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Last Name

profileKrista F.g. Huybrechts, Ph.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
AddressBrigham and Women's Hospital
General Medicine.Pharmocoepidemiology
1620 Tremont St
Boston MA 02120
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
K01MH099141     (HUYBRECHTS, KRISTA F)Aug 1, 2013 - May 31, 2018
Improved methods to assess the comparative safety of new psychiatric medications
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bateman BT, Patorno E, Desai RJ, Seely EW, Mogun H, Maeda A, Fischer MA, Hernandez-Diaz S, Huybrechts KF. Late Pregnancy ß Blocker Exposure and Risks of Neonatal Hypoglycemia and Bradycardia. Pediatrics. 2016 Sep; 138(3). PMID: 27577580.
    View in: PubMed
  2. Huybrechts KF, Hernández-Díaz S, Patorno E, Desai RJ, Mogun H, Dejene SZ, Cohen JM, Panchaud A, Cohen L, Bateman BT. Antipsychotic Use in Pregnancy and the Risk for Congenital Malformations. JAMA Psychiatry. 2016 Sep 1; 73(9):938-46. PMID: 27540849.
    View in: PubMed
  3. Desai RJ, Huybrechts KF, Bateman BT, Hernandez-Diaz S, Mogun H, Gopalakrishnan C, Patorno E, Kim SC. Brief Report: Patterns and Secular Trends in Use of Immunomodulatory Agents During Pregnancy in Women With Rheumatic Conditions. Arthritis Rheumatol. 2016 May; 68(5):1183-9. PMID: 26606742.
    View in: PubMed
  4. Ladha KS, Patorno E, Huybrechts KF, Liu J, Rathmell JP, Bateman BT. Variations in the Use of Perioperative Multimodal Analgesic Therapy. Anesthesiology. 2016 Apr; 124(4):837-45. PMID: 26835644.
    View in: PubMed
  5. Bateman BT, Franklin JM, Bykov K, Avorn J, Shrank WH, Brennan TA, Landon JE, Rathmell JP, Huybrechts KF, Fischer MA, Choudhry NK. Persistent opioid use following cesarean delivery: patterns and predictors among opioid-naïve women. Am J Obstet Gynecol. 2016 Sep; 215(3):353.e1-353.e18. PMID: 26996986; PMCID: PMC5003640 [Available on 09/01/17].
  6. Rough K, Bateman BT, Patorno E, Desai RJ, Park Y, Hernandez-Diaz S, Huybrechts KF. Suppression of Substance Abuse Claims in Medicaid Data and Rates of Diagnoses for Non-Substance Abuse Conditions. JAMA. 2016 Mar 15; 315(11):1164-6. PMID: 26978213.
    View in: PubMed
  7. Bateman BT, Butwick AJ, Huybrechts KF. In Response. Anesth Analg. 2015 Nov; 121(5):1397-8. PMID: 26484466.
    View in: PubMed
  8. Seeger JD, Bykov K, Bartels DB, Huybrechts K, Zint K, Schneeweiss S. Safety and effectiveness of dabigatran and warfarin in routine care of patients with atrial fibrillation. Thromb Haemost. 2015 Nov 25; 114(6):1277-89. PMID: 26446507.
    View in: PubMed
  9. Palmsten K, Hernández-Díaz S, Chambers CD, Mogun H, Lai S, Gilmer TP, Huybrechts KF. The Most Commonly Dispensed Prescription Medications Among Pregnant Women Enrolled in the U.S. Medicaid Program. Obstet Gynecol. 2015 Sep; 126(3):465-73. PMID: 26244530.
    View in: PubMed
  10. Huybrechts KF, Bateman BT, Hernandez-Diaz S. Maternal Antidepressant Use and Persistent Pulmonary Hypertension of the Newborn--Reply. JAMA. 2015 Sep 22-29; 314(12):1294. PMID: 26393857.
    View in: PubMed
  11. Bateman BT, Huybrechts KF, Maeda A, Desai R, Patorno E, Seely EW, Ecker JL, Allen-Coleman C, Mogun H, Hernandez-Diaz S, Fischer MA. Calcium Channel Blocker Exposure in Late Pregnancy and the Risk of Neonatal Seizures. Obstet Gynecol. 2015 Aug; 126(2):271-8. PMID: 26241414; PMCID: PMC4526118 [Available on 08/01/16].
  12. Swanson SA, Hernandez-Diaz S, Palmsten K, Mogun H, Olfson M, Huybrechts KF. Methodological considerations in assessing the effectiveness of antidepressant medication continuation during pregnancy using administrative data. Pharmacoepidemiol Drug Saf. 2015 Sep; 24(9):934-42. PMID: 26045370.
