new therapeutic targets. We use genomic tools in our studies and are developing a range of diagnostic, prognostic and therapeutic biomarkers and cell line models of brain tumors. We work on meningioma, low grade pediatric gliomas (such as ganglioglioma and pleomorphic xanthoastrocytoma), craniopharyngioma and brain metastases aiming to spark new clinical trials and to support the characterization of clinical trial with validated biomarker assays.
New Tools for Characterizing Brain Tumors:
We are using high-powered imaging techniques to investigate the function of brain tumors. Along with close collaborators, we are implementing a range of mass spectrometry imaging techniques to investigate the molecular pathology of tumors and to attempt to bring mass spectrometry diagnostics into the operating room to assist with iterative real time tissue characterization. We have strong interests in a range of new ways of imaging and characterizing brain tumors.
The Role of the Ciliogenesis Gene Program in Gliomas
Summer, 02/01/15 - 09/04/15
The research activities and funding listed below are automatically derived from
NIH ExPORTER and other sources, which might result in incorrect or missing items.
to make corrections and additions.
R01CA194005 (SANTAGATA, SANDRO)Aug 11, 2016 - Jul 31, 2021NIH/NCI
Investigating the HSF1 Cancer Network
Role: Principal Investigator
K08NS064168 (SANTAGATA, SANDRO)Sep 1, 2008 - Jul 31, 2013NIH/NINDS
Heat Shock Directed Drug Discovery For The Treatment Of Gliomas
Role: Principal Investigator
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Click the "See All" links for more information and interactive visualizations!
People who are also in this person's primary department.