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profileQiurong Ding, Ph.D.

TitlePost Doc, Visiting (Stip) (EXT)
InstitutionFaculty of Arts & Sciences
DepartmentStem Cell and Regenerative Biology
AddressCowan Laboratory
7 Divinity Ave
Cambridge MA 02138
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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wei Y, Qiu Y, Chen Y, Liu G, Zhang Y, Xu L, Ding Q. CRISPR/Cas9 with single guide RNA expression driven by small tRNA promoters showed reduced editing efficiency compared to U6 promoter. RNA. 2016 Oct 14. PMID: 27742910.
    View in: PubMed
  2. Chen Y, Liu X, Zhang Y, Wang H, Ying H, Liu M, Li D, Lui KO, Ding Q. A Self-restricted CRISPR System to Reduce Off-target Effects. Mol Ther. 2016 Sep; 24(9):1508-10. PMID: 27687135.
    View in: PubMed
  3. Wang X, Raghavan A, Chen T, Qiao L, Zhang Y, Ding Q, Musunuru K. CRISPR-Cas9 Targeting of PCSK9 in Human Hepatocytes In Vivo-Brief Report. Arterioscler Thromb Vasc Biol. 2016 May; 36(5):783-6. PMID: 26941020.
    View in: PubMed
  4. Han J, Meng Q, Xi Q, Zhang Y, Zhuang Q, Han Y, Jiang Y, Ding Q, Wu G. Interleukin-6 stimulates aerobic glycolysis by regulating PFKFB3 at early stage of colorectal cancer. Int J Oncol. 2016 Jan; 48(1):215-24. PMID: 26530697.
    View in: PubMed
  5. Han J, Jiang Y, Liu X, Meng Q, Xi Q, Zhuang Q, Han Y, Gao Y, Ding Q, Wu G. Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies. PLoS One. 2015; 10(9):e0138580. PMID: 26402223.
    View in: PubMed
  6. Wu YT, Yue F, Wang M, Lu YL, Dai J, Ding QL, Wang HL, Chen HF, Wang XF. Hereditary protein C deficiency caused by compound heterozygous mutants in two independent Chinese families. Pathology. 2014 Dec; 46(7):630-5. PMID: 25393254.
    View in: PubMed
  7. Veres A, Gosis BS, Ding Q, Collins R, Ragavendran A, Brand H, Erdin S, Cowan CA, Talkowski ME, Musunuru K. Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing. Cell Stem Cell. 2014 Jul 3; 15(1):27-30. PMID: 24996167; PMCID: PMC4082799.
  8. Ding Q, Strong A, Patel KM, Ng SL, Gosis BS, Regan SN, Cowan CA, Rader DJ, Musunuru K. Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing. Circ Res. 2014 Aug 15; 115(5):488-92. PMID: 24916110; PMCID: PMC4134749.
  9. Ding Q, Cowan CA. Liver in a dish. Cell Res. 2013 Nov; 23(11):1242-3. PMID: 23979015; PMCID: PMC3817545.
  10. Wu X, Lu YL, Ding QL, Dai J, Xi XD, Wang HL, Wang XF. [The binding mechanisms of F VIII Trp1707Ser mutation-associated inhibitor]. Zhonghua Xue Ye Xue Za Zhi. 2013 Aug; 34(8):691-5. PMID: 23978021.
    View in: PubMed
  11. Ding Q, Regan SN, Xia Y, Oostrom LA, Cowan CA, Musunuru K. Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs. Cell Stem Cell. 2013 Apr 4; 12(4):393-4. PMID: 23561441; PMCID: PMC3925309.
  12. Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA. A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell. 2013 Feb 7; 12(2):238-51. PMID: 23246482; PMCID: PMC3570604.
  13. Zhu L, Wang L, Luo X, Zhang Y, Ding Q, Jiang X, Wang X, Pan Y, Chen Y. Tollip, an intracellular trafficking protein, is a novel modulator of the transforming growth factor-ß signaling pathway. J Biol Chem. 2012 Nov 16; 287(47):39653-63. PMID: 23027871; PMCID: PMC3501082.
  14. Jiang LL, Cao YN, Wang XF, Ding QL, Xu GQ, Zhang LW, Dai J, Lu YL, Wang HL, Xi XD. [The phenotypic and genotypic diagnosis of three Chinese patients with von Willebrand disease]. Zhonghua Nei Ke Za Zhi. 2012 Oct; 51(10):788-92. PMID: 23290978.
