Profiles Header - Harvard Catalyst Profiles Header – Harvard Catalyst

Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Da-Zhi Wang, PH.D.

Title
Institution
Department
Address
Phone
Fax
Profile Picture

Biography
2004
Basil O’Connor Scholar
2008
Established Investigator Award
2014
Elected Fellow

Overview
Our lab is interested in the molecular events that control gene expression during animal development. Using muscle (cardiac, skeletal and smooth) as model systems, we study transcriptional, epigenetic and microRNA (miRNA)-mediated post-transcriptional regulation of gene expression. We apply a variety of developmental, molecular, cellular, biochemical, genetic and physiological approaches, including transgenic and knockout mouse models in our lab.

The heart is the “heart” of life. Heart disease is the number one cause of mortality and morbidity world wide. Congenital heart disease occurs in one of every one hundred live births and is the most common human birth defect. Discovery of the genetic control and molecular mechanisms of heart development is an important prerequisite to develop novel therapies for human cardiovascular disease.

Mentoring
Available: 10/15/18, Expires: 10/01/20

Congenital heart disease (CHD) affects nearly 1% of all newborns and is the most common human birth defect. Heart disease is the number one killer on both sides of the age spectrum, resulting in significant mortality and morbidity in children and adults. The lab focuses on the molecular pathways, in particular non-coding RNAs (lncRNAs and miRNAs), in heart development, cardiac function and cardiovascular. You are expected to apply a variety of state-of-art approaches, including that of molecular, cellular, biochemistry and genetic technologies as well as animal models in your projects.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL138757 (WANG, DA-ZHI) Jul 15, 2017 - Jun 30, 2021
    NIH/NHLBI
    MicroRNAs, cardiac function and cardiomyopathy
    Role: Principal Investigator
  2. R01HL125925 (WANG, DA-ZHI) Jan 1, 2016 - Dec 31, 2019
    NIH/NHLBI
    Therapeutic applications of miRNAs in myocardial and cardiac regeneration
    Role: Principal Investigator
  3. R01HL116919 (WANG, DA-ZHI) Jul 1, 2013 - Jun 30, 2017
    NIH/NHLBI
    Molecular Mechanisms of Dilated Cardiomyopathy
    Role: Principal Investigator
  4. R01HL093242 (CHEN, HONG) Jul 1, 2008 - Jun 30, 2022
    NIH/NHLBI
    Epsin in Angiogenesis and Vascular Remodeling
    Role: Co-Principal Investigator
  5. R01HL085635 (WANG, DA-ZHI) Jul 1, 2006 - Nov 30, 2015
    NIH/NHLBI
    MicroRNAs, cardiac development and function
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Huang ZP, Wang DZ. miR-22 in Smooth Muscle Cells: A Potential Therapy for Cardiovascular Disease. Circulation. 2018 Apr 24; 137(17):1842-1845. PMID: 29685931.
    View in: PubMed
  2. Diniz GP, Huang ZP, Liu J, Chen J, Ding J, Fonseca RI, Barreto-Chaves ML, Donato J, Hu X, Wang DZ. Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy. Clin Sci (Lond). 2017 Dec 15; 131(24):2885-2900. PMID: 29101298.
    View in: PubMed
  3. Huang ZP, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng ZL, Seidman CE, Seidman JG, Pu WT, Wang DZ. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest. 2015 Nov 02; 125(11):4122-34. PMID: 26436652; PMCID: PMC4639982.
  4. Nie M, Deng ZL, Liu J, Wang DZ. Noncoding RNAs, Emerging Regulators of Skeletal Muscle Development and Diseases. Biomed Res Int. 2015; 2015:676575. PMID: 26258142; PMCID: PMC4516831.
  5. Ding J, Chen J, Wang Y, Kataoka M, Ma L, Zhou P, Hu X, Lin Z, Nie M, Deng ZL, Pu WT, Wang DZ. Trbp regulates heart function through microRNA-mediated Sox6 repression. Nat Genet. 2015 Jul; 47(7):776-83. PMID: 26029872; PMCID: PMC4485565.