    View in: PubMed
  13. Huybrechts KF, Bateman BT, Palmsten K, Desai RJ, Patorno E, Gopalakrishnan C, Levin R, Mogun H, Hernandez-Diaz S. Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn. JAMA. 2015 Jun 2; 313(21):2142-51. PMID: 26034955.
    View in: PubMed
  14. Desai RJ, Huybrechts KF, Hernandez-Diaz S, Mogun H, Patorno E, Kaltenbach K, Kerzner LS, Bateman BT. Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study. BMJ. 2015; 350:h2102. PMID: 25975601; PMCID: PMC4431352.
  15. Bateman BT, Hernandez-Diaz S, Fischer MA, Seely EW, Ecker JL, Franklin JM, Desai RJ, Allen-Coleman C, Mogun H, Avorn J, Huybrechts KF. Statins and congenital malformations: cohort study. BMJ. 2015; 350:h1035. PMID: 25784688; PMCID: PMC4362473.
  16. Park Y, Franklin JM, Schneeweiss S, Levin R, Crystal S, Gerhard T, Huybrechts KF. Antipsychotics and mortality: adjusting for mortality risk scores to address confounding by terminal illness. J Am Geriatr Soc. 2015 Mar; 63(3):516-23. PMID: 25752911; PMCID: PMC4374043 [Available on 03/06/16].
  17. Franklin JM, Schneeweiss S, Huybrechts KF, Glynn RJ. Evaluating possible confounding by prescriber in comparative effectiveness research. Epidemiology. 2015 Mar; 26(2):238-41. PMID: 25643103; PMCID: PMC4347927 [Available on 03/01/16].
  18. Kesselheim AS, Huybrechts KF, Choudhry NK, Fulchino LA, Isaman DL, Kowal MK, Brennan TA. Prescription drug insurance coverage and patient health outcomes: a systematic review. Am J Public Health. 2015 Feb; 105(2):e17-30. PMID: 25521879; PMCID: PMC4318289 [Available on 02/01/16].
  19. Bateman BT, Tsen LC, Liu J, Butwick AJ, Huybrechts KF. Patterns of second-line uterotonic use in a large sample of hospitalizations for childbirth in the United States: 2007-2011. Anesth Analg. 2014 Dec; 119(6):1344-9. PMID: 25166464; PMCID: PMC4321970 [Available on 12/01/15].
  20. Bateman BT, Huybrechts KF, Fischer MA, Seely EW, Ecker JL, Oberg AS, Franklin JM, Mogun H, Hernandez-Diaz S. Chronic hypertension in pregnancy and the risk of congenital malformations: a cohort study. Am J Obstet Gynecol. 2015 Mar; 212(3):337.e1-14. PMID: 25265405; PMCID: PMC4346443 [Available on 03/01/16].
  21. Checchi KD, Huybrechts KF, Avorn J, Kesselheim AS. Electronic medication packaging devices and medication adherence: a systematic review. JAMA. 2014 Sep 24; 312(12):1237-47. PMID: 25247520; PMCID: PMC4209732.
  22. Huybrechts KF, Hernández-Díaz S, Avorn J. Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med. 2014 Sep 18; 371(12):1168-9. PMID: 25229932.
    View in: PubMed
  23. Desai RJ, Hernandez-Diaz S, Bateman BT, Huybrechts KF. In Reply: Cho et al. Obstet Gynecol. 2014 Sep; 124(3):638. PMID: 25162278.
    View in: PubMed
  24. Huybrechts KF, Palmsten K, Avorn J, Cohen LS, Holmes LB, Franklin JM, Mogun H, Levin R, Kowal M, Setoguchi S, Hernández-Díaz S. Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med. 2014 Jun 19; 370(25):2397-407. PMID: 24941178; PMCID: PMC4062924.
  25. Bateman BT, Hernandez-Diaz S, Rathmell JP, Seeger JD, Doherty M, Fischer MA, Huybrechts KF. Patterns of opioid utilization in pregnancy in a large cohort of commercial insurance beneficiaries in the United States. Anesthesiology. 2014 May; 120(5):1216-24. PMID: 24525628; PMCID: PMC3999216.
  26. Desai RJ, Hernandez-Diaz S, Bateman BT, Huybrechts KF. Increase in prescription opioid use during pregnancy among Medicaid-enrolled women. Obstet Gynecol. 2014 May; 123(5):997-1002. PMID: 24785852; PMCID: PMC4020039.