    View in: PubMed
  15. Huang H, Jin T, He J, Ding Q, Xu D, Wang L, Zhang Y, Pan Y, Wang Z, Chen Y. Progesterone and adipoQ receptor 11 links ras signaling to cardiac development in zebrafish. Arterioscler Thromb Vasc Biol. 2012 Sep; 32(9):2158-70. PMID: 22814753.
    View in: PubMed
  16. Strong A, Ding Q, Edmondson AC, Millar JS, Sachs KV, Li X, Kumaravel A, Wang MY, Ai D, Guo L, Alexander ET, Nguyen D, Lund-Katz S, Phillips MC, Morales CR, Tall AR, Kathiresan S, Fisher EA, Musunuru K, Rader DJ. Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. J Clin Invest. 2012 Aug; 122(8):2807-16. PMID: 22751103; PMCID: PMC3408750.
  17. Jiang LL, Wang XF, Ding QL, Xu GQ, Zhang LW, Dai J, Lu YL, Xi XD, Wang HL. [Genotype and function analyses of four inherited dysfibrinogenemia pedigree caused by Arg16 amino acid substitution in fibrinogen Aa chain]. Zhonghua Xue Ye Xue Za Zhi. 2012 Jun; 33(6):475-9. PMID: 22967385.
    View in: PubMed
  18. Jin T, Xu D, Ding Q, Zhang Y, Mao C, Pan Y, Wang Z, Chen Y. Identification of the topology and functional domains of PAQR10. Biochem J. 2012 May 1; 443(3):643-53. PMID: 22339580.
    View in: PubMed
  19. Xia Y, Lu QY, Lu YL, Dai J, Ding QL, Wang XF, Xi XD, Wang HL. Molecular basis of type I antithrombin deficiency in two women with recurrent venous thromboembolism in the first trimester of pregnancy. Blood Cells Mol Dis. 2012 Apr 15; 48(4):254-9. PMID: 22424603.
    View in: PubMed
  20. Zhu TN, Zhao YQ, Ding QL, Bai X, Wang XY, Wang XF, Yang RC, Wang ZY, Hua BL, Wel XQ, Ruan CG, Schlegel N. [The activity levels and prevalence of deficiency of protein C, protein S and antithrombin in Chinese Han population]. Zhonghua Xue Ye Xue Za Zhi. 2012 Feb; 33(2):127-30. PMID: 22730664.
    View in: PubMed
  21. Xia Y, Ding QL, Xu GQ, Zhang LW, Dai J, Lu YL, Wang XF, Xi XD, Wang HL. [Molecular mechanisms of recurrent venous thrombosis in two pedigrees with type I antithrombin deficiency]. Zhonghua Xue Ye Xue Za Zhi. 2011 Dec; 32(12):848-53. PMID: 22339960.
    View in: PubMed
  22. Jin T, Ding Q, Huang H, Xu D, Jiang Y, Zhou B, Li Z, Jiang X, He J, Liu W, Zhang Y, Pan Y, Wang Z, Thomas WG, Chen Y. PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. Cell Res. 2012 Apr; 22(4):661-76. PMID: 21968647; PMCID: PMC3317553.
  23. Qin HH, Wang XF, Ding QL, Lu YL, Dai J, Xi XD, Wang HL. [Molecular analysis of a patient with hemophilia A caused by FVIII His99Arg mutation]. Zhonghua Xue Ye Xue Za Zhi. 2011 Sep; 32(9):587-91. PMID: 22338150.
    View in: PubMed
  24. Luo X, Zhang Y, Ruan X, Jiang X, Zhu L, Wang X, Ding Q, Liu W, Pan Y, Wang Z, Chen Y. Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis. Diabetes. 2011 May; 60(5):1435-45. PMID: 21471512; PMCID: PMC3292316.
  25. Ouyang Q, Ding QL, Huang DD, Xu GQ, Zhang LW, Dai J, Lu YL, Wang XF, Xi XD, Wang HL. [Analysis of phenotype and genotype in three Chinese pedigrees with inherited dysfibrinogenemia]. Zhonghua Xue Ye Xue Za Zhi. 2011 Mar; 32(3):153-7. PMID: 21535951.