  6. Prendiville TW, Guo H, Lin Z, Zhou P, Stevens SM, He A, VanDusen N, Chen J, Zhong L, Wang DZ, Gao G, Pu WT. Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase. PLoS One. 2015; 10(5):e0128105. PMID: 26023924; PMCID: PMC4449121.
  7. Ding J, Wang DZ. Mystery of Trbp, tale of a RBP in the miRNA pathway. Cell Cycle. 2015; 14(19):3007-8. PMID: 26496166; PMCID: PMC4825566 [Available on 10/23/16].
  8. Liu J, Wang DZ. An epigenetic "LINK(RNA)" to pathological cardiac hypertrophy. Cell Metab. 2014 Oct 07; 20(4):555-7. PMID: 25295782; PMCID: PMC4886471.
  9. Lin Z, Zhou P, von Gise A, Gu F, Ma Q, Chen J, Guo H, van Gorp PR, Wang DZ, Pu WT. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res. 2015 Jan 02; 116(1):35-45. PMID: 25249570; PMCID: PMC4282610.
  10. Espinoza-Lewis RA, Wang DZ. Generation of a Cre knock-in into the Myocardin locus to mark early cardiac and smooth muscle cell lineages. Genesis. 2014 Oct; 52(10):879-87. PMID: 25174608; PMCID: PMC4211964.
  11. Wu G, Cai J, Han Y, Chen J, Huang ZP, Chen C, Cai Y, Huang H, Yang Y, Liu Y, Xu Z, He D, Zhang X, Hu X, Pinello L, Zhong D, He F, Yuan GC, Wang DZ, Zeng C. LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity. Circulation. 2014 Oct 21; 130(17):1452-1465. PMID: 25156994; PMCID: PMC4244705.
  12. Kataoka M, Wang DZ. Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease. Cells. 2014 Aug 22; 3(3):883-98. PMID: 25153164; PMCID: PMC4197640.
  13. Huang ZP, Wang DZ. miR-22 in cardiac remodeling and disease. Trends Cardiovasc Med. 2014 Oct; 24(7):267-72. PMID: 25218673; PMCID: PMC4171194.
  14. Lin Z, von Gise A, Zhou P, Gu F, Ma Q, Jiang J, Yau AL, Buck JN, Gouin KA, van Gorp PR, Zhou B, Chen J, Seidman JG, Wang DZ, Pu WT. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ Res. 2014 Jul 18; 115(3):354-63. PMID: 24833660; PMCID: PMC4104149.
  15. Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 Jun; 20(6):616-23. PMID: 24813252.
    View in: PubMed
  16. Neppl RL, Kataoka M, Wang DZ. Crystallin-aB regulates skeletal muscle homeostasis via modulation of argonaute2 activity. J Biol Chem. 2014 Jun 13; 289(24):17240-8. PMID: 24782307; PMCID: PMC4059164.
  17. Seok HY, Chen J, Kataoka M, Huang ZP, Ding J, Yan J, Hu X, Wang DZ. Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy. Circ Res. 2014 May 09; 114(10):1585-95. PMID: 24657879; PMCID: PMC4033580.
  18. Jiang Y, Singh P, Yin H, Zhou YX, Gui Y, Wang DZ, Zheng XL. Opposite roles of myocardin and atrogin-1 in L6 myoblast differentiation. J Cell Physiol. 2013 Oct; 228(10):1989-95. PMID: 23526547; PMCID: PMC4278347.
  19. Wu G, Huang ZP, Wang DZ. MicroRNAs in cardiac regeneration and cardiovascular disease. Sci China Life Sci. 2013 Oct; 56(10):907-13. PMID: 23974704; PMCID: PMC3972258.