  27. Palmsten K, Huybrechts KF, Kowal MK, Mogun H, Hernández-Díaz S. Validity of maternal and infant outcomes within nationwide Medicaid data. Pharmacoepidemiol Drug Saf. 2014 Jun; 23(6):646-55. PMID: 24740606; PMCID: PMC4205050.
  28. Huybrechts KF, Sanghani RS, Avorn J, Urato AC. Preterm birth and antidepressant medication use during pregnancy: a systematic review and meta-analysis. PLoS One. 2014; 9(3):e92778. PMID: 24671232; PMCID: PMC3966829.
  29. Huybrechts KF, Gerhard T, Franklin JM, Levin R, Crystal S, Schneeweiss S. Instrumental variable applications using nursing home prescribing preferences in comparative effectiveness research. Pharmacoepidemiol Drug Saf. 2014 Aug; 23(8):830-8. PMID: 24664805; PMCID: PMC4116440.
  30. Bateman BT, Mhyre JM, Hernandez-Diaz S, Huybrechts KF, Fischer MA, Creanga AA, Callaghan WM, Gagne JJ. Development of a comorbidity index for use in obstetric patients. Obstet Gynecol. 2013 Nov; 122(5):957-65. PMID: 24104771; PMCID: PMC3829199.
  31. Bateman BT, Hernandez-Diaz S, Huybrechts KF, Palmsten K, Mogun H, Ecker JL, Seely EW, Fischer MA. Outpatient calcium-channel blockers and the risk of postpartum haemorrhage: a cohort study. BJOG. 2013 Dec; 120(13):1668-76; dicussion 1676-7. PMID: 24020971; PMCID: PMC3866215.
  32. Palmsten K, Huybrechts KF, Michels KB, Williams PL, Mogun H, Setoguchi S, Hernández-Díaz S. Antidepressant use and risk for preeclampsia. Epidemiology. 2013 Sep; 24(5):682-91. PMID: 23873072; PMCID: PMC4159745.
  33. Palmsten K, Hernández-Díaz S, Huybrechts KF, Williams PL, Michels KB, Achtyes ED, Mogun H, Setoguchi S. Use of antidepressants near delivery and risk of postpartum hemorrhage: cohort study of low income women in the United States. BMJ. 2013; 347:f4877. PMID: 23965506; PMCID: PMC3748906.
  34. Gerhard T, Huybrechts K, Olfson M, Schneeweiss S, Bobo WV, Doraiswamy PM, Devanand DP, Lucas JA, Huang C, Malka ES, Levin R, Crystal S. Comparative mortality risks of antipsychotic medications in community-dwelling older adults. Br J Psychiatry. 2014 Jul; 205(1):44-51. PMID: 23929443.
    View in: PubMed
  35. Bateman BT, Huybrechts KF, Hernandez-Diaz S, Liu J, Ecker JL, Avorn J. Methylergonovine maleate and the risk of myocardial ischemia and infarction. Am J Obstet Gynecol. 2013 Nov; 209(5):459.e1-459.e13. PMID: 23850529; PMCID: PMC4103983.
  36. Palmsten K, Huybrechts KF, Mogun H, Kowal MK, Williams PL, Michels KB, Setoguchi S, Hernández-Díaz S. Harnessing the Medicaid Analytic eXtract (MAX) to Evaluate Medications in Pregnancy: Design Considerations. PLoS One. 2013; 8(6):e67405. PMID: 23840692.
    View in: PubMed
  37. Brunelli SM, Gagne JJ, Huybrechts KF, Wang SV, Patrick AR, Rothman KJ, Seeger JD. Estimation using all available covariate information versus a fixed look-back window for dichotomous covariates. Pharmacoepidemiol Drug Saf. 2013 May; 22(5):542-50. PMID: 23526818; PMCID: PMC3653131.
  38. Huybrechts KF, Palmsten K, Mogun H, Kowal M, Avorn J, Setoguchi-Iwata S, Hernández-Díaz S. National trends in antidepressant medication treatment among publicly insured pregnant women. Gen Hosp Psychiatry. 2013 May-Jun; 35(3):265-71. PMID: 23374897; PMCID: PMC4077674.
  39. Bateman BT, Hernandez-Diaz S, Huybrechts KF, Palmsten K, Mogun H, Ecker JL, Fischer MA. Patterns of outpatient antihypertensive medication use during pregnancy in a Medicaid population. Hypertension. 2012 Oct; 60(4):913-20. PMID: 22966012; PMCID: PMC3501756.