    View in: PubMed
  26. Qin HH, Wang XF, Ding QL, Xu GQ, Zhang LW, Dai J, Lu YL, Xi XD, Wang HL. [Phenotype and genotype analysis of three Chinese pedigrees with von Willebrand disease]. Zhonghua Xue Ye Xue Za Zhi. 2011 Feb; 32(2):99-102. PMID: 21429375.
    View in: PubMed
  27. Luo X, Ding Q, Wang M, Li Z, Mao K, Sun B, Pan Y, Wang Z, Zang YQ, Chen Y. In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. PLoS One. 2010; 5(4):e10149. PMID: 20405019.
    View in: PubMed
  28. Chen Q, Lu YL, Xu GQ, Ding QL, Wang XF, Xi XD, Wang HL. [Two new mutations of AT gene in type I inherited antithrombin deficiency.]. Zhonghua Xue Ye Xue Za Zhi. 2010 Mar; 31(3):145-8. PMID: 20510100.
    View in: PubMed
  29. Huang DD, Wang XF, Chen HY, Xu GQ, Zhang LW, Dai J, Lu YL, Ding QL, Xi XD, Wang HL. [Analysis of phenotype and genotype in four Chinese pedigrees with inherited coagulation factor V deficiency.]. Zhonghua Xue Ye Xue Za Zhi. 2010 Mar; 31(3):149-53. PMID: 20510101.
    View in: PubMed
  30. Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W, Liu Y. A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal. 2010 Jan 26; 3(106):ra7. PMID: 20103773; PMCID: PMC2940714.
  31. Liu HC, Mao CM, Su XY, Ruan Z, Ding QL, Wang XF, Wang HL, Xi XD. [Preparation and characterization of a monoclonal antibody against human c-Kit]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Jul; 25(7):619-22. PMID: 19737481.
    View in: PubMed
  32. Ding Q, Wang Z, Chen Y. Endocytosis of adiponectin receptor 1 through a clathrin- and Rab5-dependent pathway. Cell Res. 2009 Mar; 19(3):317-27. PMID: 18982021.
    View in: PubMed
  33. Jin PP, Wang XF, Ding QL, Fu QH, Cai XH, Shen LS, Wang HL. Ser234Leu missense mutation in the A1 domain of factor V causing moderate factor V deficiency in a Chinese family. Pathology. 2009; 41(6):566-71. PMID: 19900106.
    View in: PubMed
  34. Feng L, Xie X, Ding Q, Luo X, He J, Fan F, Liu W, Wang Z, Chen Y. Spatial regulation of Raf kinase signaling by RKTG. Proc Natl Acad Sci U S A. 2007 Sep 4; 104(36):14348-53. PMID: 17724343.
    View in: PubMed
  35. Ding Q, Jin T, Wang Z, Chen Y. Catalase potentiates retinoic acid-induced THP-1 monocyte differentiation into macrophage through inhibition of peroxisome proliferator-activated receptor gamma. J Leukoc Biol. 2007 Jun; 81(6):1568-76. PMID: 17369494.
    View in: PubMed
  36. Zhou RF, Fu QH, Wang WB, Xie S, Dai J, Ding QL, Wang XF, Wang HL, Wang ZY. Molecular mechanisms of antithrombin deficiency in two Chinese families. One novel and one recurrent point mutation in the antithrombin gene causing venous thrombosis. Thromb Haemost. 2005 Dec; 94(6):1172-6. PMID: 16411389.
    View in: PubMed
  37. Wang WB, Fu QH, Yin J, Wu WM, Ding QL, Zhou RF, Hu YQ, Wang XF, Wang ZY, Wang HL. Factor X Shanghai and disruption of translocation to the endoplasmic reticulum. Haematologica. 2005 Dec; 90(12):1659-64. PMID: 16330440.
    View in: PubMed
  38. Wang WB, Fu QH, Ding QL, Zhou RF, Wu WM, Hu YQ, Wang XF, Yan LX, Wang ZY, Wang HL. Characterization of molecular defect of 13387-9delG mutated antithrombin in inherited type I antithrombin deficiency. Blood Coagul Fibrinolysis. 2005 Mar; 16(2):149-55. PMID: 15741804.
    View in: PubMed
  39. Ding QL, Wang HL, Wang XF, Wang MS, Fu QH, Wu WM, Hu YQ, Wang ZY. [Inherited coagulation factor VII deficiency caused by double heterozygotic mutations Arg304Gln and Arg304Trp]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Aug; 20(4):279-83. PMID: 12903033.
    View in: PubMed
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