  20. Kataoka M, Huang ZP, Wang DZ. Build a braveheart: the missing linc (RNA). Circ Res. 2013 Jun 07; 112(12):1532-4. PMID: 23743224; PMCID: PMC3756483.
  21. Chen J, Huang ZP, Seok HY, Ding J, Kataoka M, Zhang Z, Hu X, Wang G, Lin Z, Wang S, Pu WT, Liao R, Wang DZ. mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res. 2013 Jun 07; 112(12):1557-66. PMID: 23575307; PMCID: PMC3756475.
  22. Huang ZP, Chen J, Seok HY, Zhang Z, Kataoka M, Hu X, Wang DZ. MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress. Circ Res. 2013 Apr 26; 112(9):1234-43. PMID: 23524588; PMCID: PMC3720677.
  23. Cao D, Wang C, Tang R, Chen H, Zhang Z, Tatsuguchi M, Wang DZ. Acetylation of myocardin is required for the activation of cardiac and smooth muscle genes. J Biol Chem. 2012 Nov 09; 287(46):38495-504. PMID: 23007391; PMCID: PMC3493894.
  24. Wang Q, Lin JL, Wu KH, Wang DZ, Reiter RS, Sinn HW, Lin CI, Lin CJ. Xin proteins and intercalated disc maturation, signaling and diseases. Front Biosci (Landmark Ed). 2012 Jun 01; 17:2566-93. PMID: 22652799; PMCID: PMC3368345.
  25. Huang ZP, Young Seok H, Zhou B, Chen J, Chen JF, Tao Y, Pu WT, Wang DZ. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ Res. 2012 Mar 16; 110(6):818-30. PMID: 22343712; PMCID: PMC3307880.
  26. Chen J, Wang DZ. microRNAs in cardiovascular development. J Mol Cell Cardiol. 2012 May; 52(5):949-57. PMID: 22300733; PMCID: PMC3721071.
  27. Espinoza-Lewis RA, Wang DZ. MicroRNAs in heart development. Curr Top Dev Biol. 2012; 100:279-317. PMID: 22449848; PMCID: PMC4888772.
  28. Huang ZP, Espinoza-Lewis R, Wang DZ. Determination of miRNA targets in skeletal muscle cells. Methods Mol Biol. 2012; 798:475-90. PMID: 22130855; PMCID: PMC4275444.
  29. Wang C, Cao D, Wang Q, Wang DZ. Synergistic activation of cardiac genes by myocardin and Tbx5. PLoS One. 2011; 6(8):e24242. PMID: 21897873; PMCID: PMC3163680.
  30. Seok HY, Tatsuguchi M, Callis TE, He A, Pu WT, Wang DZ. miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation. J Biol Chem. 2011 Oct 14; 286(41):35339-46. PMID: 21868385; PMCID: PMC3195620.
  31. Tao Y, Neppl RL, Huang ZP, Chen J, Tang RH, Cao R, Zhang Y, Jin SW, Wang DZ. The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. J Cell Biol. 2011 Aug 22; 194(4):551-65. PMID: 21859860; PMCID: PMC3160588.
  32. Deng Z, Chen JF, Wang DZ. Transgenic overexpression of miR-133a in skeletal muscle. BMC Musculoskelet Disord. 2011 May 26; 12:115. PMID: 21615921; PMCID: PMC3125252.
  33. Neppl RL, Wang DZ. 'CArG'ing for microRNAs. Gastroenterology. 2011 Jul; 141(1):24-7. PMID: 21620846.
    View in: PubMed
  34. Malizia AP, Wang DZ. MicroRNAs in cardiomyocyte development. Wiley Interdiscip Rev Syst Biol Med. 2011 Mar-Apr; 3(2):183-90. PMID: 21305703; PMCID: PMC3058499.
  35. Nguyen AT, Xiao B, Neppl RL, Kallin EM, Li J, Chen T, Wang DZ, Xiao X, Zhang Y. DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev. 2011 Feb 01; 25(3):263-74. PMID: 21289070; PMCID: PMC3034901.