  40. Huybrechts KF, Seeger JD, Rothman KJ, Glynn RJ, Avorn J, Schneeweiss S. Bias in comparative effectiveness studies due to regional variation in medical practice intensity: a legitimate concern, or much ado about nothing? Circ Cardiovasc Qual Outcomes. 2012 Sep 1; 5(5):e61-4. PMID: 22991351; PMCID: PMC3519359.
  41. Zoëga H, Rothman KJ, Huybrechts KF, Ólafsson Ö, Baldursson G, Almarsdóttir AB, Jónsdóttir S, Halldórsson M, Hernández-Diaz S, Valdimarsdóttir UA. A population-based study of stimulant drug treatment of ADHD and academic progress in children. Pediatrics. 2012 Jul; 130(1):e53-62. PMID: 22732167.
    View in: PubMed
  42. Huybrechts KF, Gerhard T, Crystal S, Olfson M, Avorn J, Levin R, Lucas JA, Schneeweiss S. Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study. BMJ. 2012; 344:e977. PMID: 22362541; PMCID: PMC3285717.
  43. Huybrechts KF, Schneeweiss S, Gerhard T, Olfson M, Avorn J, Levin R, Lucas JA, Crystal S. Comparative safety of antipsychotic medications in nursing home residents. J Am Geriatr Soc. 2012 Mar; 60(3):420-9. PMID: 22329464; PMCID: PMC3302976.
  44. Huybrechts KF, Rothman KJ, Brookhart MA, Silliman RA, Crystal S, Gerhard T, Schneeweiss S. Variation in antipsychotic treatment choice across US nursing homes. J Clin Psychopharmacol. 2012 Feb; 32(1):11-7. PMID: 22198446.
    View in: PubMed
  45. Myers JA, Rassen JA, Gagne JJ, Huybrechts KF, Schneeweiss S, Rothman KJ, Joffe MM, Glynn RJ. Effects of adjusting for instrumental variables on bias and precision of effect estimates. Am J Epidemiol. 2011 Dec 1; 174(11):1213-22. PMID: 22025356; PMCID: PMC3254160.
  46. Huybrechts KF, Brookhart MA, Rothman KJ, Silliman RA, Gerhard T, Crystal S, Schneeweiss S. Comparison of different approaches to confounding adjustment in a study on the association of antipsychotic medication with mortality in older nursing home patients. Am J Epidemiol. 2011 Nov 1; 174(9):1089-99. PMID: 21934095; PMCID: PMC3243935.
  47. Wise LA, Mikkelsen EM, Rothman KJ, Riis AH, Sørensen HT, Huybrechts KF, Hatch EE. A prospective cohort study of menstrual characteristics and time to pregnancy. Am J Epidemiol. 2011 Sep 15; 174(6):701-9. PMID: 21719742; PMCID: PMC3166706.
  48. Cosgrove L, Shi L, Creasey DE, Anaya-McKivergan M, Myers JA, Huybrechts KF. Antidepressants and breast and ovarian cancer risk: a review of the literature and researchers' financial associations with industry. PLoS One. 2011; 6(4):e18210. PMID: 21494667; PMCID: PMC3071810.
  49. Huybrechts KF, Rothman KJ, Silliman RA, Brookhart MA, Schneeweiss S. Risk of death and hospital admission for major medical events after initiation of psychotropic medications in older adults admitted to nursing homes. CMAJ. 2011 Apr 19; 183(7):E411-9. PMID: 21444611; PMCID: PMC3080558.
  50. Huybrechts KF, Mikkelsen EM, Christensen T, Riis AH, Hatch EE, Wise LA, Sørensen HT, Rothman KJ. A successful implementation of e-epidemiology: the Danish pregnancy planning study 'Snart-Gravid'. Eur J Epidemiol. 2010 May; 25(5):297-304. PMID: 20148289; PMCID: PMC2945880.
  51. Caro JJ, Huybrechts KF. Case-control studies in pharmacoeconomic research: an overview. Pharmacoeconomics. 2009; 27(8):627-34. PMID: 19712006.
    View in: PubMed
  52. Huybrechts KF, Caro JJ, Xenakis JJ, Vemmos KN. The prognostic value of the modified Rankin Scale score for long-term survival after first-ever stroke. Results from the Athens Stroke Registry. Cerebrovasc Dis. 2008; 26(4):381-7. PMID: 18753743.
    View in: PubMed
  53. Huybrechts KF, Caro JJ, O'Brien JA. Prevention and management of hyperphosphatemia with sevelamer in Canada: health and economic consequences. Value Health. 2009 Jan-Feb; 12(1):16-9. PMID: 18647261.
