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Last Name

Kevin Michael Esvelt, Ph.D.

TitleResearch Associate at the Wyss Institute
InstitutionHarvard University
DepartmentWyss Institute
AddressWyss Institute
Center for Life Sciences, 5th Floor
3 Blackfan Circle
Boston MA 02115
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A Technology Development Fellow of the Wyss Institute for Biologically Inspired Engineering, Kevin is a co-developer of the CRISPR/Cas9 system for targeted genome editing and regulation. In 2014, he described how we might use CRISPR to build RNA-guided gene drives capable of spreading genomic alterations through wild populations. This may enable a new form of ecosystem management, offering new ways to tackle diseases spread by insect vectors, evolved pesticide and herbicide resistance, and environmentally damaging invasive species. Current research interests include building safeguards for the responsible development of gene drives, exploring methods of stably altering the composition of microbial communities, and researching new tools and strategies for evolutionary engineering.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J. Safeguarding gene drive experiments in the laboratory. Science. 2015 Aug 28; 349(6251):927-9.
    View in: PubMed
  2. Yaung SJ, Esvelt KM, Church GM. Complete Genome Sequences of T4-Like Bacteriophages RB3, RB5, RB6, RB7, RB9, RB10, RB27, RB33, RB55, RB59, and RB68. Genome Announc. 2015; 3(1).
    View in: PubMed
  3. Oye KA, Esvelt KM. Gene drives raise dual-use concerns--response. Science. 2014 Aug 29; 345(6200):1010-1.
    View in: PubMed
  4. Oye KA, Esvelt K, Appleton E, Catteruccia F, Church G, Kuiken T, Lightfoot SB, McNamara J, Smidler A, Collins JP. Biotechnology. Regulating gene drives. Science. 2014 Aug 8; 345(6197):626-8.
    View in: PubMed
  5. Esvelt KM, Smidler AL, Catteruccia F, Church GM. Concerning RNA-guided gene drives for the alteration of wild populations. Elife. 2014 Jul 17; e03401.
    View in: PubMed
  6. Yaung SJ, Esvelt KM, Church GM. CRISPR/Cas9-mediated phage resistance is not impeded by the DNA modifications of phage T4. PLoS One. 2014; 9(6):e98811.
    View in: PubMed
  7. Mali P, Esvelt KM, Church GM. Cas9 as a versatile tool for engineering biology. Nat Methods. 2013 Oct; 10(10):957-63.
    View in: PubMed
  8. Esvelt KM, Mali P, Braff JL, Moosburner M, Yaung SJ, Church GM. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat Methods. 2013 Nov; 10(11):1116-21.
    View in: PubMed
  9. Mali P, Aach J, Stranges PB, Esvelt KM, Moosburner M, Kosuri S, Yang L, Church GM. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol. 2013 Sep; 31(9):833-8.
    View in: PubMed
  10. Friedland AE, Tzur YB, Esvelt KM, Colaiácovo MP, Church GM, Calarco JA. Heritable genome editing in C. elegans via a CRISPR-Cas9 system. Nat Methods. 2013 Aug; 10(8):741-3.
    View in: PubMed
  11. Dickinson BC, Leconte AM, Allen B, Esvelt KM, Liu DR. Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9007-12.
    View in: PubMed
  12. Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM. RNA-guided human genome engineering via Cas9. Science. 2013 Feb 15; 339(6121):823-6.
    View in: PubMed
  13. Esvelt KM, Wang HH. Genome-scale engineering for systems and synthetic biology. Mol Syst Biol. 2013; 9:641.
    View in: PubMed
  14. Lin A, Jimenez J, Derr J, Vera P, Manapat ML, Esvelt KM, Villanueva L, Liu DR, Chen IA. Inhibition of bacterial conjugation by phage M13 and its protein g3p: quantitative analysis and model. PLoS One. 2011; 6(5):e19991.
    View in: PubMed
  15. Esvelt KM, Carlson JC, Liu DR. A system for the continuous directed evolution of biomolecules. Nature. 2011 Apr 28; 472(7344):499-503.
    View in: PubMed
  16. Toth-Fejel S, Muller P, Ham B, Esvelt K, Dumas N, Calhoun K, Pommier R. DNA fingerprints provide a patient-specific breast cancer marker. Ann Surg Oncol. 2004 Jun; 11(6):560-7.
    View in: PubMed
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