  36. Ding J, Wang DZ. "RISCing" the heart: In vivo identification of cardiac microRNA targets by RISCome. Circ Res. 2011 Jan 07; 108(1):3-5. PMID: 21212388; PMCID: PMC4886476.
  37. Huang ZP, Neppl RL, Wang DZ. Application of microRNA in cardiac and skeletal muscle disease gene therapy. Methods Mol Biol. 2011; 709:197-210. PMID: 21194029; PMCID: PMC4886235.
  38. Chen J, Yin H, Jiang Y, Radhakrishnan SK, Huang ZP, Li J, Shi Z, Kilsdonk EP, Gui Y, Wang DZ, Zheng XL. Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation. Arterioscler Thromb Vasc Biol. 2011 Feb; 31(2):368-75. PMID: 21051663; PMCID: PMC3207238.
  39. Huang ZP, Chen JF, Regan JN, Maguire CT, Tang RH, Dong XR, Majesky MW, Wang DZ. Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2575-86. PMID: 20884876; PMCID: PMC2988089.
  40. Chen JF, Tao Y, Li J, Deng Z, Yan Z, Xiao X, Wang DZ. microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7. J Cell Biol. 2010 Sep 06; 190(5):867-79. PMID: 20819939; PMCID: PMC2935565.
  41. Mandel EM, Kaltenbrun E, Callis TE, Zeng XX, Marques SR, Yelon D, Wang DZ, Conlon FL. The BMP pathway acts to directly regulate Tbx20 in the developing heart. Development. 2010 Jun; 137(11):1919-29. PMID: 20460370; PMCID: PMC2867324.
  42. Seok HY, Wang DZ. The emerging role of microRNAs as a therapeutic target for cardiovascular disease. BioDrugs. 2010 Jun; 24(3):147-55. PMID: 20462281.
    View in: PubMed
  43. Huang ZP, Neppl RL, Wang DZ. MicroRNAs in cardiac remodeling and disease. J Cardiovasc Transl Res. 2010 Jun; 3(3):212-8. PMID: 20560042.
    View in: PubMed
  44. Wang DZ. MicroRNAs in cardiac development and remodeling. Pediatr Cardiol. 2010 Apr; 31(3):357-62. PMID: 20135107.
    View in: PubMed
  45. Sun Q, Taurin S, Sethakorn N, Long X, Imamura M, Wang DZ, Zimmer WE, Dulin NO, Miano JM. Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein. J Biol Chem. 2009 Nov 20; 284(47):32582-90. PMID: 19797053; PMCID: PMC2781672.
  46. Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, Chen JF, Deng Z, Gunn B, Shumate J, Willis MS, Selzman CH, Wang DZ. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest. 2009 Sep; 119(9):2772-86. PMID: 19726871; PMCID: PMC2735902.
  47. Neppl RL, Wang DZ. Smooth(ing) muscle differentiation by microRNAs. Cell Stem Cell. 2009 Aug 07; 5(2):130-2. PMID: 19664984; PMCID: PMC4285345.
  48. Yang L, Jiang J, Drouin LM, Agbandje-McKenna M, Chen C, Qiao C, Pu D, Hu X, Wang DZ, Li J, Xiao X. A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection. Proc Natl Acad Sci U S A. 2009 Mar 10; 106(10):3946-51. PMID: 19234115; PMCID: PMC2656185.
  49. Chen JF, Callis TE, Wang DZ. microRNAs and muscle disorders. J Cell Sci. 2009 Jan 01; 122(Pt 1):13-20. PMID: 19092056; PMCID: PMC2714401.
  50. Chen JF, Wang S, Wu Q, Cao D, Nguyen T, Chen Y, Wang DZ. Myocardin marks the earliest cardiac gene expression and plays an important role in heart development. Anat Rec (Hoboken). 2008 Oct; 291(10):1200-11. PMID: 18780304; PMCID: PMC2694184.