    View in: PubMed
  54. Huybrechts KF, Caro JJ. The Barthel Index and modified Rankin Scale as prognostic tools for long-term outcomes after stroke: a qualitative review of the literature. Curr Med Res Opin. 2007 Jul; 23(7):1627-36. PMID: 17559756.
    View in: PubMed
  55. Caro JJ, Huybrechts KF, Xenakis JG, O'Brien JA, Rajagopalan K, Lee K. Budgetary impact of treating acute bipolar mania in hospitalized patients with quetiapine: an economic analysis of clinical trials. Curr Med Res Opin. 2006 Nov; 22(11):2233-42. PMID: 17076984.
    View in: PubMed
  56. Caro JJ, Xenakis JG, Huybrechts KF. Ignoring study design heterogeneity in meta-analyses. Arch Intern Med. 2006 Oct 9; 166(18):2046; author reply 2046-7. PMID: 17030841.
    View in: PubMed
  57. Huybrechts KF, Ishak KJ, Caro JJ. Assessment of compliance with osteoporosis treatment and its consequences in a managed care population. Bone. 2006 Jun; 38(6):922-8. PMID: 16330270.
    View in: PubMed
  58. Huybrechts KF, Caro JJ, Wilson DA, O'Brien JA. Health and economic consequences of sevelamer use for hyperphosphatemia in patients on hemodialysis. Value Health. 2005 Sep-Oct; 8(5):549-61. PMID: 16176493.
    View in: PubMed
  59. Huybrechts KF, Caro JJ, London GM. Modeling the implications of changes in vascular calcification in patients on hemodialysis. Kidney Int. 2005 Apr; 67(4):1532-8. PMID: 15780108.
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  60. Caro JJ, Ishak KJ, Huybrechts KF, Raggio G, Naujoks C. The impact of compliance with osteoporosis therapy on fracture rates in actual practice. Osteoporos Int. 2004 Dec; 15(12):1003-8. PMID: 15167989.
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  61. Caro J, Huybrechts KF, Klittich WS, Jackson JD, McGuire A. Allocating funds for cardiovascular disease prevention in light of the NCEP ATP III guidelines. Am J Manag Care. 2003 Jul; 9(7):477-89. PMID: 12866627.
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  62. Ward A, Caro JJ, Green TC, Huybrechts K, Arana A, Wait S, Eleftheriou A. An international survey of patients with thalassemia major and their views about sustaining life-long desferrioxamine use. BMC Clin Pharmacol. 2002 Apr 23; 2:3. PMID: 12015817; PMCID: PMC111194.
  63. Caro JJ, Ward A, Green TC, Huybrechts K, Arana A, Wait S, Eleftheriou A. Impact of thalassemia major on patients and their families. Acta Haematol. 2002; 107(3):150-7. PMID: 11978936.
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  64. Payne KA, Huybrechts KF, Caro JJ, Craig Green TJ, Klittich WS. Long term cost-of-illness in stroke: an international review. Pharmacoeconomics. 2002; 20(12):813-25. PMID: 12236803.
    View in: PubMed
  65. Caro JJ, Huybrechts KF, Klittich WS. Secondary prevention fallacy: pitfalls in comparing with primary. Expert Rev Pharmacoecon Outcomes Res. 2001 Oct; 1(1):13-8. PMID: 19807503.
    View in: PubMed
  66. Caro JJ, Huybrechts KF, Kelley HE. Predicting treatment costs after acute ischemic stroke on the basis of patient characteristics at presentation and early dysfunction. Stroke. 2001 Jan; 32(1):100-6. PMID: 11136922.
    View in: PubMed
  67. Caro JJ, Huybrechts KF, De Backer G, De Bacquer D, Closon MC. Are the WOSCOPS clinical and economic findings generalizable to other populations? A case study for Belgium. The WOSCOPS Economic Analysis Group. West of Scotland Coronary Prevention Study. Acta Cardiol. 2000 Aug; 55(4):239-46. PMID: 11041122.
    View in: PubMed
  68. Caro JJ, Huybrechts KF, Duchesne I. Management patterns and costs of acute ischemic stroke : an international study. For the Stroke Economic Analysis Group. Stroke. 2000 Mar; 31(3):582-90. PMID: 10700489.
    View in: PubMed
  69. Caro JJ, Huybrechts KF. Stroke treatment economic model (STEM): predicting long-term costs from functional status. Stroke. 1999 Dec; 30(12):2574-9. PMID: 10582980.
    View in: PubMed
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