  51. Callis TE, Wang DZ. Taking microRNAs to heart. Trends Mol Med. 2008 Jun; 14(6):254-60. PMID: 18457996.
    View in: PubMed
  52. Tang RH, Zheng XL, Callis TE, Stansfield WE, He J, Baldwin AS, Wang DZ, Selzman CH. Myocardin inhibits cellular proliferation by inhibiting NF-kappaB(p65)-dependent cell cycle progression. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3362-7. PMID: 18296632; PMCID: PMC2265140.
  53. Chen JF, Murchison EP, Tang R, Callis TE, Tatsuguchi M, Deng Z, Rojas M, Hammond SM, Schneider MD, Selzman CH, Meissner G, Patterson C, Hannon GJ, Wang DZ. Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):2111-6. PMID: 18256189; PMCID: PMC2542870.
  54. Callis TE, Deng Z, Chen JF, Wang DZ. Muscling through the microRNA world. Exp Biol Med (Maywood). 2008 Feb; 233(2):131-8. PMID: 18222968.
    View in: PubMed
  55. Kim Y, Phan D, van Rooij E, Wang DZ, McAnally J, Qi X, Richardson JA, Hill JA, Bassel-Duby R, Olson EN. The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice. J Clin Invest. 2008 Jan; 118(1):124-32. PMID: 18079970; PMCID: PMC2129240.
  56. Long X, Creemers EE, Wang DZ, Olson EN, Miano JM. Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation. Proc Natl Acad Sci U S A. 2007 Oct 16; 104(42):16570-5. PMID: 17940050; PMCID: PMC2034223.
  57. Gustafson-Wagner EA, Sinn HW, Chen YL, Wang DZ, Reiter RS, Lin JL, Yang B, Williamson RA, Chen J, Lin CI, Lin JJ. Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H2680-92. PMID: 17766470; PMCID: PMC2394510.
  58. Tatsuguchi M, Seok HY, Callis TE, Thomson JM, Chen JF, Newman M, Rojas M, Hammond SM, Wang DZ. Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol. 2007 Jun; 42(6):1137-41. PMID: 17498736; PMCID: PMC1934409.
  59. Callis TE, Chen JF, Wang DZ. MicroRNAs in skeletal and cardiac muscle development. DNA Cell Biol. 2007 Apr; 26(4):219-25. PMID: 17465888.
    View in: PubMed
  60. Willis MS, Ike C, Li L, Wang DZ, Glass DJ, Patterson C. Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo. Circ Res. 2007 Mar 02; 100(4):456-9. PMID: 17272810; PMCID: PMC4112093.
  61. Wang H, Gilner JB, Bautch VL, Wang DZ, Wainwright BJ, Kirby SL, Patterson C. Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies. J Biol Chem. 2007 Jan 05; 282(1):782-91. PMID: 17098737.
    View in: PubMed
  62. Wang DZ. Micro or mega: how important are microRNAs in muscle? Cell Cycle. 2006 May; 5(10):1015-6. PMID: 16639081.
    View in: PubMed
  63. Xing W, Zhang TC, Cao D, Wang Z, Antos CL, Li S, Wang Y, Olson EN, Wang DZ. Myocardin induces cardiomyocyte hypertrophy. Circ Res. 2006 Apr 28; 98(8):1089-97. PMID: 16556869.
    View in: PubMed
  64. Chen JF, Mandel EM, Thomson JM, Wu Q, Callis TE, Hammond SM, Conlon FL, Wang DZ. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet. 2006 Feb; 38(2):228-33. PMID: 16380711; PMCID: PMC2538576.
  65. Callis TE, Cao D, Wang DZ. Bone morphogenetic protein signaling modulates myocardin transactivation of cardiac genes. Circ Res. 2005 Nov 11; 97(10):992-1000. PMID: 16224060; PMCID: PMC2930260.
  66. Qiu P, Ritchie RP, Fu Z, Cao D, Cumming J, Miano JM, Wang DZ, Li HJ, Li L. Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo. Circ Res. 2005 Nov 11; 97(10):983-91. PMID: 16224064.
    View in: PubMed
  67. Jung-Ching Lin J, Gustafson-Wagner EA, Sinn HW, Choi S, Jaacks SM, Wang DZ, Evans S, Li-Chun Lin J. Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin. J Med Sci. 2005 Oct; 25(5):215-222. PMID: 16708114.
    View in: PubMed
  68. Small EM, Warkman AS, Wang DZ, Sutherland LB, Olson EN, Krieg PA. Myocardin is sufficient and necessary for cardiac gene expression in Xenopus. Development. 2005 Mar; 132(5):987-97. PMID: 15673566.
    View in: PubMed
  69. Cao D, Wang Z, Zhang CL, Oh J, Xing W, Li S, Richardson JA, Wang DZ, Olson EN. Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol. 2005 Jan; 25(1):364-76. PMID: 15601857; PMCID: PMC538763.
  70. Wang DZ, Olson EN. Control of smooth muscle development by the myocardin family of transcriptional coactivators. Curr Opin Genet Dev. 2004 Oct; 14(5):558-66. PMID: 15380248.
    View in: PubMed
  71. Oh J, Wang Z, Wang DZ, Lien CL, Xing W, Olson EN. Target gene-specific modulation of myocardin activity by GATA transcription factors. Mol Cell Biol. 2004 Oct; 24(19):8519-28. PMID: 15367672; PMCID: PMC516760.
  72. Li HH, Kedar V, Zhang C, McDonough H, Arya R, Wang DZ, Patterson C. Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. J Clin Invest. 2004 Oct; 114(8):1058-71. PMID: 15489953; PMCID: PMC522252.
  73. Wang Z, Wang DZ, Hockemeyer D, McAnally J, Nordheim A, Olson EN. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature. 2004 Mar 11; 428(6979):185-9. PMID: 15014501.
    View in: PubMed
  74. Li S, Wang DZ, Wang Z, Richardson JA, Olson EN. The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9366-70. PMID: 12867591; PMCID: PMC170924.
  75. Wang Z, Wang DZ, Pipes GC, Olson EN. Myocardin is a master regulator of smooth muscle gene expression. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7129-34. PMID: 12756293; PMCID: PMC165841.
  76. Yoshida T, Sinha S, Dandré F, Wamhoff BR, Hoofnagle MH, Kremer BE, Wang DZ, Olson EN, Owens GK. Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes. Circ Res. 2003 May 02; 92(8):856-64. PMID: 12663482.
    View in: PubMed
  77. Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, Richardson JA, Nordheim A, Olson EN. Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14855-60. PMID: 12397177; PMCID: PMC137508.
  78. Shin CH, Liu ZP, Passier R, Zhang CL, Wang DZ, Harris TM, Yamagishi H, Richardson JA, Childs G, Olson EN. Modulation of cardiac growth and development by HOP, an unusual homeodomain protein. Cell. 2002 Sep 20; 110(6):725-35. PMID: 12297046.
    View in: PubMed
  79. Wang DZ, Valdez MR, McAnally J, Richardson J, Olson EN. The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development. Development. 2001 Nov; 128(22):4623-33. PMID: 11714687.
    View in: PubMed
  80. Wang D, Chang PS, Wang Z, Sutherland L, Richardson JA, Small E, Krieg PA, Olson EN. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell. 2001 Jun 29; 105(7):851-62. PMID: 11439182.
    View in: PubMed
  81. Wang DZ, Reiter RS, Lin JL, Wang Q, Williams HS, Krob SL, Schultheiss TM, Evans S, Lin JJ. Requirement of a novel gene, Xin, in cardiac morphogenesis. Development. 1999 Mar; 126(6):1281-94. PMID: 10021346.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Wang's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (332)
Explore
_
Co-Authors (16)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Tool Page Footer - Harvard Catalyst Tool Page Footer – Harvard Catalyst
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.